{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:53:31Z","timestamp":1792850011352,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991500"],"award-info":[{"award-number":["81991500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991503"],"award-info":[{"award-number":["81991503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine","award":["JYJC201904"],"award-info":[{"award-number":["JYJC201904"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18ZR1422400"],"award-info":[{"award-number":["18ZR1422400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovative Research Team on High-level Local Universities in Shanghai","award":["SSMU-ZDCX20180900"],"award-info":[{"award-number":["SSMU-ZDCX20180900"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s10753-021-01522-y","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T01:47:35Z","timestamp":1634089655000},"page":"2531-2542","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["The miR-223-3p Regulates Pyroptosis Through NLRP3-Caspase 1-GSDMD Signal Axis in Periodontitis"],"prefix":"10.1007","volume":"44","author":[{"given":"Yiru","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kecong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9458-7003","authenticated-orcid":false,"given":"Yufeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"1522_CR1","doi-asserted-by":"crossref","unstructured":"Jeppesen, D.K., A.M. Fenix, J.L. Franklin, J.N. Higginbotham, Q. Zhang, L.J. Zimmerman, D.C. Liebler, J. Ping, Q. Liu, R. Evans, W.H. Fissell, J.G. Patton, L.H. Rome, D.T. Burnette, and R.J. Coffey. 2019. Reassessment of exosome composition. Cell 177 (2).","DOI":"10.1016\/j.cell.2019.02.029"},{"key":"1522_CR2","doi-asserted-by":"crossref","unstructured":"Mathieu, M., L. Martin-Jaular, G. Lavieu, and C. Th\u00e9ry. 2019. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nature cell biology 21 (1).","DOI":"10.1038\/s41556-018-0250-9"},{"issue":"6","key":"1522_CR3","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi, H., K. Ekstr\u00f6m, A. Bossios, M. Sj\u00f6strand, J.J. Lee, and J.O. L\u00f6tvall. 2007. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature cell biology 9 (6): 654\u2013659.","journal-title":"Nature cell biology"},{"issue":"3","key":"1522_CR4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.devcel.2019.04.011","volume":"49","author":"I Wortzel","year":"2019","unstructured":"Wortzel, I., S. Dror, C.M. Kenific, and D. Lyden. 2019. Exosome-mediated metastasis: Communication from a distance. Developmental cell 49 (3): 347\u2013360.","journal-title":"Developmental cell"},{"issue":"6","key":"1522_CR5","doi-asserted-by":"publisher","first-page":"633","DOI":"10.7150\/ijbs.25018","volume":"14","author":"Y Han","year":"2018","unstructured":"Han, Y., L. Jia, Y. Zheng, and W. Li. 2018. Salivary exosomes: Emerging roles in systemic disease. International journal of biological sciences 14 (6): 633\u2013643.","journal-title":"International journal of biological sciences"},{"issue":"1","key":"1522_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s00432-015-2005-3","volume":"142","author":"A Zlotogorski-Hurvitz","year":"2016","unstructured":"Zlotogorski-Hurvitz, A., D. Dayan, G. Chaushu, T. Salo, and M. Vered. 2016. Morphological and molecular features of oral fluid-derived exosomes: Oral cancer patients versus healthy individuals. Journal of cancer research and clinical oncology 142 (1): 101\u2013110.","journal-title":"Journal of cancer research and clinical oncology"},{"key":"1522_CR7","doi-asserted-by":"crossref","unstructured":"Aqrawi, L.A., H.K. Galtung, B. Vestad, R. \u00d8vsteb\u00f8, B. Thiede, S. Rusthen, A. Young, E.M. Guerreiro, T.P. Utheim, X. Chen, A. Utheim \u00d8, \u00d8. Palm, and J.L. Jensen. 2017. Identification of potential saliva and tear biomarkers in primary Sj\u00f6gren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis. Arthritis Research and Therapy 19 (1): p. 14.","DOI":"10.1186\/s13075-017-1228-x"},{"issue":"1","key":"1522_CR8","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"C He","year":"2018","unstructured":"He, C., S. Zheng, Y. Luo, and B. Wang. 2018. Exosome theranostics: Biology and translational medicine. Theranostics 8 (1): 237\u2013255.","journal-title":"Theranostics"},{"issue":"1","key":"1522_CR9","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.1038\/s41598-018-23338-x","volume":"8","author":"Y Jin","year":"2018","unstructured":"Jin, Y., Y. Takeda, Y. Kondo, L.P. Tripathi, S. Kang, H. Takeshita, H. Kuhara, Y. Maeda, M. Higashiguchi, K. Miyake, O. Morimura, T. Koba, Y. Hayama, S. Koyama, K. Nakanishi, T. Iwasaki, S. Tetsumoto, K. Tsujino, M. Kuroyama, K. Iwahori, H. Hirata, T. Takimoto, M. Suzuki, I. Nagatomo, K. Sugimoto, Y. Fujii, H. Kida, K. Mizuguchi, M. Ito, T. Kijima, H. Rakugi, E. Mekada, I. Tachibana, and A. Kumanogoh. 2018. Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging. Science and Reports 8 (1): 5145.","journal-title":"Science and Reports"},{"key":"1522_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.oraloncology.2018.07.001","volume":"84","author":"S Nair","year":"2018","unstructured":"Nair, S., K.D. Tang, L. Kenny, and C. Punyadeera. 2018. Salivary exosomes as potential biomarkers in cancer. Oral Oncology 84: 31\u201340.","journal-title":"Oral Oncology"},{"key":"1522_CR11","doi-asserted-by":"crossref","unstructured":"Slots, J. 2017. Periodontitis: facts, fallacies and the future. Periodontology 2000 75 (1).","DOI":"10.1111\/prd.12221"},{"key":"1522_CR12","doi-asserted-by":"crossref","unstructured":"K\u00f6n\u00f6nen, E., M. Gursoy, and U.K. Gursoy.2019.Periodontitis: a multifaceted disease of tooth-supporting tissues. Journal of clinical medicine 8 (8).","DOI":"10.3390\/jcm8081135"},{"issue":"4","key":"1522_CR13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/jre.12733","volume":"55","author":"K Aral","year":"2020","unstructured":"Aral, K., M.R. Milward, Y. Kapila, A. Berdeli, and P.R. Cooper. 2020. Inflammasomes and their regulation in periodontal disease: A review. Journal of Periodontal Research 55 (4): 473\u2013487.","journal-title":"Journal of Periodontal Research"},{"key":"1522_CR14","doi-asserted-by":"crossref","unstructured":"Aral, K., E. Berdeli, P.R. Cooper, M.R. Milward, Y. Kapila, B. Karadede \u00dcnal, C.A. Aral, and A. Berdeli. 2020. Differential expression of inflammasome regulatory transcripts in periodontal disease. Journal of Periodontology 91 (5): p. 606\u2013616.","DOI":"10.1002\/JPER.19-0222"},{"key":"1522_CR15","doi-asserted-by":"crossref","unstructured":"Aral, K., M.R. Milward, and P.R. Cooper. 2020. Inflammasome dysregulation in human gingival fibroblasts in response to periodontal pathogens. Oral Diseases.","DOI":"10.1111\/odi.13760"},{"issue":"9","key":"1522_CR16","doi-asserted-by":"publisher","first-page":"6393","DOI":"10.1002\/jcp.26521","volume":"233","author":"K Naruishi","year":"2018","unstructured":"Naruishi, K., and T. Nagata. 2018. Biological effects of interleukin-6 on gingival fibroblasts: Cytokine regulation in periodontitis. Journal of Cellular Physiology 233 (9): 6393\u20136400.","journal-title":"Journal of Cellular Physiology"},{"issue":"12","key":"1522_CR17","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","volume":"122","author":"A Grebe","year":"2018","unstructured":"Grebe, A., F. Hoss, and E. Latz. 2018. NLRP3 Inflammasome and the IL-1 pathway in atherosclerosis. Circulation Research 122 (12): 1722\u20131740.","journal-title":"Circulation Research"},{"issue":"6","key":"1522_CR18","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.archoralbio.2015.03.005","volume":"60","author":"F Xue","year":"2015","unstructured":"Xue, F., R. Shu, and Y. Xie. 2015. The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry. Archives of Oral Biology 60 (6): 948\u2013958.","journal-title":"Archives of Oral Biology"},{"issue":"11","key":"1522_CR19","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1177\/0022034520933533","volume":"99","author":"Y Zang","year":"2020","unstructured":"Zang, Y., J.H. Song, S.H. Oh, J.W. Kim, M.N. Lee, X. Piao, J.W. Yang, O.S. Kim, T.S. Kim, S.H. Kim, and J.T. Koh. 2020. Targeting NLRP3 inflammasome reduces age-related experimental alveolar bone loss. Journal of Dental Research 99 (11): 1287\u20131295.","journal-title":"Journal of Dental Research"},{"issue":"8","key":"1522_CR20","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson, K.V., M. Deng, and J.P. Ting. 2019. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nature Reviews Immunology 19 (8): 477\u2013489.","journal-title":"Nature Reviews Immunology"},{"issue":"13","key":"1522_CR21","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.1016\/j.celrep.2017.12.018","volume":"21","author":"KS Schneider","year":"2017","unstructured":"Schneider, K.S., C.J. Gro\u00df, R.F. Dreier, B.S. Saller, R. Mishra, O. Gorka, R. Heilig, E. Meunier, M.S. Dick, T. \u0106ikovi\u0107, J. Sodenkamp, G. M\u00e9dard, R. Naumann, J. Ruland, B. Kuster, P. Broz, and O. Gro\u00df. 2017. The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity. Cell Reports 21 (13): 3846\u20133859.","journal-title":"Cell Reports"},{"issue":"24","key":"1522_CR22","doi-asserted-by":"publisher","first-page":"14405","DOI":"10.1111\/jcmm.16061","volume":"24","author":"FQ Long","year":"2020","unstructured":"Long, F.Q., C.X. Kou, K. Li, J. Wu, and Q.Q. Wang. 2020. MiR-223-3p inhibits rTp17-induced inflammasome activation and pyroptosis by targeting NLRP3. Journal of Cellular and Molecular Medicine 24 (24): 14405\u201314414.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"1522_CR23","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","volume":"694","author":"M Navazesh","year":"1993","unstructured":"Navazesh, M. 1993. Methods for collecting saliva. Annals of the New York Academy of Sciences 694: 72\u201377.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"1522_CR24","doi-asserted-by":"crossref","unstructured":"Kumar, P., A. Nagarajan, and P.D. Uchil. 2018. Analysis of cell viability by the lactate dehydrogenase assay. Cold Spring Harbor Protocols 2018(6).","DOI":"10.1101\/pdb.prot095497"},{"key":"1522_CR25","first-page":"2069410","volume":"2021","author":"MV Cuevas-Gonz\u00e1lez","year":"2021","unstructured":"Cuevas-Gonz\u00e1lez, M.V., F. Suaste-Olmos, A.G. Garc\u00eda-Calder\u00f3n, K.L. Tovar-Carrillo, L.F. Espinosa-Crist\u00f3bal, S.D. Nava-Mart\u00ednez, J.C. Cuevas-Gonz\u00e1lez, G. Zambrano-Galv\u00e1n, R.A. Saucedo-Acu\u00f1a, and A. Donohue-Cornejo. 2021. Expression of microRNAs in periodontal disease: A systematic review. BioMed Research International 2021: 2069410.","journal-title":"BioMed Research International"},{"issue":"5","key":"1522_CR26","doi-asserted-by":"publisher","first-page":"281","DOI":"10.5051\/jpis.2000120006","volume":"50","author":"NH Lee","year":"2020","unstructured":"Lee, N.H., E. Lee, Y.S. Kim, W.K. Kim, Y.K. Lee, and S.H. Kim. 2020. Differential expression of microRNAs in the saliva of patients with aggressive periodontitis: A pilot study of potential biomarkers for aggressive periodontitis. Journal of Periodontal & Implant Science 50 (5): 281\u2013290.","journal-title":"J Periodontal Implant Sci"},{"issue":"10","key":"1522_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1002\/JPER.18-0729","volume":"90","author":"KJ Nisha","year":"2019","unstructured":"Nisha, K.J., P. Janam, and K. Harshakumar. 2019. Identification of a novel salivary biomarker miR-143-3p for periodontal diagnosis: A proof of concept study. Journal of Periodontology 90 (10): 1149\u20131159.","journal-title":"Journal of Periodontology"},{"key":"1522_CR28","doi-asserted-by":"crossref","unstructured":"Rovas, A., A. Puriene, K. Snipaitiene, E. Punceviciene, B. Buragaite-Staponkiene, R. Matuleviciute, I. Butrimiene, and S. Jarmalaite. 2021. Analysis of periodontitis-associated miRNAs in gingival tissue, gingival crevicular fluid, saliva and blood plasma. Archives of Oral Biology 126: p. 105125.","DOI":"10.1016\/j.archoralbio.2021.105125"},{"key":"1522_CR29","doi-asserted-by":"crossref","unstructured":"Nik Mohamed Kamal, N.N.S., R.A.R. Awang, S. Mohamad, and W.N.S. Shahidan. 2020. Plasma- and saliva exosome profile reveals a distinct microRNA signature in chronic periodontitis. Frontiers in Physiology 11: p. 587381.","DOI":"10.3389\/fphys.2020.587381"},{"key":"1522_CR30","doi-asserted-by":"crossref","unstructured":"Han, P., P.M. Bartold, C. Salomon, and S. Ivanovski. 2020. Salivary small extracellular vesicles associated miRNAs in periodontal status-a pilot study. International Journal of Molecular Science 21 (8).","DOI":"10.3390\/ijms21082809"},{"key":"1522_CR31","doi-asserted-by":"crossref","unstructured":"Fujimori, K., T. Yoneda, T. Tomofuji, D. Ekuni, T. Azuma, T. Maruyama, H. Mizuno, Y. Sugiura, and M. Morita. 2019. Detection of salivary miRNAs reflecting chronic periodontitis: a pilot study. Molecules 24 (6).","DOI":"10.3390\/molecules24061034"},{"key":"1522_CR32","doi-asserted-by":"crossref","unstructured":"Yu, Z.W., J. Zhang, X. Li, Y. Wang, Y.H. Fu, and X.Y. Gao. 2020. A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications. Life sciences 240: p. 117138.","DOI":"10.1016\/j.lfs.2019.117138"},{"issue":"1","key":"1522_CR33","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/imr.12909","volume":"297","author":"M Zheng","year":"2020","unstructured":"Zheng, M., and T.-D. Kanneganti. 2020. The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunological reviews 297 (1): 26\u201338.","journal-title":"Immunological reviews"},{"issue":"7575","key":"1522_CR34","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi, J., Y. Zhao, K. Wang, X. Shi, Y. Wang, H. Huang, Y. Zhuang, T. Cai, F. Wang, and F. Shao. 2015. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526 (7575): 660\u2013665.","journal-title":"Nature"},{"issue":"8","key":"1522_CR35","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.4049\/jimmunol.1200312","volume":"189","author":"M Haneklaus","year":"2012","unstructured":"Haneklaus, M., M. Gerlic, M. Kurowska-Stolarska, A.A. Rainey, D. Pich, I.B. McInnes, W. Hammerschmidt, L.A. O\u2019Neill, and S.L. Masters. 2012. Cutting edge: MiR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1\u03b2 production. The Journal of Immunology 189 (8): 3795\u20133799.","journal-title":"The Journal of Immunology"},{"issue":"8","key":"1522_CR36","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.4049\/jimmunol.1201516","volume":"189","author":"F Bauernfeind","year":"2012","unstructured":"Bauernfeind, F., A. Rieger, F.A. Schildberg, P.A. Knolle, J.L. Schmid-Burgk, and V. Hornung. 2012. NLRP3 inflammasome activity is negatively controlled by miR-223. The Journal of Immunology 189 (8): 4175\u20134181.","journal-title":"The Journal of Immunology"},{"issue":"8","key":"1522_CR37","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.4049\/jimmunol.1801416","volume":"202","author":"N Boxberger","year":"2019","unstructured":"Boxberger, N., M. Hecker, and U.K. Zettl. 2019. Dysregulation of inflammasome priming and activation by microRNAs in human immune-mediated diseases. The Journal of Immunology 202 (8): 2177\u20132187.","journal-title":"The Journal of Immunology"},{"key":"1522_CR38","doi-asserted-by":"crossref","unstructured":"Kinoshita, T., R. Imamura, H. Kushiyama, and T. Suda. 2015. NLRP3 mediates NF-kappaB activation and cytokine induction in microbially induced and sterile inflammation. PLoS One 10 (3): p. e0119179.","DOI":"10.1371\/journal.pone.0119179"},{"issue":"8","key":"1522_CR39","doi-asserted-by":"publisher","first-page":"6295","DOI":"10.1007\/s11033-020-05659-1","volume":"47","author":"B Cheshmi","year":"2020","unstructured":"Cheshmi, B., and H. Cheshomi. 2020. Salivary exosomes: Properties, medical applications, and isolation methods. Molecular biology reports 47 (8): 6295\u20136307.","journal-title":"Molecular biology reports"},{"issue":"4","key":"1522_CR40","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi, J., W. Gao, and F. Shao. 2017. Pyroptosis: Gasdermin-mediated programmed necrotic cell death. Trends in biochemical sciences 42 (4): 245\u2013254.","journal-title":"Trends in biochemical sciences"},{"issue":"9","key":"1522_CR41","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","volume":"27","author":"SB Kovacs","year":"2017","unstructured":"Kovacs, S.B., and E.A. Miao. 2017. Gasdermins: Effectors of pyroptosis. Trends in Cell Biology 27 (9): 673\u2013684.","journal-title":"Trends in Cell Biology"},{"key":"1522_CR42","doi-asserted-by":"crossref","unstructured":"Chen, Q., X. Liu, D. Wang, J. Zheng, L. Chen, Q. Xie, X. Liu, S. Niu, G. Qu, J. Lan, J. Li, C. Yang, and D. Zou. 2021. Periodontal inflammation-triggered by periodontal ligament stem cell pyroptosis exacerbates periodontitis. Frontiers in Cell and Development Biology 9: p. 663037.","DOI":"10.3389\/fcell.2021.663037"},{"key":"1522_CR43","doi-asserted-by":"crossref","unstructured":"Yang, K., S. Xu, H. Zhao, L. Liu, X. Lv, F. Hu, L. Wang, and Q. Ji. 2021. Hypoxia and Porphyromonas gingivalis-lipopolysaccharide synergistically induce NLRP3 inflammasome activation in human gingival fibroblasts. International Immunopharmacology 94: p. 107456.","DOI":"10.1016\/j.intimp.2021.107456"},{"issue":"8","key":"1522_CR44","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1111\/odi.13198","volume":"25","author":"C Li","year":"2019","unstructured":"Li, C., W. Yin, N. Yu, D. Zhang, H. Zhao, J. Liu, J. Liu, Y. Pan, and L. Lin. 2019. miR-155 promotes macrophage pyroptosis induced by Porphyromonas gingivalis through regulating the NLRP3 inflammasome. Oral diseases 25 (8): 2030\u20132039.","journal-title":"Oral diseases"},{"key":"1522_CR45","doi-asserted-by":"crossref","unstructured":"Xie, Y., M. Sun, Y. Xia, and R. Shu. 2018. An RNA-seq screen of P. gingivalis LPS treated human gingival fibroblasts. Archives of Oral Biology 88: p. 77\u201384.","DOI":"10.1016\/j.archoralbio.2018.01.002"},{"issue":"3","key":"1522_CR46","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4248\/IJOS11046","volume":"3","author":"YF Xie","year":"2011","unstructured":"Xie, Y.F., R. Shu, S.Y. Jiang, D.L. Liu, and X.L. Zhang. 2011. Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues. International Journal of Oral Science 3 (3): 125\u2013134.","journal-title":"International Journal of Oral Science"},{"issue":"10","key":"1522_CR47","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1177\/0022034512456551","volume":"91","author":"C Stoecklin-Wasmer","year":"2012","unstructured":"Stoecklin-Wasmer, C., P. Guarnieri, R. Celenti, R.T. Demmer, M. Kebschull, and P.N. Papapanou. 2012. MicroRNAs and their target genes in gingival tissues. Journal of Dental Research 91 (10): 934\u2013940.","journal-title":"Journal of Dental Research"},{"issue":"4","key":"1522_CR48","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2334\/josnusd.56.253","volume":"56","author":"Y Ogata","year":"2014","unstructured":"Ogata, Y., S. Matsui, A. Kato, L. Zhou, Y. Nakayama, and H. Takai. 2014. MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients. Journal of Oral Science 56 (4): 253\u2013260.","journal-title":"Journal of Oral Science"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01522-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01522-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01522-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T17:40:22Z","timestamp":1638294022000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-021-01522-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1522"],"URL":"https:\/\/doi.org\/10.1007\/s10753-021-01522-y","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,12]]},"assertion":[{"value":"18 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human tissues were in accordance with the ethical standards of the Ethical Committee of Shanghai Ninth People\u2019s Hospital (the registration number is ChiCTR-OOR-1600992) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All the participants who donate the saliva and gingival tissues were confirmed with the information of this study and signed a consent form.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}