{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:52:56Z","timestamp":1790553176599,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T00:00:00Z","timestamp":1443830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s10753-015-0264-4","type":"journal-article","created":{"date-parts":[[2015,10,3]],"date-time":"2015-10-03T05:24:10Z","timestamp":1443849850000},"page":"425-433","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Activation of Neutrophils via IP3 Pathway Following Exposure to Demodex-Associated Bacterial Proteins"],"prefix":"10.1007","volume":"39","author":[{"given":"Fred","family":"McMahon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nessa","family":"Banville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Smedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Paulie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,3]]},"reference":[{"key":"264_CR1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMcp042829","volume":"352","author":"FC Powell","year":"2005","unstructured":"Powell, F.C. 2005. Rosacea. New England Journal of Medicine 352: 793\u2013803.","journal-title":"New England Journal of Medicine"},{"key":"264_CR2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jaad.2013.08.006","volume":"69","author":"AD Holmes","year":"2013","unstructured":"Holmes, A.D. 2013. Potential role of microorganisms in the pathogenesis of rosacea. Journal of American Academy of Dermatology 69: 1025\u201332.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1099\/jmm.0.048090-0","volume":"61","author":"S Jarmuda","year":"2012","unstructured":"Jarmuda, S., N. O'Reilly, R. Zaba, O. Jakubowicz, A. Szkaradkiewicz, and K. Kavanagh. 2012. The potential role of Demodex folliculorum mites and bacteria in the induction of rosacea. Journal of Medical Microbiology 61: 1504\u201310.","journal-title":"Journal of Medical Microbiology"},{"key":"264_CR4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","volume":"46","author":"J Wilkin","year":"2002","unstructured":"Wilkin, J., M. Dahl, M. Detmar, L. Drake, A. Feinstein, R. Odom, and F. Powell. 2002. Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. Journal of American Academy of Dermatology 46: 584\u201387.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaad.2004.03.030","volume":"51","author":"GH Crawford","year":"2004","unstructured":"Crawford, G.H., M.T. Pelle, and W.D. James. 2004. Rosacea: I. Etiology, pathogenesis, and subtype classification. Journal of American Academy of Dermatology 51: 327\u201341.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1468-3083.2005.01216.x","volume":"19","author":"AK Gupta","year":"2005","unstructured":"Gupta, A.K., and M.M. Chaudhry. 2005. Rosacea and its management: an overview. Journal of the European Academy of Dermatology and Venereology 19: 273\u201385.","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"264_CR7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jaad.2004.03.033","volume":"51","author":"MT Pelle","year":"2004","unstructured":"Pelle, M.T., G.H. Crawford, and W.D. James. 2004. Rosacea: II. Therapy. Journal of American Academy of Dermatology 51: 499\u2013512.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdermsci.2009.04.007","volume":"55","author":"K Yamasaki","year":"2009","unstructured":"Yamasaki, K., and R.L. Gallo. 2009. The molecular pathology of rosacea. Journal of Dermatological Science 55: 77\u201381.","journal-title":"Journal of Dermatological Science"},{"key":"264_CR9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00402621","volume":"282","author":"H Akamatsu","year":"1990","unstructured":"Akamatsu, H., M. Oguchi, S. Nishijima, Y. Asada, M. Takashi, T. Ushijima, and Y. Niwa. 1990. The inhibition of free radical generation by human neutrophils through the synergistic effect of metronidazole with palmitoleic acid: a possible mechanism of metronidazole in rosacea and acne. Archives of Dermatological Research 282: 449\u201354.","journal-title":"Archives of Dermatological Research"},{"key":"264_CR10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/1523-1747.ep12285793","volume":"86","author":"Y Miyashi","year":"1986","unstructured":"Miyashi, Y., A. Yoshioka, S. Imamura, and Y. Niwa. 1986. Effect of antibiotics on the generation of reactive oxygen species. Journal of Investigative Dermatology 86: 449\u201353.","journal-title":"Journal of Investigative Dermatology"},{"key":"264_CR11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00412920","volume":"278","author":"A Yoshioka","year":"1986","unstructured":"Yoshioka, A., Y. Miyachi, S. Imamura, and Y. Niwa. 1986. Anti-oxidant effects of retinoids on inflammatory skin diseases. Archives of Dermatological Research 278: 177\u201383.","journal-title":"Archives of Dermatological Research"},{"key":"264_CR12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0005-2744(77)90066-3","volume":"483","author":"PM Starkey","year":"1977","unstructured":"Starkey, P.M., A.J. Barrett, and M.C. Burleigh. 1977. The degradation of articular collagen by neutrophil proteinases. Biochimica et Biophysica Acta 483: 386\u201397.","journal-title":"Biochimica et Biophysica Acta"},{"key":"264_CR13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0945-053X(00)00057-3","volume":"19","author":"A Berton","year":"2000","unstructured":"Berton, A., G. Godeau, H. Emonard, K. Baba, P. Bellon, W. Hornebeck, and G. Bellon. 2000. Analysis of the ex vivo specificity of human gelatinases A and B towards skin collagen and elastic fibers by computerized morphometry. Matrix Biology 19: 139\u2013148.","journal-title":"Matrix Biology"},{"key":"264_CR14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0014-5793(03)00482-4","volume":"544","author":"JM Devaney","year":"2003","unstructured":"Devaney, J.M., C.M. Greene, C.C. Taggart, T.P. Carroll, S.J. O\u2019Neill, and N.G. McElvaney. 2003. Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Letters 544: 129\u2013132.","journal-title":"FEBS Letters"},{"key":"264_CR15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1152\/ajplung.00471.2005","volume":"291","author":"I Kuwahara","year":"2006","unstructured":"Kuwahara, I., E.P. Lillehoj, W. Lu, I.S. Singh, Y. Isohama, T. Miyata, and K.C. Kim. 2006. Neutrophil elastase induces IL-8 gene transcription and protein release through p38\/NF-\u03baB activation via EGFR trans-activation in a lung epithelial cell line. American Journal of Physiology. Lung Cellular and Molecular Physiology 291: 407\u2013416.","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"264_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2249.2005.02800.x","volume":"141","author":"G Tintinger","year":"2005","unstructured":"Tintinger, G., H.C. Steel, and R. Anderson. 2005. Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control. Clinical Experimental Immunology 141: 191\u2013200.","journal-title":"Clinical Experimental Immunology"},{"key":"264_CR17","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1182\/blood.V86.5.1649.bloodjournal8651649","volume":"86","author":"GM Bokoch","year":"1995","unstructured":"Bokoch, G.M. 1995. Chemoattractant signaling and leukocyte activation. Blood 86: 1649\u20131660.","journal-title":"Blood"},{"key":"264_CR18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1196\/annals.1302.030","volume":"1015","author":"O Binah","year":"2004","unstructured":"Binah, O., M. Shilkrut, G. Yaniv, and S. Larisch. 2004. The Fas receptor 1,4,5-IP3 cascade: a potential target for treating heart failure and arrhythmias. Annals of the New York Academy of Science 1015: 338\u2013350.","journal-title":"Annals of the New York Academy of Science"},{"key":"264_CR19","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1124\/jpet.109.157677","volume":"331","author":"MJ Wacker","year":"2009","unstructured":"Wacker, M.J., L.M. Kosloski, W.J.R. Gilbert, C.D. Touchberry, D.S. Moore, J.K. Kelly, M. Brotto, and J.A. Orr. 2009. Inhibition of thromboxane A2-induced arrhythmias and intracellular calcium changes in cardiac myocytes by blockade of the inositol trisphosphate pathway. Journal of Pharmacological and Experimental Therapeutics 331: 917\u2013924.","journal-title":"Journal of Pharmacological and Experimental Therapeutics"},{"key":"264_CR20","unstructured":"Vance, J. 1986. Demodicidosis \u2013 Do Demodex mites cause Disease? Current Concepts in Skin Disorder 10\u201318."},{"key":"264_CR21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0190-9622(93)70065-2","volume":"28","author":"E Bonner","year":"1993","unstructured":"Bonner, E., P. Eustace, and F.C. Powell. 1993. The Demodex mite population in Rosacea. Journal of American Academy of Dermatology 28: 443\u2013448.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-4362.1998.00218.x","volume":"37","author":"Z Erba\u011fci","year":"1998","unstructured":"Erba\u011fci, Z., and O. Ozg\u00f6zta\u015fi. 1998. The significance of Demodex folliculorum density in rosacea. International Journal of Dermatology 37: 421\u2013425.","journal-title":"International Journal of Dermatology"},{"key":"264_CR23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2133.2011.10662.x","volume":"166","author":"S Ni Raghallaigh","year":"2012","unstructured":"Ni Raghallaigh, S., K. Bender, N. Lacey, L. Brennan, and F.C. Powell. 2012. The fatty acid profile of the skin surface lipid layer in papulopustular rosacea. British Journal of Dermatology 166: 279\u2013287.","journal-title":"British Journal of Dermatology"},{"key":"264_CR24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaad.2003.05.005","volume":"50","author":"MV Dahl","year":"2004","unstructured":"Dahl, M.V., A.J. Ross, and P.M. Schlievert. 2004. Temperature regulates bacterial protein production: possible role in rosacea. Journal of American Academy of Dermatology 50: 266\u2013272.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2133.2007.08028.x","volume":"157","author":"N Lacey","year":"2007","unstructured":"Lacey, N., S. Delaney, K. Kavanagh, and F.C. Powell. 2007. Mite-related bacterial antigens stimulate inflammatory cells in rosacea. British Journal of Dermatology 157: 474\u2013481.","journal-title":"British Journal of Dermatology"},{"key":"264_CR26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaad.2009.12.036","volume":"64","author":"M Whitfeld","year":"2011","unstructured":"Whitfeld, M., N. Gunasingam, L. Joo Leow, K. Shirato, and V. Preda. 2011. Staphylococcus epidermidis: a possible role in the pustules of rosacea. Journal of American Academy of Dermatology 64: 49\u201352.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR27","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1139\/m95-096","volume":"41","author":"T Kuhnigk","year":"1995","unstructured":"Kuhnigk, T., E.M. Borst, A. Breunig, H. K\u00f6nig, M.D. Collins, R.A. Hutson, and P. K\u00e4mpfer. 1995. Bacillus oleronius sp. nov., a member of the hind-gut flora of the termite Reticulitermes santonensis (Feytaud). Canadian Journal of Microbiology 41: 699\u2013706.","journal-title":"Canadian Journal of Microbiology"},{"key":"264_CR28","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1469-0691.2011.03704.x","volume":"18","author":"A Szkaradkiewicz","year":"2012","unstructured":"Szkaradkiewicz, A., I. Chudzicka-Struga\u0142a, T.M. Karpi\u0144ski, O. Go\u015bli\u0144ska-Paw\u0142owska, T. Tu\u0142ecka, W. Chudzicki, A.K. Szkaradkiewicz, and R. Zaba. 2012. Bacillus oleronius and Demodex mite infestation in patients with chronic blepharitis. Clinical Microbiology and Infection 18: 1020\u20131025.","journal-title":"Clinical Microbiology and Infection"},{"key":"264_CR29","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ophtha.2009.09.057","volume":"117","author":"J Li","year":"2010","unstructured":"Li, J., N. O'Reilly, H. Sheha, R. Katz, V.K. Raju, K. Kavanagh, and S.C. Tseng. 2010. Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus microbial proteins in patients with facial rosacea. Ophthalmology 117: 870\u2013877.","journal-title":"Ophthalmology"},{"key":"264_CR30","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/j.1365-2133.2012.11114.x","volume":"167","author":"N O\u2019Reilly","year":"2012","unstructured":"O\u2019Reilly, N., N. Menezes, and K. Kavanagh. 2012. Positive correlation between serum immuno-reactivity to Demodex-associated Bacillus proteins and erythematotelangiectic rosacea. British Journal of Dermatology 167: 1032\u20131036.","journal-title":"British Journal of Dermatology"},{"key":"264_CR31","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1099\/jmm.0.065136-0","volume":"63","author":"S Jarmuda","year":"2014","unstructured":"Jarmuda, S., F. McMahon, R. Zaba, N. O\u2019Reilly, O. Jakubowicz, A. Holland, A. Szkaradkiewicz, and K. Kavanagh. 2014. Correlation between serum reactivity to Demodex-associated Bacillus oleronius proteins, and altered sebum levels and Demodex populations in erythematotelangiectatic rosacea patients. Journal of Medical Microbiology 63: 258\u2013262.","journal-title":"Journal of Medical Microbiology"},{"key":"264_CR32","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1167\/iovs.11-9295","volume":"53","author":"N O\u2019Reilly","year":"2012","unstructured":"O\u2019Reilly, N., C. Gallagher, K.R. Katikireddy, M. Clynes, F. O\u2019Sullivan, and K. Kavanagh. 2012. Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line (hTCEpi): possible implications for corneal ulcer formation in ocular rosacea. Investigative Ophthalmology and Visual Science 53: 3250\u20133259.","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"264_CR33","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1167\/iovs.14-15018","volume":"55","author":"FW McMahon","year":"2014","unstructured":"McMahon, F.W., C. Gallagher, N. O\u2019Reilly, M. Clynes, F. O\u2019Sullivan, and K. Kavanagh. 2014. Exposure of a corneal epithelial cell line (hTCEpi) to Demodex-associated Bacillus proteins results in an inflammatory response. Investigative Ophthalmology and Visual Science 55: 7019\u20137028.","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"264_CR34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1365-2133.2011.10746.x","volume":"166","author":"N O\u2019Reilly","year":"2012","unstructured":"O\u2019Reilly, N., D. Bergin, E.P. Reeves, N.G. McElvaney, and K. Kavanagh. 2012. Demodex-associated bacterial proteins induce neutrophil activation. British Journal of Dermatology 166: 753\u2013760.","journal-title":"British Journal of Dermatology"},{"key":"264_CR35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/416291a","volume":"416","author":"EP Reeves","year":"2002","unstructured":"Reeves, E.P., H. Lu, H.L. Jacobs, C.G. Messina, S. Bolsover, G. Gabella, E.O. Potma, A. Warley, J. Roes, and A.W. Segal. 2002. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416: 291\u2013297.","journal-title":"Nature"},{"key":"264_CR36","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0192-0561(86)90016-0","volume":"8","author":"RD Eichner","year":"1986","unstructured":"Eichner, R.D., M. Al Salami, P.R. Wood, and A. M\u00fcllbacher. 1986. The effect of gliotoxin upon macrophage function. International Journal of Immunopharmacology 8: 789\u2013797.","journal-title":"International Journal of Immunopharmacology"},{"key":"264_CR37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2007.04.043","volume":"130","author":"R Jayachandran","year":"2007","unstructured":"Jayachandran, R., V. Sundaramurthy, B. Combaluzier, P. Mueller, H. Korf, K. Huygen, T. Miyazaki, I. Albrecht, J. Massner, and J. Pieters. 2007. Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 130: 37\u201350.","journal-title":"Cell"},{"key":"264_CR38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-4173(86)90005-4","volume":"853","author":"F Rossi","year":"1986","unstructured":"Rossi, F. 1986. The O2-forming NADPH oxidase of the phagocytes: Nature, mechanisms of activation and function. Biochimica et Biophysica Acta 853: 65\u201389.","journal-title":"Biochimica et Biophysica Acta"},{"key":"264_CR39","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1164\/ajrccm\/141.3_Pt_2.S127","volume":"141","author":"PD Lew","year":"1990","unstructured":"Lew, P.D. 1990. Receptors and intracellular signaling in human neutrophils. The American Review of Respiratory Disease 141: S127\u2013131.","journal-title":"The American Review of Respiratory Disease"},{"key":"264_CR40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0952-7915(93)90090-F","volume":"5","author":"MM Billah","year":"1993","unstructured":"Billah, M.M. 1993. Phospholipase D and cell signaling. Current Opinions in Immunology 5: 114\u2013123.","journal-title":"Current Opinions in Immunology"},{"key":"264_CR41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0952-7915(94)90041-8","volume":"6","author":"M Thelen","year":"1994","unstructured":"Thelen, M., and U. Wirthmueller. 1994. Phospholipases and protein kinases during phagocyte activation. Current Opinions in Immunology 6: 106\u2013112.","journal-title":"Current Opinions in Immunology"},{"key":"264_CR42","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","volume":"326","author":"TD Pollard","year":"2009","unstructured":"Pollard, T.D., and J.A. Cooper. 2009. Actin, a central player in cell shape and movement. Science 326: 1208\u20131212.","journal-title":"Science"},{"key":"264_CR43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/PL00000209","volume":"49","author":"N Brink","year":"2000","unstructured":"Brink, N., M. Szamel, A.R. Young, K.P. Wittern, and J. Bergemann. 2000. Comparative quantification of IL-1beta, IL-10, IL-10r, TNFalpha and IL-7 mRNA levels in UV-irradiated human skin in vivo. Inflammation Research 49: 290\u2013296.","journal-title":"Inflammation Research"},{"key":"264_CR44","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1073\/pnas.86.16.6367","volume":"86","author":"RM Grossman","year":"1989","unstructured":"Grossman, R.M., J. Krueger, D. Yourish, A. Granelli-Piperno, D.P. Murphy, L.T. May, T.S. Kupper, P.B. Sehgal, and A.B. Gottlieb. 1989. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proceedings of the National Academy of Science of the USA 86: 6367\u20136371.","journal-title":"Proceedings of the National Academy of Science of the USA"},{"key":"264_CR45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0190-9622(82)70137-9","volume":"7","author":"R Aylesworth","year":"1982","unstructured":"Aylesworth, R., and J.C. Vance. 1982. Demodex folliculorum and Demodex brevis in cutaneous biopsies. Journal of American Academy of Dermatology 7: 583\u2013589.","journal-title":"Journal of American Academy of Dermatology"},{"key":"264_CR46","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1046\/j.1365-2230.2003.01173.x","volume":"28","author":"OE Akilov","year":"2003","unstructured":"Akilov, O.E., and K.Y. Mumcuoglu. 2003. Association between human demodicosis and HLA class I. Clinical and Experimental Dermatology 28: 70\u201373.","journal-title":"Clinical and Experimental Dermatology"},{"key":"264_CR47","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/exd.12030","volume":"21","author":"C Casas","year":"2012","unstructured":"Casas, C., C. Paul, M. Lahfa, B. Livideanu, O. Lejeune, S. Alvarez-Georges, C. Saint-Martory, A. Degouy, V. Mengeaud, H. Ginisty, E. Durbise, A.M. Schmitt, and D. Redoul\u00e8s. 2012. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Experimental Dermatology 21: 906\u2013910.","journal-title":"Experimental Dermatology"},{"key":"264_CR48","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrmicro2537","volume":"9","author":"EA Grice","year":"2011","unstructured":"Grice, E.A., and J.A. Segre. 2011. The skin microbiome. Nature Reviews Microbiology 9: 244\u2013253.","journal-title":"Nature Reviews Microbiology"},{"key":"264_CR49","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/1523-1747.ep12607634","volume":"65","author":"JJ Leyden","year":"1975","unstructured":"Leyden, J.J., K.J. McGinley, O.H. Mills, and A.M. Kligman. 1975. Propionibacterium levels in patients with and without acne vulgaris. Journal of Investigative Dermatology 65: 382\u2013384.","journal-title":"Journal of Investigative Dermatology"},{"key":"264_CR50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1365-2133.1969.tb13976.x","volume":"81","author":"DA Somerville","year":"1969","unstructured":"Somerville, D.A. 1969. The normal flora of the skin in different age groups. British Journal of Dermatology 81: 248\u2013258.","journal-title":"British Journal of Dermatology"},{"key":"264_CR51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.micpath.2014.04.002","volume":"71\u201372","author":"N Murillo","year":"2014","unstructured":"Murillo, N., J. Aubert, and D. Raoult. 2014. Microbiota of Demodex mites from rosacea patients and controls. Microbial Pathogenesis 71\u201372: 37\u201340.","journal-title":"Microbial Pathogenesis"},{"key":"264_CR52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ceca.2007.01.011","volume":"42","author":"JW Putney","year":"2007","unstructured":"Putney, J.W. 2007. Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here). Cell Calcium 42: 103\u2013110.","journal-title":"Cell Calcium"},{"key":"264_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3120001","volume":"312","author":"MJ Berridge","year":"1995","unstructured":"Berridge, M.J. 1995. Capacitative calcium entry. Biochemistry Journal 312: 1\u201311.","journal-title":"Biochemistry Journal"},{"key":"264_CR54","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.tibs.2004.02.010","volume":"29","author":"CW Taylor","year":"2004","unstructured":"Taylor, C.W., P.C. da Fonseca, and E.P. Morris. 2004. IP3 receptors: the search for structure. Trends in Biochemical Science 29: 210\u2013219.","journal-title":"Trends in Biochemical Science"},{"issue":"6","key":"264_CR55","doi-asserted-by":"crossref","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence, T. 2009. The nuclear factor NF-\u03baB pathway in inflammation. Cold Spring Harbor Perspectives in Biology 1(6): a001651.","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"264_CR56","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1600-0625.2010.01107.x","volume":"19","author":"A Mastrofrancesco","year":"2010","unstructured":"Mastrofrancesco, A., M. Ottaviani, N. Aspite, G. Cardinali, E. Izzo, K. Graupe, C.C. Zouboulis, E. Camera, and M. Picardo. 2010. Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPAR\u03b3 activation. Experimental Dermatology 19: 813\u2013820.","journal-title":"Experimental Dermatology"},{"key":"264_CR57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/2213988501307010009","volume":"7","author":"H Eishingdrelo","year":"2013","unstructured":"Eishingdrelo, H., and S. Kongsamut. 2013. Minireview: targeting GPCR activated ERK pathways for drug discovery. Current Chemical Genomics and Translational Medicine 7: 9\u201315.","journal-title":"Current Chemical Genomics and Translational Medicine"},{"key":"264_CR58","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/2045125312471963","volume":"3","author":"KM Brown","year":"2013","unstructured":"Brown, K.M., and D.K. Tracy. 2013. Lithium: the pharmacodynamic actions of the amazing ion. Therapeutic Advances in Psychopharmacology 3: 163\u2013176.","journal-title":"Therapeutic Advances in Psychopharmacology"},{"key":"264_CR59","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1074\/jbc.M111.318733","volume":"287","author":"C Kliem","year":"2012","unstructured":"Kliem, C., A. Merling, M. Giaisi, R. K\u00f6hler, P.H. Krammer, and M. Li-Weber. 2012. Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation. Journal of Biological Chemistry 287: 10200\u201310209.","journal-title":"Journal of Biological Chemistry"},{"key":"264_CR60","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neuropharm.2004.03.016","volume":"47","author":"N Galeotti","year":"2004","unstructured":"Galeotti, N., A. Bartolini, M. Calvani, R. Nicolai, and C. Ghelardini. 2004. Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Neuropharmacology 47: 286\u2013294.","journal-title":"Neuropharmacology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-015-0264-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-015-0264-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-015-0264-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T04:57:03Z","timestamp":1599627423000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-015-0264-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,3]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["264"],"URL":"https:\/\/doi.org\/10.1007\/s10753-015-0264-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,3]]}}}