{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:40:26Z","timestamp":1786981226586,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373227"],"award-info":[{"award-number":["81373227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400721"],"award-info":[{"award-number":["81400721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470947"],"award-info":[{"award-number":["81470947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2016JJ3173"],"award-info":[{"award-number":["2016JJ3173"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s10753-017-0657-7","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T02:00:21Z","timestamp":1503972021000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Functional Role of SUV39H1 in Human Renal Tubular Epithelial Cells Under High-glucose Ambiance"],"prefix":"10.1007","volume":"41","author":[{"given":"Jiayi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youming","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"657_CR1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","volume":"103","author":"L Guariguata","year":"2014","unstructured":"Guariguata, L., D.R. Whiting, I. Hambleton, J. Beagley, U. Linnenkamp, and J.E. Shaw. 2014. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice 103: 137\u2013149.","journal-title":"Diabetes Research and Clinical Practice"},{"key":"657_CR2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nrendo.2012.125","volume":"8","author":"ME Cooper","year":"2012","unstructured":"Cooper, M.E. 2012. Diabetes: treating diabetic nephropathy-still an unresolved issue. Nature Reviews. Endocrinology 8: 515\u2013516.","journal-title":"Nature Reviews. Endocrinology"},{"key":"657_CR3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","volume":"6","author":"YS Kanwar","year":"2011","unstructured":"Kanwar, Y.S., L. Sun, P. Xie, F.Y. Liu, and S. Chen. 2011. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annual Review of Pathology 6: 395\u2013423.","journal-title":"Annual Review of Pathology"},{"key":"657_CR4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ki.1991.308","volume":"40","author":"G Hasegawa","year":"1991","unstructured":"Hasegawa, G., K. Nakano, M. Sawada, K. Uno, Y. Shibayama, K. Ienaga, and M. Kondo. 1991. Possible role of tumor necrosis factor and interleukin-1 in the development of diabetic nephropathy. Kidney International 40: 1007\u20131012.","journal-title":"Kidney International"},{"key":"657_CR5","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.2337\/diab.44.10.1233","volume":"44","author":"D Suzuki","year":"1995","unstructured":"Suzuki, D., M. Miyazaki, R. Naka, T. Koji, M. Yagame, K. Jinde, M. Endoh, Y. Nomoto, and H. Sakai. 1995. In situ hybridization of interleukin 6 in diabetic nephropathy. Diabetes 44: 1233\u20131238.","journal-title":"Diabetes"},{"key":"657_CR6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0272-6386(03)00408-6","volume":"42","author":"JF Navarro","year":"2003","unstructured":"Navarro, J.F., C. Mora, M. Maca, and J. Garca. 2003. Inflammatory parameters are independently associated with urinary albumin in type 2 diabetes mellitus. American Journal of Kidney Diseases 42: 53\u201361.","journal-title":"American Journal of Kidney Diseases"},{"key":"657_CR7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1053\/meta.2003.50096","volume":"52","author":"Y Moriwaki","year":"2003","unstructured":"Moriwaki, Y., T. Yamamoto, Y. Shibutani, E. Aoki, Z. Tsutsumi, S. Takahashi, H. Okamura, M. Koga, M. Fukuchi, and T. Hada. 2003. Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism 52: 605\u2013608.","journal-title":"Metabolism"},{"key":"657_CR8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ki.2013.68","volume":"84","author":"Q Wei","year":"2013","unstructured":"Wei, Q., G. Dong, J.K. Chen, G. Ramesh, and Z. Dong. 2013. Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models. Kidney International 84: 138\u2013148.","journal-title":"Kidney International"},{"key":"657_CR9","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1096\/fj.12-214189","volume":"27","author":"A Johnson","year":"2013","unstructured":"Johnson, A., and L.A. DiPietro. 2013. Apoptosis and angiogenesis: an evolving mechanism for fibrosis. The FASEB Journal 27: 3893\u20133901.","journal-title":"The FASEB Journal"},{"key":"657_CR10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrneph.2014.116","volume":"10","author":"M Kato","year":"2014","unstructured":"Kato, M., and R. Natarajan. 2014. Diabetic nephropathy\u2014emerging epigenetic mechanisms. Nature Reviews. Nephrology 10: 517\u2013530.","journal-title":"Nature Reviews. Nephrology"},{"key":"657_CR11","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.0803623105","volume":"105","author":"LM Villeneuve","year":"2008","unstructured":"Villeneuve, L.M., M.A. Reddy, L.L. Lanting, M. Wang, L. Meng, and R. Natarajan. 2008. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proceedings of the National Academy of Sciences of the United States of America 105: 9047\u20139052.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"657_CR12","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s11892-013-0383-y","volume":"13","author":"ST Keating","year":"2013","unstructured":"Keating, S.T., and A. El-Osta. 2013. Glycemic memories and the epigenetic component of diabetic nephropathy. Current Diabetes Reports 13: 574\u2013581.","journal-title":"Current Diabetes Reports"},{"key":"657_CR13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/jir.2014.0172","volume":"36","author":"MF Li","year":"2016","unstructured":"Li, M.F., R. Zhang, T.T. Li, M.Y. Chen, L.X. Li, J.X. Lu, and W.P. Jia. 2016. High glucose increases the expression of inflammatory cytokine genes in macrophages through H3K9 methyltransferase mechanism. Journal of Interferon & Cytokine Research 36: 48\u201361.","journal-title":"Journal of Interferon & Cytokine Research"},{"key":"657_CR14","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1159\/000358686","volume":"33","author":"B Yang","year":"2014","unstructured":"Yang, B., J. Yang, J. Bai, P. Pu, J. Liu, F. Wang, and B. Ruan. 2014. Suv39h1 protects from myocardial ischemia-reperfusion injury in diabetic rats. Cellular Physiology and Biochemistry 33: 1176\u20131185.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"657_CR15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jdiacomp.2015.12.002","volume":"30","author":"X Zhu","year":"2016","unstructured":"Zhu, X., X. Xiong, S. Yuan, L. Xiao, X. Fu, Y. Yang, C. Tang, L. He, F. Liu, and L. Sun. 2016. Validation of the interstitial fibrosis and tubular atrophy on the new pathological classification in patients with diabetic nephropathy: a single-center study in China. Journal of Diabetes and its Complications 30: 537\u2013541.","journal-title":"Journal of Diabetes and its Complications"},{"key":"657_CR16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1022923508198","volume":"117","author":"G Schotta","year":"2003","unstructured":"Schotta, G., A. Ebert, and G. Reuter. 2003. SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing. Genetica 117: 149\u2013158.","journal-title":"Genetica"},{"key":"657_CR17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35065132","volume":"410","author":"M Lachner","year":"2001","unstructured":"Lachner, M., D. O'Carroll, S. Rea, K. Mechtler, and T. Jenuwein. 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410: 116\u2013120.","journal-title":"Nature"},{"key":"657_CR18","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/nar\/30.2.475","volume":"30","author":"O Vaute","year":"2002","unstructured":"Vaute, O., E. Nicolas, L. Vandel, and D. Trouche. 2002. Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Research 30: 475\u2013481.","journal-title":"Nucleic Acids Research"},{"key":"657_CR19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","volume":"82","author":"I Grgic","year":"2012","unstructured":"Grgic, I., G. Campanholle, V. Bijol, C. Wang, V.S. Sabbisetti, T. Ichimura, B.D. Humphreys, and J.V. Bonventre. 2012. Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney International 82: 172\u2013183.","journal-title":"Kidney International"},{"key":"657_CR20","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1681\/ASN.2010020218","volume":"21","author":"AB Sanz","year":"2010","unstructured":"Sanz, A.B., M.D. Sanchez-Nino, A.M. Ramos, J.A. Moreno, B. Santamaria, M. Ruiz-Ortega, J. Egido, and A. Ortiz. 2010. NF-kappaB in renal inflammation. Journal of the American Society of Nephrology 21: 1254\u20131262.","journal-title":"Journal of the American Society of Nephrology"},{"key":"657_CR21","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/ndt\/gfh207","volume":"19","author":"S Mezzano","year":"2004","unstructured":"Mezzano, S., C. Aros, A. Droguett, M.E. Burgos, L. Ardiles, C. Flores, H. Schneider, M. Ruiz-Ortega, and J. Egido. 2004. NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy. Nephrology, Dialysis, Transplantation 19: 2505\u20132512.","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"657_CR22","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/s12967-015-0710-y","volume":"13","author":"L Zhou","year":"2015","unstructured":"Zhou, L., D.Y. Xu, W.G. Sha, L. Shen, G.Y. Lu, X. Yin, and M.J. Wang. 2015. High glucose induces renal tubular epithelial injury via Sirt1\/NF-kappaB\/microR-29\/Keap1 signal pathway. Journal of Translational Medicine 13: 352.","journal-title":"Journal of Translational Medicine"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-017-0657-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-017-0657-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-017-0657-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T02:36:33Z","timestamp":1515551793000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-017-0657-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["657"],"URL":"https:\/\/doi.org\/10.1007\/s10753-017-0657-7","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]}}}