{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:40:03Z","timestamp":1768268403132,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470923"],"award-info":[{"award-number":["81470923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470986"],"award-info":[{"award-number":["81470986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770078"],"award-info":[{"award-number":["81770078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770688"],"award-info":[{"award-number":["81770688"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s10753-018-0786-7","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:47:50Z","timestamp":1524098870000},"page":"1384-1395","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Rapamycin Alleviates Hormone Imbalance-Induced Chronic Nonbacterial Inflammation in Rat Prostate Through Activating Autophagy via the mTOR\/ULK1\/ATG13 Signaling Pathway"],"prefix":"10.1007","volume":"41","author":[{"given":"Yang","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaozhao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-1099","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"issue":"6","key":"786_CR1","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1111\/andr.12273","volume":"4","author":"Y Hu","year":"2016","unstructured":"Hu, Y., X. Niu, G. Wang, J. Huang, M. Liu, et al. 2016. Chronic prostatitis\/chronic pelvic pain syndrome impairs erectile function through increased endothelial dysfunction, oxidative stress, apoptosis, and corporal fibrosis in a rat model. Andrology 4 (6): 1209\u20131216.","journal-title":"Andrology"},{"issue":"8","key":"786_CR2","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1097\/j.pain.0000000000000201","volume":"156","author":"ES Schwartz","year":"2015","unstructured":"Schwartz, E.S., A. Xie, J.H. La, and G.F. Gebhart. 2015. Nociceptive and inflammatory mediator upregulation in a mouse model of chronic prostatitis. Pain 156 (8): 1537\u20131544.","journal-title":"Pain"},{"issue":"4","key":"786_CR3","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/bju.13101","volume":"116","author":"J Rees","year":"2015","unstructured":"Rees, J., M. Abrahams, A. Doble, and A. Cooper. 2015. Diagnosis and treatment of chronic bacterial prostatitis and chronic prostatitis\/chronic pelvic pain syndrome: a consensus guideline. BJU International 116 (4): 509\u2013525.","journal-title":"BJU International"},{"key":"786_CR4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.biopha.2017.05.004","volume":"91","author":"AU Ihsan","year":"2017","unstructured":"Ihsan, A.U., F.U. Khan, W. Nawaz, M.Z. Khan, M. Yang, and X. Zhou. 2017. Establishment of a rat model of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) induced by immunization with a novel peptide T2. Biomedicine & Pharmacotherapy 91: 687\u2013692.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"8","key":"786_CR5","doi-asserted-by":"publisher","first-page":"e41941","DOI":"10.1371\/journal.pone.0041941","volume":"7","author":"JM Cohen","year":"2012","unstructured":"Cohen, J.M., A.P. Fagin, E. Hariton, J.R. Niska, M.W. Pierce, A. Kuriyama, J.S. Whelan, J.L. Jackson, and J.D. Dimitrakoff. 2012. Therapeutic intervention for chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS): a systematic review and meta-analysis. PLoS One 7 (8): e41941.","journal-title":"PLoS One"},{"key":"786_CR6","doi-asserted-by":"publisher","first-page":"28608","DOI":"10.1038\/srep28608","volume":"6","author":"C Hu","year":"2016","unstructured":"Hu, C., H. Yang, Y. Zhao, X. Chen, Y. Dong, et al. 2016. The role of inflammatory cytokines and ERK1\/2 signaling in chronic prostatitis\/chronic pelvic pain syndrome with related mental health disorders. Scientific Reports 6: 28608.","journal-title":"Scientific Reports"},{"issue":"3","key":"786_CR7","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/j.pain.0000000000000405","volume":"157","author":"RD Motrich","year":"2016","unstructured":"Motrich, R.D., M.L. Breser, L.R. Sanchez, G.J. Godoy, I. Prinz, et al. 2016. IL-17 is not essential for inflammation and chronic pelvic pain development in an experimental model of chronic prostatitis\/chronic pelvic pain syndrome. Pain 157 (3): 585\u2013597.","journal-title":"Pain"},{"key":"786_CR8","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.intimp.2016.03.046","volume":"35","author":"E Talero","year":"2016","unstructured":"Talero, E., A. Alcaide, J. Avila-Roman, S. Garcia-Maurino, D. Vendramini-Costa, et al. 2016. Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice. International Immunopharmacology 35: 248\u2013256.","journal-title":"International Immunopharmacology"},{"key":"786_CR9","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.3389\/fmicb.2017.02142","volume":"8","author":"Q Zhang","year":"2017","unstructured":"Zhang, Q., J. Sun, Y. Wang, W. He, L. Wang, Y. Zheng, J. Wu, Y. Zhang, and X. Jiang. 2017. Antimycobacterial and anti-inflammatory mechanisms of baicalin via induced autophagy in macrophages infected with Mycobacterium tuberculosis. Frontiers in Microbiology 8: 2142.","journal-title":"Frontiers in Microbiology"},{"issue":"3","key":"786_CR10","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4161\/auto.27750","volume":"10","author":"RD Junkins","year":"2014","unstructured":"Junkins, R.D., C. McCormick, and T.J. Lin. 2014. The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections. Autophagy 10 (3): 538\u2013547.","journal-title":"Autophagy"},{"issue":"31","key":"786_CR11","doi-asserted-by":"publisher","first-page":"50904","DOI":"10.18632\/oncotarget.15144","volume":"8","author":"C Nunzio De","year":"2017","unstructured":"De Nunzio, C., S. Giglio, A. Stoppacciaro, M. Gacci, R. Cirombella, et al. 2017. Autophagy deactivation is associated with severe prostatic inflammation in patients with lower urinary tract symptoms and benign prostatic hyperplasia. Oncotarget 8 (31): 50904\u201350910.","journal-title":"Oncotarget"},{"key":"786_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1741-7015-10-122","volume":"10","author":"P Bullon","year":"2012","unstructured":"Bullon, P., M.D. Cordero, J.L. Quiles, M.C. Ramirez-Tortosa, A. Gonzalez-Alonso, et al. 2012. Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation. BMC Medicine 10: 122.","journal-title":"BMC Medicine"},{"issue":"2","key":"786_CR13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jhep.2013.02.031","volume":"59","author":"P Codogno","year":"2013","unstructured":"Codogno, P., and A.J. Meijer. 2013. Autophagy in the liver. Journal of Hepatology 59 (2): 389\u2013391.","journal-title":"Journal of Hepatology"},{"issue":"6","key":"786_CR14","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1172\/JCI66339","volume":"124","author":"T Zaglia","year":"2014","unstructured":"Zaglia, T., G. Milan, A. Ruhs, M. Franzoso, E. Bertaggia, N. Pianca, A. Carpi, P. Carullo, P. Pesce, D. Sacerdoti, C. Sarais, D. Catalucci, M. Kr\u00fcger, M. Mongillo, and M. Sandri. 2014. Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. Journal of Clinical Investigation 124 (6): 2410\u20132424.","journal-title":"Journal of Clinical Investigation"},{"issue":"10","key":"786_CR15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nrendo.2014.144","volume":"10","author":"J Osorio","year":"2014","unstructured":"Osorio, J. 2014. Diabetes: Protective role of autophagy in pancreatic beta cells. Nature Reviews Endocrinology 10 (10): 575.","journal-title":"Nature Reviews Endocrinology"},{"issue":"Suppl 3","key":"786_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000342588","volume":"30","author":"M Scharl","year":"2012","unstructured":"Scharl, M., and G. Rogler. 2012. Inflammatory bowel disease: dysfunction of autophagy? Digestive Diseases 30 (Suppl 3): 12\u201319.","journal-title":"Digestive Diseases"},{"issue":"1","key":"786_CR17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.bbrc.2011.11.114","volume":"417","author":"T Yoshizaki","year":"2012","unstructured":"Yoshizaki, T., C. Kusunoki, M. Kondo, M. Yasuda, S. Kume, K. Morino, O. Sekine, S. Ugi, T. Uzu, Y. Nishio, A. Kashiwagi, and H. Maegawa. 2012. Autophagy regulates inflammation in adipocytes. Biochemical and Biophysical Research Communications 417 (1): 352\u2013357.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"6","key":"786_CR18","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1053\/j.gastro.2013.02.007","volume":"144","author":"I Gukovsky","year":"2013","unstructured":"Gukovsky, I., N. Li, J. Todoric, A. Gukovskaya, and M. Karin. 2013. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 144 (6): 1199\u20131209.","journal-title":"Gastroenterology"},{"issue":"1","key":"786_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11255-014-0845-4","volume":"47","author":"YL Jia","year":"2015","unstructured":"Jia, Y.L., X. Liu, J.Y. Yan, L.M. Chong, L. Li, A.C. Ma, L. Zhou, and Z.Y. Sun. 2015. The alteration of inflammatory markers and apoptosis on chronic prostatitis induced by estrogen and androgen. International Urology and Nephrology 47 (1): 39\u201346.","journal-title":"International Urology and Nephrology"},{"issue":"1","key":"786_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/sj.pcan.4500930","volume":"10","author":"EV Vykhovanets","year":"2007","unstructured":"Vykhovanets, E.V., M.I. Resnick, G.T. MacLennan, and S. Gupta. 2007. Experimental rodent models of prostatitis: limitations and potential. Prostate Cancer and Prostatic Diseases 10 (1): 15\u201329.","journal-title":"Prostate Cancer and Prostatic Diseases"},{"issue":"2","key":"786_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00210-016-1325-4","volume":"390","author":"MM Said","year":"2017","unstructured":"Said, M.M., and M.C. Bosland. 2017. The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate. Naunyn-Schmiedeberg's Archives of Pharmacology 390 (2): 197\u2013205.","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"issue":"2","key":"786_CR22","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.abb.2010.12.009","volume":"506","author":"Y Fujishima","year":"2011","unstructured":"Fujishima, Y., S. Nishiumi, A. Masuda, J. Inoue, N.M. Nguyen, et al. 2011. Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-kappaB activation. Archives of Biochemistry and Biophysics 506 (2): 223\u2013235.","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"6","key":"786_CR23","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1365-2796.2008.01953.x","volume":"263","author":"I Atreya","year":"2008","unstructured":"Atreya, I., R. Atreya, and M.F. Neurath. 2008. NF-kappaB in inflammatory bowel disease. Journal of Internal Medicine 263 (6): 591\u2013596.","journal-title":"Journal of Internal Medicine"},{"key":"786_CR24","doi-asserted-by":"publisher","first-page":"428508","DOI":"10.1155\/2015\/428508","volume":"2015","author":"Z Mohammed-Ali","year":"2015","unstructured":"Mohammed-Ali, Z., G.L. Cruz, and J.G. Dickhout. 2015. Crosstalk between the unfolded protein response and NF-kappaB-mediated inflammation in the progression of chronic kidney disease. Journal of Immunology Research 2015: 428508.","journal-title":"Journal of Immunology Research"},{"issue":"1","key":"786_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1530\/JOE-13-0449","volume":"221","author":"S Choi","year":"2014","unstructured":"Choi, S., H. Shin, H. Song, and H.J. Lim. 2014. Suppression of autophagic activation in the mouse uterus by estrogen and progesterone. Journal of Endocrinology 221 (1): 39\u201350.","journal-title":"Journal of Endocrinology"},{"issue":"3","key":"786_CR26","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3892\/mmr.2014.2365","volume":"10","author":"F Wang","year":"2014","unstructured":"Wang, F., J. Xiao, Y. Shen, F. Yao, and Y. Chen. 2014. Estrogen protects cardiomyocytes against lipopolysaccharide by inhibiting autophagy. Molecular Medicine Reports 10 (3): 1509\u20131512.","journal-title":"Molecular Medicine Reports"},{"issue":"7","key":"786_CR27","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1093\/humrep\/dev100","volume":"30","author":"J Mei","year":"2015","unstructured":"Mei, J., X.Y. Zhu, L.P. Jin, Z.L. Duan, D.J. Li, and M.Q. Li. 2015. Estrogen promotes the survival of human secretory phase endometrial stromal cells via CXCL12\/CXCR4 up-regulation-mediated autophagy inhibition. Human Reproduction 30 (7): 1677\u20131689.","journal-title":"Human Reproduction"},{"issue":"7","key":"786_CR28","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ncb2788","volume":"15","author":"P Boya","year":"2013","unstructured":"Boya, P., F. Reggiori, and P. Codogno. 2013. Emerging regulation and functions of autophagy. Nature Cell Biology 15 (7): 713\u2013720.","journal-title":"Nature Cell Biology"},{"issue":"4","key":"786_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.4161\/auto.19496","volume":"8","author":"DJ Klionsky","year":"2012","unstructured":"Klionsky, D.J., F.C. Abdalla, H. Abeliovich, R.T. Abraham, A. Acevedo-Arozena, et al. 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8 (4): 445\u2013544.","journal-title":"Autophagy"},{"issue":"9","key":"786_CR30","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1158\/1535-7163.MCT-16-0008","volume":"15","author":"L Li","year":"2016","unstructured":"Li, L., H. Chen, Y. Gao, Y.W. Wang, G.Q. Zhang, S.H. Pan, L. Ji, R. Kong, G. Wang, Y.H. Jia, X.W. Bai, and B. Sun. 2016. Long noncoding RNA MALAT1 promotes aggressive pancreatic cancer proliferation and metastasis via the stimulation of autophagy. Molecular Cancer Therapeutics 15 (9): 2232\u20132243.","journal-title":"Molecular Cancer Therapeutics"},{"issue":"3","key":"786_CR31","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1089\/ars.2013.5373","volume":"20","author":"K Nakahira","year":"2014","unstructured":"Nakahira, K., S.M. Cloonan, K. Mizumura, A.M. Choi, and S.W. Ryter. 2014. Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease. Antioxidants & Redox Signaling 20 (3): 474\u2013494.","journal-title":"Antioxidants & Redox Signaling"},{"key":"786_CR32","doi-asserted-by":"publisher","first-page":"e2122","DOI":"10.1038\/cddis.2015.397","volume":"7","author":"F Pei","year":"2016","unstructured":"Pei, F., H.S. Wang, Z. Chen, and L. Zhang. 2016. Autophagy regulates odontoblast differentiation by suppressing NF-kappaB activation in an inflammatory environment. Cell Death & Disease 7: e2122.","journal-title":"Cell Death & Disease"},{"issue":"5","key":"786_CR33","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.cell.2006.12.044","volume":"128","author":"X Qu","year":"2007","unstructured":"Qu, X., Z. Zou, Q. Sun, K. Luby-Phelps, P. Cheng, et al. 2007. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128 (5): 931\u2013946.","journal-title":"Cell"},{"issue":"6","key":"786_CR34","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","volume":"137","author":"R Mathew","year":"2009","unstructured":"Mathew, R., C.M. Karp, B. Beaudoin, N. Vuong, G. Chen, H.Y. Chen, K. Bray, A. Reddy, G. Bhanot, C. Gelinas, R.S. DiPaola, V. Karantza-Wadsworth, and E. White. 2009. Autophagy suppresses tumorigenesis through elimination of p62. Cell 137 (6): 1062\u20131075.","journal-title":"Cell"},{"issue":"2","key":"786_CR35","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ceb.2009.12.008","volume":"22","author":"E White","year":"2010","unstructured":"White, E., C. Karp, A.M. Strohecker, Y. Guo, and R. Mathew. 2010. Role of autophagy in suppression of inflammation and cancer. Current Opinion in Cell Biology 22 (2): 212\u2013217.","journal-title":"Current Opinion in Cell Biology"},{"issue":"6","key":"786_CR36","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1136\/annrheumdis-2012-201952","volume":"72","author":"T Bachetti","year":"2013","unstructured":"Bachetti, T., S. Chiesa, P. Castagnola, D. Bani, E. Di Zanni, et al. 2013. Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). Annals of the Rheumatic Diseases 72 (6): 1044\u20131052.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"786_CR37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00011-016-0919-0","volume":"65","author":"C Xi","year":"2016","unstructured":"Xi, C., J. Zhou, S. Du, and S. Peng. 2016. Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-kappaB-dependent inflammation. Inflammation Research 65 (4): 325\u2013341.","journal-title":"Inflammation Research"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-018-0786-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-018-0786-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-018-0786-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T19:24:21Z","timestamp":1555615461000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-018-0786-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,19]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["786"],"URL":"https:\/\/doi.org\/10.1007\/s10753-018-0786-7","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,19]]},"assertion":[{"value":"19 April 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Animal Care and Use Committee of Wuhan University Renmin Hospital. All animal care and experimental procedures were performed in accordance with the guidelines of Wuhan University Renmin Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}