{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:10:16Z","timestamp":1785323416775,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10753-020-01369-9","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T17:17:19Z","timestamp":1605028639000},"page":"704-713","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of the Association of Periodontitis and Type 1 Diabetes Mellitus Induced on Periodontal Tissues and the Duodenal Mucosa of Wistar Rats"],"prefix":"10.1007","volume":"44","author":[{"given":"Iohana Ferreira Choptian","family":"Fiorese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jossinelma Camargo","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Caroline Cust\u00f3dio","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciane","family":"Wachter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ediana Amanda","family":"Piana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Meire Costa","family":"Brancalh\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Grassioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Augusto","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3791-0334","authenticated-orcid":false,"given":"Patr\u00edcia Oehlmeyer","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"issue":"35","key":"1369_CR1","doi-asserted-by":"publisher","first-page":"7963","DOI":"10.3748\/wjg.v22.i35.7963","volume":"22","author":"R Lira-junior","year":"2016","unstructured":"Lira-junior, R., and C.M. Figueredo. 2016. Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions? World Journal of Gastroenterology 22 (35): 7963\u20137972.","journal-title":"World Journal of Gastroenterology"},{"key":"1369_CR2","doi-asserted-by":"publisher","unstructured":"Pimentel, S.P., M.Z. Casati, F.V. Ribeiro, M.G. Corr\u00eaa, F.C. Franck, B.B. Benatti, and F.R. Cirano. 2019. Impact of natural curcumin on the progression of experimental periodontitis in diabetic rats. Journal of Periodontal Research (00): 1\u201310. https:\/\/doi.org\/10.1111\/jre.12683.","DOI":"10.1111\/jre.12683"},{"key":"1369_CR3","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1902\/jop.2011.100643","volume":"82","author":"FV Ribeiro","year":"2011","unstructured":"Ribeiro, F.V., A.C. de Mendon\u00e7a, V.R. Santos, M.F. Bastos, L.C. Figueiredo, and P.M. Duarte. 2011. Cytokines and bone-related factors in systemically healthy patients with chronic periodontitis and patients with type 2 diabetes and chronic periodontitis. Journal of Periodontology 82: 1187\u20131196.","journal-title":"Journal of Periodontology"},{"key":"1369_CR4","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/jcpe.12839","volume":"45","author":"L Ziukaite","year":"2018","unstructured":"Ziukaite, L., D.E. Slot, and F.A. Van der Weijden. 2018. Prevalence of diabetes mellitus in people clinically diagnosed with periodontitis: A systematic review and meta-analysis of epidemiologic studies. Journal of Clinical Periodontology 45: 650\u2013662.","journal-title":"Journal of Clinical Periodontology"},{"issue":"38","key":"1369_CR5","first-page":"1","volume":"7","author":"SM Shanmukappa","year":"2017","unstructured":"Shanmukappa, S.M., P. Nadig, R. Puttannavar, Z. Ambareen, T.M. Gowda, and D.S. Mehta. 2017. Knowledge, attitude, and awareness among diabetic patients in davangere about the association between diabetes and periodontal disease shruthi mavinahally. Journal of International Society of Preventive Community Dentistry 7 (38): 1\u20138.","journal-title":"Journal of International Society of Preventive Community Dentistry"},{"key":"1369_CR6","volume-title":"Diretrizes da Sociedade Brasileira de Diabetes 2017\u20132018","author":"Sociedade Brasileira de Diabetes","year":"2017","unstructured":"Sociedade Brasileira de Diabetes. 2017. Diretrizes da Sociedade Brasileira de Diabetes 2017\u20132018. S\u00e3o Paulo: Clannad."},{"issue":"1","key":"1369_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","volume":"55","author":"PM Preshaw","year":"2012","unstructured":"Preshaw, P.M., A.L. Alba, D. Herrera, S. Jepsen, A. Konstantinidis, K. Makrilakis, and R. Taylor. 2012. Periodontitis and diabetes: A two-way relationship. Diabetologia 55 (1): 21\u201331.","journal-title":"Diabetologia"},{"key":"1369_CR8","unstructured":"Kerbauy, W.D., F.R. Lima, F.A. Perrella, and J.B.O. Amorim. 2008. Produtos finais de glicosila\u00e7\u00e3o avan\u00e7ada (age) e a exacerba\u00e7\u00e3o da doen\u00e7a periodontal em diab\u00e9ticos \u2013 revis\u00e3o de literatura advanced glycation end products (age) and the exacerbation of periodontal disease in diabetics patients\u2013review.\u00a0Periodontia 18 (3): 20\u201327."},{"key":"1369_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/983782","volume":"2015","author":"TA Costa","year":"2015","unstructured":"Costa, T.A., M.J.B. SIlva, P.M. Alves, J.E.Z.B. Chica, E.Z. Barcelos, M.A.A. Giani, G.P. Garlet, J.S. Silva, V. Rodrigues-J\u00fanior, D.B.R. Rodrigues, and C.R.B. Cardoso. 2015. Biomarkers of advanced disease in nongingival tissues of chronic periodontitis patients. Hindawi Publishing Corporation Mediators of Inflammation 2015: 1\u201310.","journal-title":"Hindawi Publishing Corporation Mediators of Inflammation"},{"issue":"4","key":"1369_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/154405910708600409","volume":"86","author":"A Becklen","year":"2007","unstructured":"Becklen, A., M. Ainola, M. Hukkanen, C. Gurgan, T. SORSA, and Y.T. Konttinen. 2007. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. Journal of Dental Research 86 (4): 347\u2013335.","journal-title":"Journal of Dental Research"},{"issue":"12","key":"1369_CR11","first-page":"1","volume":"12","author":"J-H Kim","year":"2017","unstructured":"Kim, J.-H., A.R. Kim, Y.H. Choi, S. Jang, G.-H. Woo, J.-H. Cha, E.-J. Bak, and Y.-J. Yoo. 2017. Tumor necrosis factor-\u03b1 antagonist diminishes osteocytic RANKL and sclerostin expression in diabetes rats with periodontitis. PLoS One 12 (12): 1\u201313.","journal-title":"PLoS One"},{"key":"1369_CR12","unstructured":"Brand\u00e3o, D.F.L.M.O., A.P.G. Silva, and L.A.M. Penteado. 2011. Rela\u00e7\u00e3o bidirecional entre a doen\u00e7a periodontal e o diabetes mellitus. Bidirectional relationship between periodontal disease and diabetes mellitus. Odontologia Cl\u00ednico-Cient\u00edfica\u00a010 (2): 117\u2013120."},{"key":"1369_CR13","unstructured":"Almeida, B.B., A.C.R. Ferreira, A.P.G. Queiroz, G.N. Dornelas, and M.M.S.T. Coelho. 2015. Condi\u00e7\u00f5es periodontais em portadores de diabetes mellitus atendidos no centro de refer\u00eancia sul fluminense de diabetes e hipertens\u00e3o de vassouras-rj periodontal conditions in patients with diabetes mellitus attended in South Fluminense reference center for diabetes and hypertension of Vassouras-RJ. Brazilian Society of Periodontology\u00a025 (4): 14\u201326."},{"issue":"12","key":"1369_CR14","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3748\/wjg.v23.i12.2106","volume":"23","author":"HV Spaendonk","year":"2017","unstructured":"Spaendonk, H.V., H. Ceuleers, L. Witters, E. Patteet, L. Joossens, K. Augustyns, A.-M. Lambeir, I. de Meester, J.G. Man, and B.Y. Winter. 2017. Regulation of intestinal permeability: The role of proteases. World Journal of Gastroenterology 23 (12): 2106\u20132123.","journal-title":"World Journal of Gastroenterology"},{"key":"1369_CR15","volume-title":"Histologia b\u00e1sica: texto e atlas","author":"LC Junqueira","year":"2017","unstructured":"Junqueira, L.C., J. Carneiro, and P. Abrahamsohn. 2017. Histologia b\u00e1sica: texto e atlas. Rio de Janeiro: Guanabara Koogan."},{"issue":"4","key":"1369_CR16","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1590\/0004-2730000002940","volume":"58","author":"ACF Moraes","year":"2014","unstructured":"Moraes, A.C.F., I.T. SIlva, B. Almeida-Pititto, and S.R.G. Ferreira. 2014. Microbiota intestinal e risco cardiometab\u00f3lico: mecanismos e modula\u00e7\u00e3o diet\u00e9tica. Arquivos Brasileiros de Endocrinologia e Metabologia 58 (4): 317\u2013327.","journal-title":"Arquivos Brasileiros de Endocrinologia e Metabologia"},{"issue":"12","key":"1369_CR17","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1902\/jop.2013.120644","volume":"84","author":"MR Messora","year":"2013","unstructured":"Messora, M.R., L.F.F. Oliveira, R.C. Foureaux, M.G. Taba-Junior, M.G. Zanger\u00f4nimo, F.A.C. Furlaneto, and L.J. Pereira. 2013. Probiotic therapy reduces periodontal tissue destruction and improves the intestinal morphology in rats with ligature-induced periodontitis. Journal of Periodontology 84 (12): 1818\u20131826.","journal-title":"Journal of Periodontology"},{"issue":"5","key":"1369_CR18","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1210\/jc.2016-3222","volume":"102","author":"S Pellegrini","year":"2017","unstructured":"Pellegrini, S., V. Sordi, A.M. Bolla, D. Saita, R. Ferrarese, F. Canducci, M. Clementi, F. Invernizzi, A. Mariani, R. Bonfanti, G. Barera, P.A. Testoni, C. Doglioni, E. Bosi, and L. Piemonti. 2017. Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota. The Journal of Clinical Endocrinology and Metabolism 102 (5): 1468\u20131477.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"1369_CR19","volume-title":"Como elaborar projetos de pesquisa","author":"AC Gil","year":"2007","unstructured":"Gil, A.C. 2007. Como elaborar projetos de pesquisa. 4th ed. Atlas: S\u00e3o Paulo.","edition":"4"},{"issue":"2","key":"1369_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0030685","volume":"7","author":"RC Branco","year":"2012","unstructured":"Branco, R.C., J.C. Oliveira, S. Grassiolli, R.A. Miranda, L.F. Barella, R.M. Gomes, L.A. Bataglini, et al. 2012. Maternal protein malnutrition does not impair insulin secretion from pancreatic islets of offspring after transplantation into diabetic rats. PLoS One 7 (2): 1\u20137.","journal-title":"PLoS One"},{"issue":"9","key":"1369_CR21","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/nu9091016","volume":"9","author":"VO Silva","year":"2017","unstructured":"Silva, V.O., R.V. Lobato, E.F. Andrade, D.R. Orlando, B.D.B. Borges, M.G. Zangeronimo, R.V. Sousa, et al. 2017. Effects of \u03b2-glucans ingestion on alveolar bone loss, intestinal morphology, systemic inflammatory profile, and pancreatic \u03b2-cell function in rats with periodontitis and diabetes. Nutrients 9 (9): 1016.","journal-title":"Nutrients"},{"issue":"4","key":"1369_CR22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1600-0765.2008.01143.x","volume":"44","author":"PO Nassar","year":"2009","unstructured":"Nassar, P.O., C.A. Nassar, M.R. Guimar\u00e3es, S.G. Aquino, D.C. Andia, M.N. Muscara, D.M. Spolidorio, et al. 2009. Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats. Journal of Periodontal Research 44 (4): 479\u2013488.","journal-title":"Journal of Periodontal Research"},{"issue":"2","key":"1369_CR23","first-page":"125","volume":"32","author":"CA Nassar","year":"2003","unstructured":"Nassar, C.A., P.O. Nassar, N.S. Inagaki, and C. Girelli Junior. 2003. Efeito de antiinflamat\u00f3rio no desenvolvimento da doen\u00e7a periodontal induzida. Avalia\u00e7\u00e3o radiogr\u00e1fica em ratos. Revista de Odontologia da UNESP 32 (2): 125\u2013130.","journal-title":"Revista de Odontologia da UNESP"},{"key":"1369_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1590\/S0004-27492003000400008","volume":"66","author":"S Matayoshi","year":"2003","unstructured":"Matayoshi, S., R.M. Santo, V. Capelozzi, P.H. Saldiva, and M.R. Alves. 2003. Proposi\u00e7\u00e3o de modelo experimental para estudo morfom\u00e9trico de vasos e c\u00e9lulas em esclera de coelhos. Arquivos Brasileiros de Oftalmologia 66: 437\u2013441.","journal-title":"Arquivos Brasileiros de Oftalmologia"},{"issue":"1","key":"1369_CR25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.medcli.2014.07.019","volume":"145","author":"A Bascones-Mart\u00ednez","year":"2015","unstructured":"Bascones-Mart\u00ednez, A., M. Mu\u00f1oz-Corcuera, and J. Bascones-Llundain. 2015. Diabetes y periodontitis: una relaci\u00f3n bidireccional. Medicina Cl\u00ednica (Barcelona) 145 (1): 31\u201335.","journal-title":"Medicina Cl\u00ednica (Barcelona)"},{"issue":"5","key":"1369_CR26","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1590\/0103-6440201601054","volume":"27","author":"LS Oliveira","year":"2016","unstructured":"Oliveira, L.S., R. Lira-Junior, C.M. Figueredo, M.B. Gomes, and R.G. Fischer. 2016. Self-reported periodontitis and complications in type 1 diabetes patients: A Brazilian Nationwide Survey. Brazilian Dental Journal 27 (5): 599\u2013603.","journal-title":"Brazilian Dental Journal"},{"issue":"1","key":"1369_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/00016357.2016.1244355","volume":"75","author":"HB Yuce","year":"2016","unstructured":"Yuce, H.B., N. Akbulut, S. Ocakli, O. Kayir, and E. Mahfuz. 2016. The effect of commercial conjugated linoleic acid products on experimental periodontitis and diabetes mellitus in Wistar rats. Acta Odontologica Scandinavica 75 (1): 21\u201329.","journal-title":"Acta Odontologica Scandinavica"},{"issue":"03","key":"1369_CR28","first-page":"17","volume":"24","author":"LFC Mattos","year":"2014","unstructured":"Mattos, L.F.C., C.M.M.L. Santos, M.A.P. Roxo, and M.L.F. Terezan. 2014. Poss\u00edvel associa\u00e7\u00e3o entre doen\u00e7a periodontal e doen\u00e7as intestinais inflamat\u00f3rias cr\u00f4nicas. Possible association between periodontal disease and chronic inflammatory bowel diseases. Braz J Periodontol 24 (03): 17\u201323.","journal-title":"Braz J Periodontol"},{"issue":"6","key":"1369_CR29","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1210\/jc.2019-00481","volume":"104","author":"J Ho","year":"2019","unstructured":"Ho, J., A.C. Nicolucci, H. Virtanen, A. Schick, J. Meddings, R.A. Reimer, and C. Huang. 2019. Effect of probiotic on microbiota, intestinal permeability and glycemic control in children with type 1 diabetes. The Journal of Clinical Endocrinology and Metabolism 104 (6): 4427\u20134440.","journal-title":"The Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01369-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10753-020-01369-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01369-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T17:20:20Z","timestamp":1616433620000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10753-020-01369-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["1369"],"URL":"https:\/\/doi.org\/10.1007\/s10753-020-01369-9","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"23 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}