{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:30:53Z","timestamp":1787027453196,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of China, Beijing, China and the Construction Engineering Special Fund of\u201cTaishan Scholars\u201d, Jinan, China","award":["81771076"],"award-info":[{"award-number":["81771076"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702684"],"award-info":[{"award-number":["81702684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s10753-018-0886-4","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T09:43:29Z","timestamp":1536140609000},"page":"221-234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Progranulin Promotes Regeneration of Inflammatory Periodontal Bone Defect in Rats via Anti-inflammation, Osteoclastogenic Inhibition, and Osteogenic Promotion"],"prefix":"10.1007","volume":"42","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-9452","authenticated-orcid":false,"given":"Pishan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,5]]},"reference":[{"issue":"Suppl 16","key":"886_CR1","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1111\/jcpe.12366","volume":"42","author":"IL Chapple","year":"2015","unstructured":"Chapple, I.L., F. Van der Weijden, C. Doerfer, et al. 2015. Primary prevention of periodontitis: Managing gingivitis. Journal of Clinical Periodontology 42 (Suppl 16): S71\u2013S76.","journal-title":"Journal of Clinical Periodontology"},{"issue":"1","key":"886_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1600-0757.2010.00347.x","volume":"53","author":"PM Bartold","year":"2010","unstructured":"Bartold, P.M., M.D. Cantley, and D.R. Haynes. 2010. Mechanisms and control of pathologic bone loss in periodontitis. Periodontology 53 (1): 55\u201369.","journal-title":"Periodontology"},{"issue":"2","key":"886_CR3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s10266-009-0104-9","volume":"97","author":"T Nakajima","year":"2009","unstructured":"Nakajima, T., and K. Yamazaki. 2009. Periodontal disease and risk of atherosclerotic coronary heart disease. Odontology 97 (2): 84\u201391.","journal-title":"Odontology"},{"issue":"9","key":"886_CR4","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1034\/j.1600-051X.2003.00371.x","volume":"30","author":"FB Mercado","year":"2003","unstructured":"Mercado, F.B., R.I. Marshall, and P.M. Bartold. 2003. Inter-relationships between rheumatoid arthritis and periodontal disease. A review. Journal of Clinical Periodontology 30 (9): 761\u2013772.","journal-title":"Journal of Clinical Periodontology"},{"issue":"s14","key":"886_CR5","first-page":"106","volume":"84","author":"IL Chapple","year":"2013","unstructured":"Chapple, I.L., and R. Genco. 2013. Diabetes and periodontal diseases: Consensus report of the joint EFP\/AAP workshop on periodontitis and systemic diseases. Journal of Clinical Periodontology 84 (s14): 106\u2013112.","journal-title":"Journal of Clinical Periodontology"},{"issue":"1","key":"886_CR6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s13287-016-0417-x","volume":"7","author":"H Zhang","year":"2016","unstructured":"Zhang, H., S. Liu, B. Zhu, Q. Xu, Y. Ding, and Y. Jin. 2016. Composite cell sheet for periodontal regeneration: Crosstalk between different types of MSCs in cell sheet facilitates complex periodontal-like tissue regeneration. Stem Cell Research & Therapy 7 (1): 168.","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"886_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13287-016-0362-8","volume":"7","author":"J Hu","year":"2016","unstructured":"Hu, J., C. Yu, Y. Xie, et al. 2016. Periodontal regeneration in swine after cell injection and cell sheet transplantation of human dental pulp stem cells following good manufacturing practice. Stem Cell Research & Therapy 7 (1): 130.","journal-title":"Stem Cell Research & Therapy"},{"issue":"1","key":"886_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-015-0023-3","volume":"6","author":"F Su","year":"2015","unstructured":"Su, F., S.S. Liu, J.L. Ma, et al. 2015. Enhancement of periodontal tissue regeneration by transplantation of osteoprotegerin-engineered periodontal ligament stem cells. Stem Cell Research & Therapy 6 (1): 1\u201314.","journal-title":"Stem Cell Research & Therapy"},{"key":"886_CR9","doi-asserted-by":"crossref","unstructured":"Choung, P.H., H. Jin, B. Jin, et al. 2015. Recombinant human plasminogen activator inhibitor-1 induces cementogenic differentiation of human periodontal ligament stem cells. Tissue Engineering. Part A 21 (23\u201324).","DOI":"10.1089\/ten.tea.2014.0399"},{"issue":"12","key":"886_CR10","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1177\/0022034510376402","volume":"89","author":"GP Garlet","year":"2010","unstructured":"Garlet, G.P. 2010. Destructive and protective roles of cytokines in periodontitis: A re-appraisal from host defense and tissue destruction viewpoints. Journal of Dental Research 89 (12): 1349\u20131363.","journal-title":"Journal of Dental Research"},{"issue":"1","key":"886_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12002","volume":"64","author":"A Cekici","year":"2014","unstructured":"Cekici, A., A. Kantarci, H. Hasturk, and T.E. Van Dyke. 2014. Inflammatory and immune pathways in the pathogenesis of periodontal disease. Periodontology 64 (1): 57\u201380.","journal-title":"Periodontology"},{"key":"886_CR12","first-page":"1","volume":"1","author":"R Zhou","year":"2018","unstructured":"Zhou, R., L. Shen, C. Yang, et al. 2018. Periodontitis may restrain the mandibular bone healing via disturbing osteogenic and osteoclastic balance. Inflammation 1: 1\u201312.","journal-title":"Inflammation"},{"issue":"3","key":"886_CR13","doi-asserted-by":"publisher","first-page":"150258","DOI":"10.1098\/rsob.150258","volume":"6","author":"N Wang","year":"2016","unstructured":"Wang, Nan, Zubin Zhou, Tianyi Wu, Wei Liu, Peipei Yin, Chenhao Pan, and Xiaowei Yu. 2016. TNF-\u03b1-induced NF-\u03baB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting \u03b2-catenin. Open Biology 6 (3): 150258.","journal-title":"Open Biology"},{"issue":"4\u20135","key":"886_CR14","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10735-015-9630-7","volume":"46","author":"Z Qin","year":"2015","unstructured":"Qin, Z., Z. Fang, Z. Lei, et al. 2015. High dose of TNF-\u03b1 suppressed osteogenic differentiation of human dental pulp stem cells by activating the Wnt\/\u03b2-catenin signaling. Journal of Molecular Histology 46 (4\u20135): 409\u2013420.","journal-title":"Journal of Molecular Histology"},{"key":"886_CR15","doi-asserted-by":"crossref","unstructured":"Wang, L.M., N. Zhao, J. Zhang, et al. 2017. Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway. Journal of Periodontal Research 53 (1).","DOI":"10.1111\/jre.12488"},{"issue":"5","key":"886_CR16","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1365-2184.2011.00769.x","volume":"44","author":"H Huang","year":"2011","unstructured":"Huang, H., N. Zhao, X. Xu, Y. Xu, S. Li, J. Zhang, and P. Yang. 2011. Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells. Cell Proliferation 44 (5): 420\u2013427.","journal-title":"Cell Proliferation"},{"issue":"4","key":"886_CR17","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.bbrc.2007.03.099","volume":"356","author":"T Mukai","year":"2007","unstructured":"Mukai, T., F. Otsuka, H. Otani, M. Yamashita, K. Takasugi, K. Inagaki, M. Yamamura, and H. Makino. 2007. TNF-alpha inhibits BMP-induced osteoblast differentiation through activating SAPK\/JNK signaling. Biochemical and Biophysical Research Communications 356 (4): 1004\u20131010.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"6","key":"886_CR18","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1096\/fj.09-144659","volume":"24","author":"JQ Feng","year":"2010","unstructured":"Feng, J.Q., F.J. Guo, B.C. Jiang, Y. Zhang, S. Frenkel, D.W. Wang, W. Tang, Y. Xie, and C.J. Liu. 2010. Granulin epithelin precursor: A bone morphogenic protein 2-inducible growth factor that activates ERK1\/2 signaling and JunB transcription factor in chondrogenesis. FASEB Journal 24 (6): 1879\u20131892.","journal-title":"FASEB Journal"},{"issue":"2","key":"886_CR19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nm816","volume":"9","author":"Z He","year":"2003","unstructured":"He, Z., C.H. Ong, J. Halper, and A. Bateman. 2003. Progranulin is a mediator of the wound response. Nature Medicine 9 (2): 225\u2013229.","journal-title":"Nature Medicine"},{"key":"886_CR20","unstructured":"Guo, Z., Li, Q., Han, Y., et al. 2012. Prevention of LPS-induced acute lung injury in mice by progranulin. Mediators of Inflammation 2012,(2012-8-15), 2012(962\u20139351): 540794."},{"issue":"1","key":"886_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1084\/jem.20091568","volume":"207","author":"F Yin","year":"2010","unstructured":"Yin, F., R. Banerjee, B. Thomas, P. Zhou, L. Qian, T. Jia, X. Ma, Y. Ma, C. Iadecola, M.F. Beal, C. Nathan, and A. Ding. 2010. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. Journal of Experimental Medicine 207 (1): 117\u2013128.","journal-title":"Journal of Experimental Medicine"},{"issue":"6028","key":"886_CR22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1126\/science.1199214","volume":"332","author":"W Tang","year":"2011","unstructured":"Tang, W., Y. Lu, Q.Y. Tian, Y. Zhang, F.J. Guo, G.Y. Liu, N.M. Syed, Y. Lai, E.A. Lin, L. Kong, J. Su, F. Yin, A.H. Ding, A. Zanin-Zhorov, M.L. Dustin, J. Tao, J. Craft, Z. Yin, J.Q. Feng, S.B. Abramson, X.P. Yu, and C.J. Liu. 2011. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332 (6028): 478\u2013484.","journal-title":"Science"},{"issue":"27","key":"886_CR23","doi-asserted-by":"publisher","first-page":"6412","DOI":"10.1016\/j.biomaterials.2013.05.030","volume":"34","author":"YP Zhao","year":"2013","unstructured":"Zhao, Y.P., Q.Y. Tian, S. Frenkel, and C.J. Liu. 2013. The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF\/TNFR signaling. Biomaterials 34 (27): 6412\u20136421.","journal-title":"Biomaterials"},{"issue":"3","key":"886_CR24","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.bbrc.2015.08.077","volume":"465","author":"T Noguchi","year":"2015","unstructured":"Noguchi, T., K. Ebina, M. Hirao, R. Kawase, T. Ohama, S. Yamashita, T. Morimoto, K. Koizumi, K. Kitaguchi, H. Matsuoka, S. Kaneshiro, and H. Yoshikawa. 2015. Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-\u03b1-induced osteoclastogenesis and promoting osteoblastic differentiation in mice. Biochemical & Biophysical Research Communications 465 (3): 638\u2013643.","journal-title":"Biochemical & Biophysical Research Communications"},{"issue":"12","key":"886_CR25","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1136\/annrheumdis-2014-205779","volume":"74","author":"Y Zhao","year":"2015","unstructured":"Zhao, Yunpeng, Ben Liu, Qingyun Tian, Jian-lu Wei, Brendon Richbourgh, and Chuan-ju Liu. 2015. Progranulin protects against osteoarthritis through interacting with TNF-\u03b1 and \u03b2-catenin signalling. Annals of the Rheumatic Diseases 74 (12): 2244\u20132253.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"13","key":"886_CR26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1089\/ten.tea.2016.0416","volume":"23","author":"N Lehmann","year":"2017","unstructured":"Lehmann, N., T. Christ, A. Daugs, O. Bloch, and S. Holinski. 2017. EDC-crosslinking of decellularized tissue-a promising approach? Tissue Engineering Part A 23 (13): 675\u2013682.","journal-title":"Tissue Engineering Part A"},{"key":"886_CR27","unstructured":"Chen, S., Xin, Y., Yu, X., Xu, Q., Pan, K., et al. 2015. Co-culture with periodontal ligament stem cells enhanced osteoblastic differentiation of MC3T3-E1 cells and osteoclastic differentiation of RAW264.7 cells. International Journal of Clinical & Experimental Pathology, 8(11): 14596."},{"issue":"3","key":"886_CR28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1601-0825.2011.01880.x","volume":"18","author":"O Fento\u011flu","year":"2012","unstructured":"Fento\u011flu, O., F.Y. Kirzio\u011flu, M. Ozdem, et al. 2012. Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment. Oral Diseases 18 (3): 299\u2013306.","journal-title":"Oral Diseases"},{"issue":"12","key":"886_CR29","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1902\/jop.1998.69.12.1419","volume":"69","author":"DT Graves","year":"1998","unstructured":"Graves, D.T., A.J. Delima, R. Assuma, S. Amar, T. Oates, and D. Cochran. 1998. Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis. Journal of Periodontology 69 (12): 1419\u20131425.","journal-title":"Journal of Periodontology"},{"issue":"10","key":"886_CR30","first-page":"1","volume":"52","author":"Y Xin","year":"2016","unstructured":"Xin, Y., H. Huang, Z. Ning, Z. Jin, and P. Yang. 2016. Inhibition of Runx2 signaling by TNF-\u03b1 in ST2 murine bone marrow stromal cells undergoing osteogenic differentiation. Vitro Cellular & Developmental Biology - Animal 52 (10): 1\u20138.","journal-title":"Vitro Cellular & Developmental Biology - Animal"},{"issue":"3","key":"886_CR31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1034\/j.1600-051x.2001.028003233.x","volume":"28","author":"AJ Delima","year":"2010","unstructured":"Delima, A.J., T. Oates, R. Assuma, et al. 2010. Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. Journal of Clinical Periodontology 28 (3): 233\u2013240.","journal-title":"Journal of Clinical Periodontology"},{"issue":"3","key":"886_CR32","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrd3669","volume":"11","author":"K Redlich","year":"2012","unstructured":"Redlich, K., and J.S. Smolen. 2012. Inflammatory bone loss: Pathogenesis and therapeutic intervention. Nature Reviews Drug Discovery 11 (3): 234\u2013250.","journal-title":"Nature Reviews Drug Discovery"},{"key":"886_CR33","doi-asserted-by":"publisher","unstructured":"Li, X., Z. Zuo, Q. Chen, et al. 2018. Progranulin is highly expressed in patients with chronic periodontitis and protects against experimental periodontitis in rats. J Periodontol . 2018 Jul 12. https:\/\/doi.org\/10.1002\/JPER.18-0132 [Epub ahead of print].","DOI":"10.1002\/JPER.18-0132"},{"issue":"2","key":"886_CR34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1084\/jem.191.2.275","volume":"191","author":"K Kobayashi","year":"2000","unstructured":"Kobayashi, K., N. Takahashi, E. Jimi, N. Udagawa, M. Takami, S. Kotake, N. Nakagawa, M. Kinosaki, K. Yamaguchi, N. Shima, H. Yasuda, T. Morinaga, K. Higashio, T.J. Martin, and T. Suda. 2000. Tumor necrosis factor \u03b1 stimulates osteoclast differentiation by a mechanism independent of the Odf\/Rankl\u2013Rank interaction. Journal of Experimental Medicine 191 (2): 275\u2013286.","journal-title":"Journal of Experimental Medicine"},{"issue":"12","key":"886_CR35","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1172\/JCI11176","volume":"106","author":"J Lam","year":"2000","unstructured":"Lam, J., S. Takeshita, J.E. Barker, O. Kanagawa, F.P. Ross, and S.L. Teitelbaum. 2000. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. Journal of Clinical Investigation 106 (12): 1481\u20131488.","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"886_CR36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","volume":"160","author":"R Assuma","year":"1998","unstructured":"Assuma, R., T. Oates, D. Cochran, S. Amar, and D.T. Graves. 1998. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J immunol 160: 403\u2013409 160 (1): 403\u2013409.","journal-title":"J immunol 160: 403\u2013409"},{"key":"886_CR37","doi-asserted-by":"publisher","first-page":"150258","DOI":"10.1098\/rsob.150258","volume":"6","author":"N Wang","year":"2016","unstructured":"Wang, N., Z. Zhou, T. Wu, W. Liu, P. Yin, C. Pan, and X. Yu. 2016. TNF-\u03b1-induced NF-\u03baB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting \u03b2-catenin. Open Biol 6: 150258.","journal-title":"Open Biol"},{"key":"886_CR38","doi-asserted-by":"publisher","first-page":"20909","DOI":"10.1038\/srep20909","volume":"6","author":"YP Zhao","year":"2016","unstructured":"Zhao, Y.P., J.L. Wei, Q.Y. Tian, A.T. Liu, Y.S. Yi, T.A. Einhorn, and C.J. Liu. 2016. Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNF\u03b1 signaling. Scientific Reports 6: 20909.","journal-title":"Scientific Reports"},{"issue":"2","key":"886_CR39","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.bone.2009.09.011","volume":"46","author":"EC Wahl","year":"2010","unstructured":"Wahl, E.C., J. Aronson, L. Liu, R.A. Skinner, M.J. Miller, G.E. Cockrell, J.L. Fowlkes, K.M. Thrailkill, R.C. Bunn, M.J.J. Ronis, and C.K. Lumpkin Jr. 2010. Direct bone formation during distraction osteogenesis does not require TNF\u03b1 receptors and elevated serum TNF\u03b1 fails to inhibit bone formation in TNFR1 deficient mice. Bone 46 (2): 410\u2013417.","journal-title":"Bone"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-018-0886-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-018-0886-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-018-0886-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:50:37Z","timestamp":1693864237000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-018-0886-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,5]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["886"],"URL":"https:\/\/doi.org\/10.1007\/s10753-018-0886-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,5]]},"assertion":[{"value":"5 September 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}