{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:40:14Z","timestamp":1740123614967,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM118602"],"award-info":[{"award-number":["R01 GM118602"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10753-019-01127-6","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T07:02:46Z","timestamp":1574233366000},"page":"370-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Directional X Chromosome Skewing of White Blood Cells from Subjects with Heterozygous Mosaicism for the Variant IRAK1 Haplotype"],"prefix":"10.1007","volume":"43","author":[{"given":"Patrick","family":"Morcillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geber","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne C.","family":"Mosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3159-3991","authenticated-orcid":false,"given":"Zoltan","family":"Spolarics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"1127_CR1","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1001\/jama.295.12.1428","volume":"295","author":"BR Migeon","year":"2006","unstructured":"Migeon, B.R. 2006. The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases. Journal of the American Medical Association 295: 1428\u20131433.","journal-title":"Journal of the American Medical Association"},{"key":"1127_CR2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S1550-8579(07)80024-6","volume":"4","author":"BR Migeon","year":"2007","unstructured":"Migeon, B.R. 2007. Why females are mosaics, X-chromosome inactivation, and sex differences in disease. Gender Medecine 4: 97\u2013105.","journal-title":"Gender Medecine"},{"key":"1127_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1097\/SHK.0b013e31802e40bd","volume":"27","author":"Z Spolarics","year":"2007","unstructured":"Spolarics, Z. 2007. The X-files of inflammation: cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection. Shock 27: 597\u2013604.","journal-title":"Shock"},{"key":"1127_CR4","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.3389\/fimmu.2017.01455","volume":"8","author":"Z Spolarics","year":"2017","unstructured":"Spolarics, Z., G. Pena, Y. Qin, R.J. Donnelly, and D.H. Livingston. 2017. Inherent X-Linked Genetic Variability and Cellular Mosaicism Unique to Females Contribute to Sex-Related Differences in the Innate Immune Response. Frontiers in Immunology 8: 1455.","journal-title":"Frontiers in Immunology"},{"key":"1127_CR5","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/ejhg.2017.128","volume":"25","author":"AA Maan","year":"2017","unstructured":"Maan, A.A., J. Eales, A. Akbarov, J. Rowland, X. Xu, M.A. Jobling, F.J. Charchar, and M. Tomaszewski. 2017. The Y chromosome: a blueprint for men's health? European Journal of Human Genetics 25: 1181\u20131188.","journal-title":"European Journal of Human Genetics"},{"key":"1127_CR6","doi-asserted-by":"crossref","unstructured":"Khan, S.I., K.L. Andrews, G.L. Jennings, A.K. Sampson, J.P.F. Chin-Dusting. 2019. Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer? International Journal of Molecular Sciences (in print).","DOI":"10.3390\/ijms20122892"},{"key":"1127_CR7","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.tig.2017.09.005","volume":"33","author":"BR Migeon","year":"2017","unstructured":"Migeon, B.R. 2017. Choosing the Active X: The Human Version of X Inactivation. Trends in Genetics 33: 899\u2013909.","journal-title":"Trends in Genetics"},{"key":"1127_CR8","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1097\/SHK.0000000000000764","volume":"47","author":"G Pena","year":"2017","unstructured":"Pena, G., C. Michalski, R.J. Donnelly, Y. Qin, Z.C. Sifri, A.C. Mosenthal, D.H. Livingston, and Z. Spolarics. 2017. Trauma-Induced Acute X Chromosome Skewing in White Blood Cells Represents an Immuno-Modulatory Mechanism Unique to Females and a Likely Contributor to Sex-Based Outcome Differences. Shock 47: 402\u2013408.","journal-title":"Shock"},{"key":"1127_CR9","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1182\/blood-2008-12-195677","volume":"113","author":"L Busque","year":"2009","unstructured":"Busque, L., Y. Paquette, S. Provost, D.C. Roy, R.L. Levine, L. Mollica, and D.G. Gilliland. 2009. Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies. Blood 113: 3472\u20133474.","journal-title":"Blood"},{"key":"1127_CR10","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1182\/blood-2008-03-143925","volume":"112","author":"SI Swierczek","year":"2008","unstructured":"Swierczek, S.I., N. Agarwal, R.H. Nussenzveig, G. Rothstein, A. Wilson, A. Artz, and J.T. Prchal. 2008. Hematopoiesis is not clonal in healthy elderly women. Blood 112: 3186\u20133193.","journal-title":"Blood"},{"key":"1127_CR11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.semcdb.2016.03.009","volume":"56","author":"M Vacca","year":"2016","unstructured":"Vacca, M., F. Della Ragione, F. Scalabri, and M. D'Esposito. 2016. X inactivation and reactivation in X-linked diseases. Seminars in Cell and Developmental Biology 56: 78\u201387.","journal-title":"Seminars in Cell and Developmental Biology"},{"key":"1127_CR12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1359\/jbmr.2003.18.3.419","volume":"18","author":"R Ishida","year":"2003","unstructured":"Ishida, R., M. Emi, Y. Ezura, H. Iwasaki, H. Yoshida, T. Suzuki, T. Hosoi, S. Inoue, M. Shiraki, H. Ito, and H. Orimo. 2003. Association of a haplotype (196Phe\/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations. Journal of Bone and Mineral Research 18: 419\u2013423.","journal-title":"Journal of Bone and Mineral Research"},{"key":"1127_CR13","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/annrheumdis-2012-201851","volume":"72","author":"KM Kaufman","year":"2013","unstructured":"Kaufman, K.M., J. Zhao, J.A. Kelly, T. Hughes, A. Adler, E. Sanchez, J.O. Ojwang, C.D. Langefeld, J.T. Ziegler, A.H. Williams, M.E. Comeau, M.C. Marion, S.B. Glenn, R.M. Cantor, J.M. Grossman, B.H. Hahn, Y.W. Song, C.Y. Yu, J.A. James, J.M. Guthridge, E.E. Brown, G.S. Alarc\u00f3n, R.P. Kimberly, J.C. Edberg, R. Ramsey-Goldman, M.A. Petri, J.D. Reveille, L.M. Vil\u00e1, J.M. Anaya, S.A. Boackle, A.M. Stevens, B.I. Freedman, L.A. Criswell, B.A. Pons Estel, Argentine Collaborative Group, J.H. Lee, J.S. Lee, D.M. Chang, R.H. Scofield, G.S. Gilkeson, J.T. Merrill, T.B. Niewold, T.J. Vyse, S.C. Bae, M.E. Alarc\u00f3n-Riquelme, BIOLUPUS network, C.O. Jacob, K. Moser Sivils, P.M. Gaffney, J.B. Harley, A.H. Sawalha, and B.P. Tsao. 2013. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Annals of the Rheumatic Diseases 72: 437\u2013444.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1127_CR14","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1164\/rccm.200603-341OC","volume":"173","author":"J Arcaroli","year":"2006","unstructured":"Arcaroli, J., E. Silva, J.P. Maloney, Q. He, D. Svetkauskaite, J.R. Murphy, and E. Abraham. 2006. Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. American Journal of Respiratory and Critical Care Medicine 173: 1335\u20131341.","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1127_CR15","first-page":"2248","volume":"124","author":"Y Fang","year":"2011","unstructured":"Fang, Y., L. Zhang, G.Q. Zhou, Z.F. Wang, Z.S. Zeng, Z.Y. Luo, L. Li, and B.C. Liu. 2011. Functional polymorphism in exon 5 and variant haplotype of the interleukin-1 receptor-associated kinase 1 gene are associated with susceptibility to and severity of sepsis in the Chinese population. Chinese Medical Journal (Engl) 124: 2248\u20132253.","journal-title":"Chinese Medical Journal (Engl)"},{"key":"1127_CR16","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1097\/CCM.0b013e3181f9f9c7","volume":"38","author":"J Toubiana","year":"2010","unstructured":"Toubiana, J., E. Courtine, F. Pene, V. Viallon, P. Asfar, C. Daubin, C. Rousseau, C. Chenot, F. Ouaaz, D. Grimaldi, et al. 2010. IRAK1 functional genetic variant affects severity of septic shock. Critical Care Medicine 38: 2287\u20132294.","journal-title":"Critical Care Medicine"},{"key":"1127_CR17","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"Auton, A., L.D. Brooks, R.M. Durbin, E.P. Garrison, H.M. Kang, J.O. Korbel, J.L. Marchini, S. McCarthy, G.A. McVean, and G.R. Abecasis. 2015. A global reference for human genetic variation. Nature 526: 68\u201374.","journal-title":"Nature"},{"key":"1127_CR18","doi-asserted-by":"crossref","unstructured":"Qin, Y., G. Pena, P. Morcillo, S. Singh, A.C. Mosenthal, D.H. Livingston, Z. Spolarics. 2019. X-Linked IRAK1 Polymorphism is Associated with Sex-Related Differences In Polymorphonuclear Granulocyte and Monocyte Activation and Response Variabilities.Shock (in print)","DOI":"10.1097\/SHK.0000000000001404"},{"key":"1127_CR19","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1097\/SLA.0000000000000918","volume":"260","author":"JL Sperry","year":"2014","unstructured":"Sperry, J.L., S. Zolin, B.S. Zuckerbraun, Y. Vodovotz, R. Namas, M.D. Neal, R.E. Ferrell, M.R. Rosengart, A.B. Peitzman, and T.R. Billiar. 2014. X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury. Annals of Surgery 260: 698\u2013703.","journal-title":"Annals of Surgery"},{"key":"1127_CR20","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.4049\/jimmunol.170.6.2833","volume":"170","author":"C Deng","year":"2003","unstructured":"Deng, C., C. Radu, A. Diab, M.F. Tsen, R. Hussain, J.S. Cowdery, M.K. Racke, and J.A. Thomas. 2003. IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. Journal of Immunology 170: 2833\u20132842.","journal-title":"Journal of Immunology"},{"key":"1127_CR21","doi-asserted-by":"publisher","first-page":"6256","DOI":"10.1073\/pnas.0901181106","volume":"106","author":"CO Jacob","year":"2009","unstructured":"Jacob, C.O., J. Zhu, D.L. Armstrong, M. Yan, J. Han, X.J. Zhou, J.A. Thomas, A. Reiff, B.L. Myones, J.O. Ojwang, K.M. Kaufman, M. Klein-Gitelman, D. McCurdy, L. Wagner-Weiner, E. Silverman, J. Ziegler, J.A. Kelly, J.T. Merrill, J.B. Harley, R. Ramsey-Goldman, L.M. Vila, S.C. Bae, T.J. Vyse, G.S. Gilkeson, P.M. Gaffney, K.L. Moser, C.D. Langefeld, R. Zidovetzki, and C. Mohan. 2009. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proceedings of the National Academy of Sciences of the United States of America 106: 6256\u20136261.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"1127_CR22","doi-asserted-by":"publisher","first-page":"29037","DOI":"10.1074\/jbc.M103815200","volume":"276","author":"LE Jensen","year":"2001","unstructured":"Jensen, L.E., and A.S. Whitehead. 2001. IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. Journal of Biological Chemistry 276: 29037\u201329044.","journal-title":"Journal of Biological Chemistry"},{"key":"1127_CR23","doi-asserted-by":"publisher","first-page":"6521","DOI":"10.1128\/MCB.25.15.6521-6532.2005","volume":"25","author":"N Rao","year":"2005","unstructured":"Rao, N., S. Nguyen, K. Ngo, and W.P. Fung-Leung. 2005. A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll\/IL-1R-induced inflammatory signaling. Molecular and Cellular Biology 25: 6521\u20136532.","journal-title":"Molecular and Cellular Biology"},{"key":"1127_CR24","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.molimm.2006.03.021","volume":"44","author":"J Su","year":"2007","unstructured":"Su, J., K. Richter, C. Zhang, Q. Gu, and L. Li. 2007. Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. Molecular Immunology 44: 900\u2013905.","journal-title":"Molecular Immunology"},{"key":"1127_CR25","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1101\/gr.143503.112","volume":"23","author":"S Gelfman","year":"2013","unstructured":"Gelfman, S., N. Cohen, A. Yearim, and G. Ast. 2013. DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure. Genome Research 23: 789\u2013799.","journal-title":"Genome Research"},{"key":"1127_CR26","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/nar\/gkt875","volume":"42","author":"HL Zhou","year":"2014","unstructured":"Zhou, H.L., G. Luo, J.A. Wise, and H. Lou. 2014. Regulation of alternative splicing by local histone modifications: potential roles for RNA-guided mechanisms. Nucleic Acids Research 42: 701\u2013713.","journal-title":"Nucleic Acids Research"},{"key":"1127_CR27","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s13104-016-2093-4","volume":"9","author":"J Yang","year":"2016","unstructured":"Yang, J., B. Kemps-Mols, M. Spruyt-Gerritse, J. Anholts, F. Claas, and M. Eikmans. 2016. The source of SYBR green master mix determines outcome of nucleic acid amplification reactions. BMC Research Notes 9: 292.","journal-title":"BMC Research Notes"},{"key":"1127_CR28","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","volume":"55","author":"SA Bustin","year":"2009","unstructured":"Bustin, S.A., V. Benes, J.A. Garson, J. Hellemans, J. Huggett, M. Kubista, R. Mueller, T. Nolan, M.W. Pfaffl, G.L. Shipley, J. Vandesompele, and C.T. Wittwer. 2009. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clinical Chemistry 55: 611\u2013622.","journal-title":"Clinical Chemistry"},{"key":"1127_CR29","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s00109-006-0097-6","volume":"84","author":"JH Schefe","year":"2006","unstructured":"Schefe, J.H., K.E. Lehmann, I.R. Buschmann, T. Unger, and H. Funke-Kaiser. 2006. Quantitative real-time RT-PCR data analysis: current concepts and the novel \"gene expression's CT difference\" formula. Journal of Molecular Medicine (Berlin, Germany) 84: 901\u2013910.","journal-title":"Journal of Molecular Medicine (Berlin, Germany)"},{"key":"1127_CR30","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1089\/cmb.2005.12.1047","volume":"12","author":"S Zhao","year":"2005","unstructured":"Zhao, S., and R.D. Fernald. 2005. Comprehensive algorithm for quantitative real-time polymerase chain reaction. Journal of Computational Biology 12: 1047\u20131064.","journal-title":"Journal of Computational Biology"},{"key":"1127_CR31","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ymeth.2012.08.011","volume":"59","author":"JM Ruijter","year":"2013","unstructured":"Ruijter, J.M., M.W. Pfaffl, S. Zhao, A.N. Spiess, G. Boggy, J. Blom, R.G. Rutledge, D. Sisti, A. Lievens, K. De Preter, et al. 2013. Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications. Methods 59: 32\u201346.","journal-title":"Methods"},{"key":"1127_CR32","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ab.2013.12.020","volume":"449","author":"J Tellinghuisen","year":"2014","unstructured":"Tellinghuisen, J., and A.N. Spiess. 2014. Comparing real-time quantitative polymerase chain reaction analysis methods for precision, linearity, and accuracy of estimating amplification efficiency. Analytical Biochemistry 449: 76\u201382.","journal-title":"Analytical Biochemistry"},{"key":"1127_CR33","first-page":"1578","volume":"9","author":"E Delabesse","year":"1995","unstructured":"Delabesse, E., S. Aral, P. Kamoun, B. Varet, and A.G. Turhan. 1995. Quantitative non-radioactive clonality analysis of human leukemic cells and progenitors using the human androgen receptor (AR) gene. Leukemia 9: 1578\u20131582.","journal-title":"Leukemia"},{"key":"1127_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ab.2006.10.018","volume":"360","author":"JG Goldsmith","year":"2007","unstructured":"Goldsmith, J.G., E.C. Ntuen, and E.C. Goldsmith. 2007. Direct quantification of gene expression using capillary electrophoresis with laser-induced fluorescence. Analytical Biochemistry 360: 23\u201329.","journal-title":"Analytical Biochemistry"},{"key":"1127_CR35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/1756-0500-4-427","volume":"4","author":"C Ledderose","year":"2011","unstructured":"Ledderose, C., J. Heyn, E. Limbeck, and S. Kreth. 2011. Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils. BMC Research Notes 4: 427.","journal-title":"BMC Research Notes"},{"key":"1127_CR36","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1097\/00003246-199907000-00024","volume":"27","author":"XM Fang","year":"1999","unstructured":"Fang, X.M., S. Schroder, A. Hoeft, and F. Stuber. 1999. Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis [see comments]. Critical Care Medicine 27: 1330\u20131334.","journal-title":"Critical Care Medicine"},{"key":"1127_CR37","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nrg2341","volume":"9","author":"MM Suzuki","year":"2008","unstructured":"Suzuki, M.M., and A. Bird. 2008. DNA methylation landscapes: provocative insights from epigenomics. Nature Reviews: Genetics 9: 465\u2013476.","journal-title":"Nature Reviews: Genetics"},{"key":"1127_CR38","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ygeno.2005.09.012","volume":"87","author":"Z Zhao","year":"2006","unstructured":"Zhao, Z., and F. Zhang. 2006. Sequence context analysis in the mouse genome: single nucleotide polymorphisms and CpG island sequences. Genomics 87: 68\u201374.","journal-title":"Genomics"},{"key":"1127_CR39","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.dnarep.2015.04.011","volume":"32","author":"A Bellacosa","year":"2015","unstructured":"Bellacosa, A., and A.C. Drohat. 2015. Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites. DNA Repair (Amst) 32: 33\u201342.","journal-title":"DNA Repair (Amst)"},{"key":"1127_CR40","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1101\/gr.104695.109","volume":"20","author":"R Shoemaker","year":"2010","unstructured":"Shoemaker, R., J. Deng, W. Wang, and K. Zhang. 2010. Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Research 20: 883\u2013889.","journal-title":"Genome Research"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-01127-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-019-01127-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-019-01127-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:40:49Z","timestamp":1605746449000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-019-01127-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1127"],"URL":"https:\/\/doi.org\/10.1007\/s10753-019-01127-6","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"type":"print","value":"0360-3997"},{"type":"electronic","value":"1573-2576"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"assertion":[{"value":"20 November 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}