{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:51:03Z","timestamp":1780429863783,"version":"3.54.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2951\/2014"],"award-info":[{"award-number":["2951\/2014"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10753-020-01385-9","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T20:02:57Z","timestamp":1606248177000},"page":"899-907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Morita-Baylis-Hillman Adduct 2-(3-Hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) Modulates Inflammatory Process In vitro and In vivo"],"prefix":"10.1007","volume":"44","author":[{"given":"Juliane Santos","family":"de Fran\u00e7a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marreiro","family":"de Sales-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyse Cristina Madruga","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ssia","family":"de Almeida Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayn\u00e1 Rodrigues","family":"Oleg\u00e1rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhuan Karlos Santos","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Gabriel","family":"Lima-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio Luiz Ara\u00fajo","family":"de Almeida Vasconcellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-7382","authenticated-orcid":false,"given":"Sandra","family":"Rodrigues-Mascarenhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"1385_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1600-065X.2008.00624.x","volume":"223","author":"WP Arend","year":"2008","unstructured":"Arend, W.P., G. Palmer, and C. Gabay. 2008. IL-1, IL-18, and IL-33 families of cytokines. Immunological Reviews 223: 20\u201338. https:\/\/doi.org\/10.1111\/j.1600-065X.2008.00624.x.","journal-title":"Immunological Reviews"},{"issue":"2","key":"1385_CR2","first-page":"158","volume":"4","author":"DC Badiu","year":"2011","unstructured":"Badiu, D.C., V. Paunescu, A. Aungurenci, and D. Pasarica. 2011. Proinflammatory cytokines in peritonitis. Journal of Medicine and Life 4 (2): 158\u2013162.","journal-title":"Journal of Medicine and Life"},{"issue":"3","key":"1385_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10555-006-9005-3","volume":"25","author":"F Balkwill","year":"2006","unstructured":"Balkwill, F. 2006. TNF-alpha in promotion and progression of cancer. Cancer Metastasis Reviews 25 (3): 409\u2013416. https:\/\/doi.org\/10.1007\/s10555-006-9005-3.","journal-title":"Cancer Metastasis Reviews"},{"issue":"Suppl 1","key":"1385_CR4","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1007\/s10875-012-9847-0","volume":"33","author":"J Candido","year":"2013","unstructured":"Candido, J., and T. Hagemann. 2013. Cancer-related inflammation. Journal of Clinical Immunology 33 (Suppl 1): S79\u2013S84. https:\/\/doi.org\/10.1007\/s10875-012-9847-0.","journal-title":"Journal of Clinical Immunology"},{"key":"1385_CR5","doi-asserted-by":"publisher","first-page":"1094520","DOI":"10.1155\/2019\/1094520","volume":"2019","author":"DCM Carvalho","year":"2019","unstructured":"Carvalho, D.C.M., L.H.A. Cavalcante-Silva, E.A. Lima, Galvao Jgfm, A.K.A. Alves, P.R.O. Feijo, L.E.M. Quintas, and S. Rodrigues-Mascarenhas. 2019. Marinobufagenin inhibits neutrophil migration and proinflammatory cytokines. Journal of Immunology Research 2019: 1094520\u20131094511. https:\/\/doi.org\/10.1155\/2019\/1094520.","journal-title":"Journal of Immunology Research"},{"key":"1385_CR6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0076-6879(09)05417-2","volume":"461","author":"JL Cash","year":"2009","unstructured":"Cash, J.L., G.E. White, and D.R. Greaves. 2009. Chapter 17. Zymosan-induced peritonitis as a simple experimental system for the study of inflammation. Methods in Enzymology 461: 379\u2013396. https:\/\/doi.org\/10.1016\/S0076-6879(09)05417-2.","journal-title":"Methods in Enzymology"},{"issue":"1","key":"1385_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","volume":"15","author":"Z Chen","year":"2019","unstructured":"Chen, Z., A. Bozec, A. Ramming, and G. Schett. 2019. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nature Reviews Rheumatology 15 (1): 9\u201317. https:\/\/doi.org\/10.1038\/s41584-018-0109-2.","journal-title":"Nature Reviews Rheumatology"},{"issue":"20","key":"1385_CR8","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1056\/NEJMp048253","volume":"351","author":"F Cominelli","year":"2004","unstructured":"Cominelli, F. 2004. Cytokine-based therapies for Crohn's disease--new paradigms. The New England Journal of Medicine 351 (20): 2045\u20132048. https:\/\/doi.org\/10.1056\/NEJMp048253.","journal-title":"The New England Journal of Medicine"},{"issue":"6917","key":"1385_CR9","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens, L.M., and Z. Werb. 2002. Inflammation and cancer. Nature 420 (6917): 860\u2013867. https:\/\/doi.org\/10.1038\/nature01322.","journal-title":"Nature"},{"issue":"10","key":"1385_CR10","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1007\/s00436-019-06403-w","volume":"118","author":"J da Camara Rocha","year":"2019","unstructured":"da Camara Rocha, J., K.A. da Franca Rodrigues, P.L. do Nascimento Neris, L.V. da Silva, F.S. Almeida, V.S. Lima, R.F. Peixoto, et al. 2019. Biological activity of Morita-Baylis-Hillman adduct homodimers in L. infantum and L. amazonensis: anti-Leishmania activity and cytotoxicity. Parasitology Research 118 (10): 3067\u20133076. https:\/\/doi.org\/10.1007\/s00436-019-06403-w.","journal-title":"Parasitology Research"},{"issue":"18","key":"1385_CR11","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.1016\/j.bmcl.2016.07.022","volume":"26","author":"WAV da Silva","year":"2016","unstructured":"da Silva, W.A.V., D.C. Rodrigues, R.G. de Oliveira, R.K.S. Mendes, T.R. Olegario, J.C. Rocha, T.S.L. Keesen, C.G. Lima-Junior, and Mlaa Vasconcellos. 2016. Synthesis and activity of novel homodimers of Morita-Baylis-Hillman adducts against Leishmania donovani: A twin drug approach. Bioorganic & Medicinal Chemistry Letters 26 (18): 4523\u20134526. https:\/\/doi.org\/10.1016\/j.bmcl.2016.07.022.","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"5","key":"1385_CR12","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/0090-6980(85)90006-1","volume":"30","author":"NS Doherty","year":"1985","unstructured":"Doherty, N.S., P. Poubelle, P. Borgeat, T.H. Beaver, G.L. Westrich, and N.L. Schrader. 1985. Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2. Prostaglandins 30 (5): 769\u2013789. https:\/\/doi.org\/10.1016\/0090-6980(85)90006-1.","journal-title":"Prostaglandins"},{"key":"1385_CR13","doi-asserted-by":"publisher","first-page":"6898505","DOI":"10.1155\/2017\/6898505","volume":"2017","author":"GV Faheina-Martins","year":"2017","unstructured":"Faheina-Martins, G.V., J.A. Leite, B.B. Dantas, C.G. Lima-Junior, Vasconcellos Mlaa, S. Rodrigues-Mascarenhas, and D.A.M. Araujo. 2017. Morita-Baylis-Hillman adducts display anti-inflammatory effects by modulating inflammatory mediator expression in RAW264.7 Cells. Mediators of Inflammation 2017: 6898505\u20136898509. https:\/\/doi.org\/10.1155\/2017\/6898505.","journal-title":"Mediators of Inflammation"},{"key":"1385_CR14","doi-asserted-by":"publisher","first-page":"9130979","DOI":"10.1155\/2016\/9130979","volume":"2016","author":"M Ghasemian","year":"2016","unstructured":"Ghasemian, M., S. Owlia, and M.B. Owlia. 2016. Review of anti-inflammatory herbal medicines. Advances in Pharmacological Sciences 2016: 9130979\u20139130911. https:\/\/doi.org\/10.1155\/2016\/9130979.","journal-title":"Advances in Pharmacological Sciences"},{"issue":"6","key":"1385_CR15","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/s1359-6101(03)00059-5","volume":"14","author":"RB Goodman","year":"2003","unstructured":"Goodman, R.B., J. Pugin, J.S. Lee, and M.A. Matthay. 2003. Cytokine-mediated inflammation in acute lung injury. Cytokine & Growth Factor Reviews 14 (6): 523\u2013535. https:\/\/doi.org\/10.1016\/s1359-6101(03)00059-5.","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"12","key":"1385_CR16","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","volume":"41","author":"Y He","year":"2016","unstructured":"He, Y., H. Hara, and G. Nunez. 2016. Mechanism and regulation of NLRP3 inflammasome activation. Trends in Biochemical Sciences 41 (12): 1012\u20131021. https:\/\/doi.org\/10.1016\/j.tibs.2016.09.002.","journal-title":"Trends in Biochemical Sciences"},{"key":"1385_CR17","unstructured":"Hillman, M, and ABUS Baylis. 1973. Reaction of acrylic type compounds with aldehydes and certain ketones: Google Patents."},{"issue":"1","key":"1385_CR18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/imr.12608","volume":"281","author":"MM Hughes","year":"2018","unstructured":"Hughes, M.M., and L.A.J. O'Neill. 2018. Metabolic regulation of NLRP3. Immunological Reviews 281 (1): 88\u201398. https:\/\/doi.org\/10.1111\/imr.12608.","journal-title":"Immunological Reviews"},{"key":"1385_CR19","doi-asserted-by":"publisher","first-page":"791060","DOI":"10.1155\/2015\/791060","volume":"2015","author":"N Inacio Pinto","year":"2015","unstructured":"Inacio Pinto, N., J. Carnier, L.M. Oyama, J.P. Otoch, P.S. Alcantara, F. Tokeshi, and C.M. Nascimento. 2015. Cancer as a proinflammatory environment: Metastasis and Cachexia. Mediators of Inflammation 2015: 791060\u2013791013. https:\/\/doi.org\/10.1155\/2015\/791060.","journal-title":"Mediators of Inflammation"},{"issue":"10","key":"1385_CR20","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/ni1112","volume":"5","author":"A Iwasaki","year":"2004","unstructured":"Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nature Immunology 5 (10): 987\u2013995. https:\/\/doi.org\/10.1038\/ni1112.","journal-title":"Nature Immunology"},{"issue":"12","key":"1385_CR21","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","volume":"18","author":"SA Jones","year":"2018","unstructured":"Jones, S.A., and B.J. Jenkins. 2018. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature Reviews. Immunology 18 (12): 773\u2013789. https:\/\/doi.org\/10.1038\/s41577-018-0066-7.","journal-title":"Nature Reviews. Immunology"},{"issue":"6","key":"1385_CR22","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s00011-007-7131-1","volume":"57","author":"E Kolaczkowska","year":"2008","unstructured":"Kolaczkowska, E., M. Barteczko, B. Plytycz, and B. Arnold. 2008. Role of lymphocytes in the course of murine zymosan-induced peritonitis. Inflammation Research 57 (6): 272\u2013278. https:\/\/doi.org\/10.1007\/s00011-007-7131-1.","journal-title":"Inflammation Research"},{"issue":"6","key":"1385_CR23","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.imbio.2009.07.001","volume":"215","author":"E Kolaczkowska","year":"2010","unstructured":"Kolaczkowska, Elzbieta, Agnieszka Koziol, Barbara Plytycz, and Bernd Arnold. 2010. Inflammatory macrophages, and not only neutrophils, die by apoptosis during acute peritonitis. Immunobiology 215 (6): 492\u2013504.","journal-title":"Immunobiology"},{"key":"1385_CR24","doi-asserted-by":"publisher","first-page":"265798","DOI":"10.1155\/2015\/265798","volume":"2015","author":"JA Leite","year":"2015","unstructured":"Leite, J.A., A.K. Alves, J.G. Galvao, M.P. Teixeira, L.H. Cavalcante-Silva, C. Scavone, A. Morrot, V.M. Rumjanek, and S. Rodrigues-Mascarenhas. 2015. Ouabain modulates zymosan-induced peritonitis in mice. Mediators of Inflammation 2015: 265798\u2013265712. https:\/\/doi.org\/10.1155\/2015\/265798.","journal-title":"Mediators of Inflammation"},{"issue":"13","key":"1385_CR25","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1016\/j.bmc.2012.04.061","volume":"20","author":"CG Lima-Junior","year":"2012","unstructured":"Lima-Junior, C.G., and M.L. Vasconcellos. 2012. Morita-Baylis-Hillman adducts: biological activities and potentialities to the discovery of new cheaper drugs. Bioorganic & Medicinal Chemistry 20 (13): 3954\u20133971. https:\/\/doi.org\/10.1016\/j.bmc.2012.04.061.","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"7","key":"1385_CR26","doi-asserted-by":"publisher","first-page":"602","DOI":"10.2174\/1573406412666160506150924","volume":"12","author":"CG Lima","year":"2016","unstructured":"Lima, C.G., G.V. Faheina-Martins, C.C. Bomfim, B.B. Dantas, E.P. Silva, D.A. Araujo, E.B. Filho, and M.L. Vasconcellos. 2016. Synthesis, cytotoxic activity on leukemia cell lines and quantitative structure-activity relationships (QSAR) studies of Morita-Baylis-Hillman adducts. Medicinal Chemistry 12 (7): 602\u2013612. https:\/\/doi.org\/10.2174\/1573406412666160506150924.","journal-title":"Medicinal Chemistry"},{"issue":"12","key":"1385_CR27","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1038\/ni1275","volume":"6","author":"AD Luster","year":"2005","unstructured":"Luster, A.D., R. Alon, and U.H. von Andrian. 2005. Immune cell migration in inflammation: present and future therapeutic targets. Nature Immunology 6 (12): 1182\u20131190. https:\/\/doi.org\/10.1038\/ni1275.","journal-title":"Nature Immunology"},{"issue":"1","key":"1385_CR28","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/imr.12615","volume":"281","author":"A Malik","year":"2018","unstructured":"Malik, A., and T.D. Kanneganti. 2018. Function and regulation of IL-1alpha in inflammatory diseases and cancer. Immunological Reviews 281 (1): 124\u2013137. https:\/\/doi.org\/10.1111\/imr.12615.","journal-title":"Immunological Reviews"},{"issue":"4","key":"1385_CR29","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/febs.14395","volume":"285","author":"A Mantovani","year":"2018","unstructured":"Mantovani, A. 2018. The inflammation - cancer connection. The FEBS Journal 285 (4): 638\u2013640. https:\/\/doi.org\/10.1111\/febs.14395.","journal-title":"The FEBS Journal"},{"issue":"7203","key":"1385_CR30","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani, A., P. Allavena, A. Sica, and F. Balkwill. 2008. Cancer-related inflammation. Nature 454 (7203): 436\u2013444. https:\/\/doi.org\/10.1038\/nature07205.","journal-title":"Nature"},{"issue":"1","key":"1385_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/imr.12614","volume":"281","author":"A Mantovani","year":"2018","unstructured":"Mantovani, A., I. Barajon, and C. Garlanda. 2018. IL-1 and IL-1 regulatory pathways in cancer progression and therapy. Immunological Reviews 281 (1): 57\u201361. https:\/\/doi.org\/10.1111\/imr.12614.","journal-title":"Immunological Reviews"},{"key":"1385_CR32","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/978-3-0348-0837-8_17","volume":"816","author":"GB Maru","year":"2014","unstructured":"Maru, G.B., K. Gandhi, A. Ramchandani, and G. Kumar. 2014. The role of inflammation in skin cancer. Advances in Experimental Medicine and Biology 816: 437\u2013469. https:\/\/doi.org\/10.1007\/978-3-0348-0837-8_17.","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"7203","key":"1385_CR33","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov, R. 2008. Origin and physiological roles of inflammation. Nature 454 (7203): 428\u2013435. https:\/\/doi.org\/10.1038\/nature07201.","journal-title":"Nature"},{"issue":"6","key":"1385_CR34","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","volume":"140","author":"R Medzhitov","year":"2010","unstructured":"Medzhitov, R. 2010. Inflammation 2010: new adventures of an old flame. Cell 140 (6): 771\u2013776. https:\/\/doi.org\/10.1016\/j.cell.2010.03.006.","journal-title":"Cell"},{"issue":"11","key":"1385_CR35","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1246\/bcsj.41.2815","volume":"41","author":"K-i Morita","year":"1968","unstructured":"Morita, Ken-ichi, Zennosuke Suzuki, and Hiromitsu Hirose. 1968. A tertiary phosphine-catalyzed reaction of acrylic compounds with aldehydes. Bulletin of the Chemical Society of Japan 41 (11): 2815\u20132815.","journal-title":"Bulletin of the Chemical Society of Japan"},{"issue":"1","key":"1385_CR36","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12199-018-0740-1","volume":"23","author":"M Murata","year":"2018","unstructured":"Murata, M. 2018. Inflammation and cancer. Environmental Health and Preventive Medicine 23 (1): 50. https:\/\/doi.org\/10.1186\/s12199-018-0740-1.","journal-title":"Environmental Health and Preventive Medicine"},{"issue":"6","key":"1385_CR37","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan, C., and A. Ding. 2010. Nonresolving inflammation. Cell 140 (6): 871\u2013882. https:\/\/doi.org\/10.1016\/j.cell.2010.02.029.","journal-title":"Cell"},{"issue":"8","key":"1385_CR38","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/ni.3790","volume":"18","author":"MG Netea","year":"2017","unstructured":"Netea, M.G., F. Balkwill, M. Chonchol, F. Cominelli, M.Y. Donath, E.J. Giamarellos-Bourboulis, D. Golenbock, M.S. Gresnigt, M.T. Heneka, H.M. Hoffman, R. Hotchkiss, L.A.B. Joosten, D.L. Kastner, M. Korte, E. Latz, P. Libby, T. Mandrup-Poulsen, A. Mantovani, K.H.G. Mills, K.L. Nowak, L.A. O'Neill, P. Pickkers, T. van der Poll, P.M. Ridker, J. Schalkwijk, D.A. Schwartz, B. Siegmund, C.J. Steer, H. Tilg, J.W.M. van der Meer, F.L. van de Veerdonk, and C.A. Dinarello. 2017. A guiding map for inflammation. Nature Immunology 18 (8): 826\u2013831. https:\/\/doi.org\/10.1038\/ni.3790.","journal-title":"Nature Immunology"},{"issue":"1","key":"1385_CR39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/ni.3320","volume":"17","author":"Y Okabe","year":"2016","unstructured":"Okabe, Y., and R. Medzhitov. 2016. Tissue biology perspective on macrophages. Nature Immunology 17 (1): 9\u201317. https:\/\/doi.org\/10.1038\/ni.3320.","journal-title":"Nature Immunology"},{"issue":"2","key":"1385_CR40","first-page":"692","volume":"9","author":"Q Pan","year":"2017","unstructured":"Pan, Q., J. Cai, Y. Peng, H. Xiao, L. Zhang, J. Chen, and H. Liu. 2017. Protective effect of a novel antibody against TLR2 on zymosan-induced acute peritonitis in NF-kappaB transgenic mice. American Journal of Translational Research 9 (2): 692\u2013699.","journal-title":"American Journal of Translational Research"},{"issue":"1","key":"1385_CR41","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/13880209.2018.1454480","volume":"56","author":"VP Ribeiro","year":"2018","unstructured":"Ribeiro, V.P., C. Arruda, M. Abd El-Salam, and J.K. Bastos. 2018. Brazilian medicinal plants with corroborated anti-inflammatory activities: a review. Pharmaceutical Biology 56 (1): 253\u2013268. https:\/\/doi.org\/10.1080\/13880209.2018.1454480.","journal-title":"Pharmaceutical Biology"},{"issue":"4","key":"1385_CR42","doi-asserted-by":"publisher","first-page":"e93936","DOI":"10.1371\/journal.pone.0093936","volume":"9","author":"JM Sandes","year":"2014","unstructured":"Sandes, J.M., A. Fontes, C.G. Regis-da-Silva, M.C. de Castro, C.G. Lima-Junior, F.P. Silva, M.L. Vasconcellos, and R.C. Figueiredo. 2014. Trypanosoma cruzi cell death induced by the Morita-Baylis-Hillman adduct 3-Hydroxy-2-methylene-3-(4-nitrophenylpropanenitrile). PLoS One 9 (4): e93936. https:\/\/doi.org\/10.1371\/journal.pone.0093936.","journal-title":"PLoS One"},{"issue":"5","key":"1385_CR43","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","volume":"1813","author":"J Scheller","year":"2011","unstructured":"Scheller, J., A. Chalaris, D. Schmidt-Arras, and S. Rose-John. 2011. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochimica et Biophysica Acta 1813 (5): 878\u2013888. https:\/\/doi.org\/10.1016\/j.bbamcr.2011.01.034.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"3","key":"1385_CR44","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.bpa.2003.12.002","volume":"18","author":"ER Sherwood","year":"2004","unstructured":"Sherwood, E.R., and T. Toliver-Kinsky. 2004. Mechanisms of the inflammatory response. Best Practice & Research. Clinical Anaesthesiology 18 (3): 385\u2013405. https:\/\/doi.org\/10.1016\/j.bpa.2003.12.002.","journal-title":"Best Practice & Research. Clinical Anaesthesiology"},{"key":"1385_CR45","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cbi.2013.11.019","volume":"209","author":"EA Socca","year":"2014","unstructured":"Socca, E.A., A. Luiz-Ferreira, F.M. de Faria, A.C. de Almeida, R.J. Dunder, L.P. Manzo, and A.R. Brito. 2014. Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats. Chemico-Biological Interactions 209: 48\u201355. https:\/\/doi.org\/10.1016\/j.cbi.2013.11.019.","journal-title":"Chemico-Biological Interactions"},{"key":"1385_CR46","doi-asserted-by":"publisher","unstructured":"Sousa, S.C., J.D. Rocha, T.S. Keesen, E.D. Silva, P.A. de Assis, J.P. de Oliveira, S.L. Capim, et al. 2017. Synthesis of 16 New hybrids from tetrahydropyrans derivatives and Morita-Baylis-Hillman adducts: in vitro screening against Leishmania donovani. Molecules 22 (2). https:\/\/doi.org\/10.3390\/molecules22020207.","DOI":"10.3390\/molecules22020207"},{"issue":"3-4","key":"1385_CR47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1515\/hc.2011.024","volume":"17","author":"Srihari","year":"2011","unstructured":"Srihari, Ejjirothu, Gangala Siva Kumar, Chebolu Naga Sesha Sai Pavan Kumar, Ratnesh Kumar Seth, Sukla Biswas, Balasubramanian Sridhar, and Vaidya Jayathirtha Rao. 2011. Synthesis and antimalarial activity of Baylis-Hillman adducts from substituted 2-chloroquinoline-3-carboxaldehydes. Heterocyclic Communications 17 (3-4): 111\u2013119.","journal-title":"Heterocyclic Communications"},{"issue":"3","key":"1385_CR48","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1179\/096805103125001586","volume":"9","author":"DM Underhill","year":"2003","unstructured":"Underhill, D.M. 2003. Macrophage recognition of zymosan particles. Journal of Endotoxin Research 9 (3): 176\u2013180. https:\/\/doi.org\/10.1179\/096805103125001586.","journal-title":"Journal of Endotoxin Research"},{"issue":"4","key":"1385_CR49","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s10753-018-0739-1","volume":"41","author":"ML Varela","year":"2018","unstructured":"Varela, M.L., M. Mogildea, I. Moreno, and A. Lopes. 2018. Acute inflammation and metabolism. Inflammation 41 (4): 1115\u20131127. https:\/\/doi.org\/10.1007\/s10753-018-0739-1.","journal-title":"Inflammation"},{"issue":"3","key":"1385_CR50","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/ps.1153","volume":"62","author":"ML Vasconcellos","year":"2006","unstructured":"Vasconcellos, M.L., T.M. Silva, C.A. Camara, R.M. Martins, K.M. Lacerda, H.M. Lopes, V.L. Pereira, R.O. de Souza, and L.T. Crespo. 2006. Baylis-Hillman adducts with molluscicidal activity against Biomphalaria glabrata. Pest Management Science 62 (3): 288\u2013292. https:\/\/doi.org\/10.1002\/ps.1153.","journal-title":"Pest Management Science"},{"issue":"2","key":"1385_CR51","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nrn3638","volume":"15","author":"JG Walsh","year":"2014","unstructured":"Walsh, J.G., D.A. Muruve, and C. Power. 2014. Inflammasomes in the CNS. Nature Reviews. Neuroscience 15 (2): 84\u201397. https:\/\/doi.org\/10.1038\/nrn3638.","journal-title":"Nature Reviews. Neuroscience"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01385-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-020-01385-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01385-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T05:04:12Z","timestamp":1621573452000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-020-01385-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1385"],"URL":"https:\/\/doi.org\/10.1007\/s10753-020-01385-9","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]},"assertion":[{"value":"29 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures adopted in this study were approved by the Universidade Federal da Para\u00edba Animal Use Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publication"}}]}}