{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:07:26Z","timestamp":1784779646803,"version":"3.55.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s10753-016-0327-1","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T04:05:23Z","timestamp":1456977923000},"page":"938-947","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["N-acetylcysteine Ameliorates Prostatitis via miR-141 Regulating Keap1\/Nrf2 Signaling"],"prefix":"10.1007","volume":"39","author":[{"given":"Liang-Liang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Dong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Quan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xian","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"issue":"5","key":"327_CR1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.urology.2009.06.078","volume":"74","author":"JQ Clemens","year":"2009","unstructured":"Clemens, J.Q., et al. 2009. Validation of a modified National Institutes of Health chronic prostatitis symptom index to assess genitourinary pain in both men and women. Urology 74(5): 983\u2013987.e3.","journal-title":"Urology"},{"issue":"4","key":"327_CR2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tcmj.2014.07.008","volume":"26","author":"J-L Chen","year":"2014","unstructured":"Chen, J.-L., S.-F. Chen, and H.-C. Kuo. 2014. Clinical assessment and management of patients with National Institutes of Health categories IIIA and IIIB chronic prostatitis\/chronic pelvic pain syndrome. Tzu Chi Medical Journal 26(4): 151\u2013156.","journal-title":"Tzu Chi Medical Journal"},{"issue":"2","key":"327_CR3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-5347(05)68562-X","volume":"162","author":"MS Litwin","year":"1999","unstructured":"Litwin, M.S., et al. 1999. The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. The Journal of urology 162(2): 369\u2013375.","journal-title":"The Journal of urology"},{"issue":"3","key":"327_CR4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/01.ju.0000136002.76898.04","volume":"172","author":"MA Pontari","year":"2004","unstructured":"Pontari, M.A., and M.R. Ruggieri. 2004. Mechanisms in prostatitis\/chronic pelvic pain syndrome. The Journal of urology 172(3): 839\u2013845.","journal-title":"The Journal of urology"},{"issue":"1","key":"327_CR5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jep.2013.10.061","volume":"151","author":"X Yang","year":"2014","unstructured":"Yang, X., et al. 2014. Multitargeted protective effect of Abacopteris penangiana against carrageenan-induced chronic prostatitis in rats. Journal of ethnopharmacology 151(1): 343\u2013351.","journal-title":"Journal of ethnopharmacology"},{"issue":"7","key":"327_CR6","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1093\/carcin\/bgh317","volume":"26","author":"GS Palapattu","year":"2005","unstructured":"Palapattu, G.S., et al. 2005. Prostate carcinogenesis and inflammation: emerging insights. Carcinogenesis 26(7): 1170\u20131181.","journal-title":"Carcinogenesis"},{"issue":"6","key":"327_CR7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","volume":"6","author":"OI Aruoma","year":"1989","unstructured":"Aruoma, O.I., et al. 1989. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biology and Medicine 6(6): 593\u2013597.","journal-title":"Free Radical Biology and Medicine"},{"issue":"5","key":"327_CR8","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/hep.510270512","volume":"27","author":"N Kawada","year":"1998","unstructured":"Kawada, N., et al. 1998. Effect of antioxidants, resveratrol, quercetin, and N\u2010acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27(5): 1265\u20131274.","journal-title":"Hepatology"},{"key":"327_CR9","doi-asserted-by":"crossref","unstructured":"Danilovic, A., et al. 2011. Protective effect of N-acetylcysteine on early outcomes of deceased renal transplantation. in Transplantation proceedings. Elsevier.","DOI":"10.1016\/j.transproceed.2011.02.020"},{"issue":"3","key":"327_CR10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0008-6363(00)00018-3","volume":"47","author":"S Cuzzocrea","year":"2000","unstructured":"Cuzzocrea, S., et al. 2000. Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovascular research 47(3): 537\u2013548.","journal-title":"Cardiovascular research"},{"issue":"5","key":"327_CR11","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/ndt\/gfk032","volume":"21","author":"N Nitescu","year":"2006","unstructured":"Nitescu, N., et al. 2006. N-acetylcysteine attenuates kidney injury in rats subjected to renal ischaemia-reperfusion. Nephrology Dialysis Transplantation 21(5): 1240\u20131247.","journal-title":"Nephrology Dialysis Transplantation"},{"issue":"1","key":"327_CR12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.rbmo.2014.09.013","volume":"30","author":"M Mahmoodi","year":"2015","unstructured":"Mahmoodi, M., et al. 2015. N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress. Reproductive biomedicine online 30(1): 101\u2013110.","journal-title":"Reproductive biomedicine online"},{"issue":"3","key":"327_CR13","first-page":"265","volume":"80","author":"PJ Millea","year":"2009","unstructured":"Millea, P.J. 2009. N-acetylcysteine: multiple clinical applications. American family physician 80(3): 265\u2013269.","journal-title":"American family physician"},{"issue":"1","key":"327_CR14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","volume":"60","author":"M Zafarullah","year":"2003","unstructured":"Zafarullah, M., et al. 2003. Molecular mechanisms of N-acetylcysteine actions. Cellular and Molecular Life Sciences CMLS 60(1): 6\u201320.","journal-title":"Cellular and Molecular Life Sciences CMLS"},{"issue":"7","key":"327_CR15","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/01.CIR.0000050628.11305.30","volume":"107","author":"M Tepel","year":"2003","unstructured":"Tepel, M., et al. 2003. The antioxidant acetylcysteine reduces cardiovascular events in patients with End-stage renal failure a randomized, controlled trial. Circulation 107(7): 992\u2013995.","journal-title":"Circulation"},{"issue":"7043","key":"327_CR16","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/435745a","volume":"435","author":"PS Meltzer","year":"2005","unstructured":"Meltzer, P.S. 2005. Cancer genomics: small RNAs with big impacts. Nature 435(7043): 745\u2013746.","journal-title":"Nature"},{"issue":"9","key":"327_CR17","volume":"5","author":"D Wang","year":"2010","unstructured":"Wang, D., et al. 2010. Human microRNA oncogenes and tumor suppressors show significantly different biological patterns: from functions to targets. PLoS One 5(9), e13067.","journal-title":"PLoS One"},{"issue":"15","key":"327_CR18","doi-asserted-by":"crossref","first-page":"6162","DOI":"10.1158\/0008-5472.CAN-08-0144","volume":"68","author":"S Ambs","year":"2008","unstructured":"Ambs, S., et al. 2008. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer research 68(15): 6162\u20136170.","journal-title":"Cancer research"},{"issue":"3","key":"327_CR19","volume":"7","author":"X Liu","year":"2012","unstructured":"Liu, X., et al. 2012. Integrated sequence-structure motifs suffice to identify microRNA precursors. PloS one 7(3), e32797.","journal-title":"PloS one"},{"key":"327_CR20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bios.2013.05.007","volume":"49","author":"H Tran","year":"2013","unstructured":"Tran, H., et al. 2013. Label-free and reagentless electrochemical detection of microRNAs using a conducting polymer nanostructured by carbon nanotubes: application to prostate cancer biomarker miR-141. Biosensors and Bioelectronics 49: 164\u2013169.","journal-title":"Biosensors and Bioelectronics"},{"issue":"30","key":"327_CR21","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell, P.S., et al. 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proceedings of the National Academy of Sciences 105(30): 10513\u201310518.","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"47","key":"327_CR22","doi-asserted-by":"crossref","first-page":"40725","DOI":"10.1074\/jbc.M111.275495","volume":"286","author":"G Eades","year":"2011","unstructured":"Eades, G., et al. 2011. miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. Journal of Biological Chemistry 286(47): 40725\u201340733.","journal-title":"Journal of Biological Chemistry"},{"issue":"36","key":"327_CR23","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1038\/onc.2012.433","volume":"32","author":"M Jaarsveld Van","year":"2013","unstructured":"Van Jaarsveld, M., et al. 2013. miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. Oncogene 32(36): 4284\u20134293.","journal-title":"Oncogene"},{"key":"327_CR24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.freeradbiomed.2013.10.811","volume":"67","author":"J Wei","year":"2014","unstructured":"Wei, J., et al. 2014. Aldose reductase regulates miR-200a-3p\/141-3p to coordinate Keap1\u2013Nrf2, Tgf\u03b21\/2, and Zeb1\/2 signaling in renal mesangial cells and the renal cortex of diabetic mice. Free Radical Biology and Medicine 67: 91\u2013102.","journal-title":"Free Radical Biology and Medicine"},{"issue":"3","key":"327_CR25","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jep.2011.01.004","volume":"134","author":"R Chen","year":"2011","unstructured":"Chen, R., et al. 2011. In vivo study of four preparative extracts of Clematis terniflora DC. for antinociceptive activity and anti-inflammatory activity in rat model of carrageenan-induced chronic non-bacterial prostatitis. Journal of ethnopharmacology 134(3): 1018\u20131023.","journal-title":"Journal of ethnopharmacology"},{"issue":"1","key":"327_CR26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2003.10.007","volume":"996","author":"Y Yu","year":"2004","unstructured":"Yu, Y., M.O. Fraser, and W.C. de Groat. 2004. Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. Brain research 996(1): 41\u201346.","journal-title":"Brain research"},{"issue":"3","key":"327_CR27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1439-0272.2007.00816.x","volume":"40","author":"T Kullisaar","year":"2008","unstructured":"Kullisaar, T., et al. 2008. Oxidative stress in leucocytospermic prostatitis patients: preliminary results. Andrologia 40(3): 161\u2013172.","journal-title":"Andrologia"},{"issue":"11","key":"327_CR28","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1158\/1535-7163.MCT-13-0296","volume":"12","author":"G Zhao","year":"2013","unstructured":"Zhao, G., et al. 2013. miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. Molecular cancer therapeutics 12(11): 2569\u20132580.","journal-title":"Molecular cancer therapeutics"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-016-0327-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-016-0327-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-016-0327-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T23:42:47Z","timestamp":1559259767000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-016-0327-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["327"],"URL":"https:\/\/doi.org\/10.1007\/s10753-016-0327-1","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,3]]}}}