{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:39:01Z","timestamp":1789850341942,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s10753-014-0054-4","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T11:21:39Z","timestamp":1415186499000},"page":"923-933","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anti-inflammatory Effects of Cavidine In Vitro and In Vivo, a Selective COX-2 Inhibitor in LPS-Induced Peritoneal Macrophages of Mouse"],"prefix":"10.1007","volume":"38","author":[{"given":"Xiaofeng","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingli","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"54_CR1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jep.2008.06.016","volume":"119","author":"SE Byeon","year":"2008","unstructured":"Byeon, S.E., J.Y. Chung, Y.G. Lee, B.H. Kim, and K.H. Kim. 2008. In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. Journal of Ethnopharmacology 119: 145\u2013152.","journal-title":"Journal of Ethnopharmacology"},{"key":"54_CR2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jep.2008.05.002","volume":"118","author":"JC Castardo","year":"2008","unstructured":"Castardo, J.C., A.S. Prudente, J. Ferreira, C.L. Guimar\u00e3es, F.D. Monache, M.F. Otuki, and D.A. Cabrini. 2008. Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema. Journal of Ethnopharmacology 118: 405\u2013411.","journal-title":"Journal of Ethnopharmacology"},{"key":"54_CR3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2013.06.017","volume":"715","author":"W Li","year":"2013","unstructured":"Li, W., H. Huang, Y. Zhang, T. Fan, X. Liu, W. Xing, and X. Niu. 2013. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-\u03b1, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-\u03baB activation and MAPK pathway. European Journal of Pharmacology 715: 62\u201371.","journal-title":"European Journal of Pharmacology"},{"key":"54_CR4","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","volume":"6","author":"CN Serhan","year":"2005","unstructured":"Serhan, C.N., and J. Savill. 2005. Resolution of inflammation: the beginning programs the end. Nature Immunology 6: 1191\u20131197.","journal-title":"Nature Immunology"},{"key":"54_CR5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1359-6101(99)00008-8","volume":"10","author":"E Shohami","year":"1999","unstructured":"Shohami, E., I. Ginis, and J.M. Hallenbeck. 1999. Dual role of tumor necrosis factor alpha in brain injury. Cytokine & Growth Factor Reviews 10: 119\u2013130.","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"54_CR6","doi-asserted-by":"crossref","first-page":"S378","DOI":"10.1016\/S0091-6749(99)70215-0","volume":"103","author":"M White","year":"1999","unstructured":"White, M. 1999. Mediators of inflammation and the inflammatory process. Journal of Allergy and Clinical Immunology 103: S378\u2013S381.","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"54_CR7","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.freeradbiomed.2011.12.023","volume":"52","author":"SK Yadav","year":"2012","unstructured":"Yadav, S.K., B. Adhikary, S. Chand, B. Maity, S.K. Bandyopadhyay, and S. Chattopadhyay. 2012. Molecular mechanism of indomethacin-induced gastropathy. Free Radical Biology and Medicine 52: 1175\u20131187.","journal-title":"Free Radical Biology and Medicine"},{"key":"54_CR8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1440-1746.2006.04400.x","volume":"22","author":"SK Natarajan","year":"2007","unstructured":"Natarajan, S.K., A. Mukhopadhya, A. Ramachandran, S. Amalanathan, G. Kurian, and K.A. Balasubramanian. 2007. Spontaneous bacterial peritonitis results in oxidative and nitrosative stress in ascitic fluid. Journal of Gastroenterology and Hepatology 22: 177\u2013181.","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"54_CR9","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/S0367-326X(00)00181-7","volume":"71","author":"L Sautebin","year":"2000","unstructured":"Sautebin, L. 2000. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia 71: S48\u2013S57.","journal-title":"Fitoterapia"},{"key":"54_CR10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00281-006-0012-9","volume":"27","author":"B Moeller","year":"2006","unstructured":"Moeller, B., and P.M. Villiger. 2006. Inhibition of IL-1, IL-6, and TNF-alpha in immune-mediated inflammatory diseases. Springer Seminars in Immunopathology 27: 391\u2013408.","journal-title":"Springer Seminars in Immunopathology"},{"key":"54_CR11","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1073\/pnas.88.7.2692","volume":"88","author":"WL Xie","year":"1991","unstructured":"Xie, W.L., J.G. Chipman, D.L. Robertson, R.L. Erikson, and D.L. Simmons. 1991. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proceedings of the National Academy of Sciences 88: 2692\u20132696.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"54_CR12","unstructured":"Abdel-Aziz, A.A.M., K.E.H., ElTahir, and Y.A. 2011. Asiri synthesis, anti-inflammatory activity and COX-1\/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study. European Journal of Medicinal Chemistry 46: 1648\u20131655."},{"issue":"5","key":"54_CR13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1098-3597(99)90088-1","volume":"1","author":"AH Soll","year":"1999","unstructured":"Soll, A.H., and D. McCarthy. 1999. NSAID-related gastrointestinal complications. Clinical Cornerstone 1(5): 42\u201356.","journal-title":"Clinical Cornerstone"},{"key":"54_CR14","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/jssc.201300036","volume":"36","author":"X Niu","year":"2013","unstructured":"Niu, X., W. Li, H. Xu, X. Liu, and L. Qi. 2013. Simultaneous quantification of 11 isoquinoline alkaloids in Corydalis impatiens (Pall.) Fisch by HPLC. Journal of Separation Science 36: 2090\u20132095.","journal-title":"Journal of Separation Science"},{"key":"54_CR15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10600-013-0554-8","volume":"49","author":"XF Niu","year":"2013","unstructured":"Niu, X.F., H.B. Xu, X. Liu, T. Fan, and L. Qi. 2013. Isoquinoline alkaloids from Corydalis impatiens. Chemistry of Natural Compounds 49: 187\u2013189.","journal-title":"Chemistry of Natural Compounds"},{"key":"54_CR16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/ptr.1154","volume":"17","author":"H Hosseinzadeh","year":"2003","unstructured":"Hosseinzadeh, H., M.H. Haddadkhodaparast, and A.R. Arash. 2003. Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth. seed extract in mice and rats. Phytotherapy Researc 17: 422\u2013425.","journal-title":"Phytotherapy Researc"},{"key":"54_CR17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0014-2999(00)00337-X","volume":"398","author":"JY Cho","year":"2000","unstructured":"Cho, J.Y., K.U. Baik, J.H. Jung, and M.H. Park. 2000. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. European Journal of Pharmacology 398: 399\u2013407.","journal-title":"European Journal of Pharmacology"},{"key":"54_CR18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.cr.7290135","volume":"12","author":"WG Feng","year":"2002","unstructured":"Feng, W.G., Y.B. Wang, J.S. Zhang, and C.L. Li. 2002. cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in murine peritoneal macrophages. Cell Research 12: 331\u2013337.","journal-title":"Cell Research"},{"key":"54_CR19","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0166-0934(88)90134-6","volume":"20","author":"R Pauwels","year":"1988","unstructured":"Pauwels, R., J. Balzarini, M. Baba, R. Snoeck, D. Schols, P. Herdewijn, and E. De Clercq. 1988. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. Journal of virological method 20: 309\u2013321.","journal-title":"Journal of virological method"},{"key":"54_CR20","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jep.2014.03.035","volume":"154","author":"LA Chibli","year":"2014","unstructured":"Chibli, L.A., K. Rodrigues, C.M. Gasparetto, N.C. Pinto, R.L. Fabri, E. Scio, and O.V. Sousa. 2014. Anti-inflammatory effects of Bryophyllum pinnatum (Lam.) Oken ethanol extract in acute and chronic cutaneous inflammation. Journal of Ethnopharmacology 154: 330\u2013338.","journal-title":"Journal of Ethnopharmacology"},{"key":"54_CR21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF01966592","volume":"17","author":"RP Carlson","year":"1985","unstructured":"Carlson, R.P., J. Chang, and A.J. Lewis. 1985. Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents. Agents and Actions 17: 197\u2013204.","journal-title":"Agents and Actions"},{"key":"54_CR22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejphar.2012.05.039","volume":"689","author":"X Niu","year":"2012","unstructured":"Niu, X., T. Fan, W. Li, W. Xing, and H. Huang. 2012. The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages. European Journal of Pharmacology 689: 262\u2013269.","journal-title":"European Journal of Pharmacology"},{"key":"54_CR23","first-page":"21","volume":"32","author":"S Banerjee","year":"2000","unstructured":"Banerjee, S., T.K. Sur, S. Mandal, P.C. Das, and S. Sikdar. 2000. Assessment of the anti-inflammatory effects of Swertia chirata in acute and chronic experimental models in male albino rats. Indian Journal of Pharmacology 32: 21\u201324.","journal-title":"Indian Journal of Pharmacology"},{"key":"54_CR24","doi-asserted-by":"crossref","first-page":"PL203","DOI":"10.1016\/S0024-3205(99)00406-3","volume":"65","author":"G Clementi","year":"1999","unstructured":"Clementi, G., A. Caruso, V.M.C. Cutuli, A. Prato, N.G. Mangano, and M. Amico-Roxas. 1999. Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats. Life Sciences 65: PL203\u2013PL208.","journal-title":"Life Sciences"},{"key":"54_CR25","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.bbalip.2007.06.002","volume":"1771","author":"M St-Onge","year":"2007","unstructured":"St-Onge, M., N. Flamand, J. Biarc, S. Picard, L. Bouchard, A.A. Dussault, C. Laflamme, M.J. James, G.E. Caughey, L.G. Cleland, P. Borgeat, and M. Pouliot. 2007. Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils. Biochimica et Biophysica Acta 1771: 1235\u20131245.","journal-title":"Biochimica et Biophysica Acta"},{"key":"54_CR26","doi-asserted-by":"crossref","unstructured":"Ribeiro, R.A., M.L. Vale, S.M. Thomazzi, A.B. Paschoalato, S. Poole, S.H. Ferreira, and F.Q. Cunha. 2000. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. European Journal of Pharmacology 387: 111\u2013118.","DOI":"10.1016\/S0014-2999(99)00790-6"},{"key":"54_CR27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.intimp.2007.11.003","volume":"8","author":"KJ Yun","year":"2008","unstructured":"Yun, K.J., J.Y. Kim, J.B. Kim, K.W. Lee, S.Y. Jeong, H.J. Park, and K.T. Lee. 2008. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-\u03baB inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. International Immunopharmacology 8: 431\u2013441.","journal-title":"International Immunopharmacology"},{"key":"54_CR28","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.fct.2007.09.111","volume":"46","author":"HJ Yoon","year":"2008","unstructured":"Yoon, H.J., M.E. Moon, H.S. Park, H.W. Kim, S.Y. Im, J.H. Lee, and Y.H. Kim. 2008. Effects of chitosan oligosaccharide (COS) on the glycerol-induced acute renal failure in vitro and in vivo. Food and Chemical Toxicology 46: 710\u2013716.","journal-title":"Food and Chemical Toxicology"},{"key":"54_CR29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada, S., R.M.J. Palmer, and E.A. Higgs. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological Reviews 43: 109\u2013142.","journal-title":"Pharmacological Reviews"},{"key":"54_CR30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0278-2391(03)00155-1","volume":"61","author":"H Nagai","year":"2003","unstructured":"Nagai, H., H. Kumamoto, M. Fukuda, and T. Takahashi. 2003. Inducible nitric oxide synthase and apoptosis-related factors in the synovial tissues of temporomandibular joints with internal derangement and osteoarthritis. Journal of Oral and Maxillofacial Surgery 61: 801\u2013807.","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"key":"54_CR31","doi-asserted-by":"crossref","first-page":"321S","DOI":"10.1378\/chest.112.6_Supplement.321S","volume":"112","author":"CA Dinarello","year":"1997","unstructured":"Dinarello, C.A. 1997. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 112: 321S\u2013329S.","journal-title":"Chest"},{"key":"54_CR32","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.4049\/jimmunol.155.6.2858","volume":"155","author":"K Fehsel","year":"1995","unstructured":"Fehsel, K., K.D. Kr\u00f6ncke, K.L. Meyer, H. Huber, V. Wahn, and V. Kolb-Bachofen. 1995. Nitric oxide induces apoptosis in mouse thymocytes. The Journal of Immunology 155: 2858\u20132865.","journal-title":"The Journal of Immunology"},{"key":"54_CR33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.intimp.2012.03.002","volume":"13","author":"SK Hong","year":"2012","unstructured":"Hong, S.K., H.J. Kim, C.S. Song, I.S. Choi, J.B. Lee, and S.Y. Park. 2012. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. International Immunopharmacology 13: 23\u201327.","journal-title":"International Immunopharmacology"},{"key":"54_CR34","first-page":"4424","volume":"56","author":"K Subbaramaiah","year":"1996","unstructured":"Subbaramaiah, K., N. Telang, J.T. Ramonetti, R. Araki, B. DeVito, B.B. Weksler, and A.J. Dannenberg. 1996. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Research 56: 4424\u20134429.","journal-title":"Cancer Research"},{"key":"54_CR35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jep.2011.04.011","volume":"136","author":"Z Utar","year":"2011","unstructured":"Utar, Z., M.A. Majid, M.I. Adenan, M.F. Jamil, and T.M. Lan. 2011. Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E2 production induced by lipopolysaccharide in RAW264.7 macrophage cells. Journal of Ethnopharmacology 136: 75\u201382.","journal-title":"Journal of Ethnopharmacology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-014-0054-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-014-0054-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-014-0054-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:44:33Z","timestamp":1747147473000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-014-0054-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["54"],"URL":"https:\/\/doi.org\/10.1007\/s10753-014-0054-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}