{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:49:16Z","timestamp":1793396956020,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10753-020-01297-8","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T18:47:37Z","timestamp":1616093257000},"page":"835-845","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hydroxysafflor Yellow A Inhibits Staphylococcus aureus-Induced Mouse Endometrial Inflammation via TLR2-Mediated NF-kB and MAPK Pathway"],"prefix":"10.1007","volume":"44","author":[{"given":"Shunzhi","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenteng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1739-3192","authenticated-orcid":false,"given":"Hongchu","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"1297_CR1","doi-asserted-by":"crossref","unstructured":"Woodward, E.M., and M.H.T. Troedsson. Inflammatory mechanisms of endometritis. Equine Veterinary Journal 47 (4): 384\u2013389.","DOI":"10.1111\/evj.12403"},{"issue":"3","key":"1297_CR2","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.fertnstert.2018.04.012","volume":"110","author":"K Kitaya","year":"2018","unstructured":"Kitaya, Kotaro, Takumi Takeuchi, Shimpei Mizuta, Hidehiko Matsubayashi, and Tomomoto Ishikawa. 2018. Endometritis: New time, new concepts. Fertility and Sterility 110 (3): 344\u2013350.","journal-title":"Fertility and Sterility"},{"issue":"6","key":"1297_CR3","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/aji.12508","volume":"75","author":"VA Kushnir","year":"2016","unstructured":"Kushnir, Vitaly A., Shirley Solouki, Tal Sarig-Meth, Mario G. Vega, David F. Albertini, Sarah K. Darmon, Liane Deligdisch, David H. Barad, and Norbert Gleicher. 2016. Systemic inflammation and autoimmunity in women with chronic endometritis. American Journal of Reproductive Immunology 75 (6): 672\u2013677.","journal-title":"American Journal of Reproductive Immunology"},{"issue":"4","key":"1297_CR4","first-page":"653","volume":"23","author":"MM Sergio","year":"2006","unstructured":"Sergio, Mella M. 2006. Daptomicina en infecciones invasoras por Staphylococcus aureus. The New England Journal of Medicine 23 (4): 653\u2013665.","journal-title":"The New England Journal of Medicine"},{"issue":"9","key":"1297_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/23744235.2017.1318219","volume":"49","author":"A Tumminello","year":"2017","unstructured":"Tumminello, Antonio, Dennis Dominguez, Lebowitz Dan, Placido Bartolone, and Ilker U\u00e7kay. 2017. Staphylococcus aureus versus streptococci in orthopaedic infections. Infectious Diseases 49 (9): 1.","journal-title":"Infectious Diseases"},{"key":"1297_CR6","doi-asserted-by":"crossref","unstructured":"Kobayashi, Scott D., Natalia Malachowa, and Frank R. DeLeo. Pathogenesis of Staphylococcus aureus abscesses. American Journal of Pathology 185 (6): 1518\u20131527.","DOI":"10.1016\/j.ajpath.2014.11.030"},{"issue":"6","key":"1297_CR7","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.ajpath.2014.11.030","volume":"185","author":"SD Kobayashi","year":"2015","unstructured":"Kobayashi, Scott D., Natalia Malachowa, and Frank R. Deleo. 2015. Infectious disease theme issue: Pathogenesis of Staphylococcus aureus abscesses. American Journal of Pathology 185 (6): 1518\u20131527.","journal-title":"American Journal of Pathology"},{"issue":"10","key":"1297_CR8","first-page":"1469","volume":"92","author":"J Smit","year":"2017","unstructured":"Smit, Jesper, Luis Eduardo L\u00f3pez-Cort\u00e9s, Reimar W. Thomsen, Henrik C. Sch\u00f8nheyder, and Mette S\u00f8gaard. 2017. Statin use and risk of community-acquired Staphylococcus aureus bacteremia. European Journal of Endocrinology 92 (10): 1469\u20131478.","journal-title":"European Journal of Endocrinology"},{"key":"1297_CR9","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s15010-019-01330-5","volume":"47","author":"JC Lam","year":"2019","unstructured":"Lam, John C., Daniel B. Gregson, Stephen Robinson, Ranjani Somayaji, and Michael D. Parkins. 2019. Epidemiology and outcome determinants of Staphylococcus aureus bacteremia revisited: A population-based study. Infection. 47: 961\u2013971.","journal-title":"Infection."},{"key":"1297_CR10","doi-asserted-by":"crossref","unstructured":"Fetsch, A., M. Contzen, K. Hartelt, A. Kleiser, S. Maassen, J. Rau, B. Kraushaar, F. Layer, and B. Strommenger. Staphylococcus aureus food-poisoning outbreak associated with the consumption of ice-cream. International Journal of Food Microbiology 187: 1\u20136.","DOI":"10.1016\/j.ijfoodmicro.2014.06.017"},{"issue":"10","key":"1297_CR11","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1139\/cjm-2017-0316","volume":"63","author":"CP Bastos","year":"2017","unstructured":"Bastos, Caroline Peixoto, Milena Tomasi Bassani, Marcia Magalh\u00e3es Mata, Graciela Volz Lopes, and Wladimir Padilha da Silva. 2017. Prevalence and expression of staphylococcal enterotoxin genes in Staphylococcus aureus isolated from food poisoning outbreaks. Canadian Journal of Microbiology 63 (10): 834\u2013840.","journal-title":"Canadian Journal of Microbiology"},{"key":"1297_CR12","doi-asserted-by":"crossref","unstructured":"Zadoks, R.N., H.G. Allore, H.W. Barkema, O.C. Sampimon, and Y.H. Schukken. 2002. Cow- and quarter-level risk factors for Streptococcus uberis and Staphylococcus aureus mastitis. Journal of Dairy Science 84 (12).","DOI":"10.3168\/jds.S0022-0302(01)74719-4"},{"issue":"4","key":"1297_CR13","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1128\/CMR.00120-16","volume":"30","author":"E Hodille","year":"2017","unstructured":"Hodille, Elisabeth, Warren Rose, Binh An Diep, Sylvain Goutelle, and Oana Dumitrescu. 2017. The role of antibiotics in modulating virulence in Staphylococcus aureus. Clinical Microbiology Reviews 30 (4): 887\u2013917.","journal-title":"Clinical Microbiology Reviews"},{"key":"1297_CR14","doi-asserted-by":"crossref","unstructured":"Chambers, Henry F., and Frank R. DeLeo. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nature Reviews Microbiology 7 (9): 629\u2013641.","DOI":"10.1038\/nrmicro2200"},{"issue":"2","key":"1297_CR15","first-page":"129","volume":"72","author":"LJ Mcgaw","year":"2010","unstructured":"Mcgaw, L.J., R. Gehring, L. Katsoulis, and J.N. Eloff. 2010. Is the use of Gunnera perpensa extracts in endometritis related to antibacterial activ. Onderstepoort Journal of Veterinary Research 72 (2): 129.","journal-title":"Onderstepoort Journal of Veterinary Research"},{"key":"1297_CR16","doi-asserted-by":"crossref","unstructured":"Wu, Haichong, Dai Ailing, Chen Xingxing, Xiaoyan Yang, Li Xiaohua, Huang Cuiqin, Jiang Kangfeng, and Ganzhen Deng. Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis. International Immunopharmacology 61: 156\u2013161.","DOI":"10.1016\/j.intimp.2018.06.002"},{"key":"1297_CR17","doi-asserted-by":"crossref","unstructured":"Wu, Haichong, Jiang Kangfeng, Yin Nannan, Xiaofei Ma, Zhao Gan, Qiu Changwei, and Ganzhen Deng. Thymol mitigates lipopolysaccharide-induced endometritis by regulating the TLR4- and ROS-mediated NF-κB signaling pathways. Oncotarget 8 (12).","DOI":"10.18632\/oncotarget.15373"},{"key":"1297_CR18","unstructured":"Bonsale, R., R. Seyed Sharifi, E. Dirandeh, N. Hedayat, A. Mojtahedin, M. Ghorbanalinia, and A. Abolghasemi. Endocannabinoids as endometrial inflammatory markers in lactating Holstein cows. Reproduction in Domestic Animals."},{"key":"1297_CR19","doi-asserted-by":"crossref","unstructured":"Xu, Xiaolong, Yuhong Guo, Zhao Jingxia, Ning Wang, Ding Junying, and Liu Qingquan. 2016. Hydroxysafflor yellow A inhibits LPS-induced NLRP3 inflammasome activation via binding to xanthine oxidase in mouse RAW264.7 macrophages. Mediators of Inflammation: 1\u201311.","DOI":"10.1155\/2016\/8172706"},{"key":"1297_CR20","doi-asserted-by":"crossref","unstructured":"Li, Jie, Shenyang Zhang, Mengru Lu, Zhibin Chen, Cong Chen, Lijuan Han, Meijuan Zhang, and Yun Xu. Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen\u2013glucose deprivation. Neuroscience Letters 535 (Complete): 51\u201356.","DOI":"10.1016\/j.neulet.2012.12.056"},{"issue":"10","key":"1297_CR21","doi-asserted-by":"publisher","first-page":"6699","DOI":"10.1039\/c9fo00654k","volume":"10","author":"X Hu","year":"2019","unstructured":"Hu, X., J. Guo, M. Xu, P. Jiang, X. Yuan, C. Zhao, T. Maimai, Y. Cao, N. Zhang, and Y. Fu. 2019. Clostridium tyrobutyricum alleviates Staphylococcus aureus-induced endometritis in mice by inhibiting endometrial barrier disruption and inflammatory response. Food & Function 10 (10): 6699\u20136710. https:\/\/doi.org\/10.1039\/c9fo00654k.","journal-title":"Food & Function"},{"key":"1297_CR22","doi-asserted-by":"publisher","first-page":"2350482","DOI":"10.1155\/2017\/2350482","volume":"2017","author":"Z Zhang","year":"2017","unstructured":"Zhang, Z., Y. Guo, Y. Liu, C. Li, M. Guo, and G. Deng. 2017. IFN-\u03c4 displays anti-inflammatory effects on Staphylococcus aureus Endometritis via inhibiting the activation of the NF-\u03baB and MAPK pathways in mice. BioMed Research International 2017: 2350482\u20132350412. https:\/\/doi.org\/10.1155\/2017\/2350482.","journal-title":"BioMed Research International"},{"issue":"2","key":"1297_CR23","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.intimp.2014.10.018","volume":"23","author":"YL Liu","year":"2014","unstructured":"Liu, Y.L., Y.J. Liu, Y. Liu, X.S. Li, S.H. Liu, Y.G. Pan, J. Zhang, Q. Liu, and Y.Y. Hao. 2014. Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways. International Immunopharmacology 23 (2): 649\u2013657. https:\/\/doi.org\/10.1016\/j.intimp.2014.10.018.","journal-title":"International Immunopharmacology"},{"issue":"4","key":"1297_CR24","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1248\/bpb.35.515","volume":"35","author":"Y Wu","year":"2012","unstructured":"Wu, Y., L. Wang, M. Jin, and B.X. Zang. 2012. Hydroxysafflor yellow A alleviates early inflammatory response of bleomycin-induced mice lung injury. Biological & Pharmaceutical Bulletin 35 (4): 515\u2013522. https:\/\/doi.org\/10.1248\/bpb.35.515.","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"1297_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1477-7827-7-55","volume":"7","author":"S Herath","year":"2009","unstructured":"Herath, S., S.T. Lilly, N.R. Santos, R.O. Gilbert, L. Goetze, C.E. Bryant, J.O. White, J. Cronin, and I.M. Sheldon. 2009. Expression of genes associated with immunity in the endometrium of cattle with disparate postpartum uterine disease and fertility. Reproductive Biology and Endocrinology 7: 55. https:\/\/doi.org\/10.1186\/1477-7827-7-55.","journal-title":"Reproductive Biology and Endocrinology"},{"key":"1297_CR26","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ejphar.2015.11.036","volume":"769","author":"Y Lv","year":"2015","unstructured":"Lv, Y., Y. Qian, L. Fu, X. Chen, H. Zhong, and X. Wei. 2015. Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway. European Journal of Pharmacology 769: 324\u2013332. https:\/\/doi.org\/10.1016\/j.ejphar.2015.11.036.","journal-title":"European Journal of Pharmacology"},{"key":"1297_CR27","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","volume":"21","author":"K Takeda","year":"2003","unstructured":"Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annual Review of Immunology 21: 335\u2013376. https:\/\/doi.org\/10.1146\/annurev.immunol.21.120601.141126.","journal-title":"Annual Review of Immunology"},{"issue":"1","key":"1297_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s13105-015-0382-3","volume":"71","author":"Y He","year":"2015","unstructured":"He, Yanhao, Qiang Liu, Yanxiang Li, Xiaofeng Yang, Weirong Wang, Tingting Li, Wei Zhang, Yuexin Cui, Chaoyun Wang, and Rong Lin. 2015. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats. Journal of Physiology and Biochemistry 71 (1): 69\u201378.","journal-title":"Journal of Physiology and Biochemistry"},{"issue":"5","key":"1297_CR29","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri2294","volume":"8","author":"CN Serhan","year":"2008","unstructured":"Serhan, Charles N., Nan Chiang, and Thomas E. Van Dyke. 2008. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nature Reviews Immunology 8 (5): 349\u2013361.","journal-title":"Nature Reviews Immunology"},{"issue":"5625","key":"1297_CR30","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1126\/science.1085536","volume":"300","author":"GM Barton","year":"2003","unstructured":"Barton, Gregory M., and Ruslan Medzhitov. 2003. Toll-like receptor signaling pathways. Science 300 (5625): 1524\u20131525.","journal-title":"Science"},{"issue":"5","key":"1297_CR31","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","volume":"13","author":"T Kawai","year":"2006","unstructured":"Kawai, Taro, and Shizuo Akira. 2006. TLR signaling. Cell Death & Differentiation 13 (5): 816\u2013825.","journal-title":"Cell Death & Differentiation"},{"key":"1297_CR32","doi-asserted-by":"crossref","unstructured":"Negishi, Hideo, Yasuyuki Fujita, Hideyuki Yanai, Shinya Sakaguchi, Xinshou Ouyang, Masahiro Shinohara, Hiroshi Takayanagi, Yusuke Ohba, Tadatsugu Taniguchi, and Kenya Honda. 2006. Evidence for licensing of IFN-\u03b3-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. 103 (41): 15136\u201315141.","DOI":"10.1073\/pnas.0607181103"},{"key":"1297_CR33","doi-asserted-by":"crossref","unstructured":"Muzio, and M. IRAK (Pelle). Family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278 (5343): 1612\u20131615.","DOI":"10.1126\/science.278.5343.1612"},{"key":"1297_CR34","doi-asserted-by":"crossref","unstructured":"Hirata, Y., T. Ohmae, W. Shibata, S. Maeda, K. Ogura, H. Yoshida, T. Kawabe, and M. Omata. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. Journal of Immunology 176 (6): 3796\u20133803.","DOI":"10.4049\/jimmunol.176.6.3796"},{"issue":"1","key":"1297_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1172\/JCI11837","volume":"107","author":"G Zhang","year":"2001","unstructured":"Zhang, Guolong, and Sankar Ghosh. 2001. Toll-like receptor\u2013mediated NF-\u03baB activation: A phylogenetically conserved paradigm in innate immunity. The Journal of Clinical Investigation 107 (1): 13\u201319.","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"1297_CR36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1189\/jlb.71.3.503","volume":"71","author":"T Vasselon","year":"2002","unstructured":"Vasselon, Thierry, William A. Hanlon, Samuel D. Wright, and Patricia A. Detmers. 2002. Toll-like receptor 2 (TLR2) mediates activation of stress-activated MAP kinase p38. Journal of Leukocyte Biology 71 (3): 503\u2013510.","journal-title":"Journal of Leukocyte Biology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01297-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-020-01297-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01297-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T22:13:18Z","timestamp":1671660798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-020-01297-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1297"],"URL":"https:\/\/doi.org\/10.1007\/s10753-020-01297-8","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"assertion":[{"value":"18 March 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}