{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:26:02Z","timestamp":1791361562411,"version":"4.3.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10753-019-01105-y","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:53:34Z","timestamp":1572051214000},"page":"155-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Involvement of Toll-like Receptor 4 in Neutrophil-Mediated Inflammation, Oxidative Stress and Tissue Damage Induced by Scorpion Venom"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-6561","authenticated-orcid":false,"given":"Dalila","family":"Khemili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-261X","authenticated-orcid":false,"given":"Fatima","family":"Laraba-Djebari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-707X","authenticated-orcid":false,"given":"Djelila","family":"Hammoudi-Triki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,26]]},"reference":[{"issue":"4","key":"1105_CR1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.etp.2008.03.006","volume":"60","author":"S Adi-Bessalem","year":"2008","unstructured":"Adi-Bessalem, Sonia, Djelila Hammoudi-Triki, and Fatima Laraba-Djebari. 2008. Pathophysiological effects of Androctonus australis hector scorpion venom: Tissue damages and inflammatory response. Experimental and Toxicologic Pathology 60 (4): 373\u2013380.","journal-title":"Experimental and Toxicologic Pathology"},{"issue":"2","key":"1105_CR2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10753-011-9338-0","volume":"35","author":"S Adi-Bessalem","year":"2012","unstructured":"Adi-Bessalem, Sonia, Amina Mendil, Djelila Hammoudi-Triki, and Fatima Laraba-Djebari. 2012. Lung immunoreactivity and airway inflammation: Their assessment after scorpion envenomation. Inflammation 35 (2): 501\u2013508.","journal-title":"Inflammation"},{"key":"1105_CR3","doi-asserted-by":"crossref","unstructured":"Adi-Bessalem, Sonia, Djelila Hammoudi-Triki, and Fatima Laraba-Djebari. 2015. Scorpion venom interactions with the immune system. In Scorpion Venoms, 87\u2013107. Springer.","DOI":"10.1007\/978-94-007-6404-0_3"},{"issue":"8","key":"1105_CR4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","volume":"2","author":"S Akira","year":"2001","unstructured":"Akira, Shizuo, Kiyoshi Takeda, and Tsuneyasu Kaisho. 2001. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nature Immunology 2 (8): 675\u2013680.","journal-title":"Nature Immunology"},{"issue":"4","key":"1105_CR5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira, Shizuo, Satoshi Uematsu, and Osamu Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124 (4): 783\u2013801.","journal-title":"Cell"},{"issue":"2","key":"1105_CR6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/CIRCRESAHA.108.181040","volume":"104","author":"YS Bae","year":"2009","unstructured":"Bae, Yun Soo, Jee Hyun Lee, Soo Ho Choi, Sunah Kim, Felicidad Almazan, Joseph L. Witztum, and Yury I. Miller. 2009. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein. Circulation Research 104 (2): 210\u2013218.","journal-title":"Circulation Research"},{"issue":"3","key":"1105_CR7","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1152\/ajpregu.00412.2003","volume":"287","author":"KA Barsness","year":"2004","unstructured":"Barsness, Katherine A., John Arcaroli, Alden H. Harken, Edward Abraham, Anirban Banerjee, Leonid Reznikov, and Robert C. McIntyre. 2004. Hemorrhage-induced acute lung injury is TLR-4 dependent. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 287 (3): R592\u2013R599.","journal-title":"American Journal of Physiology - Regulatory, Integrative and Comparative Physiology"},{"issue":"5","key":"1105_CR8","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/tx9501445","volume":"9","author":"JS Beckman","year":"1996","unstructured":"Beckman, Joseph S. 1996. Oxidative damage and tyrosine nitration from peroxynitrite. Chemical Research in Toxicology 9 (5): 836\u2013844.","journal-title":"Chemical Research in Toxicology"},{"issue":"1-2","key":"1105_CR9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, Marion M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1-2): 248\u2013254.","journal-title":"Analytical Biochemistry"},{"issue":"3","key":"1105_CR10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","volume":"78","author":"PP Bradley","year":"1982","unstructured":"Bradley, Peter P., Dennis A. Priebat, Robert D. Christensen, and Gerald Rothstein. 1982. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. Journal of Investigative Dermatology 78 (3): 206\u2013209.","journal-title":"Journal of Investigative Dermatology"},{"key":"1105_CR11","doi-asserted-by":"crossref","unstructured":"Cattaruzza, Marco, and Markus Hecker. 2008. Protein carbonylation and decarboylation: A new twist to the complex response of vascular cells to oxidative stress. American Heart Association.","DOI":"10.1161\/CIRCRESAHA.108.172148"},{"issue":"1","key":"1105_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.intimp.2015.01.008","volume":"25","author":"I Chair-Yousfi","year":"2015","unstructured":"Chair-Yousfi, I., F. Laraba-Djebari, and D. Hammoudi-Triki. 2015. Androctonus australis hector venom contributes to the interaction between neuropeptides and mast cells in pulmonary hyperresponsiveness. International Immunopharmacology 25 (1): 19\u201329. \nhttps:\/\/doi.org\/10.1016\/j.intimp.2015.01.008\n\n.","journal-title":"International Immunopharmacology"},{"issue":"5","key":"1105_CR13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/SHK.0b013e318188f7e1","volume":"31","author":"C Chen","year":"2009","unstructured":"Chen, Chang, Yanlin Wang, Zongze Zhang, Chengyao Wang, and Mian Peng. 2009. Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation. Shock 31 (5): 486\u2013492.","journal-title":"Shock"},{"issue":"2","key":"1105_CR14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2008.05.021","volume":"107","author":"J-P Chippaux","year":"2008","unstructured":"Chippaux, J.-P., and M. Goyffon. 2008. Epidemiology of scorpionism: A global appraisal. Acta Tropica 107 (2): 71\u201379.","journal-title":"Acta Tropica"},{"key":"1105_CR15","volume-title":"Catalase activity. Methods for oxygen research","author":"A Claiborne","year":"1985","unstructured":"Claiborne, A. 1985. In Catalase activity. Methods for oxygen research, ed. R.A. Greenwald. Boca Raton: CRC Press."},{"issue":"2","key":"1105_CR16","first-page":"221","volume":"140","author":"E Dousset","year":"2005","unstructured":"Dousset, E., L. Carrega, J.G. Steinberg, O. Clot-Faybesse, B. Jouirou, N. Sauze, C. Devaux, Y. Autier, Y. Jammes, and M.F. Martin-Eauclaire. 2005. Evidence that free radical generation occurs during scorpion envenomation. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 140 (2): 221\u2013226.","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"},{"issue":"9","key":"1105_CR17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.bcp.2006.07.010","volume":"72","author":"SL Doyle","year":"2006","unstructured":"Doyle, Sarah L., and Luke A.J. O\u2019Neill. 2006. Toll-like receptors: From the discovery of NF\u03baB to new insights into transcriptional regulations in innate immunity. Biochemical Pharmacology 72 (9): 1102\u20131113.","journal-title":"Biochemical Pharmacology"},{"issue":"8","key":"1105_CR18","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ncpcardio0938","volume":"4","author":"S Frantz","year":"2007","unstructured":"Frantz, Stefan, Georg Ertl, and Johann Bauersachs. 2007. Mechanisms of disease: Toll-like receptors in cardiovascular disease. Nature Clinical Practice. Cardiovascular Medicine 4 (8): 444\u2013454.","journal-title":"Nature Clinical Practice. Cardiovascular Medicine"},{"issue":"15","key":"1105_CR19","first-page":"29","volume":"2","author":"A Ghasemi","year":"2007","unstructured":"Ghasemi, Asghar, M. Hedayati, and H. Biabani. 2007. Protein precipitation methods evaluated for determination of serum nitric oxide end products by the Griess assay. JMSR 2 (15): 29\u201332.","journal-title":"JMSR"},{"issue":"9","key":"1105_CR20","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","volume":"48","author":"R Gill","year":"2010","unstructured":"Gill, Roop, Allan Tsung, and Timothy Billiar. 2010. Linking oxidative stress to inflammation: Toll-like receptors. Free Radical Biology and Medicine 48 (9): 1121\u20131132.","journal-title":"Free Radical Biology and Medicine"},{"issue":"4","key":"1105_CR21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0035-9203(03)00062-2","volume":"98","author":"D Hammoudi-Triki","year":"2004","unstructured":"Hammoudi-Triki, Dj\u00e9lila, Elisabeth Ferquel, Annie Robbe-Vincent, Cassian Bon, Val\u00e9rie Choumet, and Fatima Laraba-Djebari. 2004. Epidemiological data, clinical admission gradation and biological quantification by ELISA of scorpion envenomations in Algeria: Effect of immunotherapy. Transactions of the Royal Society of Tropical Medicine and Hygiene 98 (4): 240\u2013250.","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"issue":"7","key":"1105_CR22","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/jor.21369","volume":"29","author":"T Hirayama","year":"2011","unstructured":"Hirayama, Tomoyuki, Yasunobu Tamaki, Yuya Takakubo, Kiyoshi Iwazaki, Kan Sasaki, Toshihiko Ogino, Stuart B. Goodman, Yrj\u00f6 T. Konttinen, and Michiaki Takagi. 2011. Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles. Journal of Orthopaedic Research 29 (7): 984\u2013992.","journal-title":"Journal of Orthopaedic Research"},{"key":"1105_CR23","volume-title":"Toll-like receptor signaling: Defensive or offensive for the heart?: Am Heart Assoc","author":"M Hori","year":"2008","unstructured":"Hori, Masatsugu, and Kazuhiko Nishida. 2008. Toll-like receptor signaling: Defensive or offensive for the heart?: Am Heart Assoc."},{"issue":"12","key":"1105_CR24","doi-asserted-by":"crossref","first-page":"e966","DOI":"10.1038\/cddis.2013.493","volume":"4","author":"W Hou","year":"2013","unstructured":"Hou, W., Q. Zhang, Z. Yan, R. Chen, H.J. Zeh Iii, R. Kang, M.T. Lotze, and D. Tang. 2013. Strange attractors: DAMPs and autophagy link tumor cell death and immunity. Cell Death & Disease 4 (12): e966.","journal-title":"Cell Death & Disease"},{"issue":"7","key":"1105_CR25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0041-0101(95)00005-7","volume":"33","author":"M Ismail","year":"1995","unstructured":"Ismail, M. 1995. The scorpion envenoming syndrome. Toxicon 33 (7): 825\u2013858.","journal-title":"Toxicon"},{"issue":"1","key":"1105_CR26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","volume":"20","author":"CA Janeway Jr","year":"2002","unstructured":"Janeway, Charles A., Jr., and Ruslan Medzhitov. 2002. Innate immune recognition. Annual Review of Immunology 20 (1): 197\u2013216.","journal-title":"Annual Review of Immunology"},{"issue":"3","key":"1105_CR27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10753-017-0532-6","volume":"40","author":"A Kaddache","year":"2017","unstructured":"Kaddache, Asma, Moustapha Hassan, Fatima Laraba-Djebari, and Djelila Hammoudi-Triki. 2017. Switch of steady-state to an accelerated granulopoiesis in response to Androctonus australis hector venom. Inflammation 40 (3): 871\u2013883.","journal-title":"Inflammation"},{"issue":"5","key":"1105_CR28","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jaci.2006.02.023","volume":"117","author":"T Kaisho","year":"2006","unstructured":"Kaisho, Tsuneyasu, and Shizuo Akira. 2006. Toll-like receptor function and signaling. Journal of Allergy and Clinical Immunology 117 (5): 979\u2013987.","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"5","key":"1105_CR29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai, Taro, and Shizuo Akira. 2010. The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nature Immunology 11 (5): 373\u2013384.","journal-title":"Nature Immunology"},{"issue":"4","key":"1105_CR30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1590\/S1678-91992012000400008","volume":"18","author":"Y La\u00efd","year":"2012","unstructured":"La\u00efd, Y., L. Boutekdjiret, R. Oudjehane, F. Laraba-Djebari, H. Hellal, M. Guerinik, L. Griene, B. Alamir, R. Merad, and Jean-Philippe Chippaux. 2012. Incidence and severity of scorpion stings in Algeria. Journal of Venomous Animals and Toxins Including Tropical Diseases 18 (4): 399\u2013410.","journal-title":"Journal of Venomous Animals and Toxins Including Tropical Diseases"},{"issue":"3","key":"1105_CR31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","volume":"4","author":"JD Lambeth","year":"2004","unstructured":"Lambeth, J. David. 2004. NOX enzymes and the biology of reactive oxygen. Nature Reviews Immunology 4 (3): 181.","journal-title":"Nature Reviews Immunology"},{"issue":"5","key":"1105_CR32","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s10753-014-9898-x","volume":"37","author":"A Lamraoui","year":"2014","unstructured":"Lamraoui, Amal, Sonia Adi-Bessalem, and Fatima Laraba-Djebari. 2014. Modulation of tissue inflammatory response by histamine receptors in scorpion envenomation pathogenesis: Involvement of H4 receptor. Inflammation 37 (5): 1689\u20131704.","journal-title":"Inflammation"},{"issue":"2","key":"1105_CR33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.yexmp.2015.07.013","volume":"99","author":"A Lamraoui","year":"2015","unstructured":"Lamraoui, Amal, Sonia Adi-Bessalem, and Fatima Laraba-Djebari. 2015. Immunopathologic effects of scorpion venom on hepato-renal tissues: Involvement of lipid derived inflammatory mediators. Experimental and Molecular Pathology 99 (2): 286\u2013296.","journal-title":"Experimental and Molecular Pathology"},{"key":"1105_CR34","doi-asserted-by":"crossref","unstructured":"Laraba-Djebari, Fatima, Sonia Adi-Bessalem, and Djelila Hammoudi-Triki. 2015. Scorpion venoms: Pathogenesis and biotherapies. In Scorpion Venoms, 63\u201385. Springer.","DOI":"10.1007\/978-94-007-6404-0_2"},{"issue":"5","key":"1105_CR35","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1189\/jlb.2MR0316-117RR","volume":"100","author":"CA Leifer","year":"2016","unstructured":"Leifer, Cynthia A., and Andrei E. Medvedev. 2016. Molecular mechanisms of regulation of Toll-like receptor signaling. Journal of Leukocyte Biology 100 (5): 927\u2013941.","journal-title":"Journal of Leukocyte Biology"},{"issue":"2","key":"1105_CR36","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.3892\/mmr.2015.4663","volume":"13","author":"X Liu","year":"2016","unstructured":"Liu, Xiaomei, Rongjun Lin, Baochun Zhao, Renzheng Guan, Tang Li, and Rong Jin. 2016. Correlation between oxidative stress and the NF-\u03baB signaling pathway in the pulmonary tissues of obese asthmatic mice. Molecular Medicine Reports 13 (2): 1127\u20131134.","journal-title":"Molecular Medicine Reports"},{"issue":"3","key":"1105_CR37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0014-2999(99)00382-9","volume":"376","author":"IM Matos","year":"1999","unstructured":"Matos, Ione M., Danielle G. Souza, Danielle G. Seabra, Lineu Freire-Maia, and Mauro M. Teixeira. 1999. Effects of tachykinin NK 1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats. European Journal of Pharmacology 376 (3): 293\u2013300.","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"1105_CR38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1124\/mol.110.068064","volume":"79","author":"N Matsunaga","year":"2011","unstructured":"Matsunaga, Naoko, Noboru Tsuchimori, Tatsumi Matsumoto, and Masayuki Ii. 2011. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Molecular Pharmacology 79 (1): 34\u201341.","journal-title":"Molecular Pharmacology"},{"key":"1105_CR39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathol-020712-164023","volume":"9","author":"TN Mayadas","year":"2014","unstructured":"Mayadas, Tanya N., Xavier Cullere, and Clifford A. Lowell. 2014. The multifaceted functions of neutrophils. Annual Review of Pathology: Mechanisms of Disease 9: 181\u2013218.","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"issue":"2","key":"1105_CR40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","volume":"1","author":"R Medzhitov","year":"2001","unstructured":"Medzhitov, Ruslan. 2001. Toll-like receptors and innate immunity. Nature Reviews Immunology 1 (2): 135\u2013145.","journal-title":"Nature Reviews Immunology"},{"key":"1105_CR41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ab.2014.04.034","volume":"458","author":"CS Mesquita","year":"2014","unstructured":"Mesquita, Cristina S., Raquel Oliveira, F\u00e1tima Bento, Dulce Geraldo, Jo\u00e3o V. Rodrigues, and Jo\u00e3o C. Marcos. 2014. Simplified 2, 4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins. Analytical Biochemistry 458: 69\u201371.","journal-title":"Analytical Biochemistry"},{"issue":"4","key":"1105_CR42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/cmi.2011.7","volume":"8","author":"T-N Nguyen-Pham","year":"2011","unstructured":"Nguyen-Pham, Thanh-Nhan, Mi-Seon Lim, Truc Anh Thi Nguyen, Youn-Kyung Lee, Chun-Ji Jin, Hyun Ju Lee, Cheol Yi Hong, Jae-Sook Ahn, Deok-Hwan Yang, and Yeo-Kyeoung Kim. 2011. Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists. Cellular & Molecular Immunology 8 (4): 341\u2013347.","journal-title":"Cellular & Molecular Immunology"},{"issue":"2","key":"1105_CR43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa, Hiroshi, Nobuko Ohishi, and Kunio Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95 (2): 351\u2013358.","journal-title":"Analytical Biochemistry"},{"key":"1105_CR44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/0-387-24180-9_2","volume":"X","author":"C Pasare","year":"2005","unstructured":"Pasare, Chandrashekhar, and Ruslan Medzhitov. 2005. Toll-like receptors: Linking innate and adaptive immunity. Mechanisms of Lymphocyte Activation and Immune Regulation X: 11\u201318.","journal-title":"Mechanisms of Lymphocyte Activation and Immune Regulation"},{"issue":"3","key":"1105_CR45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jamcollsurg.2005.11.021","volume":"202","author":"JM Prince","year":"2006","unstructured":"Prince, Jose M., Ryan M. Levy, Runkuan Yang, Kevin P. Mollen, Mitchell P. Fink, Yoram Vodovotz, and Timothy R. Billiar. 2006. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. Journal of the American College of Surgeons 202 (3): 407\u2013417.","journal-title":"Journal of the American College of Surgeons"},{"issue":"10","key":"1105_CR46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003596","volume":"3","author":"WP Pulskens","year":"2008","unstructured":"Pulskens, Wilco P., Gwendoline J. Teske, Loes M. Butter, Joris J. Roelofs, Tom Van Der Poll, Sandrine Florquin, and Jaklien C. Leemans. 2008. Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia\/reperfusion injury. PLoS One 3 (10): e3596.","journal-title":"PLoS One"},{"issue":"1","key":"1105_CR47","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1038\/s41598-017-06484-6","volume":"7","author":"S Pushpakumar","year":"2017","unstructured":"Pushpakumar, Sathnur, Ren Lu, Sourav Kundu, Alejandra Gamon, Suresh C. Tyagi, and Utpal Sen. 2017. Toll-like receptor 4 deficiency reduces oxidative stress and macrophage mediated inflammation in hypertensive kidney. Scientific Reports 7 (1): 6349.","journal-title":"Scientific Reports"},{"key":"1105_CR48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","volume":"9","author":"C Rosales","year":"2018","unstructured":"Rosales, Carlos. 2018. Neutrophil: A cell with many roles in inflammation or several cell types? Frontiers in Physiology 9: 113.","journal-title":"Frontiers in Physiology"},{"key":"1105_CR49","doi-asserted-by":"crossref","unstructured":"Saidani, Chanez, Louisa B\u00e9chohra, Fatima Laraba-Djebari, and Djelila Hammoudi-Triki. 2018. Kidney inflammation and tissue injury induced by scorpion venom: Comparison with a nephrotoxic model. Toxin Reviews: 1\u20138.","DOI":"10.1080\/15569543.2018.1446028"},{"issue":"1","key":"1105_CR50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1678-9199-19-8","volume":"19","author":"H Saidi","year":"2013","unstructured":"Saidi, Hadjer, Sonia Adi-Bessalem, Djelila Hammoudi-Triki, and Fatima Laraba-Djebari. 2013. Effects of atropine and propranolol on lung inflammation in experimental envenomation: Comparison of two buthidae venoms. Journal of Venomous Animals and Toxins Including Tropical Diseases 19 (1): 8.","journal-title":"Journal of Venomous Animals and Toxins Including Tropical Diseases"},{"key":"1105_CR51","doi-asserted-by":"crossref","unstructured":"Saidi, Hadjer, Julie B\u00e9rub\u00e9, Fatima Laraba-Djebari, and Djelila Hammoudi-Triki. 2018. Involvement of alveolar macrophages and neutrophils in acute lung injury after scorpion envenomation: New pharmacological targets. Inflammation: 1\u201311.","DOI":"10.1007\/s10753-018-0731-9"},{"issue":"2-3","key":"1105_CR52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejphar.2007.06.027","volume":"571","author":"T Sha","year":"2007","unstructured":"Sha, Takukyu, Mie Sunamoto, Tomoyuki Kitazaki, Jun Sato, Masayuki Ii, and Yuji Iizawa. 2007. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model. European Journal of Pharmacology 571 (2-3): 231\u2013239.","journal-title":"European Journal of Pharmacology"},{"key":"1105_CR53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.redox.2018.02.018","volume":"16","author":"Cheryl S. Sultan","year":"2018","unstructured":"Sultan, Cheryl S., Andrea Saackel, Antonia Stank, Thomas Fleming, Maria Fedorova, Ralf Hoffmann, Rebecca C. Wade, Markus Hecker, and Andreas H. Wagner. 2018. Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biology.","journal-title":"Redox Biology"},{"issue":"1","key":"1105_CR54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.intimp.2015.05.002","volume":"27","author":"Z Taibi-Djennah","year":"2015","unstructured":"Taibi-Djennah, Zahida, and Fatima Laraba-Djebari. 2015. Effect of cytokine antibodies in the immunomodulation of inflammatory response and metabolic disorders induced by scorpion venom. International Immunopharmacology 27 (1): 122\u2013129.","journal-title":"International Immunopharmacology"},{"issue":"5","key":"1105_CR55","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0041-0101(00)00200-2","volume":"39","author":"AL Teixeira Jr","year":"2001","unstructured":"Teixeira, A.L., Jr., B.F. Fontoura, L. Freire-Maia, C.R.S. Machado, E.R.S. Camargos, and M.M. Teixeira. 2001. Evidence for a direct action of Tityus serrulatus scorpion venom on the cardiac muscle. Toxicon 39 (5): 703\u2013709.","journal-title":"Toxicon"},{"key":"1105_CR56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2017.06.006","volume":"47","author":"EA Thompson","year":"2017","unstructured":"Thompson, Elizabeth A., and Karin Lor\u00e9. 2017. Non-human primates as a model for understanding the mechanism of action of toll-like receptor-based vaccine adjuvants. Current Opinion in Immunology 47: 1\u20137.","journal-title":"Current Opinion in Immunology"},{"issue":"10","key":"1105_CR57","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1172\/JCI31008","volume":"117","author":"H Wu","year":"2007","unstructured":"Wu, Huiling, Gang Chen, Kate R. Wyburn, Jianlin Yin, Patrick Bertolino, Josette M. Eris, Stephen I. Alexander, Alexandra F. Sharland, and Steven J. Chadban. 2007. TLR4 activation mediates kidney ischemia\/reperfusion injury. The Journal of Clinical Investigation 117 (10): 2847\u20132859.","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"1105_CR58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088174","volume":"9","author":"KF Zoccal","year":"2014","unstructured":"Zoccal, Karina Furlani, Claudia da Silva Bitencourt, Francisco Wanderley Garcia Paula-Silva, Carlos Art\u00e9rio Sorgi, Karla de Castro Figueiredo Bordon, Eliane Candiani Arantes, and L\u00facia Helena Faccioli. 2014. TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators. PLoS One 9 (2): e88174.","journal-title":"PLoS One"},{"key":"1105_CR59","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.toxicon.2014.11.226","volume":"93","author":"KF Zoccal","year":"2015","unstructured":"Zoccal, Karina Furlani, Francisco Wanderley Garcia Paula-Silva, Claudia da Silva Bitencourt, Carlos Art\u00e9rio Sorgi, Karla de Castro Figueiredo Bordon, Eliane Candiani Arantes, and L\u00facia Helena Faccioli. 2015. PPAR-\u03b3 activation by Tityus serrulatus venom regulates lipid body formation and lipid mediator production. Toxicon 93: 90\u201397.","journal-title":"Toxicon"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-01105-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-019-01105-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-01105-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T23:11:35Z","timestamp":1603581095000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-019-01105-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,26]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1105"],"URL":"https:\/\/doi.org\/10.1007\/s10753-019-01105-y","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,26]]},"assertion":[{"value":"26 October 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance of Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}