{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:53:57Z","timestamp":1767970437277,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The Key Project of Natural Science of Colleges and Universities in Anhui Province","award":["grant no. KJ2019A0365"],"award-info":[{"award-number":["grant no. KJ2019A0365"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s10753-021-01517-9","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T23:05:02Z","timestamp":1630105502000},"page":"2476-2485","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Recombinant IL-35-BCG on Treg\/Th17 Cell Imbalance and Inflammatory Response in Asthmatic Newborn Mice Induced by RSV"],"prefix":"10.1007","volume":"44","author":[{"given":"Wansheng","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1963-8883","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"1517_CR1","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3389\/fimmu.2018.01249","volume":"9","author":"KH Restori","year":"2018","unstructured":"Restori, K.H., B.T. Srinivasa, B.J. Ward, and E.D. Fixman. 2018. Neonatal immunity, respiratory virus infections, and the development of asthma. Frontiers in Immunology 9: 1249.","journal-title":"Frontiers in Immunology"},{"key":"1517_CR2","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1093\/aje\/kwt248","volume":"178","author":"L Huang","year":"2013","unstructured":"Huang, L., Y. Bao, Z. Xu, et al. 2013. Neonatal bilirubin levels and childhood asthma in the US Collaborative Perinatal Project, 1959\u20131965. American Journal of Epidemiology 178: 1691\u20131697.","journal-title":"American Journal of Epidemiology"},{"key":"1517_CR3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/all.13039","volume":"72","author":"M Pollock","year":"2017","unstructured":"Pollock, M., I.P. Sinha, L. Hartling, B.H. Rowe, S. Schreiber, and R.M. Fernandes. 2017. Inhaled short-acting bronchodilators for managing emergency childhood asthma: An overview of reviews. Allergy 72: 183\u2013200.","journal-title":"Allergy"},{"key":"1517_CR4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.arbres.2015.11.008","volume":"52","author":"ML Garcia-Garcia","year":"2016","unstructured":"Garcia-Garcia, M.L., C. Calvo Rey, and Rabes T. Del Rosal. 2016. Pediatric asthma and viral infection. Archivos de Bronconeumologia 52: 269\u2013273.","journal-title":"Archivos de Bronconeumologia"},{"key":"1517_CR5","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1038\/nm.2896","volume":"18","author":"N Krishnamoorthy","year":"2012","unstructured":"Krishnamoorthy, N., A. Khare, T.B. Oriss, et al. 2012. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nature Medicine 18: 1525\u20131530.","journal-title":"Nature Medicine"},{"key":"1517_CR6","doi-asserted-by":"crossref","unstructured":"Zomer-Kooijker, K.,\u00a0 C.K. van der Ent, M.J. Ermers, et al. 2014. Increased risk of wheeze and decreased lung function after respiratory syncytial virus infection. PLoS One 9: e87162.","DOI":"10.1371\/journal.pone.0087162"},{"key":"1517_CR7","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1099\/jmm.0.000959","volume":"68","author":"L Qin","year":"2019","unstructured":"Qin, L., K. Qiu, C. Hu, L. Wang, G. Wu, and Y. Tan. 2019. Respiratory syncytial virus promoted the differentiation of Th17 cells in airway microenvironment through activation of Notch-1\/Delta3. Journal of Medical Microbiology 68: 649\u2013656.","journal-title":"Journal of Medical Microbiology"},{"key":"1517_CR8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/all.13661","volume":"74","author":"MJ Kim","year":"2019","unstructured":"Kim, M.J., D.H. Shim, H.R. Cha, et al. 2019. Chitinase 3-like 1 protein plays a critical role in respiratory syncytial virus-induced airway inflammation. Allergy 74: 685\u2013697.","journal-title":"Allergy"},{"key":"1517_CR9","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1080\/21645515.2017.1334026","volume":"13","author":"E Rey-Jurado","year":"2017","unstructured":"Rey-Jurado, E., J. Soto, N. Galvez, and A.M. Kalergis. 2017. A safe and efficient BCG vectored vaccine to prevent the disease caused by the human Respiratory Syncytial Virus. Human Vaccines & Immunotherapeutics 13: 2092\u20132097.","journal-title":"Human Vaccines & Immunotherapeutics"},{"key":"1517_CR10","doi-asserted-by":"publisher","first-page":"668","DOI":"10.7150\/ijms.12233","volume":"12","author":"SS Park","year":"2015","unstructured":"Park, S.S., E.Y. Heo, D.K. Kim, H.S. Chung, and C.H. Lee. 2015. The association of BCG vaccination with atopy and asthma in adults. International Journal of Medical Sciences 12: 668\u2013673.","journal-title":"International Journal of Medical Sciences"},{"key":"1517_CR11","doi-asserted-by":"crossref","unstructured":"Liang, P., S. Peng, M. Zhang, Y. Ma, X. Zhen, and H. Li. 2017. Huai Qi Huang corrects the balance of Th1\/Th2 and Treg\/Th17 in an ovalbumin-induced asthma mouse model. Bioscience reports\u00a037.","DOI":"10.1042\/BSR20171071"},{"key":"1517_CR12","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1016\/j.vaccine.2014.02.007","volume":"32","author":"Y Deng","year":"2014","unstructured":"Deng, Y., W. Li, Y. Luo, et al. 2014. Inhibition of IFN-gamma promotes anti-asthma effect of Mycobacterium bovis Bacillus Calmette-Guerin neonatal vaccination: A murine asthma model. Vaccine 32: 2070\u20132078.","journal-title":"Vaccine"},{"key":"1517_CR13","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jim.2014.03.005","volume":"406","author":"AF Christiaansen","year":"2014","unstructured":"Christiaansen, A.F., P.M. Boggiatto, and S.M. Varga. 2014. Limitations of Foxp3(+) Treg depletion following viral infection in DEREG mice. Journal of Immunological Methods 406: 58\u201365.","journal-title":"Journal of Immunological Methods"},{"key":"1517_CR14","doi-asserted-by":"publisher","first-page":"616","DOI":"10.3389\/fimmu.2019.00616","volume":"10","author":"M Asad","year":"2019","unstructured":"Asad, M., A. Sabur, M. Shadab, et al. 2019. EB1-3 Chain of IL-35 Along with TGF-beta synergistically regulate anti-leishmanial immunity. Frontiers in Immunology 10: 616.","journal-title":"Frontiers in Immunology"},{"key":"1517_CR15","doi-asserted-by":"crossref","unstructured":"Liu, X., H. Hu, H. Fan, et al. 2017. The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells. Medicine (Baltimore) 96: e6615.","DOI":"10.1097\/MD.0000000000006615"},{"key":"1517_CR16","doi-asserted-by":"crossref","unstructured":"Liu, W., S. Liu, M. Verma, et al. 2017. Mechanism of TH2\/TH17-predominant and neutrophilic TH2\/TH17-low subtypes of asthma. Journal of Allergy Clinical Immunology 139: 1548\u20131558 e1544.","DOI":"10.1016\/j.jaci.2016.08.032"},{"key":"1517_CR17","doi-asserted-by":"crossref","unstructured":"Wacleche, V.S., A. Landay, J.P. Routy, and P. Ancuta. 2017. The Th17 lineage: from barrier surfaces homeostasis to autoimmunity, cancer, and HIV-1 pathogenesis. Viruses 9.","DOI":"10.3390\/v9100303"},{"key":"1517_CR18","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.immuni.2016.01.008","volume":"44","author":"WJ Chae","year":"2016","unstructured":"Chae, W.J., A.K. Ehrlich, P.Y. Chan, et al. 2016. The Wnt antagonist Dickkopf-1 promotes pathological type 2 cell-mediated inflammation. Immunity 44: 246\u2013258.","journal-title":"Immunity"},{"key":"1517_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/01902148.2019.1611972","volume":"45","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y., S. Li, S. Huang, et al. 2019. IL33\/ST2 contributes to airway remodeling via p-JNK MAPK\/STAT3 signaling pathway in OVA-induced allergic airway inflammation in mice. Experimental Lung Research 45: 65\u201375.","journal-title":"Experimental Lung Research"},{"key":"1517_CR20","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.4155\/fmc.15.132","volume":"7","author":"A Kumar","year":"2015","unstructured":"Kumar, A., U.K. Singh, S.G. Kini, et al. 2015. JNK pathway signaling: A novel and smarter therapeutic targets for various biological diseases. Future Medicinal Chemistry 7: 2065\u20132086.","journal-title":"Future Medicinal Chemistry"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01517-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01517-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01517-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T17:37:29Z","timestamp":1638293849000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-021-01517-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,28]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1517"],"URL":"https:\/\/doi.org\/10.1007\/s10753-021-01517-9","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,28]]},"assertion":[{"value":"17 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by ethics committee of The First Affiliated Hospital of Bengbu Medical College. All of the procedures were in compliance with The National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}