{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:28:37Z","timestamp":1781321317675,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s10753-014-0044-6","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T11:46:54Z","timestamp":1414410414000},"page":"400-408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Lipoxin A4 Suppresses Lipopolysaccharide-Induced Hela Cell Proliferation and Migration via NF-\u03baB Pathway"],"prefix":"10.1007","volume":"38","author":[{"given":"Hua","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Qiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"issue":"2","key":"44_CR1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10555-010-9224-5","volume":"29","author":"EC Finger","year":"2010","unstructured":"Finger, E.C., and A.J. Giaccia. 2010. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Reviews 29(2): 285\u2013293.","journal-title":"Cancer Metastasis Reviews"},{"issue":"3","key":"44_CR2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1365-2796.2000.00742.x","volume":"248","author":"H Kuper","year":"2000","unstructured":"Kuper, H., H.O. Adami, and D. Trichopoulos. 2000. Infections as a major preventable cause of human cancer. Journal of Internal Medicine 248(3): 171\u2013183.","journal-title":"Journal of Internal Medicine"},{"issue":"6","key":"44_CR3","first-page":"387","volume":"6","author":"P Pisani","year":"1997","unstructured":"Pisani, P., D.M. Parkin, N. Munoz, et al. 1997. Cancer and infection: estimates of the attributable fraction in 1990. Cancer Epidemiology, Biomarkers & Prevention 6(6): 387\u2013400.","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"issue":"8","key":"44_CR4","first-page":"2085","volume":"60","author":"MA Rahman","year":"2000","unstructured":"Rahman, M.A., D.K. Dhar, R. Masunaga, et al. 2000. Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines. Cancer Research 60(8): 2085\u20132089.","journal-title":"Cancer Research"},{"key":"44_CR5","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1100\/tsw.2006.192","volume":"6","author":"T Morris","year":"2006","unstructured":"Morris, T., M. Stables, and D.W. Gilroy. 2006. New perspectives on aspirin and the endogenous control of acute inflammatory resolution. ScientificWorldJournal 6: 1048\u20131065.","journal-title":"ScientificWorldJournal"},{"issue":"1","key":"44_CR6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.canlet.2011.05.020","volume":"309","author":"H Hao","year":"2011","unstructured":"Hao, H., M. Liu, P. Wu, et al. 2011. Lipoxin A4 and its analog suppress hepatocellular carcinoma via remodeling tumor microenvironment. Cancer Letters 309(1): 85\u201394.","journal-title":"Cancer Letters"},{"issue":"8","key":"44_CR7","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1158\/1535-7163.MCT-10-0173","volume":"9","author":"Y Chen","year":"2010","unstructured":"Chen, Y., H. Hao, S. He, et al. 2010. Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Molecular Cancer Therapeutics 9(8): 2164\u20132174.","journal-title":"Molecular Cancer Therapeutics"},{"issue":"7007","key":"44_CR8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/431405a","volume":"431","author":"F Balkwill","year":"2004","unstructured":"Balkwill, F., and L.M. Coussens. 2004. Cancer: an inflammatory link. Nature 431(7007): 405\u2013406.","journal-title":"Nature"},{"issue":"1","key":"44_CR9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.abb.2008.07.002","volume":"478","author":"YS Li","year":"2008","unstructured":"Li, Y.S., P. Wu, X.Y. Zhou, et al. 2008. Formyl-peptide receptor like 1: a potent mediator of the Ca2+ release-activated Ca2+ current ICRAC. Archives of Biochemistry and Biophysics 478(1): 110\u2013118.","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"2","key":"44_CR10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1124\/jpet.300.2.385","volume":"300","author":"IM Fierro","year":"2002","unstructured":"Fierro, I.M., J.L. Kutok, and C.N. Serhan. 2002. Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). The Journal of Pharmacology and Experimental Therapeutics 300(2): 385\u2013392.","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"1","key":"44_CR11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000221379","volume":"84","author":"S Liu","year":"2009","unstructured":"Liu, S., P. Wu, D. Ye, et al. 2009. Effects of lipoxin A(4) on CoCl(2)-induced angiogenesis and its possible mechanisms in human umbilical vein endothelial cells. Pharmacology 84(1): 17\u201323.","journal-title":"Pharmacology"},{"issue":"9","key":"44_CR12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1872-034X.2009.00520.x","volume":"39","author":"XY Zhou","year":"2009","unstructured":"Zhou, X.Y., Y.S. Li, P. Wu, et al. 2009. Lipoxin A(4) inhibited hepatocyte growth factor-induced invasion of human hepatoma cells. Hepatology Research 39(9): 921\u2013930.","journal-title":"Hepatology Research"},{"issue":"4","key":"44_CR13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1530\/REP-12-0469","volume":"145","author":"J Xiong","year":"2013","unstructured":"Xiong, J., P. Zeng, X. Cheng, et al. 2013. Lipoxin A4 blocks embryo implantation by controlling estrogen receptor alpha activity. Reproduction 145(4): 411\u2013420.","journal-title":"Reproduction"},{"issue":"4","key":"44_CR14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.reprotox.2012.09.009","volume":"34","author":"F Lin","year":"2012","unstructured":"Lin, F., P. Zeng, Z. Xu, et al. 2012. Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms. Reproductive Toxicology 34(4): 677\u2013685.","journal-title":"Reproductive Toxicology"},{"issue":"10","key":"44_CR15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.placenta.2013.07.007","volume":"34","author":"F Lin","year":"2013","unstructured":"Lin, F., X. Yu, X. Zhang, et al. 2013. A synthetic analog of lipoxin A4 partially alleviates dexamethasone-induced fetal growth restriction in rats. Placenta 34(10): 941\u2013948.","journal-title":"Placenta"},{"key":"44_CR16","doi-asserted-by":"crossref","first-page":"745340","DOI":"10.1155\/2011\/745340","volume":"2011","author":"S Zheng","year":"2011","unstructured":"Zheng, S., Q. Wang, Q. He, et al. 2011. Novel biphasic role of LipoxinA(4) on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts. Mediators of Inflammation 2011: 745340.","journal-title":"Mediators of Inflammation"},{"issue":"4","key":"44_CR17","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s10753-014-9832-2","volume":"37","author":"YH Huang","year":"2014","unstructured":"Huang, Y.H., H.M. Wang, Z.Y. Cai, et al. 2014. Lipoxin A4 inhibits NF-kappaB activation and cell cycle progression in RAW264.7 cells. Inflammation 37(4): 1084\u20131090.","journal-title":"Inflammation"},{"issue":"5","key":"44_CR18","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s10753-013-9643-x","volume":"36","author":"XY Zhou","year":"2013","unstructured":"Zhou, X.Y., Z.J. Yu, D. Yan, et al. 2013. BML-111, a lipoxin receptor agonist, protected carbon tetrachloride-induced hepatic fibrosis in rats. Inflammation 36(5): 1101\u20131106.","journal-title":"Inflammation"},{"issue":"3","key":"44_CR19","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1096\/fj.11-198069","volume":"26","author":"F Simiele","year":"2012","unstructured":"Simiele, F., A. Recchiuti, D. Mattoscio, et al. 2012. Transcriptional regulation of the human FPR2\/ALX gene: evidence of a heritable genetic variant that impairs promoter activity. The FASEB Journal 26(3): 1323\u20131333.","journal-title":"The FASEB Journal"},{"issue":"1","key":"44_CR20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","volume":"18","author":"WE Naugler","year":"2008","unstructured":"Naugler, W.E., and M. Karin. 2008. NF-kappaB and cancer-identifying targets and mechanisms. Current Opinion in Genetics & Development 18(1): 19\u201326.","journal-title":"Current Opinion in Genetics & Development"},{"issue":"7007","key":"44_CR21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","volume":"431","author":"E Pikarsky","year":"2004","unstructured":"Pikarsky, E., R.M. Porat, I. Stein, et al. 2004. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431(7007): 461\u2013466.","journal-title":"Nature"},{"issue":"3","key":"44_CR22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.07.013","volume":"118","author":"FR Greten","year":"2004","unstructured":"Greten, F.R., L. Eckmann, T.F. Greten, et al. 2004. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3): 285\u2013296.","journal-title":"Cell"},{"issue":"3","key":"44_CR23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","volume":"3","author":"M Karin","year":"2002","unstructured":"Karin, M., and A. Lin. 2002. NF-kappaB at the crossroads of life and death. Nature Immunology 3(3): 221\u2013227.","journal-title":"Nature Immunology"},{"issue":"5","key":"44_CR24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF03401642","volume":"2","author":"J Cl\u00e0ria","year":"1996","unstructured":"Cl\u00e0ria, J., M.H. Lee, and C.N. Serhan. 1996. Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Molecular Medicine 2(5): 583\u2013596.","journal-title":"Molecular Medicine"},{"issue":"7092","key":"44_CR25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","volume":"441","author":"M Karin","year":"2006","unstructured":"Karin, M. 2006. Nuclear factor-kappaB in cancer development and progression. Nature 441(7092): 431\u2013436.","journal-title":"Nature"},{"issue":"1","key":"44_CR26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.1711690105","volume":"169","author":"R Holm","year":"1993","unstructured":"Holm, R., H. Skomedal, A. Helland, et al. 1993. Immunohistochemical analysis of p53 protein overexpression in normal, premalignant, and malignant tissues of the cervix uteri. The Journal of Pathology 169(1): 21\u201326.","journal-title":"The Journal of Pathology"},{"issue":"18","key":"44_CR27","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1158\/0008-5472.CAN-08-1217","volume":"68","author":"CP Bracken","year":"2008","unstructured":"Bracken, C.P., S.J. Wall, B. Barre, et al. 2008. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Research 68(18): 7621\u20137628.","journal-title":"Cancer Research"},{"issue":"5","key":"44_CR28","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1053\/jhep.2002.32676","volume":"35","author":"S Abiru","year":"2002","unstructured":"Abiru, S., K. Nakao, T. Ichikawa, et al. 2002. Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. Hepatology 35(5): 1117\u20131124.","journal-title":"Hepatology"},{"issue":"8","key":"44_CR29","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1096\/fasebj.13.8.781","volume":"13","author":"J Westermarck","year":"1999","unstructured":"Westermarck, J., and V.M. Kahari. 1999. Regulation of matrix metalloproteinase expression in tumor invasion. The FASEB Journal 13(8): 781\u2013792.","journal-title":"The FASEB Journal"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-014-0044-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-014-0044-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-014-0044-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T13:53:31Z","timestamp":1565963611000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-014-0044-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,28]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["44"],"URL":"https:\/\/doi.org\/10.1007\/s10753-014-0044-6","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,28]]}}}