{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:46:56Z","timestamp":1776278816050,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s10753-014-9958-2","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T07:06:40Z","timestamp":1404284800000},"page":"520-526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Platelet Factor 4 Protects Kidney Allograft in a Rat Kidney Transplantation Model"],"prefix":"10.1007","volume":"38","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"9958_CR1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1600-6143.2008.02159.x","volume":"8","author":"K Solez","year":"2008","unstructured":"Solez, K., R.B. Colvin, L.C. Racusen, M. Haas, B. Sis, M. Mengel, P.F. Halloran, W. Baldwin, G. Banfi, A.B. Collins, F. Cosio, D.S. David, C. Drachenberg, G. Einecke, A.B. Fogo, I.W. Gibson, D. Glotz, S.S. Iskandar, E. Kraus, E. Lerut, R.B. Mannon, M. Mihatsch, B.J. Nankivell, V. Nickeleit, J.C. Papadimitriou, P. Randhawa, H. Regele, K. Renaudin, I. Roberts, D. Seron, R.N. Smith, and M. Valente. 2008. Banff 07 classification of renal allograft pathology: updates and future directions. American Journal of Transplantation 8: 753\u2013760.","journal-title":"American Journal of Transplantation"},{"key":"9958_CR2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/MOT.0b013e32834c23a7","volume":"16","author":"RS Gaston","year":"2011","unstructured":"Gaston, R.S. 2011. Our evolving understanding of late kidney allograft failure. Current Opinion in Organ Transplantation 16: 594\u2013599.","journal-title":"Current Opinion in Organ Transplantation"},{"key":"9958_CR3","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1182\/blood-2007-01-067116","volume":"110","author":"MP Lambert","year":"2007","unstructured":"Lambert, M.P., L. Rauova, M. Bailey, M.C. Sola-Visner, M.A. Kowalska, and M. Poncz. 2007. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110: 1153\u20131160.","journal-title":"Blood"},{"key":"9958_CR4","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1182\/blood.V95.5.1533.005k01_1533_1540","volume":"95","author":"GM Arepally","year":"2000","unstructured":"Arepally, G.M., S. Kamei, K.S. Park, K. Kamei, Z.Q. Li, W. Liu, D.L. Siegel, W. Kisiel, D.B. Cines, and M. Poncz. 2000. Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. Blood 95: 1533\u20131540.","journal-title":"Blood"},{"key":"9958_CR5","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1182\/blood.V92.9.3250","volume":"92","author":"L Ziporen","year":"1998","unstructured":"Ziporen, L., Z.Q. Li, K.S. Park, P. Sabnekar, W.Y. Liu, G. Arepally, Y. Shoenfeld, T. Kieber-Emmons, D.B. Cines, and M. Poncz. 1998. Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. Blood 92: 3250\u20133259.","journal-title":"Blood"},{"key":"9958_CR6","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1182\/blood-2003-11-3994","volume":"104","author":"DE Eslin","year":"2004","unstructured":"Eslin, D.E., C. Zhang, K.J. Samuels, L. Rauova, L. Zhai, S. Niewiarowski, D.B. Cines, M. Poncz, and M.A. Kowalska. 2004. Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood 104: 3173\u20133180.","journal-title":"Blood"},{"key":"9958_CR7","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1365-2141.1995.tb05399.x","volume":"91","author":"KA Aziz","year":"1995","unstructured":"Aziz, K.A., J.C. Cawley, and M. Zuzel. 1995. Platelets prime PMN via released PF4: mechanism of priming and synergy with GM-CSF. British Journal of Haematology 91: 846\u2013853.","journal-title":"British Journal of Haematology"},{"key":"9958_CR8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jlb.58.5.575","volume":"58","author":"CS Engstad","year":"1995","unstructured":"Engstad, C.S., K. Lia, O. Rekdal, J.O. Olsen, and B. Osterud. 1995. A novel biological effect of platelet factor 4 (PF4): enhancement of LPS-induced tissue factor activity in monocytes. Journal of Leukocyte Biology 58: 575\u2013581.","journal-title":"Journal of Leukocyte Biology"},{"key":"9958_CR9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.chom.2008.07.003","volume":"4","author":"K Srivastava","year":"2008","unstructured":"Srivastava, K., I.A. Cockburn, A. Swaim, L.E. Thompson, A. Tripathi, C.A. Fletcher, E.M. Shirk, H. Sun, M.A. Kowalska, K. Fox-Talbot, D. Sullivan, F. Zavala, and C.N. Morrell. 2008. Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host & Microbe 4: 179\u2013187.","journal-title":"Cell Host & Microbe"},{"key":"9958_CR10","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.4049\/jimmunol.174.5.2680","volume":"174","author":"CY Liu","year":"2005","unstructured":"Liu, C.Y., M. Battaglia, S.H. Lee, Q.H. Sun, R.H. Aster, and G.P. Visentin. 2005. Platelet factor 4 differentially modulates CD4+CD25+ (regulatory) versus CD4+CD25\u2212 (nonregulatory) T cells. Journal of Immunology 174: 2680\u20132686.","journal-title":"Journal of Immunology"},{"key":"9958_CR11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1172\/JCI71858","volume":"124","author":"G Shi","year":"2014","unstructured":"Shi, G., D.J. Field, K.A. Ko, S. Ture, K. Srivastava, S. Levy, M.A. Kowalska, M. Poncz, D.J. Fowell, and C.N. Morrell. 2014. Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection. Journal of Clinical Investigation 124: 543\u2013552.","journal-title":"Journal of Clinical Investigation"},{"key":"9958_CR12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1242\/dmm.003533","volume":"3","author":"S Wang","year":"2010","unstructured":"Wang, S., C. Schmaderer, E. Kiss, C. Schmidt, M. Bonrouhi, S. Porubsky, N. Gretz, L. Schaefer, C.J. Kirschning, Z.V. Popovic, and H.J. Grone. 2010. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Disease Models & Mechanisms 3: 92\u2013103.","journal-title":"Disease Models & Mechanisms"},{"key":"9958_CR13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ajpath.2011.03.019","volume":"179","author":"E Kiss","year":"2011","unstructured":"Kiss, E., Z. Popovic, J. Bedke, S. Wang, M. Bonrouhi, N. Gretz, P. Stettner, D. Teupser, J. Thiery, S. Porubsky, J. Adams, and H.J. Grone. 2011. Suppression of chronic damage in renal allografts by Liver X receptor (LXR) activation relevant contribution of macrophage LXRalpha. American Journal of Pathology 179: 92\u2013103.","journal-title":"American Journal of Pathology"},{"key":"9958_CR14","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1161\/ATVBAHA.108.175257","volume":"28","author":"D Teupser","year":"2008","unstructured":"Teupser, D., D. Kretzschmar, C. Tennert, R. Burkhardt, W. Wilfert, D. Fengler, R. Naumann, A.E. Sippel, and J. Thiery. 2008. Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 28: 2009\u20132015.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9958_CR15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/01.TP.0000066354.31050.5A","volume":"76","author":"E Kiss","year":"2003","unstructured":"Kiss, E., J. Adams, H.J. Grone, and J. Wagner. 2003. Isotretinoin ameliorates renal damage in experimental acute renal allograft rejection. Transplantation 76: 480\u2013489.","journal-title":"Transplantation"},{"key":"9958_CR16","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/j.1600-6143.2009.02762.x","volume":"9","author":"C Toerne von","year":"2009","unstructured":"von Toerne, C., C. Schmidt, J. Adams, E. Kiss, J. Bedke, S. Porubsky, N. Gretz, M.T. Lindenmeyer, C.D. Cohen, H.J. Grone, and P.J. Nelson. 2009. Wnt pathway regulation in chronic renal allograft damage. American Journal of Transplantation 9: 2223\u20132239.","journal-title":"American Journal of Transplantation"},{"key":"9958_CR17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/00007890-196911000-00007","volume":"8","author":"E White","year":"1969","unstructured":"White, E., W.H. Hildemann, and Y. Mullen. 1969. Chronic kidney allograft reactions in rats. Transplantation 8: 602\u2013617.","journal-title":"Transplantation"},{"key":"9958_CR18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00007890-197107000-00006","volume":"12","author":"LW Poulter","year":"1971","unstructured":"Poulter, L.W., N.J. Bradley, and J.L. Turk. 1971. The role of macrophages in skin allograft rejection. I. Histochemical studies during first-set rejection. Transplantation 12: 40\u201344.","journal-title":"Transplantation"},{"key":"9958_CR19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0002-9440(10)62973-2","volume":"167","author":"J Adams","year":"2005","unstructured":"Adams, J., E. Kiss, A.B. Arroyo, M. Bonrouhi, Q. Sun, Z. Li, N. Gretz, A. Schnitger, C.C. Zouboulis, M. Wiesel, J. Wagner, P.J. Nelson, and H.J. Grone. 2005. 13-cis Retinoic acid inhibits development and progression of chronic allograft nephropathy. American Journal of Pathology 167: 285\u2013298.","journal-title":"American Journal of Pathology"},{"key":"9958_CR20","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1111\/j.1600-6143.2008.02321.x","volume":"8","author":"BM Vanaudenaerde","year":"2008","unstructured":"Vanaudenaerde, B.M., S.I. De Vleeschauwer, R. Vos, I. Meyts, D.M. Bullens, V. Reynders, W.A. Wuyts, D.E. Van Raemdonck, L.J. Dupont, and G.M. Verleden. 2008. The role of the IL23\/IL17 axis in bronchiolitis obliterans syndrome after lung transplantation. American Journal of Transplantation 8: 1911\u20131920.","journal-title":"American Journal of Transplantation"},{"key":"9958_CR21","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2353\/ajpath.2010.091106","volume":"177","author":"V Gorbacheva","year":"2010","unstructured":"Gorbacheva, V., R. Fan, X. Li, and A. Valujskikh. 2010. Interleukin-17 promotes early allograft inflammation. American Journal of Pathology 177: 1265\u20131273.","journal-title":"American Journal of Pathology"},{"key":"9958_CR22","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1084\/jem.20081937","volume":"205","author":"X Yuan","year":"2008","unstructured":"Yuan, X., J. Paez-Cortez, I. Schmitt-Knosalla, F. D\u2019Addio, B. Mfarrej, M. Donnarumma, A. Habicht, M.R. Clarkson, J. Iacomini, L.H. Glimcher, M.H. Sayegh, and M.J. Ansari. 2008. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. Journal of Experimental Medicine 205: 3133\u20133144.","journal-title":"Journal of Experimental Medicine"},{"key":"9958_CR23","doi-asserted-by":"crossref","first-page":"S187","DOI":"10.1161\/CIRCULATIONAHA.110.014852","volume":"124","author":"S Itoh","year":"2011","unstructured":"Itoh, S., N. Kimura, R.C. Axtell, J.B. Velotta, Y. Gong, X. Wang, N. Kajiwara, A. Nambu, E. Shimura, H. Adachi, Y. Iwakura, H. Saito, K. Okumura, K. Sudo, L. Steinman, R.C. Robbins, S. Nakae, and M.P. Fischbein. 2011. Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion. Circulation 124: S187\u2013S196.","journal-title":"Circulation"},{"key":"9958_CR24","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.4049\/jimmunol.181.6.3906","volume":"181","author":"BE Burrell","year":"2008","unstructured":"Burrell, B.E., K. Csencsits, G. Lu, S. Grabauskiene, and D.K. Bishop. 2008. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. Journal of Immunology 181: 3906\u20133914.","journal-title":"Journal of Immunology"},{"key":"9958_CR25","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1111\/j.1600-6143.2007.01958.x","volume":"7","author":"CN Morrell","year":"2007","unstructured":"Morrell, C.N., H. Sun, A.M. Swaim, and W.R. Baldwin. 2007. Platelets an inflammatory force in transplantation. American Journal of Transplantation 7: 2447\u20132454.","journal-title":"American Journal of Transplantation"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-014-9958-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-014-9958-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-014-9958-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T21:49:26Z","timestamp":1598046566000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-014-9958-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["9958"],"URL":"https:\/\/doi.org\/10.1007\/s10753-014-9958-2","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,2]]}}}