{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:56:17Z","timestamp":1794012977693,"version":"4.8.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s10753-019-00996-1","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T03:03:30Z","timestamp":1552964610000},"page":"1350-1359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["CTRP3 Alleviates Ox-LDL\u2013Induced Inflammatory Response and Endothelial Dysfunction in Mouse Aortic Endothelial Cells by Activating the PI3K\/Akt\/eNOS Pathway"],"prefix":"10.1007","volume":"42","author":[{"given":"Lei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"996_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1186\/s12906-016-1449-6","volume":"16","author":"Y Guo","year":"2016","unstructured":"Guo, Y., X.C. Liu, Y.J. Wang, Q. Li, Q. Yang, X.G. Weng, Y. Chen, W.Y. Cai, X.X. Kan, and X. Chen. 2016. Effects of Shenlian extract on experimental atherosclerosis in ApoE-deficient mice based on ultrasound biomicroscopy. Bmc Complementary & Alternative Medicine 16: 469.","journal-title":"Bmc Complementary & Alternative Medicine"},{"key":"996_CR2","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/joim.12296","volume":"276","author":"L Badimon","year":"2014","unstructured":"Badimon, L., and G. Vilahur. 2014. Thrombosis formation on atherosclerotic lesions and plaque rupture. Journal of Internal Medicine 276: 618\u2013632.","journal-title":"Journal of Internal Medicine"},{"key":"996_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s10517-012-1708-6","volume":"153","author":"YI Ragino","year":"2012","unstructured":"Ragino, Y.I., A.M. Chernjavski, Y.V. Polonskaya, A.M. Volkov, E.V. Kashtanova, A.V. Tikhonov, and S.Y. Tcimbal. 2012. Oxidation and endothelial dysfunction biomarkers of atherosclerotic plaque instability. Studies of the vascular wall and blood. Bulletin of Experimental Biology & Medicine 153: 331\u2013335.","journal-title":"Bulletin of Experimental Biology & Medicine"},{"key":"996_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2165\/00003495-200060010-00005","volume":"60","author":"DPH Chong","year":"2000","unstructured":"Chong, D.P.H., and B.S. Bachenheimer. 2000. Current, new and future treatments in Dyslipidaemia and atherosclerosis. Drugs 60: 55\u201393.","journal-title":"Drugs"},{"key":"996_CR5","doi-asserted-by":"publisher","first-page":"e55744","DOI":"10.1371\/journal.pone.0055744","volume":"8","author":"HJ Yoo","year":"2013","unstructured":"Yoo, H.J., S.Y. Hwang, H.C. Hong, H.Y. Choi, S.J. Yang, S.C. Dong, S.H. Baik, M. Bl\u00fcher, B.S. Youn, and K.M. Choi. 2013. Implication of progranulin and C1q\/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. PLoS One 8: e55744.","journal-title":"PLoS One"},{"key":"996_CR6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.bone.2015.06.011","volume":"79","author":"JY Kim","year":"2015","unstructured":"Kim, J.Y., J.Y. Min, J.M. Baek, S.J. Ahn, H.Y. Jun, K.H. Yoon, M.K. Choi, M.S. Lee, and J. Oh. 2015. CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone 79: 242\u2013251.","journal-title":"Bone"},{"key":"996_CR7","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.3390\/ijms18061097","volume":"18","author":"H Sun","year":"2017","unstructured":"Sun, H., X. Zhu, Y. Zhou, W. Cai, and L. Qiu. 2017. C1q\/TNF-related Protein-9 ameliorates ox-LDL-induced endothelial dysfunction via PGC-1\u03b1\/AMPK-mediated antioxidant enzyme induction. International Journal of Molecular Sciences 18: 1097.","journal-title":"International Journal of Molecular Sciences"},{"key":"996_CR8","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1161\/CIRCULATIONAHA.112.099937","volume":"125","author":"W Yi","year":"2012","unstructured":"Yi, W., Y. Sun, Y. Yuan, W.B. Lau, Q. Zheng, X. Wang, Y. Wang, X. Shang, E. Gao, W.J. Koch, and X.L. Ma. 2012. C1q\/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation 125: 3159\u20133169.","journal-title":"Circulation"},{"key":"996_CR9","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1002\/ibd.21647","volume":"17","author":"C Hofmann","year":"2011","unstructured":"Hofmann, C., N. Chen, F. Obermeier, G. Paul, C. B\u00fcchler, A. Kopp, W. Falk, and A. Sch\u00e4ffler. 2011. C1q\/TNF-related Protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts. Inflammatory Bowel Diseases 17: 2462\u20132471.","journal-title":"Inflammatory Bowel Diseases"},{"key":"996_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbrc.2014.06.054","volume":"452","author":"A Schmid","year":"2014","unstructured":"Schmid, A., A. Kopp, F. Hanses, T. Karrasch, and A. Sch\u00e4ffler. 2014. C1q\/TNF-related protein-3 (CTRP-3) attenuates lipopolysaccharide (LPS)-induced systemic inflammation and adipose tissue Erk-1\/-2 phosphorylation in mice in vivo. Biochemical & Biophysical Research Communications 452: 8\u201313.","journal-title":"Biochemical & Biophysical Research Communications"},{"key":"996_CR11","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1124\/jpet.115.230359","volume":"357","author":"Y Wang","year":"2016","unstructured":"Wang, Y., L. Tu, Y. Li, D. Chen, and S. Wang. 2016. Notoginsenoside R1 protects against neonatal cerebral hypoxic-ischemic injury through estrogen receptor-dependent activation of endoplasmic reticulum stress pathways. The Journal of Pharmacology and Experimental Therapeutics 357: 591\u2013605.","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"996_CR12","doi-asserted-by":"crossref","unstructured":"Pende, A., A. Denegri. 2012. An anti-inflammatory approach in the therapeutic choices for the prevention of atherosclerotic events: InTech, 158\u2013164.","DOI":"10.5772\/31565"},{"key":"996_CR13","doi-asserted-by":"publisher","first-page":"6083","DOI":"10.1007\/s13277-015-3289-2","volume":"36","author":"Y Chang","year":"2015","unstructured":"Chang, Y., Q. Wu, T. Tian, L. Li, X. Guo, Z. Feng, J. Zhou, L. Zhang, S. Zhou, and G. Feng. 2015. The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K\/Akt signaling pathway under normoxia. Tumour Biology the Journal of the International Society for Oncodevelopmental Biology & Medicine 36: 6083\u20136093.","journal-title":"Tumour Biology the Journal of the International Society for Oncodevelopmental Biology & Medicine"},{"key":"996_CR14","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.taap.2010.07.025","volume":"248","author":"HC Ou","year":"2010","unstructured":"Ou, H.C., W.J. Lee, S.D. Lee, C.Y. Huang, T.H. Chiu, K.L. Tsai, W.C. Hsu, and W.H. Sheu. 2010. Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K\/Akt\/eNOS pathway. Toxicology & Applied Pharmacology 248: 134\u2013143.","journal-title":"Toxicology & Applied Pharmacology"},{"key":"996_CR15","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1165\/rcmb.2012-0097OC","volume":"47","author":"M Wygrecka","year":"2012","unstructured":"Wygrecka, M., D. Zakrzewicz, B. Taborski, M. Didiasova, G. Kwapiszewska, K.T. Preissner, and P. Markart. 2012. TGF-\u00ce21 induces tissue factor expression in human lung fibroblasts in a PI3K\/JNK\/Akt-dependent and AP-1-dependent manner. American Journal of Respiratory Cell & Molecular Biology 47: 614\u2013627.","journal-title":"American Journal of Respiratory Cell & Molecular Biology"},{"key":"996_CR16","first-page":"141","volume":"72","author":"SS Xing","year":"2015","unstructured":"Xing, S.S., X.Y. Yang, T. Zheng, W.J. Li, D. Wu, J.Y. Chi, F. Bian, X.L. Bai, G.J. Wu, and Y.Z. Zhang. 2015. Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK\/PI3K\/Akt\/eNOS pathway. \u4e2d\u56fd\u836f\u7406\u5b66\u901a\u62a5 72: 141.","journal-title":"\u4e2d\u56fd\u836f\u7406\u5b66\u901a\u62a5"},{"key":"996_CR17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12906-016-1002-7","volume":"16","author":"T Li","year":"2016","unstructured":"Li, T., D. Li, H. Xu, H. Zhang, D. Tang, and H. Cao. 2016. Wen-Xin decoction ameliorates vascular endothelium dysfunction via the PI3K\/AKT\/eNOS pathway in experimental atherosclerosis in rats. BMC Complementary and Alternative Medicine 16: 27.","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"996_CR18","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1159\/000438526","volume":"37","author":"R Dong","year":"2015","unstructured":"Dong, R., W. Chen, W. Feng, C. Xia, D. Hu, Y. Zhang, Y. Yang, D.W. Wang, X. Xu, and L. Tu. 2015. Exogenous bradykinin inhibits tissue factor induction and deep vein thrombosis via activating the eNOS\/phosphoinositide 3-kinase\/Akt signaling pathway. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 37: 1592\u20131606.","journal-title":"Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology"},{"key":"996_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/ijo.2009.205","volume":"34","author":"G Deng","year":"2010","unstructured":"Deng, G., Y. Long, Y.R. Yu, and M.R. Li. 2010. Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS pathway. International Journal of Obesity 34: 165\u2013171.","journal-title":"International Journal of Obesity"},{"key":"996_CR20","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.atherosclerosis.2009.07.035","volume":"208","author":"X Feng","year":"2010","unstructured":"Feng, X., Y. Zhang, R. Xu, X. Xie, L. Tao, H. Gao, Y. Gao, Z. He, and H. Wang. 2010. Lipopolysaccharide up-regulates the expression of Fcalpha\/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. Atherosclerosis 208: 396\u2013405.","journal-title":"Atherosclerosis"},{"key":"996_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1741-7015-12-47","volume":"12","author":"E Matsuura","year":"2014","unstructured":"Matsuura, E., F. Atzeni, P. Sarzi-Puttini, M. Turiel, L.R. Lopez, and M.T. Nurmohamed. 2014. Is atherosclerosis an autoimmune disease? BMC Medicine 12: 47.","journal-title":"BMC Medicine"},{"key":"996_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/MAJ.0b013e318224a147","volume":"342","author":"S Mitra","year":"2011","unstructured":"Mitra, S., A. Deshmukh, R. Sachdeva, J. Lu, and J.L. Mehta. 2011. Oxidized low-density lipoprotein and atherosclerosis implications in antioxidant therapy. The American Journal of the Medical Sciences 342: 135\u2013142.","journal-title":"The American Journal of the Medical Sciences"},{"key":"996_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.biopha.2016.11.128","volume":"85","author":"Y Huang","year":"2017","unstructured":"Huang, Y., G. Wan, and J. Tao. 2017. C1q\/TNF-related protein-3 exerts the chondroprotective effects in IL-1beta-treated SW1353 cells by regulating the FGFR1 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 85: 41\u201346.","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"996_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11010-015-2531-y","volume":"409","author":"M Otani","year":"2015","unstructured":"Otani, M., S. Furukawa, S. Wakisaka, and T. Maeda. 2015. A novel adipokine C1q\/TNF-related protein 3 is expressed in developing skeletal muscle and controls myoblast proliferation and differentiation. Molecular and Cellular Biochemistry 409: 271\u2013282.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"996_CR25","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ijcard.2016.12.082","volume":"230","author":"BY Zhou","year":"2017","unstructured":"Zhou, B.Y., Y.L. Guo, N.Q. Wu, C.G. Zhu, Y. Gao, P. Qing, X.L. Li, Y. Wang, Q. Dong, G. Liu, R.X. Xu, C.J. Cui, J. Sun, and J.J. Li. 2017. Plasma big endothelin-1 levels at admission and future cardiovascular outcomes: A cohort study in patients with stable coronary artery disease. International Journal of Cardiology 230: 76\u201379.","journal-title":"International Journal of Cardiology"},{"key":"996_CR26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1055\/s-0031-1278237","volume":"16","author":"WT Jr","year":"2007","unstructured":"Jr, W.T. 2007. Coronary atherosclerosis, low-density lipoproteins and markers of thrombosis, inflammation and endothelial dysfunction. International Journal of Angiology 16: 12.","journal-title":"International Journal of Angiology"},{"key":"996_CR27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1179\/135100009X12525712409490","volume":"14","author":"S Hua","year":"2009","unstructured":"Hua, S., C. Song, C.L. Geczy, S.B. Freedman, and P.K. Witting. 2009. A role for acute-phase serum amyloid a and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis. Redox Report Communications in Free Radical Research 14: 187\u2013196.","journal-title":"Redox Report Communications in Free Radical Research"},{"key":"996_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1191\/1358863x05vm589ra","volume":"10","author":"A Tedgui","year":"2011","unstructured":"Tedgui, A. 2011. The role of inflammation in atherothrombosis: Implications for clinical practice. Vascular Medicine 10: 45\u201353.","journal-title":"Vascular Medicine"},{"key":"996_CR29","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1210\/en.2010-0571","volume":"151","author":"A Kopp","year":"2010","unstructured":"Kopp, A., M. Bala, C. Buechler, W. Falk, P. Gross, M. Neumeier, J. Sch\u00f6lmerich, and A. Sch\u00e4ffler. 2010. C1q\/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue. Endocrinology 151: 5267\u20135278.","journal-title":"Endocrinology"},{"key":"996_CR30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11010-007-9506-6","volume":"304","author":"H Akiyama","year":"2007","unstructured":"Akiyama, H., S. Furukawa, S. Wakisaka, and T. Maeda. 2007. CTRP3\/cartducin promotes proliferation and migration of endothelial cells. Molecular and Cellular Biochemistry 304: 243\u2013248.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"996_CR31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s10557-011-6341-5","volume":"25","author":"S Mitra","year":"2011","unstructured":"Mitra, S., T. Goyal, and J.L. Mehta. 2011. Oxidized LDL, LOX-1 and atherosclerosis. Cardiovascular Drugs and Therapy 25: 419\u2013429.","journal-title":"Cardiovascular Drugs and Therapy"},{"key":"996_CR32","doi-asserted-by":"crossref","first-page":"61001","DOI":"10.18632\/oncotarget.17720","volume":"8","author":"MK Qiu","year":"2017","unstructured":"Qiu, M.K., S.C. Wang, Y. Tang, C. Pan, Y. Wang, S.Q. Wang, Z.W. Quan, and J.M. Ou. 2017. Tim-3 inhibits low-density lipoprotein-induced atherogenic responses in human umbilical vein endothelial cells. Oncotarget 8: 61001\u201361010.","journal-title":"Oncotarget"},{"key":"996_CR33","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1161\/01.ATV.18.5.842","volume":"18","author":"Y Nakashima","year":"1998","unstructured":"Nakashima, Y., E.W. Raines, A.S. Plump, J.L. Breslow, and R. Ross. 1998. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse. Arteriosclerosis, Thrombosis, and Vascular Biology 18: 842\u2013851.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"996_CR34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1080\/19336918.2015.1119361","volume":"10","author":"W Zhao","year":"2016","unstructured":"Zhao, W., C. Wu, and X. Chen. 2016. Cryptotanshinone inhibits oxidized LDL-induced adhesion molecule expression via ROS dependent NF-kappaB pathways. Cell Adhesion & Migration 10: 248\u2013258.","journal-title":"Cell Adhesion & Migration"},{"key":"996_CR35","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/S0008-6363(99)00169-8","volume":"43","author":"G Kojda","year":"1999","unstructured":"Kojda, G., and D. Harrison. 1999. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovascular Research 43: 562\u2013571.","journal-title":"Cardiovascular Research"},{"key":"996_CR36","first-page":"215","volume":"6","author":"B MA","year":"2015","unstructured":"MA, B., D. I, and L. JH. 2015. Salt, angiotensin II, superoxide, and Endothelial Function. Comprehensive Physiology 6: 215.","journal-title":"Comprehensive Physiology"},{"key":"996_CR37","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1172\/JCI7818","volume":"105","author":"A Daugherty","year":"2000","unstructured":"Daugherty, A., M.W. Manning, and L.A. Cassis. 2000. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. The Journal of Clinical Investigation 105: 1605\u20131612.","journal-title":"The Journal of Clinical Investigation"},{"key":"996_CR38","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/jmv.24166","volume":"87","author":"J Suo","year":"2015","unstructured":"Suo, J., L. Zhao, J. Wang, Z. Zhu, H. Zhang, and R. Gao. 2015. Influenza virus aggravates the ox-LDL-induced apoptosis of human endothelial cells via promoting p53 signaling. Journal of Medical Virology 87: 1113\u20131123.","journal-title":"Journal of Medical Virology"},{"key":"996_CR39","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1007\/s00125-017-4232-4","volume":"60","author":"ZG Ma","year":"2017","unstructured":"Ma, Z.G., Y.P. Yuan, S.C. Xu, W.Y. Wei, C.R. Xu, X. Zhang, Q.Q. Wu, H.H. Liao, J. Ni, and Q.Z. Tang. 2017. CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats. Diabetologia 60: 1126\u20131137.","journal-title":"Diabetologia"},{"key":"996_CR40","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1177\/1074248413504994","volume":"19","author":"S Pant","year":"2014","unstructured":"Pant, S., A. Deshmukh, G.S. Gurumurthy, N.V. Pothineni, T.E. Watts, F. Romeo, and J.L. Mehta. 2014. Inflammation and atherosclerosis--revisited. Journal of Cardiovascular Pharmacology and Therapeutics 19: 170\u2013178.","journal-title":"Journal of Cardiovascular Pharmacology and Therapeutics"},{"key":"996_CR41","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s11883-002-0031-5","volume":"4","author":"JA Farmer","year":"2002","unstructured":"Farmer, J.A., and G. Torre-Amione. 2002. Atherosclerosis and inflammation. Current Atherosclerosis Reports 4: 92\u201398.","journal-title":"Current Atherosclerosis Reports"},{"key":"996_CR42","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1161\/01.CIR.95.4.1062","volume":"95","author":"D Steinberg","year":"1997","unstructured":"Steinberg, D. 1997. Lewis A. Conner Memorial Lecture. Oxidative modification of LDL and atherogenesis. Circulation 95: 1062\u20131071.","journal-title":"Circulation"},{"key":"996_CR43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3109\/10408363.2014.992063","volume":"52","author":"A Trpkovic","year":"2015","unstructured":"Trpkovic, A., I. Resanovic, J. Stanimirovic, D. Radak, S.A. Mousa, D. Cenic-Milosevic, D. Jevremovic, and E.R. Isenovic. 2015. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Critical Reviews in Clinical Laboratory Sciences 52: 70\u201385.","journal-title":"Critical Reviews in Clinical Laboratory Sciences"},{"key":"996_CR44","doi-asserted-by":"publisher","first-page":"e0136026","DOI":"10.1371\/journal.pone.0136026","volume":"10","author":"SS Wang","year":"2015","unstructured":"Wang, S.S., S.W. Hu, Q.H. Zhang, A.X. Xia, Z.X. Jiang, and X.M. Chen. 2015. Mesenchymal stem cells stabilize atherosclerotic vulnerable plaque by anti-inflammatory properties. PLoS One 10: e0136026.","journal-title":"PLoS One"},{"key":"996_CR45","doi-asserted-by":"publisher","first-page":"7458","DOI":"10.1073\/pnas.97.13.7458","volume":"97","author":"U Sch\u00f6nbeck","year":"2000","unstructured":"Sch\u00f6nbeck, U., G.K. Sukhova, K. Shimizu, F. Mach, and P. Libby. 2000. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proceedings of the National Academy of Sciences of the United States of America 97: 7458\u20137463.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"996_CR46","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1476-5381.2010.01196.x","volume":"164","author":"U Forstermann","year":"2011","unstructured":"Forstermann, U., and H. Li. 2011. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. British Journal of Pharmacology 164: 213\u2013223.","journal-title":"British Journal of Pharmacology"},{"key":"996_CR47","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.vph.2013.07.001","volume":"59","author":"WH Ning","year":"2013","unstructured":"Ning, W.H., and K. Zhao. 2013. Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases. Vascular Pharmacology 59: 76\u201382.","journal-title":"Vascular Pharmacology"},{"key":"996_CR48","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12944-017-0447-0","volume":"16","author":"Y Yao","year":"2017","unstructured":"Yao, Y., Y. Wang, Y. Zhang, and C. Liu. 2017. Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K\/Akt\/eNOS pathways. Lipids in Health and Disease 16: 77.","journal-title":"Lipids in Health and Disease"},{"key":"996_CR49","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/mnfr.201400539","volume":"59","author":"CF Garcia-Prieto","year":"2015","unstructured":"Garcia-Prieto, C.F., F. Hernandez-Nuno, D.D. Rio, G. Ruiz-Hurtado, I. Aranguez, M. Ruiz-Gayo, B. Somoza, and M.S. Fernandez-Alfonso. 2015. High-fat diet induces endothelial dysfunction through a down-regulation of the endothelial AMPK-PI3K-Akt-eNOS pathway. Molecular Nutrition & Food Research 59: 520\u2013532.","journal-title":"Molecular Nutrition & Food Research"},{"key":"996_CR50","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.vph.2015.07.004","volume":"72","author":"SS Xing","year":"2015","unstructured":"Xing, S.S., X.Y. Yang, T. Zheng, W.J. Li, D. Wu, J.Y. Chi, F. Bian, X.L. Bai, G.J. Wu, Y.Z. Zhang, C.T. Zhang, Y.H. Zhang, Y.S. Li, and S. Jin. 2015. Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK\/PI3K\/Akt\/eNOS pathway. Vascular Pharmacology 72: 141\u2013152.","journal-title":"Vascular Pharmacology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-00996-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-019-00996-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-00996-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T22:15:47Z","timestamp":1606860947000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-019-00996-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["996"],"URL":"https:\/\/doi.org\/10.1007\/s10753-019-00996-1","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"19 March 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}