{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:40:37Z","timestamp":1790181637678,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T00:00:00Z","timestamp":1530316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Science and Technology Program Funds of Jiangxi Province","award":["No. 20151BAB205085"],"award-info":[{"award-number":["No. 20151BAB205085"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10753-018-0823-6","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T04:18:20Z","timestamp":1530332300000},"page":"1804-1814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Curcumin Attenuates Airway Inflammation and Airway Remolding by Inhibiting NF-\u03baB Signaling and COX-2 in Cigarette Smoke-Induced COPD Mice"],"prefix":"10.1007","volume":"41","author":[{"given":"Jin","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,30]]},"reference":[{"key":"823_CR1","unstructured":"Organization, W.H., WHO. 2013. the top 10 causes of death. Countries."},{"issue":"3","key":"823_CR2","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1152\/physrev.00048.2006","volume":"87","author":"T Yoshida","year":"2007","unstructured":"Yoshida, T., and R.M. Tuder. 2007. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiological Reviews 87 (3): 1047\u20131082.","journal-title":"Physiological Reviews"},{"issue":"3","key":"823_CR3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.rmed.2011.11.003","volume":"106","author":"A Tamimi","year":"2012","unstructured":"Tamimi, A., D. Serdarevic, and N.A. Hanania. 2012. The effects of cigarette smoke on airway inflammation in asthma and COPD: Therapeutic implications. Respiratory Medicine 106 (3): 319\u2013328.","journal-title":"Respiratory Medicine"},{"issue":"9589","key":"823_CR4","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S0140-6736(07)61380-4","volume":"370","author":"DM Mannino","year":"2007","unstructured":"Mannino, D.M., and A.S. Buist. 2007. Global burden of COPD: Risk factors, prevalence, and future trends. The Lancet 370 (9589): 765\u2013773.","journal-title":"The Lancet"},{"key":"823_CR5","doi-asserted-by":"publisher","first-page":"413735","DOI":"10.1155\/2013\/413735","volume":"2013","author":"N Rovina","year":"2013","unstructured":"Rovina, N., A. Koutsoukou, and N.G. Koulouris. 2013. Inflammation and immune response in COPD: Where do we stand? Mediators of Inflammation 2013: 413735.","journal-title":"Mediators of Inflammation"},{"issue":"3","key":"823_CR6","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1378\/chest.115.3.829","volume":"115","author":"JD Hasday","year":"1999","unstructured":"Hasday, J.D., R. Bascom, J.J. Costa, T. Fitzgerald, and W. Dubin. 1999. Bacterial endotoxin is an active component of cigarette smoke. Chest 115 (3): 829\u2013835.","journal-title":"Chest"},{"issue":"4","key":"823_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3109\/08820139.2016.1157814","volume":"45","author":"NO Al-Harbi","year":"2016","unstructured":"Al-Harbi, N.O., et al. 2016. Dexamethasone attenuates LPS-induced acute lung injury through inhibition of NF-kappaB, COX-2, and pro-inflammatory mediators. Immunological Investigations 45 (4): 349\u2013369.","journal-title":"Immunological Investigations"},{"issue":"3","key":"823_CR8","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1183\/09031936.02.00272002","volume":"20","author":"A Stefano Di","year":"2002","unstructured":"Di Stefano, A., et al. 2002. Increased expression of nuclear factor- B in bronchial biopsies from smokers and patients with COPD. European Respiratory Journal 20 (3): 556\u2013563.","journal-title":"European Respiratory Journal"},{"key":"823_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0090-6980(02)00029-1","volume":"68-69","author":"I Morita","year":"2002","unstructured":"Morita, I. 2002. Distinct functions of COX-1 and COX-2. Prostaglandins & Other Lipid Mediators 68-69: 165\u2013175.","journal-title":"Prostaglandins & Other Lipid Mediators"},{"issue":"1","key":"823_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1096\/fj.14-268458","volume":"30","author":"J Cheng","year":"2016","unstructured":"Cheng, J., R.T. Dackor, J.A. Bradbury, H. Li, L.M. DeGraff, L.K. Hong, D. King, F.B. Lih, A. Gruzdev, M.L. Edin, G.S. Travlos, G.P. Flake, K.B. Tomer, and D.C. Zeldin. 2016. Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis. The FASEB Journal 30 (1): 160\u2013173.","journal-title":"The FASEB Journal"},{"issue":"7","key":"823_CR11","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1440-1843.2008.01365.x","volume":"13","author":"Y Chen","year":"2008","unstructured":"Chen, Y., et al. 2008. Enhanced levels of prostaglandin E2 and matrix metalloproteinase-2 correlate with the severity of airflow limitation in stable COPD. Respirology 13 (7): 1014\u20131021.","journal-title":"Respirology"},{"issue":"3","key":"823_CR12","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/cea.12697","volume":"46","author":"NN Rumzhum","year":"2016","unstructured":"Rumzhum, N.N., and A.J. Ammit. 2016. Cyclooxygenase 2: Its regulation, role and impact in airway inflammation. Clinical and Experimental Allergy 46 (3): 397\u2013410.","journal-title":"Clinical and Experimental Allergy"},{"key":"823_CR13","unstructured":"Brouk, B. 1975. Plants consumed by man. QUARTERLY REVIEW OF BIOLOGY."},{"issue":"13","key":"823_CR14","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/j.ejca.2005.05.009","volume":"41","author":"RA Sharma","year":"2005","unstructured":"Sharma, R.A., A.J. Gescher, and W.P. Steward. 2005. Curcumin: The story so far. European Journal of Cancer 41 (13): 1955\u20131968.","journal-title":"European Journal of Cancer"},{"key":"823_CR15","first-page":"1","volume":"2013","author":"IT Lee","year":"2013","unstructured":"Lee, I.T., and C.-M. Yang. 2013. Inflammatory signalings involved in airway and pulmonary diseases. Mediators of Inflammation 2013: 1\u201312.","journal-title":"Mediators of Inflammation"},{"key":"823_CR16","first-page":"191624","volume":"2014","author":"Z Fan","year":"2014","unstructured":"Fan, Z., et al. 2014. The protective effects of curcumin on experimental acute liver lesion induced by intestinal ischemia-reperfusion through inhibiting the pathway of NF-kappaB in a rat model. Oxidative Medicine and Cellular Longevity 2014: 191624.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"2","key":"823_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1179\/2045772313Y.0000000179","volume":"38","author":"H Ni","year":"2015","unstructured":"Ni, H., W. Jin, T. Zhu, J. Wang, B. Yuan, J. Jiang, W. Liang, and Z. Ma. 2015. Curcumin modulates TLR4\/NF-kappaB inflammatory signaling pathway following traumatic spinal cord injury in rats. The Journal of Spinal Cord Medicine 38 (2): 199\u2013206.","journal-title":"The Journal of Spinal Cord Medicine"},{"key":"823_CR18","doi-asserted-by":"crossref","unstructured":"Wang, J., et al. 2017. Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1\u03b2 is mediated by curcumin via inhibition of NF-\u03baB signaling in rat chondrocytes. Molecular Medicine Reports.","DOI":"10.3892\/mmr.2017.6771"},{"issue":"2","key":"823_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1177\/1753465807086096","volume":"1","author":"A Sharafkhaneh","year":"2007","unstructured":"Sharafkhaneh, A., S. Velamuri, V. Badmaev, C. Lan, and N. Hanania. 2007. The potential role of natural agents in treatment of airway inflammation. Therapeutic Advances in Respiratory Disease 1 (2): 105\u2013120.","journal-title":"Therapeutic Advances in Respiratory Disease"},{"issue":"6","key":"823_CR20","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s10753-016-0430-3","volume":"39","author":"J Chen","year":"2016","unstructured":"Chen, J., X. Yang, W. Zhang, D. Peng, Y. Xia, Y. Lu, X. Han, G. Song, J. Zhu, and R. Liu. 2016. Therapeutic effects of resveratrol in a mouse model of LPS and cigarette smoke-induced COPD. Inflammation 39 (6): 1949\u20131959.","journal-title":"Inflammation"},{"key":"823_CR21","doi-asserted-by":"crossref","unstructured":"Liu, R., P. Wang, C. Wu, J. Chen, C. Li, Y. Xie, Q. Wang, J. Liu, H. He, and J. Zhu. 2017. Therapeutic effects of Hedyotis diffusa Willd in a COPD mouse model challenged with LPS and smoke. Experimental and Therapeutic Medicine.","DOI":"10.3892\/etm.2018.5851"},{"issue":"1","key":"823_CR22","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1746-6148-9-123","volume":"9","author":"K Robert","year":"2013","unstructured":"Robert, K. 2013. Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology\u2014A systematic review. BMC Veterinary Research 9 (1): 123.","journal-title":"BMC Veterinary Research"},{"issue":"3","key":"823_CR23","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.pupt.2010.01.002","volume":"23","author":"S Rajendrasozhan","year":"2010","unstructured":"Rajendrasozhan, S., J.W. Hwang, H. Yao, N. Kishore, and I. Rahman. 2010. Anti-inflammatory effect of a selective I\u03baB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulmonary Pharmacology & Therapeutics 23 (3): 172\u2013181.","journal-title":"Pulmonary Pharmacology & Therapeutics"},{"issue":"9","key":"823_CR24","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1093\/carcin\/23.9.1511","volume":"23","author":"RJ Anto","year":"2002","unstructured":"Anto, R.J., A. Mukhopadhyay, S. Shishodia, C.G. Gairola, and B.B. Aggarwal. 2002. Cigarette smoke condensate activates nuclear transcription factor-\u03baB through phosphorylation and degradation of I\u03baB\u03b1: Correlation with induction of cyclooxygenase-2. Carcinogenesis 23 (9): 1511\u20131518.","journal-title":"Carcinogenesis"},{"issue":"12","key":"823_CR25","doi-asserted-by":"publisher","first-page":"6257","DOI":"10.4049\/jimmunol.170.12.6257","volume":"170","author":"ME Poynter","year":"2003","unstructured":"Poynter, M.E., C.G. Irvin, and Y.M. Janssen-Heininger. 2003. A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation. Journal of Immunology 170 (12): 6257\u20136265.","journal-title":"Journal of Immunology"},{"key":"823_CR26","doi-asserted-by":"crossref","first-page":"5292346","DOI":"10.1155\/2016\/5292346","volume":"2016","author":"W Liu","year":"2016","unstructured":"Liu, W., H.L. Jiang, L.L. Cai, M. Yan, S.J. Dong, and B. Mao. 2016. Tanreqing injection attenuates lipopolysaccharide-induced airway inflammation through MAPK\/NF-kappaB signaling pathways in rats model. Evidence-based Complementary and Alternative Medicine 2016: 5292346.","journal-title":"Evidence-based Complementary and Alternative Medicine"},{"issue":"8","key":"823_CR27","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1111\/j.1476-5381.2010.00857.x","volume":"160","author":"EL Hardaker","year":"2010","unstructured":"Hardaker, E.L., M.S. Freeman, N. Dale, P. Bahra, F. Raza, K.H. Banner, and C. Poll. 2010. Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung. British Journal of Pharmacology 160 (8): 1985\u20131996.","journal-title":"British Journal of Pharmacology"},{"issue":"1","key":"823_CR28","doi-asserted-by":"publisher","first-page":"15454","DOI":"10.1038\/s41598-017-15685-y","volume":"7","author":"J Shu","year":"2017","unstructured":"Shu, J., D. Li, H. Ouyang, J. Huang, Z. Long, Z. Liang, Y. Chen, Y. Chen, Q. Zheng, M. Kuang, H. Tang, J. Wang, and W. Lu. 2017. Comparison and evaluation of two different methods to establish the cigarette smoke exposure mouse model of COPD. Scientific Reports 7 (1): 15454.","journal-title":"Scientific Reports"},{"issue":"3","key":"823_CR29","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.jep.2010.07.026","volume":"136","author":"SW Oh","year":"2011","unstructured":"Oh, S.W., J.Y. Cha, J.E. Jung, B.C. Chang, H.J. Kwon, B.R. Lee, and D.Y. Kim. 2011. Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-\u03baB inhibition. Journal of Ethnopharmacology 136 (3): 414\u2013421.","journal-title":"Journal of Ethnopharmacology"},{"issue":"5","key":"823_CR30","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/sj.icb.7100044","volume":"85","author":"T Makinde","year":"2007","unstructured":"Makinde, T., R.F. Murphy, and D.K. Agrawal. 2007. The regulatory role of TGF-beta in airway remodeling in asthma. Immunology and Cell Biology 85 (5): 348\u2013356.","journal-title":"Immunology and Cell Biology"},{"issue":"5","key":"823_CR31","doi-asserted-by":"publisher","first-page":"151S","DOI":"10.1378\/chest.121.5_suppl.151S","volume":"121","author":"RA Stockley","year":"2002","unstructured":"Stockley, R.A. 2002. Neutrophils and the pathogenesis of COPD. Chest 121 (5): 151S\u2013155S.","journal-title":"Chest"},{"issue":"1","key":"823_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1465-9921-11-28","volume":"11","author":"WA Neveu","year":"2010","unstructured":"Neveu, W.A., et al. 2010. Elevation of IL-6 in the allergic asthmatic airway is independent of inflammation but associates with loss of central airway function. Respiratory Research 11 (1): 1\u201310.","journal-title":"Respiratory Research"},{"issue":"3","key":"823_CR33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10787-017-0334-3","volume":"25","author":"A Kumari","year":"2017","unstructured":"Kumari, A., D. Dash, and R. Singh. 2017. Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-\u03b1 and TGF-\u03b21) in murine model. Inflammopharmacology 25 (3): 329\u2013341.","journal-title":"Inflammopharmacology"},{"issue":"5","key":"823_CR34","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/resp.12542","volume":"20","author":"W Gao","year":"2015","unstructured":"Gao, W., L. Li, Y. Wang, S. Zhang, I.M. Adcock, P.J. Barnes, M. Huang, and X. Yao. 2015. Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease? Respirology 20 (5): 722\u2013729.","journal-title":"Respirology"},{"issue":"8","key":"823_CR35","doi-asserted-by":"publisher","first-page":"648","DOI":"10.3109\/08958371003610966","volume":"22","author":"ML Hernandez","year":"2010","unstructured":"Hernandez, M.L., B. Harris, J.C. Lay, P.A. Bromberg, D. Diaz-Sanchez, R.B. Devlin, S.R. Kleeberger, N.E. Alexis, and D.B. Peden. 2010. Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge. Inhalation Toxicology 22 (8): 648\u2013656.","journal-title":"Inhalation Toxicology"},{"issue":"3","key":"823_CR36","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cyto.2011.02.018","volume":"54","author":"J Zhang","year":"2011","unstructured":"Zhang, J., L. Wu, and J.M. Qu. 2011. Inhibited proliferation of human lung fibroblasts by LPS is through IL-6 and IL-8 release. Cytokine 54 (3): 289\u2013295.","journal-title":"Cytokine"},{"issue":"1","key":"823_CR37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10753-015-0221-2","volume":"39","author":"XY Fan","year":"2016","unstructured":"Fan, X.Y., B. Chen, Z.S. Lu, Z.F. Jiang, and S.Q. Zhang. 2016. Poly-l-arginine acts synergistically with LPS to promote the release of IL-6 and IL-8 via p38\/ERK signaling pathways in NCI-H292 cells. Inflammation 39 (1): 47\u201353.","journal-title":"Inflammation"},{"issue":"5","key":"823_CR38","doi-asserted-by":"publisher","first-page":"142S","DOI":"10.1378\/chest.121.5_suppl.142S","volume":"121","author":"CA Pettersen","year":"2002","unstructured":"Pettersen, C.A., and K.B. Adler. 2002. Airways inflammation and COPD: Epithelial-neutrophil interactions. Chest 121 (5): 142S\u2013150S.","journal-title":"Chest"},{"issue":"8","key":"823_CR39","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1513\/pats.200605-117SF","volume":"3","author":"SH Randell","year":"2006","unstructured":"Randell, S.H. 2006. Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society 3 (8): 718\u2013725.","journal-title":"Proceedings of the American Thoracic Society"},{"issue":"2","key":"823_CR40","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1164\/rccm.200607-1062OC","volume":"176","author":"L Cohen","year":"2007","unstructured":"Cohen, L., X. E, J. Tarsi, T. Ramkumar, T.K. Horiuchi, R. Cochran, S. DeMartino, K.B. Schechtman, I. Hussain, M.J. Holtzman, M. Castro, and and the NHLBI Severe Asthma Research Program (SARP). 2007. Epithelial cell proliferation contributes to airway remodeling in severe asthma. American Journal of Respiratory and Critical Care Medicine 176 (2): 138\u2013145.","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"10","key":"823_CR41","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nri910","volume":"2","author":"Q Li","year":"2002","unstructured":"Li, Q., and I.M. Verma. 2002. NF-kappaB regulation in the immune system. Nature Reviews. Immunology 2 (10): 725\u2013734.","journal-title":"Nature Reviews. Immunology"},{"issue":"1","key":"823_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI11830","volume":"107","author":"PP Tak","year":"2001","unstructured":"Tak, P.P., and G.S. Firestein. 2001. NF-kappaB: A key role in inflammatory diseases. Journal of Clinical Investigation 107 (1): 7\u201311.","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"823_CR43","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","volume":"16","author":"S Ghosh","year":"1998","unstructured":"Ghosh, S., M.J. May, and E.B. Kopp. 1998. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annual Review of Immunology 16 (1): 225\u2013260.","journal-title":"Annual Review of Immunology"},{"issue":"1","key":"823_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2172-5-10","volume":"5","author":"JP Mizgerd","year":"2004","unstructured":"Mizgerd, J.P., M.M. Lupa, and M.S. Spieker. 2004. NF-\u03baB p50 facilitates neutrophil accumulation during LPS-induced pulmonary inflammation. BMC Immunology 5 (1): 10.","journal-title":"BMC Immunology"},{"issue":"5","key":"823_CR45","first-page":"1619","volume":"27","author":"JY Wang","year":"2012","unstructured":"Wang, J.Y., L. Chen, Z. Zheng, Q. Wang, J. Guo, and L. Xu. 2012. Cinobufocini inhibits NF-kappaB and COX-2 activation induced by TNF-alpha in lung adenocarcinoma cells. Oncology Reports 27 (5): 1619\u20131624.","journal-title":"Oncology Reports"},{"issue":"9204","key":"823_CR46","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/S0140-6736(99)12031-2","volume":"355","author":"DA Willoughby","year":"2000","unstructured":"Willoughby, D.A., A.R. Moore, and P.R. Colville-Nash. 2000. COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease. The Lancet 355 (9204): 646\u2013648.","journal-title":"The Lancet"},{"issue":"12","key":"823_CR47","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1002\/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B","volume":"89","author":"RA Soslow","year":"2000","unstructured":"Soslow, R.A., A.J. Dannenberg, D. Rush, B.M. Woerner, K.N. Khan, J. Masferrer, and A.T. Koki. 2000. COX-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer 89 (12): 2637\u20132645.","journal-title":"Cancer"},{"issue":"34","key":"823_CR48","doi-asserted-by":"publisher","first-page":"21181","DOI":"10.1074\/jbc.272.34.21181","volume":"272","author":"M Yu","year":"1997","unstructured":"Yu, M., D. Ives, and C.S. Ramesha. 1997. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. Journal of Biological Chemistry 272 (34): 21181\u201321186.","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"823_CR49","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1124\/jpet.105.088542","volume":"315","author":"H Liu","year":"2005","unstructured":"Liu, H., A.M. Mamoon, and J.M. Farley Sr. 2005. Prostanoids secreted by alveolar macrophages enhance ionic currents in swine tracheal submucosal gland cells. The Journal of Pharmacology and Experimental Therapeutics 315 (2): 729\u2013739.","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"5","key":"823_CR50","doi-asserted-by":"publisher","first-page":"L797","DOI":"10.1152\/ajplung.00513.2005","volume":"290","author":"GY Park","year":"2006","unstructured":"Park, G.Y., and J.W. Christman. 2006. Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. American Journal of Physiology. Lung Cellular and Molecular Physiology 290 (5): L797\u2013L805.","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"issue":"2","key":"823_CR51","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1152\/ajplung.90593.2008","volume":"298","author":"M Profita","year":"2010","unstructured":"Profita, M., et al. 2010. Chronic obstructive pulmonary disease and neutrophil infiltration: Role of cigarette smoke and cyclooxygenase products. American Journal of Physiology. Lung Cellular and Molecular Physiology 298 (2): 261\u2013269.","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-018-0823-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-018-0823-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-018-0823-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T13:11:52Z","timestamp":1751721112000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-018-0823-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,30]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["823"],"URL":"https:\/\/doi.org\/10.1007\/s10753-018-0823-6","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,30]]},"assertion":[{"value":"30 June 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The entire experiments were reviewed and proved by the Institutional Animal Experimental Ethics Committee of Nanchang University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}