{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:17:30Z","timestamp":1787167050138,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["NSF 30872433"],"award-info":[{"award-number":["NSF 30872433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-016-0330-6","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:23:30Z","timestamp":1457396610000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Propofol Protects Rats and Human Alveolar Epithelial Cells Against Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting HMGB1 Expression"],"prefix":"10.1007","author":[{"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"330_CR1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5492\/wjccm.v1.i2.50","volume":"1","author":"CF Su","year":"2012","unstructured":"Su, C.F., S.J. Kao, and H.I. Chen. 2012. Acute respiratory distress syndrome and lung injury: pathogenetic mechanism and therapeutic implication. World Journal Critical Care Medicine 1: 50\u201360.","journal-title":"World Journal Critical Care Medicine"},{"key":"330_CR2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-3083.2009.02255.x","volume":"69","author":"A Castellheim","year":"2009","unstructured":"Castellheim, A., O.L. Brekke, T. Espevik, M. Harboe, and T.E. Mollnes. 2009. Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis. Scandinavian Journal of Immunology 69: 479\u2013491.","journal-title":"Scandinavian Journal of Immunology"},{"key":"330_CR3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jss.2013.10.009","volume":"187","author":"H Jing","year":"2014","unstructured":"Jing, H., J. Yao, X. Liu, H. Fan, F. Zhang, Z. Li, X. Tian, and Y. Zhou. 2014. Fish-oil emulsion (omega-3 polyunsaturated fatty acids) attenuates acute lung injury induced by intestinal ischemia-reperfusion through adenosine 5\u2032-monophosphate-activated protein kinase-sirtuin1 pathway. Journal of Surgical Research 187: 252\u2013261.","journal-title":"Journal of Surgical Research"},{"key":"330_CR4","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/TA.0000000000000602","volume":"78","author":"Z Song","year":"2015","unstructured":"Song, Z., X. Zhao, Y. Gao, M. Liu, M. Hou, H. Jin, and Y. Cui. 2015. Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK\/STAT signaling pathway in rats. Journal Trauma Acute Care Surgery 78: 980\u2013987.","journal-title":"Journal Trauma Acute Care Surgery"},{"key":"330_CR5","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1038\/srep12463","volume":"5","author":"WC Lin","year":"2015","unstructured":"Lin, W.C., C.W. Chen, Y.W. Huang, L. Chao, J. Chao, Y.S. Lin, and C.F. Lin. 2015. Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. Scientific Reports 5: 12463.","journal-title":"Scientific Reports"},{"key":"330_CR6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1586\/1744666X.2014.909730","volume":"10","author":"B Lu","year":"2014","unstructured":"Lu, B., C. Wang, M. Wang, W. Li, F. Chen, K.J. Tracey, and H. Wang. 2014. Molecular mechanism and therapeutic modulation of high mobility group box 1 release and action: an updated review. Expert Review of Clinical Immunology 10: 713\u2013727.","journal-title":"Expert Review of Clinical Immunology"},{"key":"330_CR7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2119\/molmed.2014.00176","volume":"20","author":"NM Agalave","year":"2015","unstructured":"Agalave, N.M., and C.I. Svensson. 2015. Extracellular high-mobility group box 1 protein (HMGB1) as a mediator of persistent pain. Molecular Medicine 20: 569\u2013578.","journal-title":"Molecular Medicine"},{"key":"330_CR8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1517\/14728222.2014.863876","volume":"18","author":"H Wang","year":"2014","unstructured":"Wang, H., M.F. Ward, and A.E. Sama. 2014. Targeting HMGB1 in the treatment of sepsis. Expert Opinion on Therapeutic Targets 18: 257\u2013268.","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"330_CR9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","volume":"285","author":"H Wang","year":"1999","unstructured":"Wang, H., O. Bloom, M. Zhang, J.M. Vishnubhakat, M. Ombrellino, J. Che, A. Frazier, H. Yang, S. Ivanova, L. Borovikova, K.R. Manogue, E. Faist, E. Abraham, J. Andersson, U. Andersson, P.E. Molina, N.N. Abumrad, A. Sama, and K.J. Tracey. 1999. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285: 248\u2013251.","journal-title":"Science"},{"key":"330_CR10","first-page":"245","volume":"17","author":"W Lutz","year":"2004","unstructured":"Lutz, W., and J. Stetkiewicz. 2004. High mobility group box 1 protein as a late-acting mediator of acute lung inflammation. International Journal of Occupational Medicine and Environmental Health 17: 245\u2013254.","journal-title":"International Journal of Occupational Medicine and Environmental Health"},{"key":"330_CR11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1073\/pnas.2434651100","volume":"101","author":"H Yang","year":"2004","unstructured":"Yang, H., M. Ochani, J. Li, X. Qiang, M. Tanovic, H.E. Harris, S.M. Susarla, L. Ulloa, H. Wang, R. DiRaimo, C.J. Czura, J. Roth, H.S. Warren, M.P. Fink, M.J. Fenton, U. Andersson, and K.J. Tracey. 2004. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proceedings of the National Academy of Sciences of the United States of America 101: 296\u2013301.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"330_CR12","doi-asserted-by":"crossref","first-page":"21052","DOI":"10.1073\/pnas.1216195109","volume":"109","author":"C Ye","year":"2012","unstructured":"Ye, C., J.G. Choi, S. Abraham, H. Wu, D. Diaz, D. Terreros, P. Shankar, and N. Manjunath. 2012. Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model. Proceedings of the National Academy of Sciences of the United States of America 109: 21052\u201321057.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"330_CR13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10456-008-9093-5","volume":"11","author":"JR Beijnum van","year":"2008","unstructured":"van Beijnum, J.R., W.A. Buurman, and A.W. Griffioen. 2008. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis 11: 91\u201399.","journal-title":"Angiogenesis"},{"key":"330_CR14","doi-asserted-by":"crossref","first-page":"C917","DOI":"10.1152\/ajpcell.00401.2005","volume":"290","author":"JS Park","year":"2006","unstructured":"Park, J.S., F. Gamboni-Robertson, Q. He, D. Svetkauskaite, J.Y. Kim, D. Strassheim, J.W. Sohn, S. Yamada, I. Maruyama, A. Banerjee, A. Ishizaka, and E. Abraham. 2006. High mobility group box 1 protein interacts with multiple toll-like receptors. American Journal of Physiology - Cell Physiology 290: C917\u2013C924.","journal-title":"American Journal of Physiology - Cell Physiology"},{"key":"330_CR15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2119\/molmed.2012.00306","volume":"19","author":"S Kim","year":"2013","unstructured":"Kim, S., S.Y. Kim, J.P. Pribis, M. Lotze, K.P. Mollen, R. Shapiro, P. Loughran, M.J. Scott, and T.R. Billiar. 2013. Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14. Molecular Medicine 19: 88\u201398.","journal-title":"Molecular Medicine"},{"key":"330_CR16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.atherosclerosis.2013.09.010","volume":"231","author":"Y Hirata","year":"2013","unstructured":"Hirata, Y., H. Kurobe, M. Higashida, D. Fukuda, M. Shimabukuro, K. Tanaka, Y. Higashikuni, T. Kitagawa, and M. Sata. 2013. HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9. Atherosclerosis 231: 227\u2013233.","journal-title":"Atherosclerosis"},{"key":"330_CR17","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.jss.2010.12.034","volume":"168","author":"HG Bao","year":"2011","unstructured":"Bao, H.G., and S. Li. 2011. Effects of propofol on the outcomes of rats with sepsis. Journal of Surgical Research 168: e111\u2013e115.","journal-title":"Journal of Surgical Research"},{"key":"330_CR18","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s11033-009-9456-z","volume":"36","author":"XM Song","year":"2009","unstructured":"Song, X.M., Y.L. Wang, J.G. Li, C.Y. Wang, Q. Zhou, Z.Z. Zhang, and H. Liang. 2009. Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. Molecular Biology Reports 36: 2345\u20132351.","journal-title":"Molecular Biology Reports"},{"key":"330_CR19","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cbi.2009.06.011","volume":"181","author":"WT Chiu","year":"2009","unstructured":"Chiu, W.T., Y.L. Lin, C.W. Chou, and R.M. Chen. 2009. Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1\/2-ERK1\/2-IKK-NFkappaB. Chemico-Biological Interactions 181: 430\u2013439.","journal-title":"Chemico-Biological Interactions"},{"key":"330_CR20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/1414-431X20122379","volume":"46","author":"L Ma","year":"2013","unstructured":"Ma, L., X.Y. Wu, L.H. Zhang, W.M. Chen, A. Uchiyama, T. Mashimo, and Y. Fujino. 2013. Propofol exerts anti-inflammatory effects in rats with lipopolysaccharide-induced acute lung injury by inhibition of CD14 and TLR4 expression. Brazilian Journal of Medical and Biological Research 46: 299\u2013305.","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"330_CR21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1590\/1414-431X20144222","volume":"48","author":"T Wang","year":"2015","unstructured":"Wang, T., X.Y. Wei, B. Liu, L.J. Wang, and L.H. Jiang. 2015. Effects of propofol on lipopolysaccharide-induced expression and release of HMGB1 in macrophages. Brazilian Journal of Medical and Biological Research 48: 286\u2013291.","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"330_CR22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/ANA.0b013e31828c6af5","volume":"25","author":"C Liang","year":"2013","unstructured":"Liang, C., J. Cang, H. Wang, and Z. Xue. 2013. Propofol attenuates cerebral ischemia\/reperfusion injury partially using heme oxygenase-1. Journal of Neurosurgical Anesthesiology 25: 311\u2013316.","journal-title":"Journal of Neurosurgical Anesthesiology"},{"key":"330_CR23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.phrs.2009.04.007","volume":"60","author":"W Shen","year":"2009","unstructured":"Shen, W., J. Gan, S. Xu, G. Jiang, and H. Wu. 2009. Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway. Pharmacological Research 60: 296\u2013302.","journal-title":"Pharmacological Research"},{"key":"330_CR24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.pupt.2006.03.006","volume":"20","author":"CH Chu","year":"2007","unstructured":"Chu, C.H., D. David Liu, Y.H. Hsu, K.C. Lee, and H.I. Chen. 2007. Propofol exerts protective effects on the acute lung injury induced by endotoxin in rats. Pulmonary Pharmacology & Therapeutics 20: 503\u2013512.","journal-title":"Pulmonary Pharmacology & Therapeutics"},{"key":"330_CR25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1674-8301(10)60052-8","volume":"24","author":"S Li","year":"2010","unstructured":"Li, S., H. Bao, L. Han, and L. Liu. 2010. Effects of propofol on early and late cytokines in lipopolysaccharide-induced septic shock in rats. Journal Biomedical Research 24: 389\u2013394.","journal-title":"Journal Biomedical Research"},{"key":"330_CR26","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00540-012-1539-7","volume":"27","author":"L Wei","year":"2013","unstructured":"Wei, L., H. Matsumoto, and H. Yamaguchi. 2013. Propofol attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production through p38 MAPK and SAPK\/JNK in alveolar epithelial cells. Journal of Anesthesia 27: 366\u2013373.","journal-title":"Journal of Anesthesia"},{"key":"330_CR27","doi-asserted-by":"crossref","unstructured":"Zhao L.L., Hu G.C., Zhu S.S., Li J.F. and Liu G.J. 2014. Propofol pretreatment attenuates lipopolysaccharide-induced acute lung injury in rats by activating the phosphoinositide-3-kinase\/Akt pathway. Brazilian Journal of Medical and Biological Research.","DOI":"10.1590\/1414-431X20143949"},{"key":"330_CR28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.18388\/abp.2013_2006","volume":"60","author":"D Gokcinar","year":"2013","unstructured":"Gokcinar, D., V. Ergin, A. Cumaoglu, A. Menevse, and A. Aricioglu. 2013. Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. Acta Biochimica Polonica 60: 451\u2013456.","journal-title":"Acta Biochimica Polonica"},{"key":"330_CR29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2015.04.002","volume":"26","author":"G Feng","year":"2015","unstructured":"Feng, G., B. Sun, and T.Z. Li. 2015. Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4\/NF-kappaB pathway. International Immunopharmacology 26: 392\u2013400.","journal-title":"International Immunopharmacology"},{"key":"330_CR30","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10753-015-0127-z","volume":"38","author":"Z Tianzhu","year":"2015","unstructured":"Tianzhu, Z., and W. Shumin. 2015. Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR\/NF-kappaB pathways. Inflammation 38: 1529\u20131536.","journal-title":"Inflammation"},{"key":"330_CR31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","volume":"5","author":"T Kawasaki","year":"2014","unstructured":"Kawasaki, T., and T. Kawai. 2014. Toll-like receptor signaling pathways. Frontiers in Immunology 5: 461.","journal-title":"Frontiers in Immunology"},{"key":"330_CR32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jss.2012.07.017","volume":"181","author":"Y Chang","year":"2013","unstructured":"Chang, Y., X. Huang, Z. Liu, G. Han, L. Huang, Y.C. Xiong, and Z. Wang. 2013. Dexmedetomidine inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated macrophages in vitro. Journal of Surgical Research 181: 308\u2013314.","journal-title":"Journal of Surgical Research"},{"key":"330_CR33","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1016\/j.jss.2012.02.012","volume":"179","author":"Z Liu","year":"2013","unstructured":"Liu, Z., J. Zhang, X. Huang, L. Huang, S. Li, and Z. Wang. 2013. Magnesium sulfate inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated RAW264.7 macrophages in vitro. Journal of Surgical Research 179: e189\u2013e195.","journal-title":"Journal of Surgical Research"},{"key":"330_CR34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jss.2012.04.045","volume":"180","author":"Z Liu","year":"2013","unstructured":"Liu, Z., Y. Chang, J. Zhang, X. Huang, J. Jiang, S. Li, and Z. Wang. 2013. Magnesium deficiency promotes secretion of high-mobility group box 1 protein from lipopolysaccharide-activated macrophages in vitro. Journal of Surgical Research 180: 310\u2013316.","journal-title":"Journal of Surgical Research"},{"key":"330_CR35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jss.2013.08.015","volume":"186","author":"Q Yang","year":"2014","unstructured":"Yang, Q., X. Liu, Z. Yao, S. Mao, Q. Wei, and Y. Chang. 2014. Penehyclidine hydrochloride inhibits the release of high-mobility group box 1 in lipopolysaccharide-activated RAW264.7 cells and cecal ligation and puncture-induced septic mice. Journal of Surgical Research 186: 310\u2013317.","journal-title":"Journal of Surgical Research"},{"key":"330_CR36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2044.1987.tb02936.x","volume":"42","author":"N Mackenzie","year":"1987","unstructured":"Mackenzie, N., and I.S. Grant. 1987. Propofol for intravenous sedation. Anaesthesia 42: 3\u20136.","journal-title":"Anaesthesia"},{"key":"330_CR37","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/bjp.2008.45","volume":"153","author":"H Shao","year":"2008","unstructured":"Shao, H., J. Li, Y. Zhou, Z. Ge, J. Fan, Z. Shao, and Y. Zeng. 2008. Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic\/reperfused rat heart: role of cardiolipin. British Journal of Pharmacology 153: 1641\u20131649.","journal-title":"British Journal of Pharmacology"},{"key":"330_CR38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2010.08.012","volume":"1356","author":"J Li","year":"2010","unstructured":"Li, J., B. Han, X. Ma, and S. Qi. 2010. The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats. Brain Research 1356: 11\u201323.","journal-title":"Brain Research"},{"key":"330_CR39","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/sj.bjp.0704912","volume":"137","author":"Y Karashima","year":"2002","unstructured":"Karashima, Y., M. Oike, S. Takahashi, and Y. Ito. 2002. Propofol prevents endothelial dysfunction induced by glucose overload. British Journal of Pharmacology 137: 683\u2013691.","journal-title":"British Journal of Pharmacology"},{"key":"330_CR40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1213\/01.ane.0000281046.77228.91","volume":"105","author":"B Wang","year":"2007","unstructured":"Wang, B., T. Luo, D. Chen, and D.M. Ansley. 2007. Propofol reduces apoptosis and up-regulates endothelial nitric oxide synthase protein expression in hydrogen peroxide-stimulated human umbilical vein endothelial cells. Anesthesia and Analgesia 105: 1027\u20131033. Table of contents.","journal-title":"Anesthesia and Analgesia"},{"key":"330_CR41","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00134-003-1905-x","volume":"29","author":"B Vasile","year":"2003","unstructured":"Vasile, B., F. Rasulo, A. Candiani, and N. Latronico. 2003. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Medicine 29: 1417\u20131425.","journal-title":"Intensive Care Medicine"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-016-0330-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-016-0330-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-016-0330-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T05:23:51Z","timestamp":1567661031000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-016-0330-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,8]]},"references-count":41,"alternative-id":["330"],"URL":"https:\/\/doi.org\/10.1007\/s10753-016-0330-6","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,8]]}}}