{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:24:19Z","timestamp":1793316259992,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s10753-019-01086-y","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T10:24:43Z","timestamp":1567074283000},"page":"2226-2235","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Interference of Skin Scratching Attenuates Accumulation of Neutrophils in Murine Allergic Contact Dermatitis Model"],"prefix":"10.1007","volume":"42","author":[{"given":"Hiroyasu","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Mandokoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Yabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risako","family":"Kon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutomo","family":"Ikarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzo","family":"Kamei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,29]]},"reference":[{"key":"1086_CR1","first-page":"1140","volume":"286","author":"T Andoh","year":"1998","unstructured":"Andoh, T., T. Nagasawa, M. Satoh, and Y. Kuraishi. 1998. Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. The Journal of Pharmacology and Experimental Therapeutics 286: 1140\u20131145.","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"1086_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nn.3619","volume":"17","author":"DM Bautista","year":"2014","unstructured":"Bautista, D.M., S.R. Wilson, and M.A. Hoon. 2014. Why we scratch an itch: The molecules, cells and circuits of itch. Nature Neuroscience 17: 175\u2013182.","journal-title":"Nature Neuroscience"},{"key":"1086_CR3","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/0016-5085(92)90102-5","volume":"102","author":"NV Bergasa","year":"1992","unstructured":"Bergasa, N.V., T.L. Talbot, D.W. Alling, J.M. Schmitt, E.C. Walker, B.L. Baker, J.C. Korenman, Y. Park, J.H. Hoofnagle, and E.A. Jones. 1992. A controlled trial of naloxone infusions for the pruritus of chronic cholestasis. Gastroenterology 102: 544\u2013549.","journal-title":"Gastroenterology"},{"key":"1086_CR4","first-page":"564","volume":"17","author":"PJ Coenraads","year":"2007","unstructured":"Coenraads, P.J., and M. Goncalo. 2007. Skin diseases with high public health impact. Contact dermatitis. European Journal of Dermatology 17: 564\u2013565.","journal-title":"European Journal of Dermatology"},{"key":"1086_CR5","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.4049\/jimmunol.167.11.6503","volume":"167","author":"L Del Rio","year":"2001","unstructured":"Del Rio, L., S. Bennouna, J. Salinas, and E.Y. Denkers. 2001. CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection. Journal of Immunology 167: 6503\u20136509.","journal-title":"Journal of Immunology"},{"key":"1086_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1681\/ASN.2013101061","volume":"26","author":"EM Disteldorf","year":"2015","unstructured":"Disteldorf, E.M., C.F. Krebs, H.J. Paust, J.E. Turner, G. Nouailles, A. Tittel, C. Meyer-Schwesinger, G. Stege, S. Brix, J. Velden, T. Wiech, U. Helmchen, O.M. Steinmetz, A. Peters, S.B. Bennstein, A. Kaffke, C. Llanto, S.A. Lira, H.W. Mittrucker, R.A. Stahl, C. Kurts, S.H. Kaufmann, and U. Panzer. 2015. CXCL5 drives neutrophil recruitment in TH17-mediated GN. Journal of the American Society of Nephrology 26: 55\u201366.","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1062\u20131076","key":"1086_CR7","volume":"49","author":"T Girbl","year":"2018","unstructured":"Girbl, T., T. Lenn, L. Perez, L. Rolas, A. Barkaway, A. Thiriot, C. Del Fresno, E. Lynam, E. Hub, M. Thelen, G. Graham, R. Alon, D. Sancho, U.H. von Andrian, M.B. Voisin, A. Rot, and S. Nourshargh. 2018. Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis. Immunity 49 (1062\u20131076): e1066.","journal-title":"Immunity"},{"key":"1086_CR8","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","volume":"130","author":"JK Gittler","year":"2012","unstructured":"Gittler, J.K., A. Shemer, M. Suarez-Farinas, J. Fuentes-Duculan, K.J. Gulewicz, C.Q. Wang, H. Mitsui, I. Cardinale, Strong C. de Guzman, J.G. Krueger, and E. Guttman-Yassky. 2012. Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. The Journal of Allergy and Clinical Immunology 130: 1344\u20131354.","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"1086_CR9","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1182\/blood-2006-11-057299","volume":"110","author":"DS Grenda","year":"2007","unstructured":"Grenda, D.S., M. Murakami, J. Ghatak, J. Xia, L.A. Boxer, D. Dale, M.C. Dinauer, and D.C. Link. 2007. Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood 110: 4179\u20134187.","journal-title":"Blood"},{"key":"1086_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/jid.2008.106","volume":"129","author":"H Jin","year":"2009","unstructured":"Jin, H., R. He, M. Oyoshi, and R.S. Geha. 2009. Animal models of atopic dermatitis. The Journal of Investigative Dermatology 129: 31\u201340.","journal-title":"The Journal of Investigative Dermatology"},{"key":"1086_CR11","doi-asserted-by":"publisher","first-page":"4634","DOI":"10.4049\/jimmunol.166.7.4634","volume":"166","author":"T Kielian","year":"2001","unstructured":"Kielian, T., B. Barry, and W.F. Hickey. 2001. CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses. Journal of Immunology 166: 4634\u20134643.","journal-title":"Journal of Immunology"},{"key":"1086_CR12","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S1567-5769(01)00173-4","volume":"2","author":"I Kimber","year":"2002","unstructured":"Kimber, I., D.A. Basketter, G.F. Gerberick, and R.J. Dearman. 2002. Allergic contact dermatitis. International Immunopharmacology 2: 201\u2013211.","journal-title":"International Immunopharmacology"},{"key":"1086_CR13","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1001\/archderm.135.12.1522","volume":"135","author":"PA Klein","year":"1999","unstructured":"Klein, P.A., and R.A. Clark. 1999. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Archives of Dermatology 135: 1522\u20131525.","journal-title":"Archives of Dermatology"},{"key":"1086_CR14","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.4049\/jimmunol.166.2.1233","volume":"166","author":"PG Knott","year":"2001","unstructured":"Knott, P.G., P.R. Gater, P.J. Dunford, M.E. Fuentes, and C.P. Bertrand. 2001. Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. Journal of Immunology 166: 1233\u20131240.","journal-title":"Journal of Immunology"},{"key":"1086_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska, E., and P. Kubes. 2013. Neutrophil recruitment and function in health and inflammation. Nature Reviews. Immunology 13: 159\u2013175.","journal-title":"Nature Reviews. Immunology"},{"key":"1086_CR16","doi-asserted-by":"publisher","first-page":"740987","DOI":"10.1155\/2012\/740987","volume":"2012","author":"FM Konrad","year":"2012","unstructured":"Konrad, F.M., and J. Reutershan. 2012. CXCR2 in acute lung injury. Mediators of Inflammation 2012: 740987.","journal-title":"Mediators of Inflammation"},{"key":"1086_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1176\/appi.psy.46.4.373","volume":"46","author":"R Mahtani","year":"2005","unstructured":"Mahtani, R., N. Parekh, I. Mangat, and S. Bhalerao. 2005. Alleviating the itch-scratch cycle in atopic dermatitis. Psychosomatics 46: 373\u2013374.","journal-title":"Psychosomatics"},{"key":"1086_CR18","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/labinvest.2012.14","volume":"92","author":"K Matsumoto","year":"2012","unstructured":"Matsumoto, K., M.W. Lo, T. Hosoya, K. Tashima, H. Takayama, T. Murayama, and S. Horie. 2012. Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. Laboratory Investigation 92: 769\u2013782.","journal-title":"Laboratory Investigation"},{"key":"1086_CR19","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/00130832-200410000-00007","volume":"4","author":"I Mittermann","year":"2004","unstructured":"Mittermann, I., K.J. Aichberger, R. Bunder, N. Mothes, H. Renz, and R. Valenta. 2004. Autoimmunity and atopic dermatitis. Current Opinion in Allergy and Clinical Immunology 4: 367\u2013371.","journal-title":"Current Opinion in Allergy and Clinical Immunology"},{"key":"1086_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0190-9622(89)80353-6","volume":"21","author":"EW Monroe","year":"1989","unstructured":"Monroe, E.W. 1989. Efficacy and safety of nalmefene in patients with severe pruritus caused by chronic urticaria and atopic dermatitis. Journal of the American Academy of Dermatology 21: 135\u2013136.","journal-title":"Journal of the American Academy of Dermatology"},{"key":"1086_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1469-7580.2005.00445.x","volume":"207","author":"PN Moynagh","year":"2005","unstructured":"Moynagh, P.N. 2005. The interleukin-1 signalling pathway in astrocytes: A key contributor to inflammation in the brain. Journal of Anatomy 207: 265\u2013269.","journal-title":"Journal of Anatomy"},{"key":"1086_CR22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000063138","volume":"205","author":"J Munday","year":"2002","unstructured":"Munday, J., R. Bloomfield, M. Goldman, H. Robey, G.J. Kitowska, Z. Gwiezdziski, A. Wankiewicz, R. Marks, F. Protas-Drozd, and M. Mikaszewska. 2002. Chlorpheniramine is no more effective than placebo in relieving the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component. Dermatology 205: 40\u201345.","journal-title":"Dermatology"},{"key":"1086_CR23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jaci.2018.11.014","volume":"143","author":"S Nakajima","year":"2019","unstructured":"Nakajima, S., T. Nomura, J. Common, and K. Kabashima. 2019. Insights into atopic dermatitis gained from genetically defined mouse models. The Journal of Allergy and Clinical Immunology 143: 13\u201325.","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"1086_CR24","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.immuni.2012.06.018","volume":"37","author":"MK Oyoshi","year":"2012","unstructured":"Oyoshi, M.K., R. He, Y. Li, S. Mondal, J. Yoon, R. Afshar, M. Chen, D.M. Lee, H.R. Luo, A.D. Luster, J.S. Cho, L.S. Miller, A. Larson, G.F. Murphy, and R.S. Geha. 2012. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity 37: 747\u2013758.","journal-title":"Immunity"},{"key":"1086_CR25","first-page":"2391","volume":"63","author":"JL Pfenninger","year":"2001","unstructured":"Pfenninger, J.L., and G.G. Zainea. 2001. Common anorectal conditions: Part I. Symptoms and complaints. American Family Physician 63: 2391\u20132398.","journal-title":"American Family Physician"},{"key":"1086_CR26","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1164\/rccm.201708-1590OC","volume":"197","author":"B Reidel","year":"2018","unstructured":"Reidel, B., G. Radicioni, P.W. Clapp, A.A. Ford, S. Abdelwahab, M.E. Rebuli, P. Haridass, N.E. Alexis, I. Jaspers, and M. Kesimer. 2018. E-cigarette use causes a unique innate immune response in the lung, involving increased neutrophilic activation and altered mucin secretion. American Journal of Respiratory and Critical Care Medicine 197: 492\u2013501.","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1086_CR27","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00011-017-1048-0","volume":"66","author":"H Sakai","year":"2017","unstructured":"Sakai, H., K. Sato, F. Sato, Y. Kai, K. Mandokoro, K. Matsumoto, S. Kato, T. Yumoto, M. Narita, and Y. Chiba. 2017. Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling. Inflammation Research 66: 663\u2013678.","journal-title":"Inflammation Research"},{"key":"1086_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/1440-1681.12839","volume":"45","author":"H Sakai","year":"2018","unstructured":"Sakai, H., S. Yabe, K. Sato, Y. Kai, F. Sato, T. Yumoto, Y. Inoue, M. Narita, K. Matsumoto, S. Kato, and Y. Chiba. 2018. ELR(+) chemokine-mediated neutrophil recruitment is involved in 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity. Clinical and Experimental Pharmacology & Physiology 45: 27\u201333.","journal-title":"Clinical and Experimental Pharmacology & Physiology"},{"key":"1086_CR29","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/nm.3912","volume":"21","author":"M Shiratori-Hayashi","year":"2015","unstructured":"Shiratori-Hayashi, M., K. Koga, H. Tozaki-Saitoh, Y. Kohro, H. Toyonaga, C. Yamaguchi, A. Hasegawa, T. Nakahara, J. Hachisuka, S. Akira, H. Okano, M. Furue, K. Inoue, and M. Tsuda. 2015. STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. Nature Medicine 21: 927\u2013931.","journal-title":"Nature Medicine"},{"key":"1086_CR30","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/S0195-5616(88)50110-9","volume":"18","author":"KI Timm","year":"1988","unstructured":"Timm, K.I. 1988. Pruritus in rabbits, rodents, and ferrets. The Veterinary Clinics of North America. Small Animal Practice 18: 1077\u20131091.","journal-title":"The Veterinary Clinics of North America. Small Animal Practice"},{"key":"1086_CR31","doi-asserted-by":"publisher","first-page":"17406","DOI":"10.1038\/s41598-018-35699-4","volume":"8","author":"K Ueno","year":"2018","unstructured":"Ueno, K., M. Urai, K. Izawa, Y. Otani, N. Yanagihara, M. Kataoka, S. Takatsuka, M. Abe, H. Hasegawa, K. Shimizu, T. Kitamura, J. Kitaura, Y. Miyazaki, and Y. Kinjo. 2018. Mouse LIMR3\/CD300f is a negative regulator of the antimicrobial activity of neutrophils. Scientific Reports 8: 17406.","journal-title":"Scientific Reports"},{"key":"1086_CR32","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/j.1476-5381.2009.00367.x","volume":"158","author":"SM Vieira","year":"2009","unstructured":"Vieira, S.M., H.P. Lemos, R. Grespan, M.H. Napimoga, D. Dal-Secco, A. Freitas, T.M. Cunha, W.A. Verri Jr., D.A. Souza-Junior, M.C. Jamur, K.S. Fernandes, C. Oliver, J.S. Silva, M.M. Teixeira, and F.Q. Cunha. 2009. A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC\/CXCL1 and LIX\/CXCL5. British Journal of Pharmacology 158: 779\u2013789.","journal-title":"British Journal of Pharmacology"},{"key":"1086_CR33","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1111\/j.1365-2133.1990.tb14732.x","volume":"122","author":"CF Wahlgren","year":"1990","unstructured":"Wahlgren, C.F., O. Hagermark, and R. Bergstrom. 1990. The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. The British Journal of Dermatology 122: 545\u2013551.","journal-title":"The British Journal of Dermatology"},{"key":"1086_CR34","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","volume":"387","author":"S Weidinger","year":"2016","unstructured":"Weidinger, S., and N. Novak. 2016. Atopic dermatitis. Lancet 387: 1109\u20131122.","journal-title":"Lancet"},{"key":"1086_CR35","doi-asserted-by":"publisher","first-page":"30619","DOI":"10.1074\/jbc.270.51.30619","volume":"270","author":"LD Wood","year":"1995","unstructured":"Wood, L.D., and A. Richmond. 1995. Constitutive and cytokine-induced expression of the melanoma growth stimulatory activity\/GRO alpha gene requires both NF-kappa B and novel constitutive factors. The Journal of Biological Chemistry 270: 30619\u201330626.","journal-title":"The Journal of Biological Chemistry"},{"key":"1086_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0168-0102(99)00070-X","volume":"35","author":"T Yamaguchi","year":"1999","unstructured":"Yamaguchi, T., T. Nagasawa, M. Satoh, and Y. Kuraishi. 1999. Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. Neuroscience Research 35: 77\u201383.","journal-title":"Neuroscience Research"},{"key":"1086_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003117","volume":"3","author":"I Zineh","year":"2008","unstructured":"Zineh, I., A.L. Beitelshees, G.J. Welder, W. Hou, N. Chegini, J. Wu, S. Cresci, M.A. Province, and J.A. Spertus. 2008. Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and modulatory effect of statins. PLoS One 3: e3117.","journal-title":"PLoS One"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-01086-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-019-01086-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-01086-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T23:15:17Z","timestamp":1598570117000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-019-01086-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,29]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1086"],"URL":"https:\/\/doi.org\/10.1007\/s10753-019-01086-y","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,29]]},"assertion":[{"value":"29 August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All animal experiments were approved by the Animal Care Committee of the Hoshi University, Tokyo, Japan (permission code: 30-091).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Standards"}}]}}