{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:58:56Z","timestamp":1762253936101,"version":"3.37.3"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10753-021-01562-4","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T16:55:25Z","timestamp":1633452925000},"page":"509-527","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mast Cells Modulate the Immune Response and Redox Status of the Gastrointestinal Tract in Induced Venom Pathogenesis"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-3222","authenticated-orcid":false,"given":"Nehla","family":"Zerarka-Chabane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-261X","authenticated-orcid":false,"given":"Fatima","family":"Laraba-Djebari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-707X","authenticated-orcid":false,"given":"Djelila","family":"Hammoudi-Triki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"1562_CR1","doi-asserted-by":"crossref","unstructured":"Adi-Bessalem, S., D. Hammoudi-Triki, and F. Laraba-Djebari. 2015. Scorpion venom interactions with the immune system. In Scorpion Venoms, 87\u2013107. Dordrecht: Springer Netherlands.","DOI":"10.1007\/978-94-007-6404-0_3"},{"issue":"2","key":"1562_CR2","first-page":"245","volume":"30","author":"M Gueron","year":"1992","unstructured":"Gueron, M., R. Ilia, and S. Sofer. 1992. The cardiovascular system after scorpion envenomation A review. Journal of Toxicology: Clinical Toxicology 30 (2): 245\u2013258.","journal-title":"Journal of Toxicology: Clinical Toxicology"},{"issue":"3","key":"1562_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.taap.2006.11.003","volume":"218","author":"D Hammoudi-Triki","year":"2007","unstructured":"Hammoudi-Triki, D., et al. 2007. Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in rats: Optimization of antivenom therapy. Toxicology and Applied Pharmacology 218 (3): 205\u2013214.","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"2","key":"1562_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/toxins11020063","volume":"11","author":"M-F Martin-Eauclaire","year":"2019","unstructured":"Martin-Eauclaire, M.-F., et al. 2019. Serotherapy against voltage-gated sodium channel-targeting \u03b1-toxins from androctonus scorpion venom. Toxins 11 (2): 63.","journal-title":"Toxins"},{"issue":"10","key":"1562_CR5","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/S0399-8320(05)88173-4","volume":"29","author":"M Bahloul","year":"2005","unstructured":"Bahloul, M., et al. 2005. Gastrointestinal manifestations in severe scorpion envenomation. Gastroent\u00e9rologie Clinique et Biologique 29 (10): 1001\u20131005.","journal-title":"Gastroent\u00e9rologie Clinique et Biologique"},{"key":"1562_CR6","doi-asserted-by":"crossref","unstructured":"Kvietys, P.R., and D.N. Granger. 1993. The vascular endothelium in gastrointestinal inflammation. In Immunopharmacology of the gastrointestinal system, 69\u201394. Amsterdam: Elsevier.","DOI":"10.1016\/B978-0-12-732860-7.50011-3"},{"issue":"4","key":"1562_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1590\/S0100-879X1999000400009","volume":"32","author":"F Bucaretchi","year":"1999","unstructured":"Bucaretchi, F., et al. 1999. Effect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats. Brazilian Journal of Medical and Biological Research 32 (4): 431\u2013434.","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"8","key":"1562_CR8","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.toxicon.2004.08.021","volume":"44","author":"G D'suze","year":"2004","unstructured":"D\u2019suze, G., et al. 2004. Histophatological changes and inflammatory response induced by Tityus discrepans scorpion venom in rams. Toxicon 44 (8): 851\u2013860.","journal-title":"Toxicon"},{"issue":"1","key":"1562_CR9","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0041-0101(73)90156-6","volume":"11","author":"JC Melo","year":"1973","unstructured":"Melo, J.C., et al. 1973. Mechanism of action of purified scorpion toxin on the isolated rat intestine. Toxicon 11 (1): 81\u201384.","journal-title":"Toxicon"},{"issue":"9","key":"1562_CR10","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1590\/S0100-879X2000000900010","volume":"33","author":"L Troncon","year":"2000","unstructured":"Troncon, L., et al. 2000. Inhibition of gastric emptying and intestinal transit in anesthetized rats by a Tityus serrulatus scorpion toxin. Brazilian Journal of Medical and Biological Research 33 (9): 1053\u20131058.","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"5","key":"1562_CR11","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1007\/s10753-014-9898-x","volume":"37","author":"A Lamraoui","year":"2014","unstructured":"Lamraoui, A., S. Adi-Bessalem, and F. Laraba-Djebari. 2014. Modulation of tissue inflammatory response by histamine receptors in scorpion envenomation pathogenesis: Involvement of H4 receptor. Inflammation 37 (5): 1689\u20131704.","journal-title":"Inflammation"},{"key":"1562_CR12","doi-asserted-by":"crossref","unstructured":"De Winter, B.Y., R.M. van den Wijngaard, and W.J. de Jonge. 2012. Intestinal mast cells in gut inflammation and motility disturbances. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822(1):66\u201373.","DOI":"10.1016\/j.bbadis.2011.03.016"},{"key":"1562_CR13","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ejphar.2017.09.044","volume":"818","author":"P Conti","year":"2018","unstructured":"Conti, P., et al. 2018. Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37. European Journal of Pharmacology 818: 294\u2013299.","journal-title":"European Journal of Pharmacology"},{"issue":"11","key":"1562_CR14","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S0041-0101(00)00083-0","volume":"38","author":"K Konno","year":"2000","unstructured":"Konno, K., et al. 2000. Structure and biological activities of eumenine mastoparan-AF (EMP-AF) a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado). Toxicon 38 (11): 1505\u20131515.","journal-title":"Toxicon"},{"issue":"3","key":"1562_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0014-2999(99)00382-9","volume":"376","author":"IM Matos","year":"1999","unstructured":"Matos, I.M., et al. 1999. Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats. European Journal of Pharmacology 376 (3): 293\u2013300.","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"1562_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.intimp.2015.01.008","volume":"25","author":"I Cha\u00efr-Yousfi","year":"2015","unstructured":"Cha\u00efr-Yousfi, I., F. Laraba-Djebari, and D. Hammoudi-Triki. 2015. Androctonus australis hector venom contributes to the interaction between neuropeptides and mast cells in pulmonary hyperresponsiveness. International Immunopharmacology 25 (1): 19\u201329.","journal-title":"International Immunopharmacology"},{"key":"1562_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.2911721","volume":"243","author":"G MacQueen","year":"1989","unstructured":"MacQueen, G., et al. 1989. Conditioned secretion of rat mast cell protease II release by mucosal mast cells. Science 243: 83\u201385.","journal-title":"Science"},{"issue":"4","key":"1562_CR18","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/j.jaci.2018.10.054","volume":"144","author":"A Dudeck","year":"2019","unstructured":"Dudeck, A., et al. 2019. Mast cells as protectors of health. Journal of Allergy and Clinical Immunology 144 (4): S4\u2013S18.","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"2","key":"1562_CR19","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/cmi.2014.73","volume":"12","author":"M Becker","year":"2015","unstructured":"Becker, M., et al. 2015. Mast cells as rapid innate sensors of cytomegalovirus by TLR3\/TRIF signaling-dependent and-independent mechanisms. Cellular & Molecular Immunology 12 (2): 192\u2013201.","journal-title":"Cellular & Molecular Immunology"},{"key":"1562_CR20","doi-asserted-by":"crossref","unstructured":"Zoccal, K.F., et al. 2014. TLR2 TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators. PLoS One 9(2):e88174.","DOI":"10.1371\/journal.pone.0088174"},{"issue":"11","key":"1562_CR21","doi-asserted-by":"publisher","first-page":"L1294","DOI":"10.1152\/ajplung.00031.2015","volume":"309","author":"AN Rizzo","year":"2015","unstructured":"Rizzo, A.N., et al. 2015. Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 309 (11): L1294\u2013L1304.","journal-title":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},{"issue":"2\u20133","key":"1562_CR22","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.toxicon.2009.08.009","volume":"55","author":"NG Nascimento","year":"2010","unstructured":"Nascimento, N.G., et al. 2010. Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. Toxicon 55 (2\u20133): 343\u2013352.","journal-title":"Toxicon"},{"issue":"6","key":"1562_CR23","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","volume":"87","author":"J Krawisz","year":"1984","unstructured":"Krawisz, J., P. Sharon, and W. Stenson. 1984. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models. Gastroenterology 87 (6): 1344\u20131350.","journal-title":"Gastroenterology"},{"issue":"5\u20136","key":"1562_CR24","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1007\/BF00242276","volume":"72","author":"M Nevill","year":"1996","unstructured":"Nevill, M., et al. 1996. Growth hormone responses to treadmill sprinting in sprint-and endurance-trained athletes. European Journal of Applied Physiology and Occupational Physiology 72 (5\u20136): 460\u2013467.","journal-title":"European Journal of Applied Physiology and Occupational Physiology"},{"key":"1562_CR25","doi-asserted-by":"crossref","unstructured":"Griess, P. 1879. Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt \u201eUeber einige Azoverbindungen\u201d. Berichte der deutschen chemischen Gesellschaft 12(1):426\u2013428.","DOI":"10.1002\/cber.187901201117"},{"issue":"5","key":"1562_CR26","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1063\/1.872845","volume":"5","author":"J Terry","year":"1998","unstructured":"Terry, J., et al. 1998. Volume recombination and opacity in Alcator C-Mod divertor plasmas. Physics of Plasmas 5 (5): 1759\u20131766.","journal-title":"Physics of Plasmas"},{"issue":"1\u20132","key":"1562_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0022-1759(80)90340-3","volume":"38","author":"E Pick","year":"1980","unstructured":"Pick, E., and Y. Keisari. 1980. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. Journal of Immunological Methods 38 (1\u20132): 161\u2013170.","journal-title":"Journal of Immunological Methods"},{"key":"1562_CR28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi, H. 1984. [13] Catalase in vitro. Methods in Enzymology 105: 121\u2013126.","journal-title":"Methods in Enzymology"},{"issue":"19","key":"1562_CR29","doi-asserted-by":"publisher","first-page":"6006","DOI":"10.1021\/jo00124a005","volume":"60","author":"MJ Plunkett","year":"1995","unstructured":"Plunkett, M.J., and J.A. Ellman. 1995. A silicon-based linker for traceless solid-phase synthesis. The Journal of Organic Chemistry 60 (19): 6006\u20136007.","journal-title":"The Journal of Organic Chemistry"},{"issue":"1\u20132","key":"1562_CR30","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72 (1\u20132): 248\u2013254.","journal-title":"Analytical Biochemistry"},{"key":"1562_CR31","doi-asserted-by":"crossref","unstructured":"Petricevich, V.L. 2006. Balance between pro-and anti-inflammatory cytokines in mice treated with Centruroides noxius scorpion venom. Mediators of Inflammation 2006.","DOI":"10.1155\/MI\/2006\/54273"},{"issue":"4\u20135","key":"1562_CR32","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.etp.2008.03.006","volume":"60","author":"S Adi-Bessalem","year":"2008","unstructured":"Adi-Bessalem, S., D. Hammoudi-Triki, and F. Laraba-Djebari. 2008. Pathophysiological effects of Androctonus australis hector scorpion venom: Tissue damages and inflammatory response. Experimental and Toxicologic Pathology 60 (4\u20135): 373\u2013380.","journal-title":"Experimental and Toxicologic Pathology"},{"issue":"1","key":"1562_CR33","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0041-0101(98)00174-3","volume":"37","author":"H Daisley","year":"1999","unstructured":"Daisley, H., D. Alexander, and P. Pitt-Miller. 1999. Acute myocarditis following Tityus trinitatis envenoming: Morphological and pathophysiological characteristics. Toxicon 37 (1): 159\u2013165.","journal-title":"Toxicon"},{"issue":"9","key":"1562_CR34","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0041-0101(02)00145-9","volume":"40","author":"CAM de D\u00e0vila","year":"2002","unstructured":"de D\u00e0vila, C.A.M., et al. 2002. Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation. Toxicon 40 (9): 1339\u20131346.","journal-title":"Toxicon"},{"issue":"2","key":"1562_CR35","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000330241","volume":"19","author":"R Raouraoua-Boukari","year":"2012","unstructured":"Raouraoua-Boukari, R., et al. 2012. Immunomodulation of the inflammatory response induced by Androctonus australis hector neurotoxins: Biomarker interactions. NeuroImmunoModulation 19 (2): 103\u2013110.","journal-title":"NeuroImmunoModulation"},{"issue":"7\u20138","key":"1562_CR36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.etp.2015.04.002","volume":"67","author":"N Bekkari","year":"2015","unstructured":"Bekkari, N., M.-F. Martin-Eauclaire, and F. Laraba-Djebari. 2015. Complement system and immunological mediators: Their involvements in the induced inflammatory process by Androctonus australis hector venom and its toxic components. Experimental and Toxicologic Pathology 67 (7\u20138): 389\u2013397.","journal-title":"Experimental and Toxicologic Pathology"},{"issue":"3","key":"1562_CR37","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.toxicon.2007.10.007","volume":"51","author":"YD Rattmann","year":"2008","unstructured":"Rattmann, Y.D., et al. 2008. Vascular permeability and vasodilation induced by the Loxosceles intermedia venom in rats: Involvement of mast cell degranulation histamine and 5-HT receptors. Toxicon 51 (3): 363\u2013372.","journal-title":"Toxicon"},{"issue":"5","key":"1562_CR38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1056\/NEJMra1401108","volume":"371","author":"GK Isbister","year":"2014","unstructured":"Isbister, G.K., and H.S. Bawaskar. 2014. Scorpion envenomation. New England Journal of Medicine 371 (5): 457\u2013463.","journal-title":"New England Journal of Medicine"},{"key":"1562_CR39","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.toxicon.2015.10.015","volume":"108","author":"MB Pucca","year":"2015","unstructured":"Pucca, M.B., et al. 2015. Tityus serrulatus venom\u2013a lethal cocktail. Toxicon 108: 272\u2013284.","journal-title":"Toxicon"},{"key":"1562_CR40","doi-asserted-by":"crossref","unstructured":"Ballout, J., and M. Diener. 2019. Interactions between rat submucosal neurons and mast cells are modified by cytokines and neurotransmitters. European Journal of Pharmacology 864:172713.","DOI":"10.1016\/j.ejphar.2019.172713"},{"issue":"1","key":"1562_CR41","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/1097-0185(20010101)262:1<79::AID-AR1013>3.0.CO;2-K","volume":"262","author":"KA Sharkey","year":"2001","unstructured":"Sharkey, K.A., and A.B. Kroese. 2001. Consequences of intestinal inflammation on the enteric nervous system: Neuronal activation induced by inflammatory mediators. The Anatomical Record: An Official Publication of the American Association of Anatomists 262 (1): 79\u201390.","journal-title":"The Anatomical Record: An Official Publication of the American Association of Anatomists"},{"issue":"1","key":"1562_CR42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1196\/annals.1366.024","volume":"1088","author":"HW Koon","year":"2006","unstructured":"Koon, H.W., and C. Pothoulakis. 2006. Immunomodulatory properties of substance P: The gastrointestinal system as a model. Annals of the New York Academy of Sciences 1088 (1): 23\u201340.","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"1","key":"1562_CR43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.autneu.2006.10.003","volume":"133","author":"L Van Nassauw","year":"2007","unstructured":"Van Nassauw, L., D. Adriaensen, and J.-P. Timmermans. 2007. The bidirectional communication between neurons and mast cells within the gastrointestinal tract. Autonomic Neuroscience 133 (1): 91\u2013103.","journal-title":"Autonomic Neuroscience"},{"issue":"6","key":"1562_CR44","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000371493","volume":"22","author":"Z Taibi-Djennah","year":"2015","unstructured":"Taibi-Djennah, Z., M.-F. Matin-Eauclaire, and F. Laraba-Djebari. 2015. Systemic responses following brain injuries and inflammatory process activation induced by a neurotoxin of Androctonus scorpion venom. NeuroImmunoModulation 22 (6): 347\u2013357.","journal-title":"NeuroImmunoModulation"},{"issue":"1","key":"1562_CR45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/1523-1747.ep12510590","volume":"79","author":"SH Pincus","year":"1982","unstructured":"Pincus, S.H., A.-M. DiNapoli, and W.R. Schooley. 1982. Superoxide production by eosinophils: Activation by histamine. Journal of Investigative Dermatology 79 (1): 53\u201357.","journal-title":"Journal of Investigative Dermatology"},{"key":"1562_CR46","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.actatropica.2018.06.013","volume":"185","author":"I Saidoune-Malek","year":"2018","unstructured":"Saidoune-Malek, I., A. Ait-Lounis, and F. Laraba-Djebari. 2018. TNF-\u03b1 antagonist improves oxidative stress and lipid disorders induced by scorpion venom in the intestinal tissue. Acta Tropica 185: 307\u2013313.","journal-title":"Acta Tropica"},{"issue":"2","key":"1562_CR47","first-page":"221","volume":"140","author":"E Dousset","year":"2005","unstructured":"Dousset, E., et al. 2005. Evidence that free radical generation occurs during scorpion envenomation. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 140 (2): 221\u2013226.","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"},{"issue":"4","key":"1562_CR48","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00280-011-1780-z","volume":"69","author":"RCP Lima-J\u00fanior","year":"2012","unstructured":"Lima-J\u00fanior, R.C.P., et al. 2012. Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: Role of cytokines on inducible nitric oxide synthase activation. Cancer Chemotherapy and Pharmacology 69 (4): 931\u2013942.","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"1","key":"1562_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-230X-11-90","volume":"11","author":"RF Leit\u00e3o","year":"2011","unstructured":"Leit\u00e3o, R.F., et al. 2011. Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents. BMC Gastroenterology 11 (1): 1\u201310.","journal-title":"BMC Gastroenterology"},{"issue":"1","key":"1562_CR50","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00726-010-0633-0","volume":"42","author":"JW Little","year":"2012","unstructured":"Little, J.W., T. Doyle, and D. Salvemini. 2012. Reactive nitroxidative species and nociceptive processing: Determining the roles for nitric oxide superoxide and peroxynitrite in pain. Amino Acids 42 (1): 75\u201394.","journal-title":"Amino Acids"},{"key":"1562_CR51","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.fct.2018.06.040","volume":"118","author":"K Natarajan","year":"2018","unstructured":"Natarajan, K., et al. 2018. NF-\u03baB-iNOS-COX2-TNF \u03b1 inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats. Food and Chemical Toxicology 118: 766\u2013783.","journal-title":"Food and Chemical Toxicology"},{"issue":"2","key":"1562_CR52","first-page":"63","volume":"17","author":"M Mohora","year":"2007","unstructured":"Mohora, M., et al. 2007. The sources and the targets of oxidative stress in the etiology of diabetic complications. Romanian Journal of Biophysics 17 (2): 63\u201384.","journal-title":"Romanian Journal of Biophysics"},{"issue":"5","key":"1562_CR53","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1021\/tx9501445","volume":"9","author":"JS Beckman","year":"1996","unstructured":"Beckman, J.S. 1996. Oxidative damage and tyrosine nitration from peroxynitrite. Chemical Research in Toxicology 9 (5): 836\u2013844.","journal-title":"Chemical Research in Toxicology"},{"issue":"4","key":"1562_CR54","doi-asserted-by":"publisher","first-page":"489","DOI":"10.2174\/1568010054526287","volume":"4","author":"H Kimura","year":"2005","unstructured":"Kimura, H., et al. 2005. Toxicity and roles of reactive oxygen species. Current Drug Targets-Inflammation & Allergy 4 (4): 489\u2013495.","journal-title":"Current Drug Targets-Inflammation & Allergy"},{"key":"1562_CR55","doi-asserted-by":"crossref","unstructured":"Lardinois, O.M., M.M. Mestdagh, and P.G. Rouxhet. 1996. Reversible inhibition and irreversible inactivation of catalase in presence of hydrogen peroxide. Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology 1295(2):222\u2013238.","DOI":"10.1016\/0167-4838(96)00043-X"},{"key":"1562_CR56","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.redox.2018.02.018","volume":"16","author":"CS Sultan","year":"2018","unstructured":"Sultan, C.S., et al. 2018. Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox Biology 16: 113\u2013122.","journal-title":"Redox Biology"},{"key":"1562_CR57","doi-asserted-by":"crossref","unstructured":"Casado\u2010Bedmar, M., et al. 2019. Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis. Neurogastroenterology & Motility 31(3):e13503.","DOI":"10.1111\/nmo.13503"},{"issue":"3","key":"1562_CR58","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1080\/003655202317284246","volume":"37","author":"X Xu","year":"2002","unstructured":"Xu, X., et al. 2002. Mast cells involvement in the inflammation and fibrosis development of the TNBS-induced rat model of colitis. Scandinavian Journal of Gastroenterology 37 (3): 330\u2013337.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"1562_CR59","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.coph.2015.11.005","volume":"25","author":"G Boeckxstaens","year":"2015","unstructured":"Boeckxstaens, G. 2015. Mast cells and inflammatory bowel disease. Current Opinion in Pharmacology 25: 45\u201349.","journal-title":"Current Opinion in Pharmacology"},{"issue":"7","key":"1562_CR60","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1182\/blood-2003-09-3146","volume":"103","author":"JL Pennock","year":"2004","unstructured":"Pennock, J.L., and R.K. Grencis. 2004. In vivo exit of c-kit+\/CD49dhi\/\u03b27+ mucosal mast cell precursors from the bone marrow following infection with the intestinal nematode Trichinella spiralis. Blood 103 (7): 2655\u20132660.","journal-title":"Blood"},{"issue":"1","key":"1562_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2172-11-32","volume":"11","author":"MC Jamur","year":"2010","unstructured":"Jamur, M.C., et al. 2010. Mast cell repopulation of the peritoneal cavity: Contribution of mast cell progenitors versus bone marrow derived committed mast cell precursors. BMC Immunology 11 (1): 1\u201312.","journal-title":"BMC Immunology"},{"issue":"3","key":"1562_CR62","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s10753-017-0532-6","volume":"40","author":"A Kaddache","year":"2017","unstructured":"Kaddache, A., et al. 2017. Switch of steady-state to an accelerated granulopoiesis in response to Androctonus australis hector venom. Inflammation 40 (3): 871\u2013883.","journal-title":"Inflammation"},{"key":"1562_CR63","doi-asserted-by":"crossref","unstructured":"de Almeida Buranello, P.A., et al. 2010. The lectin ArtinM induces recruitment of rat mast cells from the bone marrow to the peritoneal cavity. PloS One 5(3):e9776.","DOI":"10.1371\/journal.pone.0009776"},{"key":"1562_CR64","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.ejphar.2016.02.018","volume":"778","author":"SC Bischoff","year":"2016","unstructured":"Bischoff, S.C. 2016. Mast cells in gastrointestinal disorders. European Journal of Pharmacology 778: 139\u2013145.","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"1562_CR65","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1053\/j.gastro.2005.08.005","volume":"129","author":"M Tonini","year":"2005","unstructured":"Tonini, M., et al. 2005. 5-HT7 receptors modulate peristalsis and accommodation in the guinea pig ileum. Gastroenterology 129 (5): 1557\u20131566.","journal-title":"Gastroenterology"},{"issue":"3","key":"1562_CR66","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1053\/j.gastro.2003.11.055","volume":"126","author":"G Barbara","year":"2004","unstructured":"Barbara, G., et al. 2004. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 126 (3): 693\u2013702.","journal-title":"Gastroenterology"},{"issue":"12","key":"1562_CR67","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1007\/s10620-008-0279-x","volume":"53","author":"E Sand","year":"2008","unstructured":"Sand, E., A. Themner-Persson, and E. Ekblad. 2008. Infiltration of mast cells in rat colon is a consequence of ischemia\/reperfusion. Digestive Diseases and Sciences 53 (12): 3158\u20133169.","journal-title":"Digestive Diseases and Sciences"},{"issue":"7","key":"1562_CR68","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/S0041-0101(96)00219-X","volume":"35","author":"M Correa","year":"1997","unstructured":"Correa, M., et al. 1997. Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I. Toxicon 35 (7): 1053\u20131067.","journal-title":"Toxicon"},{"issue":"3","key":"1562_CR69","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.toxicon.2011.12.011","volume":"59","author":"M Heidarpour","year":"2012","unstructured":"Heidarpour, M., et al. 2012. Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice. Toxicon 59 (3): 373\u2013378.","journal-title":"Toxicon"},{"issue":"4","key":"1562_CR70","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/0041-0101(81)90004-0","volume":"19","author":"JL Babcock","year":"1981","unstructured":"Babcock, J.L., et al. 1981. Systemic effect in mice of venom apparatus extract and toxin from the brown recluse spider (Loxosceles reclusa). Toxicon 19 (4): 463\u2013471.","journal-title":"Toxicon"},{"issue":"4","key":"1562_CR71","doi-asserted-by":"publisher","first-page":"651","DOI":"10.4269\/ajtmh.1968.17.651","volume":"17","author":"CW Smith","year":"1968","unstructured":"Smith, C.W., and D.W. Micks. 1968. A comparative study of the venom and other components of three species of Loxosceles. The American Journal of Tropical Medicine and Hygiene 17 (4): 651\u2013656.","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"issue":"1\u20133","key":"1562_CR72","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ejphar.2007.07.057","volume":"575","author":"T Liu","year":"2007","unstructured":"Liu, T., et al. 2007. Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom. European Journal of Pharmacology 575 (1\u20133): 46\u201356.","journal-title":"European Journal of Pharmacology"},{"issue":"3","key":"1562_CR73","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1124\/jpet.102.046581","volume":"305","author":"CL Hofstra","year":"2003","unstructured":"Hofstra, C.L., et al. 2003. Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells. Journal of Pharmacology and Experimental Therapeutics 305 (3): 1212\u20131221.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"1562_CR74","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.bbrc.2009.12.139","volume":"391","author":"E Sanchez-Miranda","year":"2010","unstructured":"Sanchez-Miranda, E., A. Ibarra-Sanchez, and C. Gonzalez-Espinosa. 2010. Fyn kinase controls Fc\u03b5RI receptor-operated calcium entry necessary for full degranulation in mast cells. Biochemical and Biophysical Research Communications 391 (4): 1714\u20131720.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"3","key":"1562_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc12786","volume":"17","author":"IK Kim","year":"2013","unstructured":"Kim, I.K., et al. 2013. Effect of tyrosine kinase inhibitors imatinib and nilotinib in murine lipopolysaccharide-induced acute lung injury during neutropenia recovery. Critical Care 17 (3): 1\u201311.","journal-title":"Critical Care"},{"issue":"7","key":"1562_CR76","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1096\/fj.07-105627","volume":"22","author":"A Akhmetshina","year":"2008","unstructured":"Akhmetshina, A., et al. 2008. Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis. The FASEB Journal 22 (7): 2214\u20132222.","journal-title":"The FASEB Journal"},{"issue":"4\u20135","key":"1562_CR77","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10067-003-0716-3","volume":"22","author":"K Miyachi","year":"2003","unstructured":"Miyachi, K., et al. 2003. Efficacy of imatinib mesylate (STI571) treatment for a patient with rheumatoid arthritis developing chronic myelogenous leukemia. Clinical Rheumatology 22 (4\u20135): 329\u2013332.","journal-title":"Clinical Rheumatology"},{"key":"1562_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2036.2006.00019.x","volume":"24","author":"N Oshitani","year":"2006","unstructured":"Oshitani, N., et al. 2006. Significance of activated mast cells in submucosa and muscularis propria of patients with Crohn\u2019s disease detected by a novel antimast cell surface molecule antibody. Alimentary Pharmacology & Therapeutics 24: 1\u20137.","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"7","key":"1562_CR79","doi-asserted-by":"publisher","first-page":"e325","DOI":"10.1111\/j.1365-2982.2012.01941.x","volume":"24","author":"K Vaali","year":"2012","unstructured":"Vaali, K., et al. 2012. Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy. Neurogastroenterology & Motility 24 (7): e325\u2013e335.","journal-title":"Neurogastroenterology & Motility"},{"issue":"1","key":"1562_CR80","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-3024.1993.tb00572.x","volume":"15","author":"R Grencis","year":"1993","unstructured":"Grencis, R., et al. 1993. The in vivo role of stem cell factor (c-kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice. Parasite Immunology 15 (1): 55\u201359.","journal-title":"Parasite Immunology"},{"key":"1562_CR81","doi-asserted-by":"crossref","unstructured":"Louza, G.S., L.L.G. do Carmo, and I.M. Concei\u00e7\u00e3o. 2020. Effect of Tityus serrulatus scorpion venom on isolated jejunum: A very useful tool to study the interaction between neurons in the enteric nervous system. Autonomic Neuroscience 227:102676.","DOI":"10.1016\/j.autneu.2020.102676"},{"issue":"1","key":"1562_CR82","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0306-4522(02)00139-2","volume":"113","author":"A Bicalho","year":"2002","unstructured":"Bicalho, A., et al. 2002. Investigation of the modulation of glutamate release by sodium channels using neurotoxins. Neuroscience 113 (1): 115\u2013123.","journal-title":"Neuroscience"},{"issue":"3","key":"1562_CR83","first-page":"404","volume":"149","author":"C Borja-Oliveira","year":"2009","unstructured":"Borja-Oliveira, C., et al. 2009. Positive inotropic effects of Tityus cambridgei and T. serrulatus scorpion venoms on skeletal muscle. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 149 (3): 404\u2013408.","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"},{"issue":"6","key":"1562_CR84","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/intimm\/dxx040","volume":"29","author":"T Voisin","year":"2017","unstructured":"Voisin, T., A. Bouvier, and I.M. Chiu. 2017. Neuro-immune interactions in allergic diseases: Nnovel targets for therapeutics. International Immunology 29 (6): 247\u2013261.","journal-title":"International Immunology"},{"issue":"7","key":"1562_CR85","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/0041-0101(95)00005-7","volume":"33","author":"M Ismail","year":"1995","unstructured":"Ismail, M. 1995. The scorpion envenoming syndrome. Toxicon 33 (7): 825\u2013858.","journal-title":"Toxicon"},{"issue":"2","key":"1562_CR86","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1046\/j.1432-1327.1999.00625.x","volume":"264","author":"LD Possani","year":"1999","unstructured":"Possani, L.D., et al. 1999. Scorpion toxins specific for Na+-channels. European Journal of Biochemistry 264 (2): 287\u2013300.","journal-title":"European Journal of Biochemistry"},{"issue":"10","key":"1562_CR87","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0041-0101(88)90258-9","volume":"26","author":"S Sofer","year":"1988","unstructured":"Sofer, S., and M. Gueron. 1988. Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: Hemodynamic and neurological aspects. Toxicon 26 (10): 931\u2013939.","journal-title":"Toxicon"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01562-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01562-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-021-01562-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T10:34:20Z","timestamp":1650278060000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-021-01562-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1562"],"URL":"https:\/\/doi.org\/10.1007\/s10753-021-01562-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"type":"print","value":"0360-3997"},{"type":"electronic","value":"1573-2576"}],"subject":[],"published":{"date-parts":[[2021,10,5]]},"assertion":[{"value":"22 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"All animal experiments were performed following guidelines for the care of laboratory animals and approved by the European Community Council Directive (86\/609\/EEC).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}