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The increase of airway smooth muscle (ASM) mass is a fundamental component of bronchial remodeling in AA, yet the pathophysiological mechanisms and clinical outcomes associated with ASM modulation are still elusive. The objective of this study is to compare the expression level of \u03b2-dystroglycan (\u03b2-DG) in ASM in AA subjects and a healthy control group and to investigate the relationship between eosinophils and \u03b2-DG in ASM in patients with AA. Thirteen AA patients and seven control subjects were analyzed for the ASM area and eosinophil cells. Bronchial biopsies were stained by \u03b2-DG and eosinophil cationic protein (ECP) using immunohistochemistry. The proportion of ASM with \u03b2-DG staining was greater in those with AA than in the healthy control group (mean (95% CI) (28.3% (23.8\u201332.7%) <jats:italic>vs.<\/jats:italic> 16.4% (14.1\u201318.5%), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The number of ECP positive cells was higher in patients with AA than in the control group (4056 (3819\u20134296) <jats:italic>vs.<\/jats:italic> 466 (395\u2013537) cells\/mm<jats:sup>2<\/jats:sup><jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). In AA, the number of ECP positive cells was significantly correlated to the \u03b2-DG expression in ASM (<jats:italic>r<\/jats:italic>\u2009=\u20090.77, <jats:italic>P<\/jats:italic>\u2009=\u20090.002). There is an increased \u03b2-DG expression in ASM and a higher number of ECP positive cells in the bronchial biopsy of those with AA than those in the control group. The increased expression of \u03b2-DG in ASM in AA subjects correlates with the number of eosinophils, suggesting a role for this cell in airway remodeling in AA.<\/jats:p>","DOI":"10.1007\/s10753-020-01401-y","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T08:15:19Z","timestamp":1612944919000},"page":"1060-1068","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association Between \u03b2-Dystroglycan in Airway Smooth Muscle and Eosinophils in Allergic Asthma"],"prefix":"10.1007","volume":"44","author":[{"given":"Suhayla H.","family":"Shareef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-874X","authenticated-orcid":false,"given":"Kawa","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Janson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"1401_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mrfmmm.2009.09.005","volume":"690","author":"JR Murdoch","year":"2010","unstructured":"Murdoch, J.R., and C.M. 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Science translational medicine 2015, 7:284ra260\u2013284ra260.","DOI":"10.1126\/scitranslmed.aaa0282"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01401-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-020-01401-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-020-01401-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T05:14:40Z","timestamp":1674969280000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-020-01401-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1401"],"URL":"https:\/\/doi.org\/10.1007\/s10753-020-01401-y","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"type":"print","value":"0360-3997"},{"type":"electronic","value":"1573-2576"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"8 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The study conformed to the Declaration of Helsinki and was approved by the ethics committee at the Faculty of Medicine at the University of Uppsala (Dnr 93\/364). Written informed consent was obtained from each participant and bronchial biopsies were taken according to the guidelines of the local ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}