{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:53:41Z","timestamp":1792727621325,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s10753-021-01492-1","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T20:03:23Z","timestamp":1622750603000},"page":"2193-2202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Vanillin Attenuates Cadmium-Induced Lung Injury Through Inhibition of Inflammation and Lung Barrier Dysfunction Through Activating AhR"],"prefix":"10.1007","volume":"44","author":[{"given":"Xueshibojie","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-3211","authenticated-orcid":false,"given":"Chengbi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"1492_CR1","doi-asserted-by":"publisher","first-page":"15754","DOI":"10.1074\/jbc.RA120.013632","volume":"295","author":"JL Larson-Casey","year":"2020","unstructured":"Larson-Casey, J.L., L.L. Gu, O. Fiehn, and A.B. Carter. 2020. Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages. Journal of Biological Chemistry 295: 15754\u201315766.","journal-title":"Journal of Biological Chemistry"},{"key":"1492_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00595-005-3124-2","volume":"36","author":"CS Ng","year":"2006","unstructured":"Ng, C.S., S. Wan, A.A. Arifi, and A.P. Yim. 2006. Inflammatory response to pulmonary ischemia-reperfusion injury. Surgery Today 36: 205\u2013214.","journal-title":"Surgery Today"},{"key":"1492_CR3","doi-asserted-by":"publisher","first-page":"136300","DOI":"10.1016\/j.scitotenv.2019.136300","volume":"710","author":"C Tao","year":"2020","unstructured":"Tao, C., Y.X. Pei, L. Zhang, and Y.M. Zhang. 2020. Microbial communities respond to microenvironments in lungs of mice under simulated exposure to cadmium aerosols. Science of the Total Environment 710: 136300.","journal-title":"Science of the Total Environment"},{"key":"1492_CR4","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1097\/00003246-200001000-00039","volume":"28","author":"E Abraham","year":"2000","unstructured":"Abraham, E., M.A. Matthay, C.A. Dinarello, J.L. Vincent, J. Cohen, S.M. Opal, M. Glauser, P. Parsons, C.J. Fisher Jr., and J.E. Repine. 2000. Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Critical Care Medicine 28: 232\u2013235.","journal-title":"Critical Care Medicine"},{"key":"1492_CR5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0749-0704(05)70111-1","volume":"16","author":"AM Fein","year":"2000","unstructured":"Fein, A.M., and M.G. Calalang-Colucci. 2000. Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Critical Care Clinics 16: 289\u2013317.","journal-title":"Critical Care Clinics"},{"key":"1492_CR6","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1055\/s-2006-948288","volume":"27","author":"LB Ware","year":"2006","unstructured":"Ware, L.B. 2006. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Seminars in Respiratory and Critical Care Medicine 27: 337\u2013349.","journal-title":"Seminars in Respiratory and Critical Care Medicine"},{"key":"1492_CR7","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1056\/NEJMoa051693","volume":"354","author":"KP Steinberg","year":"2006","unstructured":"Steinberg, K.P., L.D. Hudson, R.B. Goodman, C.L. Hough, P.N. Lanken, R. Hyzy, B.T. Thompson, M. Ancukiewicz, and L. National Heart. 2006. Blood Institute Acute Respiratory Distress Syndrome Clinical Trials N: Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. The New England Journal of Medicine 354: 1671\u20131684.","journal-title":"The New England Journal of Medicine"},{"key":"1492_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/0002-9343(85)90361-4","volume":"78","author":"RA Garibaldi","year":"1985","unstructured":"Garibaldi, R.A. 1985. Epidemiology of community-acquired respiratory tract infections in adults. Incidence, etiology, and impact. The American Journal of Medicine 78: 32\u201337.","journal-title":"The American Journal of Medicine"},{"key":"1492_CR9","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrmicro3231","volume":"12","author":"JA McCullers","year":"2014","unstructured":"McCullers, J.A. 2014. The co-pathogenesis of influenza viruses with bacteria in the lung. Nature Reviews. Microbiology 12: 252\u2013262.","journal-title":"Nature Reviews. Microbiology"},{"key":"1492_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"YC Lu","year":"2008","unstructured":"Lu, Y.C., W.C. Yeh, and P.S. Ohashi. 2008. LPS\/TLR4 signal transduction pathway. Cytokine 42: 145\u2013151.","journal-title":"Cytokine"},{"key":"1492_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/path.1491","volume":"202","author":"M Bhatia","year":"2004","unstructured":"Bhatia, M., and S. Moochhala. 2004. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. The Journal of Pathology 202: 145\u2013156.","journal-title":"The Journal of Pathology"},{"key":"1492_CR12","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.seppur.2009.02.010","volume":"66","author":"MNM Ibrahim","year":"2009","unstructured":"Ibrahim, M.N.M., C.S. Sipaut, and N.N.M. Yusof. 2009. Purification of vanillin by a molecular imprinting polymer technique. Separation and Purification Technology 66: 450\u2013456.","journal-title":"Separation and Purification Technology"},{"key":"1492_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.taap.2018.12.022","volume":"365","author":"WJ Guo","year":"2019","unstructured":"Guo, W.J., B.R. Liu, G.Q. Hu, X.C. Kan, Y.W. Li, Q. Gong, D.W. Xu, H. Ma, Y. Cao, B.X. Huang, S. Fu, and J. Liu. 2019. Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice. Toxicology and Applied Pharmacology 365: 9\u201318.","journal-title":"Toxicology and Applied Pharmacology"},{"key":"1492_CR14","doi-asserted-by":"crossref","unstructured":"Yan, X., D.F. Liu, X.Y. Zhang, D. Liu, S.Y. Xu, G.X. Chen, B.X. Huang, W.Z. Ren, W. Wang, S.P. Fu, and J.X. Liu. 2017. Vanillin protects dopaminergic neurons against inflammation-mediated cell death by inhibiting ERK1\/2, P38 and the NF-kappa B signaling pathway. International Journal of Molecular Sciences 18.","DOI":"10.3390\/ijms18020389"},{"key":"1492_CR15","doi-asserted-by":"publisher","first-page":"113021","DOI":"10.1016\/j.envpol.2019.113021","volume":"254","author":"C Wang","year":"2019","unstructured":"Wang, C., Z. Wei, Z. Han, J. Wang, X. Zhang, Y. Wang, Q. Liu, and Z. Yang. 2019. Neutrophil extracellular traps promote cadmium chloride-induced lung injury in mice. Environmental Pollution 254: 113021.","journal-title":"Environmental Pollution"},{"key":"1492_CR16","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S0889-1591(03)00048-5","volume":"17","author":"PH Black","year":"2003","unstructured":"Black, P.H. 2003. The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain, Behavior, and Immunity 17: 350\u2013364.","journal-title":"Brain, Behavior, and Immunity"},{"key":"1492_CR17","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan, C., and A.H. Ding. 2010. Nonresolving Inflammation. Cell 140: 871\u2013882.","journal-title":"Cell"},{"key":"1492_CR18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02914538","volume":"9","author":"M Berger","year":"1991","unstructured":"Berger, M. 1991. Inflammation in the lung in cystic-fibrosis - a vicious cycle that does more harm than good. Clinical Reviews in Allergy 9: 119\u2013142.","journal-title":"Clinical Reviews in Allergy"},{"key":"1492_CR19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cyto.2004.05.008","volume":"30","author":"CC Hessle","year":"2005","unstructured":"Hessle, C.C., B. Andersson, and A.E. Wold. 2005. Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes. Cytokine 30: 311\u2013318.","journal-title":"Cytokine"},{"key":"1492_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1023\/B:BIRY.0000016344.59411.ee","volume":"69","author":"J Arnhold","year":"2004","unstructured":"Arnhold, J. 2004. Free radicals - friends or foes? - Properties, functions, and secretion of human myeloperoxidase. Biochemistry-Moscow 69: 4\u20139.","journal-title":"Biochemistry-Moscow"},{"key":"1492_CR21","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/cr.2009.137","volume":"20","author":"FY Wan","year":"2010","unstructured":"Wan, F.Y., and M.J. Lenardo. 2010. The nuclear signaling of NF-kappa B: current knowledge, new insights, and future perspectives. Cell Research 20: 24\u201333.","journal-title":"Cell Research"},{"key":"1492_CR22","doi-asserted-by":"publisher","first-page":"48928","DOI":"10.1074\/jbc.M304802200","volume":"278","author":"N Silverman","year":"2003","unstructured":"Silverman, N., R. Zhou, R.L. Erlich, M. Hunter, E. Bernstein, D. Schneider, and T. Maniatis. 2003. Immune activation of NF-kappa B and JNK requires Drosophila TAK1. Journal of Biological Chemistry 278: 48928\u201348934.","journal-title":"Journal of Biological Chemistry"},{"key":"1492_CR23","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.3168\/jds.2015-10330","volume":"99","author":"JJ Wang","year":"2016","unstructured":"Wang, J.J., C.M. Guo, Z.K. Wei, X.X. He, J.H. Kou, E.S. Zhou, Z.T. Yang, and Y.H. Fu. 2016. Morin suppresses inflammatory cytokine expression by downregulation of nuclear factor-kappa B and mitogen-activated protein kinase (MAPK) signaling pathways in lipopolysaccharide-stimulated primary bovine mammary epithelial cells. Journal of Dairy Science 99: 3016\u20133022.","journal-title":"Journal of Dairy Science"},{"key":"1492_CR24","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1359-6101(02)00026-6","volume":"13","author":"T Hanada","year":"2002","unstructured":"Hanada, T., and A. Yoshimura. 2002. Regulation of cytokine signaling and inflammation. Cytokine & Growth Factor Reviews 13: 413\u2013421.","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"1492_CR25","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1182\/blood-2004-12-4709","volume":"106","author":"S Appel","year":"2005","unstructured":"Appel, S., V. Mirakaj, A. Bringmann, M.M. Weck, F. Grunebach, and P. Brossart. 2005. PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways. Blood 106: 3888\u20133894.","journal-title":"Blood"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01492-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01492-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01492-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T18:21:00Z","timestamp":1672338060000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-021-01492-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1492"],"URL":"https:\/\/doi.org\/10.1007\/s10753-021-01492-1","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]},"assertion":[{"value":"10 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the experimental protocols in this study were approved by the Institutional Animal Care and Use Committee of Jilin University. All authors consent to participate this research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"<b>A<\/b>ll authors consent to publish this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}