{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:44Z","timestamp":1790717084592,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970941"],"award-info":[{"award-number":["81970941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["PAPD, 2018-87"],"award-info":[{"award-number":["PAPD, 2018-87"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["Grant Nos. BE2021723"],"award-info":[{"award-number":["Grant Nos. BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["Grant Nos. BE2021723"],"award-info":[{"award-number":["Grant Nos. BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["Grant Nos. BE2021723"],"award-info":[{"award-number":["Grant Nos. BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["Grant Nos. BE2021723"],"award-info":[{"award-number":["Grant Nos. BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["Grant Nos. BE2021723"],"award-info":[{"award-number":["Grant Nos. BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["Grant Nos. BE2021723"],"award-info":[{"award-number":["Grant Nos. BE2021723"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s10753-023-01793-7","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T12:57:25Z","timestamp":1680699445000},"page":"1077-1090","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["E. coli LPS\/TLR4\/NF-\u03baB Signaling Pathway Regulates Th17\/Treg Balance Mediating Inflammatory Responses in Oral Lichen Planus"],"prefix":"10.1007","volume":"46","author":[{"given":"Mengna","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"issue":"4","key":"1793_CR1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1111\/odi.13323","volume":"27","author":"MA Gonzalez-Moles","year":"2021","unstructured":"Gonzalez-Moles, M.A., S. Warnakulasuriya, I. Gonzalez-Ruiz, L. Gonzalez-Ruiz, A. Ayen, D. Lenouvel, I. Ruiz-Avila, and P. Ramos-Garcia. 2021. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis. Oral Diseases 27 (4): 813\u2013828. https:\/\/doi.org\/10.1111\/odi.13323.","journal-title":"Oral Diseases"},{"key":"1793_CR2","unstructured":"Shiva, A., A. Zamanian, S. Arab, and M. Boloki. 2018. Immunohistochemical study of p53 expression in patients with erosive and non-erosive oral lichen planus. Journal of Dentistry (Shiraz)\u00a019(2):118\u2013123. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29854885."},{"issue":"1","key":"1793_CR3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jds.2021.06.013","volume":"17","author":"ZD Zhu","year":"2022","unstructured":"Zhu, Z.D., X.M. Ren, M.M. Zhou, Q.M. Chen, H. Hua, and C.L. Li. 2022. Salivary cytokine profile in patients with oral lichen planus. Journal of Dental Sciences 17 (1): 100\u2013105. https:\/\/doi.org\/10.1016\/j.jds.2021.06.013.","journal-title":"Journal of Dental Sciences"},{"issue":"9","key":"1793_CR4","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/s41579-020-0367-2","volume":"18","author":"WE Ruff","year":"2020","unstructured":"Ruff, W.E., T.M. Greiling, and M.A. Kriegel. 2020. Host-microbiota interactions in immune-mediated diseases. Nature Reviews Microbiology 18 (9): 521\u2013538. https:\/\/doi.org\/10.1038\/s41579-020-0367-2.","journal-title":"Nature Reviews Microbiology"},{"key":"1793_CR5","doi-asserted-by":"publisher","unstructured":"Rusthen, S., A.K. Kristoffersen, A. Young, H.K. Galtung, B.E. Petrovski, O. Palm, M. Enersen, and J.L. Jensen. 2019. Dysbiotic salivary microbiota in dry mouth and primary Sjogren\u2019s syndrome patients. PLoS One\u00a014(6):e0218319. https:\/\/doi.org\/10.1371\/journal.pone.0218319.","DOI":"10.1371\/journal.pone.0218319"},{"issue":"1","key":"1793_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13075-020-02348-z","volume":"22","author":"Y Hamamoto","year":"2020","unstructured":"Hamamoto, Y., K. Ouhara, S. Munenaga, M. Shoji, T. Ozawa, J. Hisatsune, I. Kado, M. Kajiya, S. Matsuda, T. Kawai, N. Mizuno, T. Fujita, S. Hirata, K. Tanimoto, K. Nakayama, H. Kishi, E. Sugiyama, and H. Kurihara. 2020. Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model. Arthritis Research & Therapy 22 (1): 249. https:\/\/doi.org\/10.1186\/s13075-020-02348-z.","journal-title":"Arthritis Research & Therapy"},{"key":"1793_CR7","doi-asserted-by":"publisher","first-page":"23561","DOI":"10.1038\/srep23561","volume":"6","author":"CS De Paiva","year":"2016","unstructured":"De Paiva, C.S., D.B. Jones, M.E. Stern, F. Bian, Q.L. Moore, S. Corbiere, C.F. Streckfus, D.S. Hutchinson, N.J. Ajami, J.F. Petrosino, and S.C. Pflugfelder. 2016. Altered mucosal microbiome diversity and disease severity in sjogren syndrome. Science and Reports 6: 23561. https:\/\/doi.org\/10.1038\/srep23561.","journal-title":"Science and Reports"},{"key":"1793_CR8","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3389\/fmicb.2020.00629","volume":"11","author":"X Wang","year":"2020","unstructured":"Wang, X., Z. Zhao, N. Tang, Y. Zhao, J. Xu, L. Li, L. Qian, J. Zhang, and Y. Fan. 2020. Microbial community analysis of saliva and biopsies in patients with oral lichen planus. Frontiers in Microbiology 11: 629. https:\/\/doi.org\/10.3389\/fmicb.2020.00629.","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"1793_CR9","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1038\/s41598-020-60449-w","volume":"10","author":"K Baek","year":"2020","unstructured":"Baek, K., J. Lee, A. Lee, J. Lee, H.J. Yoon, H.K. Park, J. Chun, and Y. Choi. 2020. Characterization of intratissue bacterial communities and isolation of Escherichia coli from oral lichen planus lesions. Science and Reports 10 (1): 3495. https:\/\/doi.org\/10.1038\/s41598-020-60449-w.","journal-title":"Science and Reports"},{"issue":"2","key":"1793_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","volume":"42","author":"YC Lu","year":"2008","unstructured":"Lu, Y.C., W.C. Yeh, and P.S. Ohashi. 2008. LPS\/TLR4 signal transduction pathway. Cytokine 42 (2): 145\u2013151. https:\/\/doi.org\/10.1016\/j.cyto.2008.01.006.","journal-title":"Cytokine"},{"key":"1793_CR11","doi-asserted-by":"publisher","unstructured":"Rogier, R., T.H.A. Ederveen, J. Boekhorst, H. Wopereis, J.U. Scher, J. Manasson, S.J.C.M. Frambach, J. Knol, J. Garssen, P.M. Van Der Kraan, M.I. Koenders, W.B. Van Den Berg, S.a.F.T. Van Hijum, and S. Abdollahi-Roodsaz. 2017. Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis. Microbiome 5(1). https:\/\/doi.org\/10.1186\/s40168-017-0278-2.","DOI":"10.1186\/s40168-017-0278-2"},{"key":"1793_CR12","doi-asserted-by":"publisher","unstructured":"Qu, Y., X. Li, F. Xu, S. Zhao, X. Wu, Y. Wang, and J. Xie. 2021. Kaempferol alleviates murine experimental colitis by restoring gut microbiota and inhibiting the LPS-TLR4-NF-kappaB axis. Frontiers in Immunology\u00a012: 679897. https:\/\/doi.org\/10.3389\/fimmu.2021.679897.","DOI":"10.3389\/fimmu.2021.679897"},{"key":"1793_CR13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jep.2016.05.044","volume":"189","author":"GD Kang","year":"2016","unstructured":"Kang, G.D., and D.H. Kim. 2016. Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17\/Treg imbalance. Journal of Ethnopharmacology 189: 175\u2013185. https:\/\/doi.org\/10.1016\/j.jep.2016.05.044.","journal-title":"Journal of Ethnopharmacology"},{"issue":"5","key":"1793_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.archoralbio.2011.10.013","volume":"57","author":"SB Janardhanam","year":"2012","unstructured":"Janardhanam, S.B., S. Prakasam, V.T. Swaminathan, K.N. Kodumudi, S.L. Zunt, and M. Srinivasan. 2012. Differential expression of TLR-2 and TLR-4 in the epithelial cells in oral lichen planus. Archives of Oral Biology 57 (5): 495\u2013502. https:\/\/doi.org\/10.1016\/j.archoralbio.2011.10.013.","journal-title":"Archives of Oral Biology"},{"issue":"2","key":"1793_CR15","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/jop.12655","volume":"47","author":"Q Zeng","year":"2018","unstructured":"Zeng, Q., X. Yang, X. Chen, J. Xia, B. Cheng, and X. Tao. 2018. Porphyromonas gingivalis lipopolysaccharide induces over production of CC chemokine ligand 2 via toll-like receptor-4 in oral lichen planus. Journal of Oral Pathology and Medicine 47 (2): 166\u2013172. https:\/\/doi.org\/10.1111\/jop.12655.","journal-title":"Journal of Oral Pathology and Medicine"},{"issue":"3","key":"1793_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.1600-0714.2006.00402.x","volume":"35","author":"M Ichimura","year":"2006","unstructured":"Ichimura, M., K. Hiratsuka, N. Ogura, T. Utsunomiya, H. Sakamaki, T. Kondoh, Y. Abiko, S. Otake, and M. Yamamoto. 2006. Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus. Journal of Oral Pathology and Medicine 35 (3): 167\u2013174. https:\/\/doi.org\/10.1111\/j.1600-0714.2006.00402.x.","journal-title":"Journal of Oral Pathology and Medicine"},{"issue":"4","key":"1793_CR17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/jop.12928","volume":"49","author":"J Shan","year":"2020","unstructured":"Shan, J., C. Shen, J. Fang, S. Li, and Y. Fan. 2020. Potential roles of the CCL17-CCR4 axis in immunopathogenesis of oral lichen planus. Journal of Oral Pathology and Medicine 49 (4): 328\u2013334. https:\/\/doi.org\/10.1111\/jop.12928.","journal-title":"Journal of Oral Pathology and Medicine"},{"issue":"4","key":"1793_CR18","doi-asserted-by":"publisher","first-page":"384","DOI":"10.7518\/hxkq.2018.04.007","volume":"36","author":"PR Jia","year":"2018","unstructured":"Jia, P.R., Y.Y. Huang, Y. Wang, and Y. Cai. 2018. Correlations between the T helper cell 17\/regulatory T cells balance in peripheral blood of patients with oral lichen planus and clinical characteristics. West China Journal of Stomatology 36 (4): 384\u2013388. https:\/\/doi.org\/10.7518\/hxkq.2018.04.007.","journal-title":"West China Journal of Stomatology"},{"issue":"6","key":"1793_CR19","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/PAI.0000000000000096","volume":"23","author":"BV Monteiro","year":"2015","unstructured":"Monteiro, B.V., S. Pereira Jdos, C.F. Nonaka, G.P. Godoy, E.J. Da Silveira, and M.C. Miguel. 2015. Immunoexpression of Th17-related cytokines in oral lichen planus. Applied Immunohistochemistry & Molecular Morphology 23 (6): 409\u2013415. https:\/\/doi.org\/10.1097\/PAI.0000000000000096.","journal-title":"Applied Immunohistochemistry & Molecular Morphology"},{"issue":"6","key":"1793_CR20","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/jop.12405","volume":"45","author":"H Wang","year":"2016","unstructured":"Wang, H., D. Zhang, Q. Han, X. Zhao, X. Zeng, Y. Xu, Z. Sun, and Q. Chen. 2016. Role of distinct CD4(+) T helper subset in pathogenesis of oral lichen planus. Journal of Oral Pathology and Medicine 45 (6): 385\u2013393. https:\/\/doi.org\/10.1111\/jop.12405.","journal-title":"Journal of Oral Pathology and Medicine"},{"issue":"9","key":"1793_CR21","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1034\/j.1600-0714.2003.00125.x","volume":"32","author":"EH Van Der Meij","year":"2003","unstructured":"Van Der Meij, E.H., and I. Van Der Waal. 2003. Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications. Journal of Oral Pathology and Medicine 32 (9): 507\u2013512. https:\/\/doi.org\/10.1034\/j.1600-0714.2003.00125.x.","journal-title":"Journal of Oral Pathology and Medicine"},{"key":"1793_CR22","doi-asserted-by":"publisher","unstructured":"Choi, S.C., J. Brown, M. Gong, Y. Ge, M. Zadeh, W. Li, B.P. Croker, G. Michailidis, T.J. Garrett, M. Mohamadzadeh, and L. Morel. 2020. Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice. Science Translational Medicine\u00a012 (551). https:\/\/doi.org\/10.1126\/scitranslmed.aax2220.","DOI":"10.1126\/scitranslmed.aax2220"},{"issue":"3","key":"1793_CR23","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1002\/hep.30349","volume":"70","author":"L Munoz","year":"2019","unstructured":"Munoz, L., M.J. Borrero, M. Ubeda, E. Conde, R. Del Campo, M. Rodriguez-Serrano, M. Lario, A.M. Sanchez-Diaz, O. Pastor, D. Diaz, L. Garcia-Bermejo, J. Monserrat, M. Alvarez-Mon, and A. Albillos. 2019. Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis. Hepatology 70 (3): 925\u2013938. https:\/\/doi.org\/10.1002\/hep.30349.","journal-title":"Hepatology"},{"key":"1793_CR24","doi-asserted-by":"publisher","unstructured":"Puppala, E.R., S. Jain, P. Saha, M. Rachamalla, S. Np, S.S. Yalamarthi, M. Abubakar, A. Chaudhary, D. Chamundeswari, M. Usn, J.K. Gangasani, and V.G.M. Naidu. 2022. Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4\/NF-kappaB and Keap1\/Nrf2 signaling pathways: a comprehensive study on in-vitro and in-vivo experimental models. Phytomedicine\u00a097:153926. https:\/\/doi.org\/10.1016\/j.phymed.2022.153926.","DOI":"10.1016\/j.phymed.2022.153926"},{"key":"1793_CR25","doi-asserted-by":"publisher","unstructured":"Khan, A., B. Shal, A.U. Khan, T. Bibi, S.U. Islam, M.W. Baig, I.U. Haq, H. Ali, S. Ahmad, and S. Khan. 2021. Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2\/HO-1 and TLR4\/NF-kappaB signaling. Neurochemistry International\u00a0151:105211. https:\/\/doi.org\/10.1016\/j.neuint.2021.105211.","DOI":"10.1016\/j.neuint.2021.105211"},{"issue":"12","key":"1793_CR26","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1002\/iub.2564","volume":"73","author":"Y Li","year":"2021","unstructured":"Li, Y., M.Y. Jiang, J.Y. Chen, Z.W. Xu, J.W. Zhang, T. Li, L.L. Zhang, and W. Wei. 2021. CP-25 exerts therapeutic effects in mice with dextran sodium sulfate-induced colitis by inhibiting GRK2 translocation to downregulate the TLR4-NF-kappaB-NLRP3 inflammasome signaling pathway in macrophages. IUBMB Life 73 (12): 1406\u20131422. https:\/\/doi.org\/10.1002\/iub.2564.","journal-title":"IUBMB Life"},{"issue":"2","key":"1793_CR27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.gene.2012.07.045","volume":"508","author":"Y Ge","year":"2012","unstructured":"Ge, Y., Y. Xu, W. Sun, Z. Man, L. Zhu, X. Xia, L. Zhao, Y. Zhao, and X. Wang. 2012. The molecular mechanisms of the effect of Dexamethasone and Cyclosporin A on TLR4 \/NF-kappaB signaling pathway activation in oral lichen planus. Gene 508 (2): 157\u2013164. https:\/\/doi.org\/10.1016\/j.gene.2012.07.045.","journal-title":"Gene"},{"issue":"1","key":"1793_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.immuni.2016.11.007","volume":"46","author":"JK Ryu","year":"2017","unstructured":"Ryu, J.K., S.J. Kim, S.H. Rah, J.I. Kang, H.E. Jung, D. Lee, H.K. Lee, J.O. Lee, B.S. Park, T.Y. Yoon, and H.M. Kim. 2017. Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14, and TLR4-MD2 for efficient LPS recognition and transfer. Immunity 46 (1): 38\u201350. https:\/\/doi.org\/10.1016\/j.immuni.2016.11.007.","journal-title":"Immunity"},{"issue":"6","key":"1793_CR29","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.4049\/jimmunol.180.6.4308","volume":"180","author":"K De Filippo","year":"2008","unstructured":"De Filippo, K., R.B. Henderson, M. Laschinger, and N. Hogg. 2008. Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. The Journal of Immunology 180 (6): 4308\u20134315. https:\/\/doi.org\/10.4049\/jimmunol.180.6.4308.","journal-title":"The Journal of Immunology"},{"key":"1793_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.intimp.2019.01.011","volume":"69","author":"Q Xiao","year":"2019","unstructured":"Xiao, Q., X. Zhu, S. Yang, J. Wang, R. Yin, J. Song, A. Ma, and X. Pan. 2019. LPS induces CXCL16 expression in HUVECs through the miR-146a-mediated TLR4 pathway. International Immunopharmacology 69: 143\u2013149. https:\/\/doi.org\/10.1016\/j.intimp.2019.01.011.","journal-title":"International Immunopharmacology"},{"issue":"11","key":"1793_CR31","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1080\/02713683.2021.1929326","volume":"46","author":"DN Hu","year":"2021","unstructured":"Hu, D.N., R. Zhang, S. Yao, C.E. Iacob, W.E. Yang, R. Rosen, and S.F. Yang. 2021. Cultured human uveal melanocytes express\/secrete CXCL1 and CXCL2 constitutively and increased by lipopolysaccharide via activation of toll-like receptor 4. Current Eye Research 46 (11): 1681\u20131694. https:\/\/doi.org\/10.1080\/02713683.2021.1929326.","journal-title":"Current Eye Research"},{"issue":"9","key":"1793_CR32","doi-asserted-by":"publisher","first-page":"6155","DOI":"10.4049\/jimmunol.175.9.6155","volume":"175","author":"AK De","year":"2005","unstructured":"De, A.K., C.L. Miller-Graziano, S.E. Calvano, K. Laudanski, S.F. Lowry, L.L. Moldawer, D.G. Remick Jr., N. Rajicic, D. Schoenfeld, and R.G. Tompkins. 2005. Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation. The Journal of Immunology 175 (9): 6155\u20136162. https:\/\/doi.org\/10.4049\/jimmunol.175.9.6155.","journal-title":"The Journal of Immunology"},{"issue":"10","key":"1793_CR33","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.micinf.2014.08.005","volume":"16","author":"L Zhao","year":"2014","unstructured":"Zhao, L., J. Xia, X. Wang, and F. Xu. 2014. Transcriptional regulation of CCL20 expression. Microbes and Infection 16 (10): 864\u2013870. https:\/\/doi.org\/10.1016\/j.micinf.2014.08.005.","journal-title":"Microbes and Infection"},{"issue":"1","key":"1793_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.cyto.2015.02.002","volume":"74","author":"SM Paulissen","year":"2015","unstructured":"Paulissen, S.M., J.P. Van Hamburg, W. Dankers, and E. Lubberts. 2015. The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis. Cytokine 74 (1): 43\u201353. https:\/\/doi.org\/10.1016\/j.cyto.2015.02.002.","journal-title":"Cytokine"},{"issue":"8","key":"1793_CR35","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1084\/jem.20070663","volume":"204","author":"F Annunziato","year":"2007","unstructured":"Annunziato, F., L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Fili, S. Ferri, F. Frosali, F. Giudici, P. Romagnani, P. Parronchi, F. Tonelli, E. Maggi, and S. Romagnani. 2007. Phenotypic and functional features of human Th17 cells. Journal of Experimental Medicine 204 (8): 1849\u20131861. https:\/\/doi.org\/10.1084\/jem.20070663.","journal-title":"Journal of Experimental Medicine"},{"issue":"6","key":"1793_CR36","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/ni1467","volume":"8","author":"EV Acosta-Rodriguez","year":"2007","unstructured":"Acosta-Rodriguez, E.V., L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, and G. Napolitani. 2007. Surface phenotype and antigenic specificity of human interleukin 17\u2013producing T helper memory cells. Nature Immunology 8 (6): 639\u2013646. https:\/\/doi.org\/10.1038\/ni1467.","journal-title":"Nature Immunology"},{"issue":"3","key":"1793_CR37","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/cyto.a.24272","volume":"99","author":"SR Wang","year":"2021","unstructured":"Wang, S.R., N. Zhong, X.M. Zhang, Z.B. Zhao, R. Balderas, L. Li, and Z.X. Lian. 2021. OMIP 071: A 31-parameter flow cytometry panel for in-depth immunophenotyping of human T-cell subsets using surface markers. Cytometry. Part A 99 (3): 273\u2013277. https:\/\/doi.org\/10.1002\/cyto.a.24272.","journal-title":"Cytometry. Part A"},{"issue":"10","key":"1793_CR38","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.it.2012.05.004","volume":"33","author":"F Annunziato","year":"2012","unstructured":"Annunziato, F., L. Cosmi, F. Liotta, E. Maggi, and S. Romagnani. 2012. Defining the human T helper 17 cell phenotype. Trends in Immunology 33 (10): 505\u2013512. https:\/\/doi.org\/10.1016\/j.it.2012.05.004.","journal-title":"Trends in Immunology"},{"issue":"4","key":"1793_CR39","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.smim.2013.10.009","volume":"25","author":"M Kleinewietfeld","year":"2013","unstructured":"Kleinewietfeld, M., and D.A. Hafler. 2013. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Seminars in Immunology 25 (4): 305\u2013312. https:\/\/doi.org\/10.1016\/j.smim.2013.10.009.","journal-title":"Seminars in Immunology"},{"issue":"1","key":"1793_CR40","doi-asserted-by":"publisher","first-page":"214","DOI":"10.4049\/jimmunol.180.1.214","volume":"180","author":"SP Singh","year":"2008","unstructured":"Singh, S.P., H.H. Zhang, J.F. Foley, M.N. Hedrick, and J.M. Farber. 2008. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. The Journal of Immunology 180 (1): 214\u2013221. https:\/\/doi.org\/10.4049\/jimmunol.180.1.214.","journal-title":"The Journal of Immunology"},{"issue":"6","key":"1793_CR41","doi-asserted-by":"publisher","first-page":"4081","DOI":"10.1167\/iovs.12-11216","volume":"54","author":"TH Dohlman","year":"2013","unstructured":"Dohlman, T.H., S.K. Chauhan, S. Kodati, J. Hua, Y. Chen, M. Omoto, Z. Sadrai, and R. Dana. 2013. The CCR6\/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease. Investigative Ophthalmology & Visual Science 54 (6): 4081\u20134091. https:\/\/doi.org\/10.1167\/iovs.12-11216.","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"1","key":"1793_CR42","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cyto.2014.11.029","volume":"72","author":"AY Lee","year":"2015","unstructured":"Lee, A.Y., T.K. Phan, M.D. Hulett, and H. Korner. 2015. The relationship between CCR6 and its binding partners: Does the CCR6-CCL20 axis have to be extended? Cytokine 72 (1): 97\u2013101. https:\/\/doi.org\/10.1016\/j.cyto.2014.11.029.","journal-title":"Cytokine"},{"issue":"2","key":"1793_CR43","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2332\/allergolint.R-07-159","volume":"57","author":"T Aranami","year":"2008","unstructured":"Aranami, T., and T. Yamamura. 2008. Th17 Cells and autoimmune encephalomyelitis (EAE\/MS). Allergology International 57 (2): 115\u2013120. https:\/\/doi.org\/10.2332\/allergolint.R-07-159.","journal-title":"Allergology International"},{"issue":"12","key":"1793_CR44","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1002\/bies.201000063","volume":"32","author":"I Comerford","year":"2010","unstructured":"Comerford, I., M. Bunting, K. Fenix, S. Haylock-Jacobs, W. Litchfield, Y. Harata-Lee, M. Turvey, J. Brazzatti, C. Gregor, P. Nguyen, E. Kara, and S.R. Mccoll. 2010. An immune paradox: How can the same chemokine axis regulate both immune tolerance and activation?: CCR6\/CCL20: A chemokine axis balancing immunological tolerance and inflammation in autoimmune disease. BioEssays 32 (12): 1067\u20131076. https:\/\/doi.org\/10.1002\/bies.201000063.","journal-title":"BioEssays"},{"key":"1793_CR45","doi-asserted-by":"publisher","unstructured":"Yu, Q., X.M. Lou, and Y. He. 2015. Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. PLoS One\u00a010(3):e0120855. https:\/\/doi.org\/10.1371\/journal.pone.0120855.","DOI":"10.1371\/journal.pone.0120855"},{"key":"1793_CR46","doi-asserted-by":"publisher","unstructured":"Meitei, H.T., N. Jadhav, and G. Lal. 2021. CCR6-CCL20 axis as a therapeutic target for autoimmune diseases. Autoimmunity Reviews\u00a020(7):102846. https:\/\/doi.org\/10.1016\/j.autrev.2021.102846.","DOI":"10.1016\/j.autrev.2021.102846"},{"issue":"12","key":"1793_CR47","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1084\/jem.20071397","volume":"204","author":"K Hirota","year":"2007","unstructured":"Hirota, K., H. Yoshitomi, M. Hashimoto, S. Maeda, S. Teradaira, N. Sugimoto, T. Yamaguchi, T. Nomura, H. Ito, T. Nakamura, N. Sakaguchi, and S. Sakaguchi. 2007. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. Journal of Experimental Medicine 204 (12): 2803\u20132812. https:\/\/doi.org\/10.1084\/jem.20071397.","journal-title":"Journal of Experimental Medicine"},{"key":"1793_CR48","doi-asserted-by":"publisher","unstructured":"Lou, H., J. Fang, P. Li, W. Zhou, Y. Wang, E. Fan, Y. Li, H. Wang, Z. Liu, L. Xiao, C. Wang, and L. Zhang. 2015. Frequency, suppressive capacity, recruitment and induction mechanisms of regulatory T cells in sinonasal squamous cell carcinoma and nasal inverted papilloma. PLoS One\u00a010(5):e0126463. https:\/\/doi.org\/10.1371\/journal.pone.0126463.","DOI":"10.1371\/journal.pone.0126463"},{"key":"1793_CR49","doi-asserted-by":"publisher","unstructured":"Sakai, R., M. Ito, K. Yoshimoto, S. Chikuma, T. Kurasawa, T. Kondo, K. Suzuki, T. Takeuchi, K. Amano, and A. Yoshimura. 2020. Tocilizumab monotherapy uncovered the role of the CCL22\/17-CCR4(+) Treg axis during remission of crescentic glomerulonephritis. Clinical Translational Immunology\u00a09(11):e1203. https:\/\/doi.org\/10.1002\/cti2.1203.","DOI":"10.1002\/cti2.1203"},{"issue":"6","key":"1793_CR50","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1084\/jem.194.6.847","volume":"194","author":"A Iellem","year":"2001","unstructured":"Iellem, A., M. Mariani, R. Lang, H. Recalde, P. Panina-Bordignon, F. Sinigaglia, and D. D\u2019ambrosio. 2001. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. Journal of Experimental Medicine 194 (6): 847\u2013853. https:\/\/doi.org\/10.1084\/jem.194.6.847.","journal-title":"Journal of Experimental Medicine"},{"issue":"1","key":"1793_CR51","doi-asserted-by":"publisher","first-page":"1905958","DOI":"10.1080\/20002297.2021.1905958","volume":"13","author":"H Min","year":"2021","unstructured":"Min, H., K. Baek, A. Lee, Y.J. Seok, and Y. Choi. 2021. Genomic characterization of four Escherichia coli strains isolated from oral lichen planus biopsies. Journal of Oral Microbiology 13 (1): 1905958. https:\/\/doi.org\/10.1080\/20002297.2021.1905958.","journal-title":"Journal of Oral Microbiology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01793-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01793-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01793-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T23:42:42Z","timestamp":1684280562000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-023-01793-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["1793"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01793-7","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,5]]},"assertion":[{"value":"7 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Nanjing Medical University (No. 2019\u2013281).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}