{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:28:16Z","timestamp":1775521696857,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T00:00:00Z","timestamp":1467676800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s10753-016-0399-y","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T01:56:36Z","timestamp":1467683796000},"page":"1649-1659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Melatonin Alters the Mechanical and Thermal Hyperalgesia Induced by Orofacial Pain Model in Rats"],"prefix":"10.1007","volume":"39","author":[{"given":"Vanessa Leal","family":"Scarabelot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liciane Fernandes","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren Naomi Spezia","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Cristina","family":"de Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania Giotti","family":"Cioato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joice S.","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Quevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolnei","family":"Caumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraci Lucena da Silva","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"issue":"5","key":"399_CR1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s10439-009-9659-4","volume":"37","author":"S Ingawal\u00e9","year":"2009","unstructured":"Ingawal\u00e9, S., and T. Goswami. 2009. Temporomandibular joint: disorders, treatments, and biomechanics. Annals of Biomedical Engineering 37(5): 976\u2013996.","journal-title":"Annals of Biomedical Engineering"},{"issue":"4","key":"399_CR2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/joms.2003.50096","volume":"61","author":"MS Detamore","year":"2003","unstructured":"Detamore, M.S., and K.A. Athanasiou. 2003. Structure and function of the temporomandibular joint disc: implications for tissue engineering. Journal of Oral Maxillofacial Surgery 61(4): 494\u2013506.","journal-title":"Journal of Oral Maxillofacial Surgery"},{"issue":"6","key":"399_CR3","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/sleep\/32.6.779","volume":"32","author":"MT Smith","year":"2009","unstructured":"Smith, M.T., E.M. Wickwire, E.G. Grace, R.R. Edwards, L.F. Buenaver, S. Peterson, B. Klick, and J.A. Haythornthwaite. 2009. Sleep disorders and their association with laboratory pain sensitivity in temporomandibular joint disorder. Sleep 32(6): 779\u2013790.","journal-title":"Sleep"},{"issue":"2","key":"399_CR4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.5664\/jcsm.3452","volume":"10","author":"B Dubrovsky","year":"2014","unstructured":"Dubrovsky, B., K.G. Raphael, G.J. Lavigne, M.N. Janal, D.A. Sirois, P.E. Wigren, L.V. Nemelivsky, J.J. Klausner, and A.C. Krieger. 2014. Polysomnographic investigation of sleep and respiratory parameters in women with temporomandibular pain disorders. Journal of Clinical Sleep Medicine 10(2): 195\u2013201.","journal-title":"Journal of Clinical Sleep Medicine"},{"issue":"4","key":"399_CR5","first-page":"339","volume":"23","author":"PA Cunali","year":"2009","unstructured":"Cunali, P.A., F.R. Almeida, C.D. Santos, N.Y. Valdrighi, L.S. Nascimento, C. Dal\u2019Fabbro, S. Tufik, and L.R. Bittencourt. 2009. Prevalence of temporomandibular disorders in obstructive sleep apnea patients referred for oral appliance therapy. Journal of Orofacial Pain 23(4): 339\u2013344.","journal-title":"Journal of Orofacial Pain"},{"key":"399_CR6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cyto.2015.11.005","volume":"77","author":"SV Kellesarian","year":"2016","unstructured":"Kellesarian, S.V., A.A. Al-Kheraif, F. Vohra, A. Ghanem, H. Malmstrom, G.E. Romanos, and F. Javed. 2016. Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: a systematic review. Cytokine 77: 98\u2013106.","journal-title":"Cytokine"},{"issue":"7","key":"399_CR7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0003-9969(01)00024-3","volume":"46","author":"LC Anderson","year":"2001","unstructured":"Anderson, L.C., and R.D. Rao. 2001. Interleukin-6 and nerve growth factor levels in peripheral nerve and brainstem after trigeminal nerve injury in the rat. Archives of Oral Biology 46(7): 633\u2013640.","journal-title":"Archives of Oral Biology"},{"key":"399_CR8","first-page":"5","volume":"21","author":"K Shimizu","year":"2009","unstructured":"Shimizu, K., W. Guo, H. Wang, S. Zou, S.C. La Graize, K. Iwata, F. Wei, R. Dubner, and K. Ren. 2009. Differential involvement of trigeminal transition zone and laminated subnucleuscaudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors. Molecular Pain 21: 5\u201375.","journal-title":"Molecular Pain"},{"issue":"3","key":"399_CR9","first-page":"319","volume":"11","author":"A Peimani","year":"2014","unstructured":"Peimani, A., and F. Sardary. 2014. Effect of low level laser on healing of temporomandibular joint osteoarthritis in rats. Journal of Dentistry (Tehran, Iran) 11(3): 319\u2013327.","journal-title":"Journal of Dentistry (Tehran, Iran)"},{"key":"399_CR10","first-page":"359","volume":"5","author":"G Laste","year":"2012","unstructured":"Laste, G., I.C. Macedo, J.R. Rozisky, F.R. Silva, W. Caumo, and I.L.S. Torres. 2012. Melatonin administration reduces inflammatory pain in rats. Journal of Pain Research 5: 359\u2013362.","journal-title":"Journal of Pain Research"},{"issue":"6","key":"399_CR11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000380912","volume":"22","author":"G Laste","year":"2015","unstructured":"Laste, G., J. Ripoll Rozisky, W. Caumo, and I. Lucena da Silva Torres. 2015. Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. Neuroimmunomodulation 22(6): 358\u201364.","journal-title":"Neuroimmunomodulation"},{"key":"399_CR12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbr.2013.07.051","volume":"256","author":"L Zhang","year":"2013","unstructured":"Zhang, L., H.Q. Zhang, X.Y. Liang, H.F. Zhang, T. Zhang, and F.E. Liu. 2013. Melatonin ameliorates cognitive impairment induced by sleep deprivation in rats: role of oxidative stress, BDNF and CaMKII. Behavioural Brain Research 256: 72\u201381.","journal-title":"Behavioural Brain Research"},{"issue":"4","key":"399_CR13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10409230903044914","volume":"44","author":"RJ Reiter","year":"2009","unstructured":"Reiter, R.J., S.D. Paredes, L.C. Manchester, and D.X. Tan. 2009. Reducing oxidative\/nitrosative stress: a newly-discovered genre for melatonin. Critical Reviews in Biochemistry and Molecular Biology 44(4): 175\u2013200.","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"issue":"32","key":"399_CR14","first-page":"2991","volume":"8","author":"F Huang","year":"2013","unstructured":"Huang, F., H. He, W. Fan, Y. Liu, H. Zhou, and B. Cheng. 2013. Orofacial inflammatory pain affects the expression of MT1 and NADPH-d in rat caudal spinal trigeminal nucleus and trigeminal ganglion. Neural Regeneration Research 8(32): 2991\u20133002.","journal-title":"Neural Regeneration Research"},{"key":"399_CR15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.j.pain.0000460311.71572.5f","volume":"156","author":"M Lopez-Canul","year":"2015","unstructured":"Lopez-Canul, M., E. Palazzo, S. Dominguez-Lopez, L. Luongo, B. Lacoste, S. Comal, D. Angeloni, F. Fraschini, S. Boccella, G. Spadoni, A. Bedini, G. Tarzia, S. Maione, V. Granados-Soto, and G. Gobbi. 2015. Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain 156: 305\u2013317.","journal-title":"Pain"},{"issue":"1\u20132","key":"399_CR16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neulet.2004.01.080","volume":"360","author":"R Noseda","year":"2004","unstructured":"Noseda, R., A. Hern\u00e1ndez, L. Valladares, M. Mondaca, C. Laurido, and R. Soto-Moyano. 2004. Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT2 receptor-dependent. Neuroscience Letters 360(1\u20132): 41\u201344.","journal-title":"Neuroscience Letters"},{"issue":"3","key":"399_CR17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jpainsymman.2012.08.019","volume":"46","author":"LP Vidor","year":"2013","unstructured":"Vidor, L.P., I.L.S. Torres, I.C.C. de Souza, F. Fregni, and C. Caumo. 2013. Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. Journal of Pain Symptom Management 46(3): 422\u2013432.","journal-title":"Journal of Pain Symptom Management"},{"issue":"1","key":"399_CR18","first-page":"66","volume":"7","author":"JG Li","year":"2015","unstructured":"Li, J.G., J.J. Lin, Z.L. Wang, W.K. Cai, P.N. Wang, Q. Jia, A.S. Zhang, G.Y. Wu, G.X. Zhu, and L.X. Ni. 2015. Melatonin attenuates inflammation of acute pulpitis subjected to dental pulp injury. American Journal of Translational Research 7(1): 66\u201378.","journal-title":"American Journal of Translational Research"},{"issue":"1","key":"399_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568008043340071","volume":"4","author":"DP Cardinali","year":"2004","unstructured":"Cardinali, D.P., A.P. Garc\u00eda, P. Cano, and A.I. Esquifino. 2004. Melatonin role in experimental arthritis. Current Drug Targets Immune, Endocrine and Metabol Disorders 4(1): 1\u201310.","journal-title":"Current Drug Targets Immune, Endocrine and Metabol Disorders"},{"key":"399_CR20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.mcn.2005.11.008","volume":"31","author":"J Zhao","year":"2006","unstructured":"Zhao, J., A. Seereeram, M.A. Nassar, A. Levato, S. Pezet, G. Hathaway, C. Morenilla-Palao, C. Stirling, M. Fitzgerald, S.B. McMahon, M. Rios, and J.N. Wood. 2006. Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Molecular and Cellular Neuroscience 31: 539\u2013548.","journal-title":"Molecular and Cellular Neuroscience"},{"issue":"9","key":"399_CR21","first-page":"373","volume":"2016","author":"DS Chang","year":"2016","unstructured":"Chang, D.S., E. Hsu, D.G. Hottinger, and S.P. Cohen. 2016. Anti-nerve growth factor in pain management: current evidence. Journal of Pain Research 2016(9): 373\u2013383.","journal-title":"Journal of Pain Research"},{"issue":"2","key":"399_CR22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.1997.tb00342.x","volume":"23","author":"S Cuzzocrea","year":"1997","unstructured":"Cuzzocrea, S., B. Zingarelli, E. Gilad, P. Hake, A.L. Salzman, and C. Szab\u00f3. 1997. Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. Journal of Pineal Research 23(2): 106\u2013116.","journal-title":"Journal of Pineal Research"},{"key":"399_CR23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-079X.2010.00796.x","volume":"49","author":"E Esposito","year":"2010","unstructured":"Esposito, E., I. Paterniti, E. Mazzon, P. Bramanti, and S. Cuzzocrea. 2010. Melatonin reduces hyperalgesia associated with inflammation. Journal of Pineal Research 49: 321\u2013331.","journal-title":"Journal of Pineal Research"},{"issue":"15\u201316","key":"399_CR24","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.lfs.2009.01.024","volume":"84","author":"M Ambriz-Tututi","year":"2009","unstructured":"Ambriz-Tututi, M., H.I. Rocha-Gonz\u00e1lez, S.L. Cruz, and V. Granados-Soto. 2009. Melatonin: a hormone that modulates pain. Life Science 84(15\u201316): 489\u2013498.","journal-title":"Life Science"},{"issue":"7","key":"399_CR25","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1523\/JNEUROSCI.09-07-02581.1989","volume":"9","author":"DR Weaver","year":"1989","unstructured":"Weaver, D.R., S.A. Rivkees, and S.M. Reppert. 1989. Localization and characterization of melatonin receptors in rodent brain by in vitro autoradiography. Journal of Neurosciences 9(7): 2581\u20132590.","journal-title":"Journal of Neurosciences"},{"issue":"4","key":"399_CR26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1600-079X.1995.tb00186.x","volume":"19","author":"LM Williams","year":"1995","unstructured":"Williams, L.M., L.T. Hannah, M.H. Hastings, and E.S. Maywood. 1995. Melatonin receptors in the rat brain and pituitary. Journal of Pineal Research 19(4): 173\u2013177.","journal-title":"Journal of Pineal Research"},{"issue":"3","key":"399_CR27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pain.2007.01.025","volume":"132","author":"M Ambriz-Tututi","year":"2007","unstructured":"Ambriz-Tututi, M., and V. Granados-Soto. 2007. Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors. Pain 132(3): 273\u2013280.","journal-title":"Pain"},{"issue":"3","key":"399_CR28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1152\/physrev.1998.78.3.687","volume":"78","author":"J Vanecek","year":"1998","unstructured":"Vanecek, J. 1998. Cellular mechanisms of melatonin action. Physiological Reviews 78(3): 687\u2013721.","journal-title":"Physiological Reviews"},{"key":"399_CR29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejphar.2007.09.006","volume":"577","author":"R Arreola-Espino","year":"2007","unstructured":"Arreola-Espino, R., H. Urquiza-Mar\u00edn, M. Ambriz-Tututi, C.I. Araiza-Salda\u00f1a, N.L. Caram-Salas, H.I. Rocha-Gonz\u00e1lez, T. Mixcoatl-Zecuatl, and V. Granados-Soto. 2007. Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats. European Journal of Pharmacology 577: 203\u2013210.","journal-title":"European Journal of Pharmacology"},{"issue":"6","key":"399_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny, C., W.J. Browne, I.C. Cuthill, M. Emerson, and D.G. Altman. 2010. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biology 8(6): 1\u20136.","journal-title":"PLoS Biology"},{"issue":"2","key":"399_CR31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.expneurol.2008.08.005","volume":"214","author":"Y Yamasaki","year":"2008","unstructured":"Yamasaki, Y., K. Ren, M. Shimada, and K. Iwata. 2008. Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats. Experimental Neurology 214(2): 209\u2013218.","journal-title":"Experimental Neurology"},{"key":"399_CR32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pain.2005.05.013","volume":"117","author":"DA Bereiter","year":"2005","unstructured":"Bereiter, D.A., K. Okamoto, and D.F. Bereiter. 2005. Effect of persistent monoarthritis of the temporomandibular joint region on acute mustard oil-induced excitation of trigeminal subnucleus caudalis neurons in male and female rats. Pain 117: 58\u201367.","journal-title":"Pain"},{"issue":"3","key":"399_CR33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00221-005-0218-4","volume":"170","author":"K Okamoto","year":"2006","unstructured":"Okamoto, K., A. Kimura, T. Donishi, H. Imbe, K. Goda, K. Kawanishi, Y. Tamai, and E. Senba. 2006. Persistent monoarthritis of the temporomandibular joint region enhances nocifensive behavior and lumbar spinal Fos expression after noxious stimulation to the hindpaw in rats. Experimental Brain Research 170(3): 358\u2013367.","journal-title":"Experimental Brain Research"},{"issue":"9","key":"399_CR34","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.3109\/07420528.2013.800088","volume":"30","author":"G Laste","year":"2013","unstructured":"Laste, G., L. Vidor, I.C. de Macedo, J.R. Rozisky, L. Medeiros, A. de Souza, L. Meurer, I.C. de Souza, I.L. Torres, and W. Caumo. 2013. Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. Chronobiology International 30(9): 1077\u20131088.","journal-title":"Chronobiology International"},{"issue":"3","key":"399_CR35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-079X.2011.00895.x","volume":"51","author":"M Wilhelmsen","year":"2011","unstructured":"Wilhelmsen, M., I. Amirian, R.J. Reiter, J. Rosenberg, and I. G\u00f6genur. 2011. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. Journal of Pineal Research 51(3): 270\u2013277.","journal-title":"Journal of Pineal Research"},{"issue":"3","key":"399_CR36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0304-3959(94)00231-3","volume":"62","author":"MH Ossipov","year":"1995","unstructured":"Ossipov, M.H., C.J. Kovelowski, M.L. Nichols, V.J. Hruby, and F. Porreca. 1995. Characterization of supra spinal antinociceptive actions of opioid delta agonists in the rat. Pain 62(3): 287\u2013293.","journal-title":"Pain"},{"key":"399_CR37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2012.10.009","volume":"1489","author":"LNS Spezia Adachi","year":"2012","unstructured":"Spezia Adachi, L.N.S., W. Caumo, G. Laste, L.F. Medeiros, J.R. Rozisky, A. Souza, F. Fregni, and I.L.S. Torres. 2012. Reversal of chronic stress-induced pain by transcranial direct current stimulation (tDCS) in an animal model. Brain Research 1489: 17\u201326.","journal-title":"Brain Research"},{"issue":"3","key":"399_CR38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF02246552","volume":"122","author":"R Caggiula","year":"1995","unstructured":"Caggiula, R., L.H. Epstein, K.A. Perkins, and S. Saylor. 1995. Different methods of assessing nicotine-induced antinociception may engage different neural mechanisms. Psychopharmacology 122(3): 301\u2013306.","journal-title":"Psychopharmacology"},{"issue":"9","key":"399_CR39","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1073\/pnas.93.9.3995","volume":"93","author":"M Rubinstein","year":"1996","unstructured":"Rubinstein, M., J.S. Mogil, M. Jap\u00f3n, E.C. Chan, R.G. Allen, and M.J. Low. 1996. Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. Proceedings of the National Academy of Sciences 93(9): 3995\u20134000.","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"399_CR40","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0163-1047(87)90850-8","volume":"48","author":"CA Netto","year":"1987","unstructured":"Netto, C.A., B. Siegfried, and I. Izquierdo. 1987. Analgesia induced by exposure to a novel environment in rats: effect of concurrent and post-training stressful stimulation. Behavioral and Neural Biology 48(2): 304\u2013309.","journal-title":"Behavioral and Neural Biology"},{"key":"399_CR41","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248\u2013254.","journal-title":"Analytical Biochemistry"},{"issue":"5","key":"399_CR42","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3346\/jkms.2015.30.5.552","volume":"30","author":"SH Kim","year":"2015","unstructured":"Kim, S.H., C.N. Son, H.J. Lee, H.C. Cho, S.W. Jung, J.A. Hur, W.K. Baek, H.R. Jung, and J.H. Hong. 2015. Infliximab partially alleviates the bite force reduction in a mouse model of temporomandibular joint pain. Journal of Korean Medical Science 30(5): 552\u2013558.","journal-title":"Journal of Korean Medical Science"},{"key":"399_CR43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-8741(01)00194-5","volume":"75","author":"N Maleki","year":"2001","unstructured":"Maleki, N., A. Garjani, H. Nazemiyeh, N. Nilfouroushan, A.T. Eftekhar Sadat, Z. Allameh, and N. Hasannia. 2001. Potent anti-inflammatory activities of hydroalcoholic extract from aerial parts of Stachys inflata on rats. Ethnopharmacology 75: 213\u2013218.","journal-title":"Ethnopharmacology"},{"key":"399_CR44","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1440-1681.2008.05009.x","volume":"35","author":"J Zaringhalam","year":"2008","unstructured":"Zaringhalam, J., H. Manaheji, N. Mghsoodi, B. Farokhi, and V. Mirzaiee. 2008. Spinal mu-opioid receptor expression and hyperalgesia with dexamethasone in chronic adjuvant arthritis rats. Clinical and Experimental Pharmacology and Physiology 35: 1309\u20131315.","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"399_CR45","first-page":"34","volume":"19","author":"R Spears","year":"2005","unstructured":"Spears, R., L.A. Dees, M. Sapozhnikov, L.L. Bellinger, and B. Hutchins. 2005. Temporal changes in inflammatory mediator concentrations in an adjuvant model of temporomandibular joint inflammation. Journal of Orofacial Pain 19: 34\u201340.","journal-title":"Journal of Orofacial Pain"},{"key":"399_CR46","first-page":"300","volume":"80","author":"G Woolfe","year":"1944","unstructured":"Woolfe, G., and A.D. MacDonald. 1944. The evaluation of the analgesic action of pethidine hydrochloride. Journal of Pharmacology and Experimental Therapeutics 80: 300\u2013307.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"399_CR47","first-page":"597","volume":"53","author":"D Bars Le","year":"2001","unstructured":"Le Bars, D., M. Gozariu, and S.W. Cadden. 2001. Animal models of nociception. Pharmacol Reviews 53(4): 597\u2013652.","journal-title":"Pharmacol Reviews"},{"issue":"1","key":"399_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(98)00048-3","volume":"57","author":"MJ Millan","year":"1999","unstructured":"Millan, M.J. 1999. The induction of pain: an integrative review. Progress in Neurobiology 57(1): 1\u2013164.","journal-title":"Progress in Neurobiology"},{"issue":"1","key":"399_CR49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0304-3959(96)03105-3","volume":"67","author":"QP Ma","year":"1996","unstructured":"Ma, Q.P., and C.J. Woolf. 1996. Progressive tactile hypersensitivity: an inflammation-induced incremental increase in the excitability of the spinal cord. Pain 67(1): 97\u2013106.","journal-title":"Pain"},{"key":"399_CR50","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/384360a0","volume":"384","author":"S Neumann","year":"1996","unstructured":"Neumann, S., T.P. Doubell, T. Leslie, and C. Wolff. 1996. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons. Nature 384: 360\u2013364.","journal-title":"Nature"},{"key":"399_CR51","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.brainresbull.2009.12.001","volume":"81","author":"V Srinivasan","year":"2010","unstructured":"Srinivasan, V., S.R. Pandi-Perumal, D.W. Spence, A. Moscovitch, I. Trakht, G.M. Brown, and D.P. Cardinali. 2010. Potential use of melatonergic drugs in analgesia: mechanisms of action. Brain Research Bulletin 81: 362\u2013371.","journal-title":"Brain Research Bulletin"},{"issue":"3","key":"399_CR52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pain.2007.01.025","volume":"132","author":"M Ambriz-Tututi","year":"2007","unstructured":"Ambriz-Tututi, M., and V. Granados-Soto. 2007. Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors. Pain 132(3): 273\u2013280.","journal-title":"Pain"},{"key":"399_CR53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(00)00421-0","volume":"403","author":"CX Yu","year":"2000","unstructured":"Yu, C.X., C.B. Zhu, S.F. Xu, X.D. Cao, and G.C. Wu. 2000. The analgesic effects of peripheral and central administration of melatonin in rats. European Journal of Pharmacology 403: 49\u201353.","journal-title":"European Journal of Pharmacology"},{"key":"399_CR54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0197-0186(94)90100-7","volume":"24","author":"PJ Morgan","year":"1994","unstructured":"Morgan, P.J., P. Barret, E. Howell, and R. Helliwell. 1994. Melatonin receptors: localization, molecular pharmacology and physiological significance. Neurochemistry International 24: 101\u2013146.","journal-title":"Neurochemistry International"},{"issue":"4","key":"399_CR55","first-page":"274","volume":"150","author":"V Srinivasan","year":"2012","unstructured":"Srinivasan, V., R. Zakaria, H. Jeet Singh, and D. Acuna-Castroviejo. 2012. Melatonin and its agonists in pain modulation and its clinical application. Archives Italiennes de Biologie 150(4): 274\u2013289.","journal-title":"Archives Italiennes de Biologie"},{"key":"399_CR56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.brainres.2009.06.094","volume":"1288","author":"S Wang","year":"2009","unstructured":"Wang, S., L. Zhang, G. Lim, B. Sung, Y. Tian, C.W. Chou, H. Hernstadt, G. Rusanescu, Y. Ma, and J.A. Mao. 2009. Combined effect of dextromethorphan and melatonin on neuropathic pain behavior in rats. Brain Research 1288: 42\u201349.","journal-title":"Brain Research"},{"key":"399_CR57","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.pneurobio.2008.04.004","volume":"85","author":"A Merighi","year":"2008","unstructured":"Merighi, A., C. Salio, A. Ghirri, L. Lossi, F. Ferrini, C. Betelli, and R. Bardoni. 2008. BDNF as a pain modulator. Progress in Neurobiology 85: 297\u2013317.","journal-title":"Progress in Neurobiology"},{"issue":"32","key":"399_CR58","doi-asserted-by":"crossref","first-page":"22196","DOI":"10.1074\/jbc.M114.580381","volume":"289","author":"W Tao","year":"2014","unstructured":"Tao, W., Q. Chen, W. Zhou, Y. Wang, L. Wang, and Z. Zhang. 2014. Persistent inflammation-induced up-regulation of brain-derived neurotrophic factor (BDNF) promotes synaptic delivery of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunits in descending pain modulatory circuits. The Journal of Biolical Chemistry 289(32): 22196\u201322204.","journal-title":"The Journal of Biolical Chemistry"},{"issue":"2","key":"399_CR59","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mcn.2007.02.019","volume":"35","author":"MV Caldeira","year":"2007","unstructured":"Caldeira, M.V., C.V. Melo, D.B. Pereira, R.F. Carvalho, A.L. Carvalho, and C.B. Duarte. 2007. BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons. Molecular and Cellular Neuroscience 35(2): 208\u2013219.","journal-title":"Molecular and Cellular Neuroscience"},{"key":"399_CR60","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pnpbp.2015.06.016","volume":"64","author":"PR Filho","year":"2015","unstructured":"Filho, P.R., R. Vercelino, S.G. Cioato, L.F. Medeiros, C. Oliveira, V.L. Scarabelot, A. Souza, J.R. Rozisky, A.S. Quevedo, L.N. Adachi, P.R. Sanches, F. Fregni, W. Caumo, and I.L. Torres. 2015. Transcranial direct current stimulation (tDCS) reverts behavioral alterations and brainstem BDNF level increase induced by neuropathic pain model: long-lasting effect. Progress in Neuro-psychopharmacol & Biological Psychiatry 64: 44\u201351.","journal-title":"Progress in Neuro-psychopharmacol & Biological Psychiatry"},{"issue":"5","key":"399_CR61","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00221-015-4212-1","volume":"233","author":"LNS Spezia Adachi","year":"2015","unstructured":"Spezia Adachi, L.N.S., A. Quevedo, A. Souza, V.L. Scarabelot, J.R. Rozisky, C. Oliveira, P. Marques, L.F. Medeiros, F. Fregni, W. Caumo, and I.L.S. Torres. 2015. Exogenously induced brain activation regulates neuronal activity by top-down modulation: conceptualized model for electrical brain stimulation. Experimental Brain Research 233(5): 1377\u20131389.","journal-title":"Experimental Brain Research"},{"issue":"1\u20133","key":"399_CR62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2012.04.021","volume":"687","author":"N Raivio","year":"2012","unstructured":"Raivio, N., E. Tiraboschi, S.T. Saarikoski, E. Castr\u00e9n, and K. Kiianmaa. 2012. Brain-derived neurotrophic factor expression after acute administration of ethanol. European Journal of Pharmacology 687(1\u20133): 9\u201313.","journal-title":"European Journal of Pharmacology"},{"key":"399_CR63","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00213-009-1562-z","volume":"205","author":"S Kumar","year":"2009","unstructured":"Kumar, S., P. Porcu, D.F. Werner, D.B. Matthews, J.L. Diaz-Granados, S. Helfand, and A.L. Morrow. 2009. The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 205: 529\u2013564.","journal-title":"Psychopharmacology (Berl)"},{"issue":"9","key":"399_CR64","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1007\/s11064-009-9950-7","volume":"34","author":"YY Jing","year":"2009","unstructured":"Jing, Y.Y., J.Y. Wang, X.L. Li, Z.H. Wang, L. Pei, M.M. Pan, X.P. Dong, G.X. Fan, and Y.K. Yuan. 2009. Nerve growth factor of red nucleus involvement in pain induced by spared nerve injury of the rat sciatic nerve. Neurochemical Research 34(9): 1612\u20131618.","journal-title":"Neurochemical Research"},{"issue":"13","key":"399_CR65","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1523\/JNEUROSCI.19-13-05482.1999","volume":"19","author":"S Pezet","year":"1999","unstructured":"Pezet, S., B. Ont\u00e9niente, G. Grannec, and B. Calvino. 1999. Chronic pain is associated with increased TrkA immunoreactivity in spinoreticular neurons. The Journal of Neuroscience 19(13): 5482\u20135492.","journal-title":"The Journal of Neuroscience"},{"issue":"2","key":"399_CR66","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.neuroscience.2009.10.045","volume":"165","author":"ZY Wang","year":"2010","unstructured":"Wang, Z.Y., T. Miki, K.Y. Lee, T. Yokoyama, T. Kusaka, K. Sumitani, K. Warita, Y. Matsumoto, T. Yakura, N. Hosomi, K. Ameno, K.S. Bedi, and Y. Takeuchi. 2010. Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand\/receptor systems in the mouse cerebellum. Neuroscience 165(2): 485\u2013491.","journal-title":"Neuroscience"},{"issue":"3","key":"399_CR67","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0143-4179(98)90039-7","volume":"32","author":"V Coiro","year":"1998","unstructured":"Coiro, V., and P.P. Vescovi. 1998. Alcoholism abolishes the effects of melatonin on growth hormone secretion in humans. Neuropeptides 32(3): 211\u2013214.","journal-title":"Neuropeptides"},{"issue":"18","key":"399_CR68","first-page":"1054","volume":"5","author":"MIG Campos","year":"2006","unstructured":"Campos, M.I.G., P.S.F. Campos, and S.R.P. Line. 2006. Inflammatory cytokines activity in temporomandibular joint disorders: a review of literature. Brazilian Journal of Oral Science 5(18): 1054\u20131062.","journal-title":"Brazilian Journal of Oral Science"},{"issue":"1","key":"399_CR69","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/AJP.0b013e3181eef761","volume":"27","author":"KL Heffner","year":"2011","unstructured":"Heffner, K.L., C.R. France, Z. Trost, H.M. Ng, and W.R. Pigeon. 2011. Chronic low back pain, sleep disturbance, and interleukin-6. The Clinical Journal of Pain 27(1): 35\u201341.","journal-title":"The Clinical Journal of Pain"},{"key":"399_CR70","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","volume":"29","author":"W Ouyang","year":"2011","unstructured":"Ouyang, W., S. Rutz, N.K. Crellin, P.A. Valdez, and S.G. Hymowitz. 2011. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annual Review of Immunology 29: 71\u2013109.","journal-title":"Annual Review of Immunology"},{"key":"399_CR71","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pbb.2015.05.011","volume":"135","author":"RV Schunck","year":"2015","unstructured":"Schunck, R.V., I.L. Torres, G. Laste, A. de Souza, I.C. Macedo, M.T. Valle, J.L. Salom\u00f3n, S. Moreira, J. Kuo, M.D. Arbo, E. Dallegrave, and M.B. Leal. 2015. Protracted alcohol abstinence induces analgesia in rats: possible relationships with BDNF and interleukin-10. Pharmacology, Biochemestry, and Behavior 135: 64\u201369.","journal-title":"Pharmacology, Biochemestry, and Behavior"},{"key":"399_CR72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physbeh.2013.11.009","volume":"125","author":"GC Nascimento","year":"2014","unstructured":"Nascimento, G.C., and C.R.A. Leite-Panissi. 2014. Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint. Physiology & Behavior 125: 1\u20137.","journal-title":"Physiology & Behavior"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-016-0399-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-016-0399-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-016-0399-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T02:20:33Z","timestamp":1718677233000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-016-0399-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,5]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["399"],"URL":"https:\/\/doi.org\/10.1007\/s10753-016-0399-y","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,5]]}}}