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The aim of the present study was to investigate the protective effect of resveratrol (RSV) in a CCl<jats:sub>4<\/jats:sub>-induced rat model of HF. We demonstrate that the administration of RSV effectively improves liver function and ameliorates liver fibrosis by reducing collagen deposition and reversing the expression of COL1A1 and PPAR-\u03b3. Treatment efficacy of RSV could be attributed to reversed epithelial-mesenchymal transition progress with upregulated expression of E-cadherin and downregulated N-cadherin, vimentin, and \u03b1-SMA. Moreover, RSV significantly decreased the levels of endoplasmic reticulum stress (ERS)-related proteins CHOP; Bip; cleaved caspase-3, caspase-7, and caspase-12; Bax; and Bak while promotes the expression of anti-apoptosis protein Bcl2. The important role of ERS in HF was confirmed by using 4-PBA, an ERS inhibitor, which markedly ameliorated CCl<jats:sub>4<\/jats:sub>-induced HF. Further, mechanistic studies demonstrated that RSV significantly decreased CCl<jats:sub>4<\/jats:sub>-induced transforming growth factor-\u03b2 synthesis and inflammatory factor (tumor necrosis factor-\u03b1 and interleukin-6) expression and reduced the inflammation of hepatic stellate cells by inhibiting the NF-\u03baB pathway <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. In conclusion, the results suggested that RSV ameliorated HF in associated with decreased ERS-induced apoptosis and inflammation in rats.<\/jats:p>","DOI":"10.1007\/s10753-021-01586-w","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T12:02:41Z","timestamp":1643198561000},"page":"812-823","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Resveratrol Alleviates Hepatic Fibrosis in Associated with Decreased Endoplasmic Reticulum Stress-Mediated Apoptosis and Inflammation"],"prefix":"10.1007","volume":"45","author":[{"given":"Zhenyu","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0351-5184","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"1586_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1590\/S1679-45082015RW3164","volume":"13","author":"RF Meirelles Junior","year":"2015","unstructured":"Meirelles Junior, R.F., P. 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