{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:17:48Z","timestamp":1770038268138,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The National Key R&D Program of China","award":["2017YPD0500204"],"award-info":[{"award-number":["2017YPD0500204"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s10753-017-0692-4","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T05:58:16Z","timestamp":1511157496000},"page":"368-377","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characteristic Comparison of Meningitis and Non-meningitis of Streptococcus suis in an Experimentally Infected Porcine Model"],"prefix":"10.1007","volume":"41","author":[{"given":"Yingying","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanggang","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rining","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liancheng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"692_CR1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1053\/jcpa.2001.0522","volume":"126","author":"LW Madsen","year":"2002","unstructured":"Madsen, L.W., B. Svensmark, K. Elvestad, B. Aalbaek, and H.E. Jensen. 2002. Streptococcus suis serotype 2 infection in pigs: new diagnostic and pathogenetic aspects. Journal of Comparative Pathology 126: 57\u201365.","journal-title":"Journal of Comparative Pathology"},{"key":"692_CR2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.vetmic.2007.10.028","volume":"128","author":"A Beineke","year":"2008","unstructured":"Beineke, A., K. Bennecke, C. Neis, C. Schroder, K.H. Waldmann, W. Baumgartner, et al. 2008. Comparative evaluation of virulence and pathology of Streptococcus suis serotypes 2 and 9 in experimentally infected growers. Veterinary Microbiology 128: 423\u2013430.","journal-title":"Veterinary Microbiology"},{"key":"692_CR3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3201\/eid1206.051194","volume":"12","author":"H Yu","year":"2006","unstructured":"Yu, H., H. Jing, Z. Chen, H. Zheng, X. Zhu, H. Wang, et al. 2006. Human Streptococcus suis outbreak, Sichuan, China. Emerging Infectious Diseases 12: 914\u2013920.","journal-title":"Emerging Infectious Diseases"},{"key":"692_CR4","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1002\/pmic.200700294","volume":"7","author":"W Zhang","year":"2007","unstructured":"Zhang, W., and C.P. Lu. 2007. Immunoproteomics of extracellular proteins of Chinese virulent strains of Streptococcus suis type 2. Proteomics 7: 4468\u20134476.","journal-title":"Proteomics"},{"key":"692_CR5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1086\/596763","volume":"48","author":"HF Wertheim","year":"2009","unstructured":"Wertheim, H.F., H.D. Nghia, W. Taylor, and C. Schultsz. 2009. Streptococcus suis: an emerging human pathogen. Clinical Infectious Diseases 48: 617\u2013625.","journal-title":"Clinical Infectious Diseases"},{"key":"692_CR6","first-page":"1105","volume":"20","author":"VT Huong","year":"2014","unstructured":"Huong, V.T., N. Ha, N.T. Huy, P. Horby, H.D. Nghia, V.D. Thiem, et al. 2014. Epidemiology, clinical manifestations, and outcomes of Streptococcus suis infection in humans. Emerging Infectious Diseases 20: 1105\u20131114.","journal-title":"Emerging Infectious Diseases"},{"key":"692_CR7","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3201\/eid2102.140961","volume":"21","author":"P Praphasiri","year":"2015","unstructured":"Praphasiri, P., J.T. Owusu, S. Thammathitiwat, D. Ditsungnoen, P. Boonmongkon, O. Sangwichian, et al. 2015. Streptococcus suis infection in hospitalized patients, Nakhon Phanom Province, Thailand. Emerging Infectious Diseases 21: 345\u2013348.","journal-title":"Emerging Infectious Diseases"},{"key":"692_CR8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1471-2164-12-253","volume":"12","author":"M Liu","year":"2011","unstructured":"Liu, M., L. Fang, C. Tan, T. Long, H. Chen, and S. Xiao. 2011. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics 12: 253.","journal-title":"BMC Genomics"},{"key":"692_CR9","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","volume":"179","author":"MC Dominguez-Punaro","year":"2007","unstructured":"Dominguez-Punaro, M.C., M. Segura, M.M. Plante, S. Lacouture, S. Rivest, and M. Gottschalk. 2007. Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. Journal of Immunology 179: 1842\u20131854.","journal-title":"Journal of Immunology"},{"key":"692_CR10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.pediatrneurol.2013.08.016","volume":"50","author":"R Prasad","year":"2014","unstructured":"Prasad, R., R. Kapoor, R. Srivastava, O.P. Mishra, and T.B. Singh. 2014. Cerebrospinal fluid TNF-alpha, IL-6, and IL-8 in children with bacterial meningitis. Pediatric Neurology 50: 60\u201365.","journal-title":"Pediatric Neurology"},{"key":"692_CR11","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S1413-8670(11)70162-3","volume":"15","author":"JV Pinto","year":"2011","unstructured":"Pinto, J.V., M.C. Rebelo, R.N. Gomes, E.F. Assis, H.C. Castro-Faria-Neto, and M.N. Boia. 2011. IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis. The Brazilian Journal of Infectious Diseases 15: 156\u2013158.","journal-title":"The Brazilian Journal of Infectious Diseases"},{"key":"692_CR12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1574-695X.2008.00476.x","volume":"54","author":"D Grenier","year":"2008","unstructured":"Grenier, D., and C. Bodet. 2008. Streptococcus suis stimulates ICAM-1 shedding from microvascular endothelial cells. FEMS Immunology and Medical Microbiology 54: 271\u2013276.","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"692_CR13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2249.2003.02189.x","volume":"133","author":"D Al-Numani","year":"2003","unstructured":"Al-Numani, D., M. Segura, M. Dore, and M. Gottschalk. 2003. Up-regulation of ICAM-1, CD11a\/CD18 and CD11c\/CD18 on human THP-1 monocytes stimulated by Streptococcus suis serotype 2. Clinical and Experimental Immunology 133: 67\u201377.","journal-title":"Clinical and Experimental Immunology"},{"key":"692_CR14","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/ncomms1474","volume":"2","author":"A Banerjee","year":"2011","unstructured":"Banerjee, A., B.J. Kim, E.M. Carmona, A.S. Cutting, M.A. Gurney, C. Carlos, et al. 2011. Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration. Nature Communications 2: 462.","journal-title":"Nature Communications"},{"key":"692_CR15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-5793(98)00173-2","volume":"424","author":"DI Utepbergenov","year":"1998","unstructured":"Utepbergenov, D.I., K. Mertsch, A. Sporbert, K. Tenz, M. Paul, R.F. Haseloff, et al. 1998. Nitric oxide protects blood-brain barrier in vitro from hypoxia\/reoxygenation-mediated injury. FEBS Letters 424: 197\u2013201.","journal-title":"FEBS Letters"},{"key":"692_CR16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijantimicag.2015.01.014","volume":"46","author":"M Vivas","year":"2015","unstructured":"Vivas, M., E. Force, F. Tubau, H.C. El, J. Ariza, and C. Cabellos. 2015. Effect of dexamethasone on the efficacy of daptomycin in the therapy of experimental pneumococcal meningitis. International Journal of Antimicrobial Agents 46: 28\u201332.","journal-title":"International Journal of Antimicrobial Agents"},{"issue":"549\u201377","key":"692_CR17","first-page":"vi","volume":"13","author":"U Koedel","year":"1999","unstructured":"Koedel, U., and H.W. Pfister. 1999. Models of experimental bacterial meningitis. Role and limitations. Infectious Disease Clinics of North America 13 (549\u201377): vi.","journal-title":"Infectious Disease Clinics of North America"},{"key":"692_CR18","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12866-016-0718-3","volume":"16","author":"A Greeff de","year":"2016","unstructured":"de Greeff, A., S. van Selm, H. Buys, J.F. Harders-Westerveen, R.N. Tunjungputri, Q. de Mast, et al. 2016. Pneumococcal colonization and invasive disease studied in a porcine model. BMC Microbiology 16: 102.","journal-title":"BMC Microbiology"},{"key":"692_CR19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.vetmic.2014.08.010","volume":"173","author":"Y Bi","year":"2014","unstructured":"Bi, Y., J. Li, L. Yang, S. Zhang, Y. Li, X. Jia, et al. 2014. Assessment of the pathogenesis of Streptococcus suis type 2 infection in piglets for understanding streptococcal toxic shock-like syndrome, meningitis, and sequelae. Veterinary Microbiology 173: 299\u2013309.","journal-title":"Veterinary Microbiology"},{"key":"692_CR20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-1135(97)00131-4","volume":"58","author":"U Vecht","year":"1997","unstructured":"Vecht, U., N. Stockhofe-Zurwieden, B.J. Tetenburg, H.J. Wisselink, and H.E. Smith. 1997. Virulence of Streptococcus suis type 2 for mice and pigs appeared host-specific. Veterinary Microbiology 58: 53\u201360.","journal-title":"Veterinary Microbiology"},{"key":"692_CR21","doi-asserted-by":"crossref","unstructured":"Greenlee-Wacker, M.C., and W.M. Nauseef. 2017. IFN-gamma targets macrophage-mediated immune responses toward Staphylococcus aureus. Journal of Leukocyte Biology 101 (3): 751\u2013758.","DOI":"10.1189\/jlb.4A1215-565RR"},{"key":"692_CR22","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1172\/JCI200317335","volume":"112","author":"KS Doran","year":"2003","unstructured":"Doran, K.S., G.Y. Liu, and V. Nizet. 2003. Group B streptococcal beta-hemolysin\/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. The Journal of Clinical Investigation 112: 736\u2013744.","journal-title":"The Journal of Clinical Investigation"},{"key":"692_CR23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cyto.2010.03.001","volume":"51","author":"T Asano","year":"2010","unstructured":"Asano, T., K. Ichiki, S. Koizumi, K. Kaizu, T. Hatori, O. Fujino, et al. 2010. IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children. Cytokine 51: 101\u2013106.","journal-title":"Cytokine"},{"key":"692_CR24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2478\/v10039-012-0013-y","volume":"57","author":"M Bociaga-Jasik","year":"2012","unstructured":"Bociaga-Jasik, M., A. Garlicki, A. Ciesla, A. Kalinowska-Nowak, I. Sobczyk-Krupiarz, and T. Mach. 2012. The diagnostic value of cytokine and nitric oxide concentrations in cerebrospinal fluid for the differential diagnosis of meningitis. Advances in Medical Sciences 57: 142\u2013147.","journal-title":"Advances in Medical Sciences"},{"key":"692_CR25","doi-asserted-by":"crossref","first-page":"e2964","DOI":"10.1371\/journal.pone.0002964","volume":"3","author":"NM Sorge van","year":"2008","unstructured":"van Sorge, N.M., C.M. Ebrahimi, S.M. McGillivray, D. Quach, M. Sabet, D.G. Guiney, et al. 2008. Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis. PLoS One 3: e2964.","journal-title":"PLoS One"},{"key":"692_CR26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/JCM.19.2.187-190.1984","volume":"19","author":"LJ Scolea La","year":"1984","unstructured":"La Scolea, L.J., and D. Dryja. 1984. Quantitation of bacteria in cerebrospinal fluid and blood of children with meningitis and its diagnostic significance. Journal of Clinical Microbiology 19: 187\u2013190.","journal-title":"Journal of Clinical Microbiology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-017-0692-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-017-0692-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-017-0692-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T04:06:14Z","timestamp":1603339574000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-017-0692-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["692"],"URL":"https:\/\/doi.org\/10.1007\/s10753-017-0692-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]}}}