{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:54:25Z","timestamp":1787496865318,"version":"build-2736575974"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s10753-021-01560-6","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T06:02:56Z","timestamp":1631512976000},"page":"445-459","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Infliximab and Tocilizumab Reduce Anxiety-Like Behaviour and Improve Cognitive Performance in a Juvenile Collagen\u2013Induced Arthritis Rat Model"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-9748","authenticated-orcid":false,"given":"Frideriki","family":"Poutoglidou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryssa","family":"Pourzitaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eleni","family":"Manthou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Saitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Malliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kouvelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"1560_CR1","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","volume":"369","author":"A Ravelli","year":"2007","unstructured":"Ravelli, A., and A. Martini. 2007. Juvenile idiopathic arthritis. Lancet 369: 767\u2013778.","journal-title":"Lancet"},{"key":"1560_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jbspin.2013.09.003","volume":"81","author":"S Thierry","year":"2014","unstructured":"Thierry, S., B. Fautrel, I. Lemelle, and F. Guillemin. 2014. Prevalence and incidence of juvenile idiopathic arthritis: A systematic review. Joint, Bone, Spine 81: 112\u2013117.","journal-title":"Joint, Bone, Spine"},{"key":"1560_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/BOR.0000000000000417","volume":"29","author":"G Giancane","year":"2017","unstructured":"Giancane, G., A. Alongi, and A. Ravelli. 2017. Update on the pathogenesis and treatment of juvenile idiopathic arthritis. Current Opinion in Rheumatology 29: 523\u2013529.","journal-title":"Current Opinion in Rheumatology"},{"key":"1560_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1358\/mf.2004.26.5.831324","volume":"26","author":"S Appenzeller","year":"2004","unstructured":"Appenzeller, S., M.B. Bertolo, and L.T. Costallat. 2004. Cognitive impairment in rheumatoid arthritis. Methods and Findings in Experimental and Clinical Pharmacology 26: 339\u2013343.","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"1560_CR5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/RHU.0000000000000489","volume":"23","author":"KM Fiest","year":"2017","unstructured":"Fiest, K.M., C.A. Hitchon, C.N. Bernstein, C.A. Peschken, J.R. Walker, L.A. Graff, R. Zarychanski, A. Abou-Setta, S.B. Patten, J. Sareen, J. Bolton, R.A. Marrie, and the CIHR team. . 2017. Systematic review and meta-analysis of interventions for depression and anxiety in persons with rheumatoid arthritis. Journal of Clinical Rheumatology 23: 425\u2013434.","journal-title":"Journal of Clinical Rheumatology"},{"key":"1560_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/acr.23243","volume":"70","author":"T Meade","year":"2018","unstructured":"Meade, T., N. Manolios, S.R. Cumming, P.G. Conaghan, and P. Katz. 2018. Cognitive impairment in rheumatoid arthritis: A systematic review. Arthritis Care Res (Hoboken) 70: 39\u201352.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1560_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2147\/OARRR.S174408","volume":"11","author":"DC Fair","year":"2019","unstructured":"Fair, D.C., M. Rodriguez, A.M. Knight, and T.B. Rubinstein. 2019. Depression and anxiety in patients with juvenile idiopathic arthritis: Current insights and impact on quality of life, a systematic review. Open Access Rheumatology: Research and Reviews 11: 237\u2013252.","journal-title":"Open Access Rheumatology: Research and Reviews"},{"key":"1560_CR8","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1007\/s10067-019-04900-y","volume":"39","author":"AR Machin","year":"2020","unstructured":"Machin, A.R., O. Babatunde, R. Haththotuwa, I. Scott, M. Blagojevic-Bucknall, N. Corp, C.A. Chew-Graham, and S.L. Hider. 2020. The association between anxiety and disease activity and quality of life in rheumatoid arthritis: A systematic review and meta-analysis. Clinical Rheumatology 39: 1471\u20131482.","journal-title":"Clinical Rheumatology"},{"key":"1560_CR9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s12035-008-8026-z","volume":"37","author":"N Quan","year":"2008","unstructured":"Quan, N. 2008. Immune-to-brain signaling: How important are the blood-brain barrier-independent pathways? Molecular Neurobiology 37: 142\u2013152.","journal-title":"Molecular Neurobiology"},{"key":"1560_CR10","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","volume":"46","author":"SS Chavan","year":"2017","unstructured":"Chavan, S.S., V.A. Pavlov, and K.J. Tracey. 2017. Mechanisms and therapeutic relevance of neuro-immune communication. Immunity 46: 927\u2013942.","journal-title":"Immunity"},{"key":"1560_CR11","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1152\/physrev.00039.2016","volume":"98","author":"R Dantzer","year":"2018","unstructured":"Dantzer, R. 2018. Neuroimmune interactions: From the brain to the immune system and vice versa. Physiological Reviews 98: 477\u2013504.","journal-title":"Physiological Reviews"},{"key":"1560_CR12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1159\/000097202","volume":"2","author":"WA Banks","year":"1995","unstructured":"Banks, W.A., A.J. Kastin, and R.D. Broadwell. 1995. Passage of cytokines across the blood-brain barrier. NeuroImmunoModulation 2: 241\u2013248.","journal-title":"NeuroImmunoModulation"},{"key":"1560_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.yfrne.2011.12.002","volume":"33","author":"MA Galic","year":"2012","unstructured":"Galic, M.A., K. Riazi, and Q.J. Pittman. 2012. Cytokines and brain excitability. Frontiers in Neuroendocrinology 33: 116\u2013125.","journal-title":"Frontiers in Neuroendocrinology"},{"key":"1560_CR14","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.nbd.2009.11.015","volume":"37","author":"JM Loftis","year":"2010","unstructured":"Loftis, J.M., M. Huckans, and B.J. Morasco. 2010. Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies. Neurobiology of Diseases 37: 519\u2013533.","journal-title":"Neurobiology of Diseases"},{"key":"1560_CR15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fpsyt.2019.00030","volume":"10","author":"H Himmerich","year":"2019","unstructured":"Himmerich, H., O. Patsalos, N. Lichtblau, M.A.A. Ibrahim, and B. Dalton. 2019. Cytokine research in depression: Principles, challenges, and open questions. Front Psychiatry. 10: 30.","journal-title":"Front Psychiatry."},{"key":"1560_CR16","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jpsychores.2007.03.001","volume":"63","author":"S Chandrashekara","year":"2007","unstructured":"Chandrashekara, S., K. Jayashree, H.B. Veeranna, H.S. Vadiraj, M.N. Ramesh, A. Shobha, Y. Sarvanan, and Y.K. Vikram. 2007. Effects of anxiety on TNF-alpha levels during psychological stress. Journal of Psychosomatic Research 63: 65\u201369.","journal-title":"Journal of Psychosomatic Research"},{"key":"1560_CR17","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1016\/j.psyneuen.2013.01.002","volume":"38","author":"HE Duivis","year":"2013","unstructured":"Duivis, H.E., N. Vogelzangs, N. Kupper, P. de Jonge, and B.W. Penninx. 2013. Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: Findings from the Netherlands Study of Depression and Anxiety (NESDA). Psychoneuroendocrinology 38: 1573\u20131585.","journal-title":"Psychoneuroendocrinology"},{"key":"1560_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.genhosppsych.2018.04.003","volume":"53","author":"OY Alshogran","year":"2018","unstructured":"Alshogran, O.Y., A.A. Khalil, A.O. Oweis, S.M. Altawalbeh, and M.A.Y. Alqudah. 2018. Association of brain-derived neurotrophic factor and interleukin-6 serum levels with depressive and anxiety symptoms in hemodialysis patients. General Hospital Psychiatry 53: 25\u201331.","journal-title":"General Hospital Psychiatry"},{"key":"1560_CR19","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s11011-014-9551-2","volume":"29","author":"I Trapero","year":"2014","unstructured":"Trapero, I., and O. Cauli. 2014. Interleukin 6 and cognitive dysfunction. Metabolic Brain Disease 29: 593\u2013608.","journal-title":"Metabolic Brain Disease"},{"key":"1560_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jad.2015.08.058","volume":"188","author":"JD Rosenblat","year":"2015","unstructured":"Rosenblat, J.D., E. Brietzke, R.B. Mansur, N.A. Maruschak, Y. Lee, and R.S. McIntyre. 2015. Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: Evidence, pathophysiology and treatment implications. Journal of Affective Disorders 188: 149\u2013159.","journal-title":"Journal of Affective Disorders"},{"key":"1560_CR21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/psyg.12218","volume":"17","author":"YS Kim","year":"2017","unstructured":"Kim, Y.S., K.J. Lee, and H. Kim. 2017. Serum tumour necrosis factor-alpha and interleukin-6 levels in Alzheimer\u2019s disease and mild cognitive impairment. Psychogeriatrics 17: 224\u2013230.","journal-title":"Psychogeriatrics"},{"key":"1560_CR22","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/jnnp-2018-319148","volume":"90","author":"XN Shen","year":"2019","unstructured":"Shen, X.N., L.D. Niu, Y.J. Wang, X.P. Cao, Q. Liu, L. Tan, C. Zhang, and J.T. Yu. 2019. Inflammatory markers in Alzheimer\u2019s disease and mild cognitive impairment: A meta-analysis and systematic review of 170 studies. Journal of Neurology, Neurosurgery and Psychiatry 90: 590\u2013598.","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"1560_CR23","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","volume":"11","author":"S Bathina","year":"2015","unstructured":"Bathina, S., and U.N. Das. 2015. Brain-derived neurotrophic factor and its clinical implications. Archives of Medical Science 11: 1164\u20131178.","journal-title":"Archives of Medical Science"},{"key":"1560_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","volume":"246","author":"JC Felger","year":"2013","unstructured":"Felger, J.C., and F.E. Lotrich. 2013. Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications. Neuroscience 246: 199\u2013229.","journal-title":"Neuroscience"},{"key":"1560_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fnint.2013.00055","volume":"7","author":"S Suliman","year":"2013","unstructured":"Suliman, S., S.M. Hemmings, and S. Seedat. 2013. Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: Systematic review and meta-regression analysis. Frontiers in Integrative Neuroscience 7: 55.","journal-title":"Frontiers in Integrative Neuroscience"},{"key":"1560_CR26","doi-asserted-by":"crossref","unstructured":"Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., Altman, D. G. 2010. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 8:e1000412.","DOI":"10.1371\/journal.pbio.1000412"},{"key":"1560_CR27","doi-asserted-by":"crossref","unstructured":"Rosloniec, E. F., Cremer, M., Kang, A. H., Myers, L. K., Brand, D. D. 2010. Collagen-induced arthritis. Curr Protoc Immunol Chapter 15: Unit 15 5 1\u201325.","DOI":"10.1002\/0471142735.im1505s89"},{"key":"1560_CR28","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.pharep.2014.08.009","volume":"67","author":"SE Bilasy","year":"2015","unstructured":"Bilasy, S.E., S.S. Essawy, M.F. Mandour, E.A. Ali, and S.A. Zaitone. 2015. Myelosuppressive and hepatotoxic potential of leflunomide and methotrexate combination in a rat model of rheumatoid arthritis. Pharmacological Reports 67: 102\u2013114.","journal-title":"Pharmacological Reports"},{"key":"1560_CR29","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/bcpt.12037","volume":"112","author":"A Karson","year":"2013","unstructured":"Karson, A., T. Demirtas, D. Bayramgurler, F. Balci, and T. Utkan. 2013. Chronic administration of infliximab (TNF-alpha inhibitor) decreases depression and anxiety-like behaviour in rat model of chronic mild stress. Basic & Clinical Pharmacology & Toxicology 112: 335\u2013340.","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"1560_CR30","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1177\/1933719115612134","volume":"23","author":"MI Taskin","year":"2016","unstructured":"Taskin, M.I., A.C. Gungor, E. Adali, A. Yay, G.O. Onder, and U. Inceboz. 2016. A humanized anti-interleukin 6 receptor monoclonal antibody, tocilizumab, for the treatment of endometriosis in a rat model. Reproductive Sciences 23: 662\u2013669.","journal-title":"Reproductive Sciences"},{"key":"1560_CR31","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bbr.2014.01.007","volume":"263","author":"MR Marques","year":"2014","unstructured":"Marques, M.R., F. Stigger, E. Segabinazi, O.A. Augustin, S. Barbosa, F.V. Piazza, M. Achaval, and S. Marcuzzo. 2014. Beneficial effects of early environmental enrichment on motor development and spinal cord plasticity in a rat model of cerebral palsy. Behavioural Brain Research 263: 149\u2013157.","journal-title":"Behavioural Brain Research"},{"key":"1560_CR32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/15287394.2019.1625474","volume":"82","author":"C Rosique","year":"2019","unstructured":"Rosique, C., D. Lebsir, P. Lestaevel, S. Benatia, P. Guigon, F. Caire-Maurisier, M. Benderitter, D. Bennouna, M. Souidi, and J.C. Martin. 2019. Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics. Journal of Toxicology and Environmental Health. Part A 82: 603\u2013615.","journal-title":"Journal of Toxicology and Environmental Health. Part A"},{"key":"1560_CR33","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.lfs.2009.09.002","volume":"85","author":"D Kouvelas","year":"2009","unstructured":"Kouvelas, D., C. Pourzitaki, G. Papazisis, K. Tsilkos, M. Chourdakis, and M.M. Kraus. 2009. Chronic aortic denervation decreases anxiety and impairs social memory in rats. Life Sciences 85: 602\u2013608.","journal-title":"Life Sciences"},{"key":"1560_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nprot.2007.44","volume":"2","author":"AA Walf","year":"2007","unstructured":"Walf, A.A., and C.A. Frye. 2007. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nature Protocols 2: 322\u2013328.","journal-title":"Nature Protocols"},{"key":"1560_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/BF02244871","volume":"116","author":"JK Shepherd","year":"1994","unstructured":"Shepherd, J.K., S.S. Grewal, A. Fletcher, D.J. Bill, and C.T. Dourish. 1994. Behavioural and pharmacological characterisation of the elevated \u201czero-maze\u201d as an animal model of anxiety. Psychopharmacology (Berl) 116: 56\u201364.","journal-title":"Psychopharmacology (Berl)"},{"key":"1560_CR36","first-page":"307","volume":"10","author":"T Suzuki","year":"1990","unstructured":"Suzuki, T., M. Inayama, and M. Misawa. 1990. The effect of diazepam on exploratory behavior and its strain differences in inbred rats. Yakubutsu, Seishin, Kodo 10: 307\u2013314.","journal-title":"Yakubutsu, Seishin, Kodo"},{"key":"1560_CR37","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF00175185","volume":"89","author":"HP Kaesermann","year":"1986","unstructured":"Kaesermann, H.P. 1986. Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action. Psychopharmacology (Berl) 89: 31\u201337.","journal-title":"Psychopharmacology (Berl)"},{"key":"1560_CR38","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/BF00518192","volume":"91","author":"R Dantzer","year":"1987","unstructured":"Dantzer, R., R.M. Bluthe, G.F. Koob, and M. Le Moal. 1987. Modulation of social memory in male rats by neurohypophyseal peptides. Psychopharmacology (Berl) 91: 363\u2013368.","journal-title":"Psychopharmacology (Berl)"},{"key":"1560_CR39","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0028-3908(96)00169-4","volume":"36","author":"S Letty","year":"1997","unstructured":"Letty, S., R. Child, A. Dumuis, A. Pantaloni, J. Bockaert, and G. Rondouin. 1997. 5-HT4 receptors improve social olfactory memory in the rat. Neuropharmacology 36: 681\u2013687.","journal-title":"Neuropharmacology"},{"key":"1560_CR40","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1037\/0735-7044.98.5.908","volume":"98","author":"TF Sawyer","year":"1984","unstructured":"Sawyer, T.F., A.K. Hengehold, and W.A. Perez. 1984. Chemosensory and hormonal mediation of social memory in male rats. Behavioral Neuroscience 98: 908\u2013913.","journal-title":"Behavioral Neuroscience"},{"key":"1560_CR41","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1254\/jphs.FPE05006X","volume":"101","author":"DS Dimitrova","year":"2006","unstructured":"Dimitrova, D.S., and D.P. Getova-Spassova. 2006. Effects of galantamine and donepezil on active and passive avoidance tests in rats with induced hypoxia. Journal of Pharmacological Sciences 101: 199\u2013204.","journal-title":"Journal of Pharmacological Sciences"},{"key":"1560_CR42","doi-asserted-by":"crossref","unstructured":"Faridkia, Z., Yaghmaei, P., Nassiri-Asl, M. 2016. Protective effect of quinine on chemical kindling and passive avoidance test in rats. Iran Red Crescent Med J 18: e25490.","DOI":"10.5812\/ircmj.25490"},{"key":"1560_CR43","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2002","unstructured":"Paxinos, G., and C. Watson. 2002. The rat brain in stereotaxic coordinates, 4th ed. New York: Academic Press.","edition":"4"},{"key":"1560_CR44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K.J., and T.D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402\u2013408.","journal-title":"Methods"},{"key":"1560_CR45","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nprot.2007.173","volume":"2","author":"DD Brand","year":"2007","unstructured":"Brand, D.D., K.A. Latham, and E.F. Rosloniec. 2007. Collagen-induced arthritis. Nature Protocols 2: 1269\u20131275.","journal-title":"Nature Protocols"},{"key":"1560_CR46","first-page":"377","volume":"1","author":"A Bendele","year":"2001","unstructured":"Bendele, A. 2001. Animal models of rheumatoid arthritis. Journal of Musculoskeletal and Neuronal Interactions 1: 377\u2013385.","journal-title":"Journal of Musculoskeletal and Neuronal Interactions"},{"key":"1560_CR47","first-page":"624","volume":"4","author":"P Sengupta","year":"2013","unstructured":"Sengupta, P. 2013. The laboratory rat: Relating its age with human\u2019s. IInt J Prev Med 4: 624\u2013630.","journal-title":"IInt J Prev Med"},{"key":"1560_CR48","first-page":"S98","volume":"31","author":"S Verazza","year":"2013","unstructured":"Verazza, S., G. Negro, D. Marafon, A. Consolaro, A. Martini, and A. Ravelli. 2013. Possible discontinuation of therapies after clinical remission in juvenile idiopathic arthritis. Clinical and Experimental Rheumatology 31: S98-101.","journal-title":"Clinical and Experimental Rheumatology"},{"key":"1560_CR49","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3892\/etm.2014.2149","volume":"9","author":"P Jiang","year":"2015","unstructured":"Jiang, P., Q. Ling, H. Liu, and W. Tu. 2015. Intracisternal administration of an interleukin-6 receptor antagonist attenuates surgery-induced cognitive impairment by inhibition of neuroinflammatory responses in aged rats. Experimental and Therapeutic Medicine 9: 982\u2013986.","journal-title":"Experimental and Therapeutic Medicine"},{"key":"1560_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11010-016-2762-6","volume":"420","author":"HK Elcioglu","year":"2016","unstructured":"Elcioglu, H.K., E. Aslan, S. Ahmad, S. Alan, E. Salva, O.H. Elcioglu, and L. Kabasakal. 2016. Tocilizumab\u2019s effect on cognitive deficits induced by intracerebroventricular administration of streptozotocin in Alzheimer\u2019s model. Molecular and Cellular Biochemistry 420: 21\u201328.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"1560_CR51","unstructured":"Stone, R. H., Hong, J., Jeong, H. 2014. Pharmacokinetics of monoclonal antibodies used for inflammatory bowel diseases in pregnant women. J Clin Toxicol. 4."},{"key":"1560_CR52","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S1566-0702(00)00231-9","volume":"85","author":"GN Luheshi","year":"2000","unstructured":"Luheshi, G.N., R.M. Bluthe, D. Rushforth, N. Mulcahy, J.P. Konsman, M. Goldbach, and R. Dantzer. 2000. Vagotomy attenuates the behavioural but not the pyrogenic effects of interleukin-1 in rats. Autonomic Neuroscience 85: 127\u2013132.","journal-title":"Autonomic Neuroscience"},{"key":"1560_CR53","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.psychres.2019.01.100","volume":"273","author":"CD Wiener","year":"2019","unstructured":"Wiener, C.D., F.P. Moreira, L.V. Portela, N.R. Strogulski, D.R. Lara, R. da Silva, L.D. de Souza, and M., Jansen, K., Oses, J. P. . 2019. Interleukin-6 and Interleukin-10 in mood disorders: A population-based study. Psychiatry Research 273: 685\u2013689.","journal-title":"Psychiatry Research"},{"key":"1560_CR54","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/sj.mp.4002006","volume":"12","author":"N Muller","year":"2007","unstructured":"Muller, N., and M.J. Schwarz. 2007. The immune-mediated alteration of serotonin and glutamate: Towards an integrated view of depression. Molecular Psychiatry 12: 988\u20131000.","journal-title":"Molecular Psychiatry"},{"key":"1560_CR55","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.neulet.2010.07.035","volume":"482","author":"T Nishioku","year":"2010","unstructured":"Nishioku, T., A. Yamauchi, F. Takata, T. Watanabe, K. Furusho, H. Shuto, A. Yamauchi, and Y. Kataoka. 2010. Disruption of the blood-brain barrier in collagen-induced arthritic mice. Neuroscience Letters 482: 208\u2013211.","journal-title":"Neuroscience Letters"},{"key":"1560_CR56","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.neuroscience.2011.05.044","volume":"189","author":"T Nishioku","year":"2011","unstructured":"Nishioku, T., K. Furusho, A. Tomita, H. Ohishi, S. Dohgu, H. Shuto, A. Yamautsi, and Y. Kataoka. 2011. Potential role for S100A4 in the disruption of the blood-brain barrier in collagen-induced arthritic mice, an animal model of rheumatoid arthritis. Neuroscience 189: 286\u2013292.","journal-title":"Neuroscience"},{"key":"1560_CR57","doi-asserted-by":"crossref","unstructured":"Mokotedi, L., Millen, A. M. E., Mogane, C., Gomes, M., Woodiwiss, A. J., Norton, G. R., Michel, F. S. 2019. Associations of inflammatory markers and vascular cell adhesion molecule-1 with endothelial dysfunction in collagen-induced arthritis. Eur J Pharmacol 865: 172786.","DOI":"10.1016\/j.ejphar.2019.172786"},{"key":"1560_CR58","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11060-005-9044-6","volume":"78","author":"AB Lassman","year":"2006","unstructured":"Lassman, A.B., L.E. Abrey, G.D. Shah, K.S. Panageas, M. Begemann, M.G. Malkin, and J.J. Raizer. 2006. Systemic high-dose intravenous methotrexate for central nervous system metastases. Journal of Neuro-oncology 78: 255\u2013260.","journal-title":"Journal of Neuro-oncology"},{"key":"1560_CR59","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fnbeh.2017.00101","volume":"11","author":"J Murinova","year":"2017","unstructured":"Murinova, J., N. Hlavacova, M. Chmelova, and I. Riecansky. 2017. The evidence for altered BDNF expression in the brain of rats reared or housed in social isolation: A systematic review. Frontiers in Behavioral Neuroscience 11: 101.","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"1560_CR60","first-page":"1651","volume":"7","author":"M Yang","year":"2012","unstructured":"Yang, M., J. Kim, S.H. Kim, J.S. Kim, T. Shin, and C. Moon. 2012. Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment. Neural Regeneration Research 7: 1651\u20131658.","journal-title":"Neural Regeneration Research"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01560-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01560-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01560-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T12:21:32Z","timestamp":1666786892000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-021-01560-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,13]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1560"],"URL":"https:\/\/doi.org\/10.1007\/s10753-021-01560-6","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,13]]},"assertion":[{"value":"3 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"The study was approved by the Directorate of Veterinary Services of the Region of Central Macedonia according to national legislation (Presidential Decree 56\/2013, in conformance with the European Directive (2010\/63\/EU) (reference number: 668476(3484) 21643(87), 06\/10\/2019).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}