{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:43:24Z","timestamp":1768441404925,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Foreign Science and Technology Cooperation Project of Science and Technology Department in Anhui Province, China","award":["201904b11020042"],"award-info":[{"award-number":["201904b11020042"]}]},{"name":"Natural Science Foundation of Anhui","award":["1908085MH253"],"award-info":[{"award-number":["1908085MH253"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10753-020-01367-x","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:06:46Z","timestamp":1603919206000},"page":"682-692","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP"],"prefix":"10.1007","volume":"44","author":[{"given":"Qingshan","family":"Ji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuechun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4582-3257","authenticated-orcid":false,"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"issue":"12","key":"1367_CR1","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1111\/myc.12822","volume":"61","author":"S Mahmoudi","year":"2018","unstructured":"Mahmoudi, S., A. Masoomi, K. Ahmadikia, S.A. Tabatabaei, M. Soleimani, S. Rezaie, H. Ghahvechian, and A. Banafsheafshan. 2018. Fungal keratitis: an overview of clinical and laboratory aspects. Mycoses 61 (12): 916\u2013930. https:\/\/doi.org\/10.1111\/myc.12822.","journal-title":"Mycoses"},{"key":"1367_CR2","doi-asserted-by":"publisher","first-page":"103802","DOI":"10.1016\/j.micpath.2019.103802","volume":"138","author":"L Niu","year":"2020","unstructured":"Niu, L., X. Liu, Z. Ma, Y. Yin, L. Sun, L. Yang, and Y. Zheng. 2020. Fungal keratitis: pathogenesis, diagnosis and prevention. Microbial Pathogenesis 138: 103802. https:\/\/doi.org\/10.1016\/j.micpath.2019.103802.","journal-title":"Microbial Pathogenesis"},{"key":"1367_CR3","doi-asserted-by":"publisher","unstructured":"Sharma, P., N. Sharma, P. Mishra, J. Joseph, D.K. Mishra, P. Garg, and S. Roy. 2019. Differential expression of antimicrobial peptides in Streptococcus pneumoniae keratitis and STAT3-dependent expression of LL-37 by Streptococcus pneumoniae in human corneal epithelial cells. Pathogens 8 (1). https:\/\/doi.org\/10.3390\/pathogens8010031.","DOI":"10.3390\/pathogens8010031"},{"issue":"3","key":"1367_CR4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3347\/kjp.2019.57.3.217","volume":"57","author":"HJ Sohn","year":"2019","unstructured":"Sohn, H.J., G.E. Seo, J.H. Lee, A.J. Ham, Y.H. Oh, H. Kang, and H.J. Shin. 2019. Cytopathic change and inflammatory response of human corneal epithelial cells induced by Acanthamoeba castellanii Trophozoites and cysts. The Korean Journal of Parasitology 57 (3): 217\u2013223. https:\/\/doi.org\/10.3347\/kjp.2019.57.3.217.","journal-title":"The Korean Journal of Parasitology"},{"key":"1367_CR5","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.3389\/fimmu.2018.01595","volume":"9","author":"G Varricchi","year":"2018","unstructured":"Varricchi, G., A. Pecoraro, G. Marone, G. Criscuolo, G. Spadaro, A. Genovese, and G. Marone. 2018. Thymic stromal Lymphopoietin isoforms, inflammatory disorders, and cancer. Frontiers in Immunology 9: 1595. https:\/\/doi.org\/10.3389\/fimmu.2018.01595.","journal-title":"Frontiers in Immunology"},{"issue":"6","key":"1367_CR6","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1167\/iovs.08-3074","volume":"50","author":"P Ma","year":"2009","unstructured":"Ma, P., F. Bian, Z. Wang, X. Zheng, S. Chotikavanich, S.C. Pflugfelder, and D.Q. Li. 2009. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Investigative Ophthalmology & Visual Science 50 (6): 2702\u20132709. https:\/\/doi.org\/10.1167\/iovs.08-3074.","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"1367_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.molimm.2015.12.014","volume":"71","author":"X Ren","year":"2016","unstructured":"Ren, X., L. Wang, and X. Wu. 2016. A potential link between TSLP\/TSLPR\/STAT5 and TLR2\/MyD88\/NF\u03baB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance. Molecular Immunology 71: 98\u2013106. https:\/\/doi.org\/10.1016\/j.molimm.2015.12.014.","journal-title":"Molecular Immunology"},{"key":"1367_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.exer.2019.02.020","volume":"182","author":"C Dai","year":"2019","unstructured":"Dai, C., J. Wu, C. Chen, and X. Wu. 2019. Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection. Experimental Eye Research 182: 19\u201329. https:\/\/doi.org\/10.1016\/j.exer.2019.02.020.","journal-title":"Experimental Eye Research"},{"issue":"6","key":"1367_CR9","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/ceo.12706","volume":"44","author":"L Wang","year":"2016","unstructured":"Wang, L., L. Wang, and X. Wu. 2016. Aspergillus fumigatus promotes T helper type 2 responses through thymic stromal lymphopoietin production by human corneal epithelial cells. Clinical & Experimental Ophthalmology 44 (6): 492\u2013501. https:\/\/doi.org\/10.1111\/ceo.12706.","journal-title":"Clinical & Experimental Ophthalmology"},{"key":"1367_CR10","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.exer.2018.03.014","volume":"171","author":"L Sun","year":"2018","unstructured":"Sun, L., C. Chen, J. Wu, C. Dai, and X. Wu. 2018. TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis. Experimental Eye Research 171: 120\u2013130. https:\/\/doi.org\/10.1016\/j.exer.2018.03.014.","journal-title":"Experimental Eye Research"},{"issue":"10","key":"1367_CR11","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1167\/iovs.18-24672","volume":"59","author":"X Cui","year":"2018","unstructured":"Cui, X., N. Gao, R. Me, J. Xu, and F.X. Yu. 2018. TSLP protects corneas from Pseudomonas aeruginosa infection by regulating dendritic cells and IL-23-IL-17 pathway. Investigative Ophthalmology & Visual Science 59 (10): 4228\u20134237. https:\/\/doi.org\/10.1167\/iovs.18-24672.","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"1367_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.exer.2014.10.014","volume":"129","author":"J Hu","year":"2014","unstructured":"Hu, J., Y. Hu, S. Chen, C. Dong, J. Zhang, Y. Li, J. Yang, X. Han, X. Zhu, and G. Xu. 2014. Role of activated macrophages in experimental Fusarium solani keratitis. Experimental Eye Research 129: 57\u201365. https:\/\/doi.org\/10.1016\/j.exer.2014.10.014.","journal-title":"Experimental Eye Research"},{"key":"1367_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.intimp.2017.08.006","volume":"52","author":"J Lin","year":"2017","unstructured":"Lin, J., K. He, G. Zhao, C. Li, L. Hu, G. Zhu, Y. Niu, and G. Hao. 2017. Mincle inhibits neutrophils and macrophages apoptosis in A. fumigatus keratitis. International Immunopharmacology 52: 101\u2013109. https:\/\/doi.org\/10.1016\/j.intimp.2017.08.006.","journal-title":"International Immunopharmacology"},{"issue":"1","key":"1367_CR14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","volume":"277","author":"SM Man","year":"2017","unstructured":"Man, S.M., R. Karki, and T.D. Kanneganti. 2017. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunological Reviews 277 (1): 61\u201375. https:\/\/doi.org\/10.1111\/imr.12534.","journal-title":"Immunological Reviews"},{"key":"1367_CR15","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3389\/fimmu.2018.01121","volume":"9","author":"W Qu","year":"2018","unstructured":"Qu, W., Y. Wang, Y. Wu, Y. Liu, K. Chen, X. Liu, Z. Zou, X. Huang, and M. Wu. 2018. Pseudomonas aeruginosa triggering receptors expressed on myeloid cells 2 promotes corneal resistance against by inhibiting caspase-1-dependent pyroptosis. Frontiers in Immunology 9: 1121. https:\/\/doi.org\/10.3389\/fimmu.2018.01121.","journal-title":"Frontiers in Immunology"},{"key":"1367_CR16","doi-asserted-by":"publisher","unstructured":"Soumelis, V., and Y.J. Liu. 2020. The discovery of human TSLP as a critical epithelial cytokine in type 2 immunity and allergic disease. Nature Immunology. https:\/\/doi.org\/10.1038\/s41590-020-0720-7.","DOI":"10.1038\/s41590-020-0720-7"},{"issue":"4","key":"1367_CR17","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/alr.22504","volume":"10","author":"R Huang","year":"2020","unstructured":"Huang, R., W. Mao, G. Wang, J. Ding, Y. Sun, G. Gao, P. Dong, and Z. Sun. 2020. Synergistic relationship between TSLP and IL-33\/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia. International forum of allergy & rhinology 10 (4): 511\u2013520. https:\/\/doi.org\/10.1002\/alr.22504.","journal-title":"International forum of allergy & rhinology"},{"key":"1367_CR18","doi-asserted-by":"publisher","unstructured":"Lai, J.F., L.J. Thompson, and S.F. Ziegler. 2020. TSLP drives acute T2-cell differentiation in lungs. The Journal of allergy and clinical immunology. https:\/\/doi.org\/10.1016\/j.jaci.2020.03.032.","DOI":"10.1016\/j.jaci.2020.03.032"},{"key":"1367_CR19","doi-asserted-by":"publisher","unstructured":"Li, S., Z. Yi, M. Deng, M.J. Scott, C. Yang, W. Li, Z. Lei, N.M. Santerre, P. Loughran, and T.R. Billiar. 2019. TSLP protects against liver I\/R injury via activation of the PI3K\/Akt pathway. JCI insight 4 (22). https:\/\/doi.org\/10.1172\/jci.insight.129013.","DOI":"10.1172\/jci.insight.129013"},{"issue":"2","key":"1367_CR20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.alit.2016.06.011","volume":"66","author":"T Kato","year":"2017","unstructured":"Kato, T., H. Kouzaki, K. Matsumoto, J. Hosoi, and T. Shimizu. 2017. The effect of calprotectin on TSLP and IL-25 production from airway epithelial cells. Allergology international : official journal of the Japanese Society of Allergology 66 (2): 281\u2013289. https:\/\/doi.org\/10.1016\/j.alit.2016.06.011.","journal-title":"Allergology international : official journal of the Japanese Society of Allergology"},{"issue":"7081","key":"1367_CR21","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nature04515","volume":"440","author":"S Mariathasan","year":"2006","unstructured":"Mariathasan, S., D.S. Weiss, K. Newton, J. McBride, K. O'Rourke, M. Roose-Girma, W.P. Lee, Y. Weinrauch, D.M. Monack, and V.M. Dixit. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440 (7081): 228\u2013232. https:\/\/doi.org\/10.1038\/nature04515.","journal-title":"Nature"},{"issue":"5","key":"1367_CR22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.molcel.2007.01.032","volume":"25","author":"B Faustin","year":"2007","unstructured":"Faustin, B., L. Lartigue, J.M. Bruey, F. Luciano, E. Sergienko, B. Bailly-Maitre, N. Volkmann, D. Hanein, I. Rouiller, and J.C. Reed. 2007. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Molecular Cell 25 (5): 713\u2013724. https:\/\/doi.org\/10.1016\/j.molcel.2007.01.032.","journal-title":"Molecular Cell"},{"issue":"2","key":"1367_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12563","volume":"52","author":"Z Zhaolin","year":"2019","unstructured":"Zhaolin, Z., L. Guohua, W. Shiyuan, and W. Zuo. 2019. Role of pyroptosis in cardiovascular disease. Cell Proliferation 52 (2): e12563. https:\/\/doi.org\/10.1111\/cpr.12563.","journal-title":"Cell Proliferation"},{"issue":"2","key":"1367_CR24","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.3892\/mmr.2017.8217","volume":"17","author":"X Yu","year":"2018","unstructured":"Yu, X., Y. Peng, H. Liang, K. Fu, Z. Zhao, C. Xie, L. Zhou, and K. Zhang. 2018. TSLP\/TSLPR promote angiogenesis following ischemic stroke via activation of the PI3K\/AKT pathway. Molecular Medicine Reports 17 (2): 3411\u20133417. https:\/\/doi.org\/10.3892\/mmr.2017.8217.","journal-title":"Molecular Medicine Reports"},{"issue":"5","key":"1367_CR25","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41385-019-0187-8","volume":"12","author":"R Deng","year":"2019","unstructured":"Deng, R., X. Chen, Y. Zhang, F. Bian, N. Gao, J. Hu, C. Wang, R.G. de Souza, F. Lu, S.C. Pflugfelder, and D.Q. Li. 2019. Short ragweed pollen promotes M2 macrophage polarization via TSLP\/TSLPR\/OX40L signaling in allergic inflammation. Mucosal Immunology 12 (5): 1141\u20131149. https:\/\/doi.org\/10.1038\/s41385-019-0187-8.","journal-title":"Mucosal Immunology"},{"issue":"1","key":"1367_CR26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000369684","volume":"35","author":"J Dong","year":"2015","unstructured":"Dong, J., J. Dong, J. Lin, B. Wang, S. He, C. Wu, K.K. Kushwaha, N. Mohabeer, Y. Su, H. Fang, K. Huang, and D. Li. 2015. Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K\/Akt signaling pathway. Cellular Physiology and Biochemistry 35 (1): 160\u2013174. https:\/\/doi.org\/10.1159\/000369684.","journal-title":"Cellular Physiology and Biochemistry"}],"updated-by":[{"DOI":"10.1007\/s10753-021-01502-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000}}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01367-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-020-01367-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01367-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T17:23:34Z","timestamp":1626110614000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-020-01367-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,28]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["1367"],"URL":"https:\/\/doi.org\/10.1007\/s10753-020-01367-x","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s10753-021-01502-2","asserted-by":"object"}]},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,28]]},"assertion":[{"value":"2 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10753-021-01502-2","URL":"https:\/\/doi.org\/10.1007\/s10753-021-01502-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}