{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:10:48Z","timestamp":1792145448418,"version":"4.4.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10753-020-01384-w","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T19:12:31Z","timestamp":1609787551000},"page":"890-898","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tadalafil Alleviates LPS-Induced Inflammation and Oxidative Stress of RWPE-1 Cell by Regulating the Akt\/Nrf2 Signaling Pathway"],"prefix":"10.1007","volume":"44","author":[{"given":"Xiaoqing","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-7553","authenticated-orcid":false,"given":"Yun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"issue":"2","key":"1384_CR1","first-page":"9273","volume":"25","author":"TA Abdel-Meguid","year":"2018","unstructured":"Abdel-Meguid, T.A., H.A. Mosli, H. Farsi, A. Alsayyad, A. Tayib, M. Sait, and A. Abdelsalam. 2018. Treatment of refractory category III nonbacterial chronic prostatitis\/chronic pelvic pain syndrome with intraprostatic injection of onabotulinumtoxinA: a prospective controlled study. The Canadian Journal of Urology 25 (2): 9273\u20139280.","journal-title":"The Canadian Journal of Urology"},{"issue":"2","key":"1384_CR2","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/pcan.2016.8","volume":"19","author":"AS Polackwich","year":"2016","unstructured":"Polackwich, A.S., and D.A. Shoskes. 2016. Chronic prostatitis\/chronic pelvic pain syndrome: a review of evaluation and therapy. Prostate Cancer and Prostatic Diseases 19 (2): 132\u2013138.","journal-title":"Prostate Cancer and Prostatic Diseases"},{"key":"1384_CR3","first-page":"75","volume":"10","author":"G Paulis","year":"2018","unstructured":"Paulis, G. 2018. Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy. Res Rep Urol 10: 75\u201387.","journal-title":"Res Rep Urol"},{"key":"1384_CR4","doi-asserted-by":"publisher","first-page":"173313","DOI":"10.1016\/j.ejphar.2020.173313","volume":"882","author":"S Shimizu","year":"2020","unstructured":"Shimizu, S., Y. Nagao, T. Kataoka, S. Kamada, T. Shimizu, Y. Higashi, and M. Saito. 2020. Protective effects of tadalafil on prostatic hyperplasia in spontaneously hypertensive rats. European Journal of Pharmacology 882: 173313.","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"1384_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/iju.14122","volume":"27","author":"I Hiramatsu","year":"2020","unstructured":"Hiramatsu, I., A. Tsujimura, M. Soejima, A. Yoshiyama, Y. Nagashima, K. Ishikawa, Y. Uesaka, T. Nozaki, T. Ogishima, M. Shirai, I. Mitsuhashi, S. Sugimura, T. Mizuno, K. Noto, Y. Shigeta, J. Takasu, S. Honda, S. Iwata, and S. Horie. 2020. Tadalafil is sufficiently effective for severe chronic prostatitis\/chronic pelvic pain syndrome in patients with benign prostatic hyperplasia. International Journal of Urology 27 (1): 53\u201357.","journal-title":"International Journal of Urology"},{"issue":"6","key":"1384_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/jvp.12805","volume":"42","author":"N Dearakhshandeh","year":"2019","unstructured":"Dearakhshandeh, N., A. Mogheiseh, S. Nazifi, M.S. Ahrari Khafi, M. Abbaszadeh Hasiri, and K. Golchin-Rad. 2019. Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH-induced dogs with an anti-proliferative agent called tadalafil. Journal of Veterinary Pharmacology and Therapeutics 42 (6): 665\u2013672.","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"issue":"1","key":"1384_CR7","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12894-019-0525-x","volume":"19","author":"M Sugimoto","year":"2019","unstructured":"Sugimoto, M., X. Zhang, N. Ueda, H. Tsunemori, R. Taoka, Y. Hayashida, H. Hirama, Y. Miyauchi, Y. Matsuoka, H. Naito, Y. Osaki, and Y. Kekehi. 2019. A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis. BMC Urology 19 (1): 99.","journal-title":"BMC Urology"},{"issue":"4","key":"1384_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jphs.2019.10.005","volume":"141","author":"T Ogihara","year":"2019","unstructured":"Ogihara, T., T. Nakagawa, M. Hayashi, M. Koyanagi, A. Yonezawa, T. Omura, S. Nakagawa, N. Kitada, S. Imai, and K. Matsubara. 2019. Improvement of peripheral vascular impairment by a phosphodiesterase type 5 inhibitor tadalafil prevents oxaliplatin-induced peripheral neuropathy in mice. Journal of Pharmacological Sciences 141 (4): 131\u2013138.","journal-title":"Journal of Pharmacological Sciences"},{"key":"1384_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejphar.2017.06.010","volume":"810","author":"A Yamamura","year":"2017","unstructured":"Yamamura, A., E. Fujitomi, N. Ohara, K. Tsukamoto, M. Sato, and H. Yamamura. 2017. Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro. European Journal of Pharmacology 810: 44\u201350.","journal-title":"European Journal of Pharmacology"},{"issue":"19","key":"1384_CR10","doi-asserted-by":"publisher","first-page":"12014","DOI":"10.1074\/jbc.M114.615377","volume":"290","author":"HJ Lee","year":"2015","unstructured":"Lee, H.J., D. Feliers, M.M. Mariappan, K. Sataranatarajan, G.G. Choudhury, Y. Gorin, and B.S. Kasinath. 2015. Tadalafil integrates nitric oxide-hydrogen sulfide signaling to inhibit high glucose-induced matrix protein synthesis in podocytes. The Journal of Biological Chemistry 290 (19): 12014\u201312026.","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"1384_CR11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00011-017-1094-7","volume":"67","author":"FO Dos Santos Gomes","year":"2018","unstructured":"Dos Santos Gomes, F.O., et al. 2018. Intraurethral injection with LPS: an effective experimental model of prostatic inflammation. Inflammation Research 67 (1): 43\u201355.","journal-title":"Inflammation Research"},{"key":"1384_CR12","doi-asserted-by":"crossref","unstructured":"Locatelli, M., et al. 2018. Graminex pollen: phenolic pattern, colorimetric analysis and protective effects in immortalized prostate cells (PC3) and rat prostate challenged with LPS. Molecules (5): 23.","DOI":"10.3390\/molecules23051145"},{"issue":"9","key":"1384_CR13","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1080\/15384101.2019.1593644","volume":"18","author":"X Xu","year":"2019","unstructured":"Xu, X., J. Hou, J. Lv, Y. Huang, J. Pu, and L. Wang. 2019. Overexpression of lncRNA GAS5 suppresses prostatic epithelial cell proliferation by regulating COX-2 in chronic non-bacterial prostatitis. Cell Cycle 18 (9): 923\u2013931.","journal-title":"Cell Cycle"},{"issue":"3","key":"1384_CR14","doi-asserted-by":"publisher","first-page":"E21","DOI":"10.1097\/CNJ.0000000000000745","volume":"37","author":"A Smothers","year":"2020","unstructured":"Smothers, A., S. Young, and L. Constantine. 2020. Management of chronic nonbacterial prostatitis and chronic pelvic pain syndrome in the adult male patient with comorbid conditions. Journal of Christian Nursing 37 (3): E21\u2013E26.","journal-title":"Journal of Christian Nursing"},{"issue":"13","key":"1384_CR15","doi-asserted-by":"publisher","first-page":"21015","DOI":"10.18632\/oncotarget.15472","volume":"8","author":"L Xuanfei","year":"2017","unstructured":"Xuanfei, L., C. Hao, Y. Zhujun, L. Yanming, and G. Jianping. 2017. Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2\/3 signaling pathway. Oncotarget 8 (13): 21015\u201321030.","journal-title":"Oncotarget"},{"issue":"10","key":"1384_CR16","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1007\/s10495-015-1160-y","volume":"20","author":"F Rizvi","year":"2015","unstructured":"Rizvi, F., A. Mathur, and P. Kakkar. 2015. Morin mitigates acetaminophen-induced liver injury by potentiating Nrf2 regulated survival mechanism through molecular intervention in PHLPP2-Akt-Gsk3beta axis. Apoptosis 20 (10): 1296\u20131306.","journal-title":"Apoptosis"},{"key":"1384_CR17","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.reprotox.2020.06.015","volume":"96","author":"BA Abdel-Wahab","year":"2020","unstructured":"Abdel-Wahab, B.A., S.A. Alkahtani, and E.A.M. Elagab. 2020. Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2\/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male rats. Reproductive Toxicology 96: 165\u2013174.","journal-title":"Reproductive Toxicology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01384-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-020-01384-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01384-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T01:06:02Z","timestamp":1621559162000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-020-01384-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1384"],"URL":"https:\/\/doi.org\/10.1007\/s10753-020-01384-w","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"20 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patients Consent for Publication"}}]}}