{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:34:49Z","timestamp":1762353289439,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s10753-022-01773-3","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T13:04:58Z","timestamp":1671800698000},"page":"853-860","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Angiopoietin-2 Single Nucleotide Polymorphism in Patients with Rheumatoid Arthritis"],"prefix":"10.1007","volume":"46","author":[{"given":"Samah Ismail","family":"Nasef","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alia","family":"Ellawindy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya Mohamed","family":"Askar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa AbdelKreem","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-3791","authenticated-orcid":false,"given":"Hanan Hassan","family":"Omar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"1773_CR1","doi-asserted-by":"publisher","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","volume":"4","author":"JS Smolen","year":"2018","unstructured":"Smolen, J.S., D. Aletaha, A. Barton, G.R. Burmester, P. Emery, G.S. Firestein, et al. 2018. Rheumatoid arthritis. Nature Reviews Disease Primers 4: 18001.","journal-title":"Nature Reviews Disease Primers"},{"issue":"6","key":"1773_CR2","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.autrev.2017.04.005","volume":"16","author":"A Leblond","year":"2017","unstructured":"Leblond, A., Y. Allanore, and J. Avouac. 2017. Targeting synovial neoangiogenesis in rheumatoid arthritis. Autoimmunity Reviews 16 (6): 594\u2013601.","journal-title":"Autoimmunity Reviews"},{"key":"1773_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.07.009","volume":"126","author":"Y Li","year":"2018","unstructured":"Li, Y., Y. Liu, C. Wang, W.R. Xia, J.Y. Zheng, J. Yang, et al. 2018. Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1\u03b1\/VEGF axis. Free Radical Biology & Medicine 126: 1\u201314.","journal-title":"Free Radical Biology & Medicine"},{"key":"1773_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174500","volume":"910","author":"Y Wang","year":"2021","unstructured":"Wang, Y., H. Wu, and R. Deng. 2021. Angiogenesis as a potential treatment strategy for rheumatoid arthritis. European Journal of Pharmacology 910: 174500.","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"1773_CR5","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/s12276-020-0443-8","volume":"52","author":"JW Kim","year":"2020","unstructured":"Kim, J.W., J.-S. Kong, S. Lee, S.-A. Yoo, J.H. Koh, J. Jin, et al. 2020. Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis. Experimental & Molecular Medicine. 52 (5): 843\u2013853.","journal-title":"Experimental & Molecular Medicine."},{"issue":"13","key":"1773_CR6","doi-asserted-by":"publisher","first-page":"7071","DOI":"10.3390\/ijms23137071","volume":"23","author":"F Khodadust","year":"2022","unstructured":"Khodadust, F., A. Ezdoglian, M.M. Steinz, J.R. van Beijnum, G.J.C. Zwezerijnen, G. Jansen, et al. 2022. Systematic review: targeted molecular imaging of angiogenesis and its mediators in rheumatoid arthritis. International Journal of Molecular Sciences 23 (13): 7071.","journal-title":"International Journal of Molecular Sciences"},{"key":"1773_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/nyas.12726","volume":"1347","author":"A Scholz","year":"2015","unstructured":"Scholz, A., K.H. Plate, and Y. Reiss. 2015. Angiopoietin-2: A multifaceted cytokine that functions in both angiogenesis and inflammation. Annals of the New York Academy of Sciences 1347: 45\u201351.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"1773_CR8","doi-asserted-by":"publisher","first-page":"117080","DOI":"10.1016\/j.lfs.2019.117080","volume":"239","author":"G Nicolini","year":"2019","unstructured":"Nicolini, G., F. Forini, C. Kusmic, G. Iervasi, and S. Balzan. 2019. Angiopoietin 2 signal complexity in cardiovascular disease and cancer. Life Sciences 239: 117080.","journal-title":"Life Sciences"},{"issue":"14","key":"1773_CR9","doi-asserted-by":"publisher","first-page":"4911","DOI":"10.3390\/ijms21144911","volume":"21","author":"DS Mikhaylenko","year":"2020","unstructured":"Mikhaylenko, D.S., M.V. Nemtsova, I.V. Bure, E.B. Kuznetsova, E.A. Alekseeva, V.V. Tarasov, et al. 2020. Genetic polymorphisms associated with rheumatoid arthritis development and antirheumatic therapy response. International Journal of Molecular Sciences 21 (14): 4911.","journal-title":"International Journal of Molecular Sciences"},{"key":"1773_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","volume":"110","author":"HU Scherer","year":"2020","unstructured":"Scherer, H.U., T. H\u00e4upl, and G.R. Burmester. 2020. The etiology of rheumatoid arthritis. Journal of Autoimmunity 110: 102400.","journal-title":"Journal of Autoimmunity"},{"issue":"4","key":"1773_CR11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00281-017-0630-4","volume":"39","author":"S Viatte","year":"2017","unstructured":"Viatte, S., and A. Barton. 2017. Genetics of rheumatoid arthritis susceptibility, severity, and treatment response. Seminars in Immunopathology 39 (4): 395\u2013408.","journal-title":"Seminars in Immunopathology"},{"issue":"2","key":"1773_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/rheumatology\/keu323","volume":"55","author":"A Yarwood","year":"2016","unstructured":"Yarwood, A., T.W. Huizinga, and J. Worthington. 2016. The genetics of rheumatoid arthritis: Risk and protection in different stages of the evolution of RA. Rheumatology (Oxford) 55 (2): 199\u2013209.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"1773_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41598-020-79544-z","volume":"11","author":"JM Wang","year":"2021","unstructured":"Wang, J.M., W.D. Xu, Z.C. Yuan, Q. Wu, J. Zhou, and A.F. Huang. 2021. Serum levels and gene polymorphisms of angiopoietin 2 in systemic lupus erythematosus patients. Science and Reports 11 (1): 10.","journal-title":"Science and Reports"},{"issue":"2","key":"1773_CR14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.7150\/ijms.30582","volume":"16","author":"C Dai","year":"2019","unstructured":"Dai, C., S.J. Kuo, J. Zhao, L. Jin, L. Kang, L. Wang, et al. 2019. Correlation between genetic polymorphism of angiopoietin-2 gene and clinical aspects of rheumatoid arthritis. International Journal of Medical Sciences 16 (2): 331\u2013336.","journal-title":"International Journal of Medical Sciences"},{"issue":"13","key":"1773_CR15","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.7150\/jca.31134","volume":"10","author":"W Hu","year":"2019","unstructured":"Hu, W., C.H. Tang, H.T. Chen, J. Zhao, L. Jin, L. Kang, et al. 2019. Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population. Journal of Cancer 10 (13): 2935\u20132941.","journal-title":"Journal of Cancer"},{"issue":"2","key":"1773_CR16","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2478\/rrlm-2020-0020","volume":"28","author":"J Szederjesi","year":"2020","unstructured":"Szederjesi, J., A. Lazar, M. Petrisor, A. Hutanu, F. Tripon, A.M. Georgescu, et al. 2020. Genetic variability of ANG2-35G>C gene as a predictor factor in sepsis. Revista Romana de Medicina de Laborator 28 (2): 175\u2013184.","journal-title":"Revista Romana de Medicina de Laborator"},{"issue":"12","key":"1773_CR17","first-page":"16121","volume":"131","author":"M Michalska-Jakubus","year":"2021","unstructured":"Michalska-Jakubus, M., M. Rusek, M. Kowal, and D. Krasowska. 2021. Preliminary observations on ANGPT1 and ANGPT2 polymorphisms in systemic sclerosis: ANGPT2 rs2442598 and rs3739390 are associated with disease susceptibility and diffuse disease subtype. Polish Archives of Internal Medicine 131 (12): 16121.","journal-title":"Polish Archives of Internal Medicine"},{"issue":"1","key":"1773_CR18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12882-020-01935-1","volume":"21","author":"PK Bhatraju","year":"2020","unstructured":"Bhatraju, P.K., M. Cohen, R.J. Nagao, E.D. Morrell, S. Kosamo, X.Y. Chai, et al. 2020. Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. BMC Nephrology 21 (1): 284.","journal-title":"BMC Nephrology"},{"issue":"2","key":"1773_CR19","first-page":"97","volume":"23","author":"H Omar","year":"2016","unstructured":"Omar, H., A.T. Abdellah, H. Abdalla, S.I. Nasef, and H. Omar. 2016. Angiopoietin-2 as A biomarker for echocardiographic abnormalities and carotid atherosclerosis in rheumatoid arthritis patients. The Egyptian Journal of Immunology 23 (2): 97\u2013108.","journal-title":"The Egyptian Journal of Immunology"},{"issue":"5","key":"1773_CR20","first-page":"761","volume":"31","author":"R L\u00f3pez-Mej\u00edas","year":"2013","unstructured":"L\u00f3pez-Mej\u00edas, R., A. Corrales, F. Genre, J.L. Hern\u00e1ndez, R. Ochoa, R. Blanco, et al. 2013. Angiopoietin-2 serum levels correlate with severity, early onset and cardiovascular disease in patients with rheumatoid arthritis. Clinical & Experimental Rheumatology 31 (5): 761\u2013766.","journal-title":"Clinical & Experimental Rheumatology"},{"issue":"6","key":"1773_CR21","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1080\/08820139.2022.2058404","volume":"51","author":"HH Omar","year":"2022","unstructured":"Omar, H.H., S.I. Nasef, and M.M. Anani. 2022. The association of angiopoietin-2 1064 C\/T Rs3020221 gene polymorphism with knee osteoarthritis. Immunological Investigations 51 (6): 1820\u20131832.","journal-title":"Immunological Investigations"},{"issue":"9","key":"1773_CR22","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha, D., T. Neogi, A.J. Silman, J. Funovits, D.T. Felson, C.O. Bingham 3rd., et al. 2010. 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis and Rheumatism 62 (9): 2569\u20132581.","journal-title":"Arthritis and Rheumatism"},{"key":"1773_CR23","unstructured":"Dean AG, Sullivan KM, Soe MM. OpenEpi:open source Epidemiologic Statistics for Public Health, version3.01. Updated 2013\/04\/06 https:\/\/www.openepi.com\/SampleSize\/SSPropor.htm"},{"issue":"5","key":"1773_CR24","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/acr.21649","volume":"64","author":"J Anderson","year":"2012","unstructured":"Anderson, J., L. Caplan, J. Yazdany, M.L. Robbins, T. Neogi, K. Michaud, et al. 2012. Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice. Arthritis Care & Research 64 (5): 640\u2013647.","journal-title":"Arthritis Care & Research"},{"issue":"5","key":"1773_CR25","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3390\/cells8050471","volume":"8","author":"RG Akwii","year":"2019","unstructured":"Akwii, R.G., M.S. Sajib, F.T. Zahra, and C.M. Mikelis. 2019. Role of angiopoietin-2 in vascular physiology and pathophysiology. Cells 8 (5): 471.","journal-title":"Cells"},{"issue":"6","key":"1773_CR26","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.3390\/cancers12061506","volume":"12","author":"D Butkiewicz","year":"2020","unstructured":"Butkiewicz, D., A. Gdowicz-K\u0142osok, M. Krze\u015bniak, T. Rutkowski, A. Krzywon, A.J. Cortez, et al. 2020. Association of genetic variants in ANGPT\/TEK and VEGF\/VEGFR with progression and survival in head and neck squamous cell carcinoma treated with radiotherapy or radiochemotherapy. Cancers 12 (6): 1506.","journal-title":"Cancers"},{"issue":"7","key":"1773_CR27","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3390\/cancers11071023","volume":"11","author":"G Marisi","year":"2019","unstructured":"Marisi, G., E. Petracci, F. Raimondi, L. Faloppi, F.G. Foschi, G. Lauletta, et al. 2019. ANGPT2 and NOS3 polymorphisms and clinical outcome in advanced hepatocellular carcinoma patients receiving sorafenib. Cancers 11 (7): 1023.","journal-title":"Cancers"},{"key":"1773_CR28","unstructured":"NCBI. https:\/\/www.ncbi.nlm.nih.gov\/SNP\/snp_ref.cgi?locusId=285"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-022-01773-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-022-01773-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-022-01773-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T03:35:10Z","timestamp":1684294510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-022-01773-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["1773"],"URL":"https:\/\/doi.org\/10.1007\/s10753-022-01773-3","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"type":"print","value":"0360-3997"},{"type":"electronic","value":"1573-2576"}],"subject":[],"published":{"date-parts":[[2022,12,23]]},"assertion":[{"value":"8 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the research ethics committee of the Faculty of Medicine, Suez Canal University, ID no. 5065#, which conducted according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All the participants in this study\u00a0provided an informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}