{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:32:33Z","timestamp":1793867553638,"version":"4.6.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Provincial Education Foundation of Jiangxi","award":["GJJ190094"],"award-info":[{"award-number":["GJJ190094"]}]},{"name":"Health Commission Foundation of Jiangxi Province","award":["202310513"],"award-info":[{"award-number":["202310513"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81960457"],"award-info":[{"award-number":["No. 81960457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s10753-023-01822-5","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T21:01:49Z","timestamp":1682456509000},"page":"1471-1492","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Melatonin-Driven NLRP3 Inflammation Inhibition Via Regulation of NF-\u03baB Nucleocytoplasmic Transport: Implications for Postoperative Cognitive Dysfunction"],"prefix":"10.1007","volume":"46","author":[{"given":"Hong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gufeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"1822_CR1","doi-asserted-by":"crossref","unstructured":"Needham, M.J., C.E. Webb, and D.C. Bryden. 2017. Postoperative cognitive dysfunction and dementia: what we need to know and do. British Journal of Anaesthesia\u00a0119 (suppl_1):\u00a0 i115-i125.","DOI":"10.1093\/bja\/aex354"},{"issue":"4","key":"1822_CR2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/S0047-6374(03)00027-7","volume":"124","author":"M Pedersen","year":"2003","unstructured":"Pedersen, M., H. Bruunsgaard, N. Weis, H.W. Hendel, B.U. Andreassen, E. Eldrup, F. Dela, and B.K. Pedersen. 2003. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mechanisms of Ageing and Development 124 (4): 495\u2013502.","journal-title":"Mechanisms of ageing and development"},{"issue":"6","key":"1822_CR3","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1182\/blood-2004-07-2599","volume":"105","author":"L Ferrucci","year":"2005","unstructured":"Ferrucci, L., A. Corsi, F. Lauretani, S. Bandinelli, B. Bartali, D.D. Taub, J.M. Guralnik, and D.L. Longo. 2005. The origins of age-related proinflammatory state. Blood 105 (6): 2294\u20132299.","journal-title":"Blood"},{"issue":"1","key":"1822_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/imr.12295","volume":"265","author":"EL Goldberg","year":"2015","unstructured":"Goldberg, E.L., and V.D. Dixit. 2015. Drivers of age-related inflammation and strategies for healthspan extension. Immunological Reviews 265 (1): 63\u201374.","journal-title":"Immunological reviews"},{"key":"1822_CR5","doi-asserted-by":"crossref","unstructured":"Wang, L., Y.Q. Zhai, L.L. Xu, C. Qiao, X.L. Sun, J.H. Ding, M. Lu, and G. Hu. 2014. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Experimental Neurology 251 (22\u201329).","DOI":"10.1016\/j.expneurol.2013.11.001"},{"key":"1822_CR6","doi-asserted-by":"crossref","unstructured":"Zhang, L., F. Xiao, J. Zhang, X. Wang, J. Ying, G. Wei, S. Chen, X. Huang, W. Yu, X. Liu, Q. Zheng, G. Xu, S. Yu, and F. Hua. 2021. Dexmedetomidine mitigated NLRP3-mediated neuroinflammation via the ubiquitin-autophagy pathway to improve perioperative neurocognitive disorder in mice. Frontiers in Pharmacology 12 (646265).","DOI":"10.3389\/fphar.2021.646265"},{"issue":"7","key":"1822_CR7","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91229","volume":"2","author":"X Feng","year":"2017","unstructured":"Feng, X., M. Valdearcos, Y. Uchida, D. Lutrin, M. Maze, and S.K. Koliwad. 2017. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI insight 2 (7): e91229.","journal-title":"JCI insight"},{"issue":"1","key":"1822_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrneurol.2014.226","volume":"11","author":"D Athauda","year":"2015","unstructured":"Athauda, D., and T. Foltynie. 2015. The ongoing pursuit of neuroprotective therapies in Parkinson disease. Nature Reviews Neurology 11 (1): 25\u201340.","journal-title":"Nature reviews Neurology"},{"issue":"1","key":"1822_CR9","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12974-021-02206-y","volume":"18","author":"K Oberman","year":"2021","unstructured":"Oberman, K., I. Hovens, J. de Haan, J. Falcao-Salles, B. van Leeuwen, and R. Schoemaker. 2021. Acute pre-operative ibuprofen improves cognition in a rat model for postoperative cognitive dysfunction. Journal of Neuroinflammation 18 (1): 156.","journal-title":"Journal of neuroinflammation"},{"issue":"11","key":"1822_CR10","first-page":"4971","volume":"23","author":"YB Wang","year":"2019","unstructured":"Wang, Y.B., Z. Chen, J. Li, and J. Shi. 2019. Parecoxib improves the cognitive function of POCD rats via attenuating COX-2. European Review for Medical and Pharmacological Sciences 23 (11): 4971\u20134979.","journal-title":"European review for medical and pharmacological sciences"},{"issue":"7","key":"1822_CR11","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1590\/0004-282X20150057","volume":"73","author":"TB Bassani","year":"2015","unstructured":"Bassani, T.B., M.A. Vital, and L.K. Rauh. 2015. Neuroinflammation in the pathophysiology of Parkinson\u2019s disease and therapeutic evidence of anti-inflammatory drugs. Arquivos De Neuro-psiquiatria 73 (7): 616\u2013623.","journal-title":"Arquivos de neuro-psiquiatria"},{"key":"1822_CR12","doi-asserted-by":"crossref","unstructured":"Feng, Y.S., Z.X. Tan, L.Y. Wu, F. Dong, and F. Zhang. 2020. The involvement of NLRP3 inflammasome in the treatment of Alzheimer\u2019s disease. Ageing Research Reviews 64 (101192).","DOI":"10.1016\/j.arr.2020.101192"},{"key":"1822_CR13","doi-asserted-by":"crossref","unstructured":"Hou, Y., Y. Wei, S. Lautrup, B. Yang, Y. Wang, S. Cordonnier, M.P. Mattson, D.L. Croteau, and V.A. Bohr. 2021. NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer\u2019s disease via cGAS-STING. Proceedings of the National Academy of Sciences of the United States of America\u00a0118 (37).","DOI":"10.1073\/pnas.2011226118"},{"key":"1822_CR14","doi-asserted-by":"crossref","unstructured":"Han, X., S. Zhao, H. Song, T. Xu, Q. Fang, G. Hu, and L. Sun. 2021. Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: implications in Parkinson\u2019s disease. Redox Biology 41 (101911).","DOI":"10.1016\/j.redox.2021.101911"},{"issue":"11","key":"1822_CR15","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1080\/15548627.2019.1596481","volume":"15","author":"X Han","year":"2019","unstructured":"Han, X., S. Sun, Y. Sun, Q. Song, J. Zhu, N. Song, M. Chen, T. Sun, M. Xia, J. Ding, M. Lu, H. Yao, and G. Hu. 2019. Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: Implications for Parkinson disease. Autophagy 15 (11): 1860\u20131881.","journal-title":"Autophagy"},{"issue":"1","key":"1822_CR16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","volume":"55","author":"TV Rohm","year":"2022","unstructured":"Rohm, T.V., D.T. Meier, J.M. Olefsky, and M.Y. Donath. 2022. Inflammation in obesity, diabetes, and related disorders. Immunity 55 (1): 31\u201355.","journal-title":"Immunity"},{"issue":"8","key":"1822_CR17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","volume":"17","author":"MSJ Mangan","year":"2018","unstructured":"Mangan, M.S.J., E.J. Olhava, W.R. Roush, H.M. Seidel, G.D. Glick, and E. Latz. 2018. Targeting the NLRP3 inflammasome in inflammatory diseases. Nature Reviews Drug Discovery 17 (8): 588\u2013606.","journal-title":"Nature reviews Drug discovery"},{"key":"1822_CR18","doi-asserted-by":"crossref","unstructured":"Wang, L., and A.V. Hauenstein. 2020. The NLRP3 inflammasome: mechanism of action, role in disease and therapies. Molecular Aspects of Medicine\u00a076 (100889).","DOI":"10.1016\/j.mam.2020.100889"},{"issue":"9","key":"1822_CR19","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","volume":"43","author":"D Capece","year":"2022","unstructured":"Capece, D., D. Verzella, I. Flati, P. Arboretto, J. Cornice, and G. Franzoso. 2022. NF-\u03baB: Blending metabolism, immunity, and inflammation. Trends in Immunology 43 (9): 757\u2013775.","journal-title":"Trends in immunology"},{"key":"1822_CR20","doi-asserted-by":"crossref","unstructured":"Barnabei, L., E. Laplantine, W. Mbongo, F. Rieux-Laucat, and R. Weil. 2021. NF-\u03baB: At the borders of autoimmunity and inflammation. Frontiers in Immunology 12 (716469).","DOI":"10.3389\/fimmu.2021.716469"},{"key":"1822_CR21","doi-asserted-by":"crossref","unstructured":"Xu, S., H. Chen, H. Ni, and Q. Dai. 2021. Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-\u03baB\/NLRP3 pathway. Atherosclerosis\u00a0317 (1\u20139).","DOI":"10.1016\/j.atherosclerosis.2020.11.021"},{"issue":"10","key":"1822_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.470","volume":"8","author":"HJ Sun","year":"2017","unstructured":"Sun, H.J., X.S. Ren, X.Q. Xiong, Y.Z. Chen, M.X. Zhao, J.J. Wang, Y.B. Zhou, Y. Han, Q. Chen, Y.H. Li, Y.M. Kang, and G.Q. Zhu. 2017. NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension. Cell Death & Disease 8 (10): e3074.","journal-title":"Cell death & disease"},{"issue":"1","key":"1822_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41401-020-0411-9","volume":"42","author":"YJ Fu","year":"2021","unstructured":"Fu, Y.J., B. Xu, S.W. Huang, X. Luo, X.L. Deng, S. Luo, C. Liu, Q. Wang, J.Y. Chen, and L. Zhou. 2021. Baicalin prevents LPS-induced activation of TLR4\/NF-\u03baB p65 pathway and inflammation in mice via inhibiting the expression of CD14. Acta Pharmacologica Sinica 42 (1): 88\u201396.","journal-title":"Acta pharmacologica Sinica"},{"key":"1822_CR24","doi-asserted-by":"crossref","unstructured":"Yu, X., X. Meng, M. Xu, X. Zhang, Y. Zhang, G. Ding, S. Huang, A. Zhang, and Z. Jia. 2018. Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-\u03baB and improving mitochondrial function. EBioMedicine 36 (266\u2013280).","DOI":"10.1016\/j.ebiom.2018.09.031"},{"issue":"5","key":"1822_CR25","first-page":"325","volume":"29","author":"RJ Reiter","year":"2014","unstructured":"Reiter, R.J., D.X. Tan, and A. Galano. 2014. Melatonin: Exceeding expectations. Physiology (Bethesda, Md) 29 (5): 325\u2013333.","journal-title":"Physiology (Bethesda, Md)"},{"issue":"6","key":"1822_CR26","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1210\/er.2018-00084","volume":"39","author":"J Cipolla-Neto","year":"2018","unstructured":"Cipolla-Neto, J., and F.G.D. Amaral. 2018. Melatonin as a hormone: New physiological and clinical insights. Endocrine Reviews 39 (6): 990\u20131028.","journal-title":"Endocrine reviews"},{"issue":"4","key":"1822_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12525","volume":"65","author":"R Hardeland","year":"2018","unstructured":"Hardeland, R. 2018. Melatonin and inflammation-Story of a double-edged blade. Journal of Pineal Research 65 (4): e12525.","journal-title":"Journal of pineal research"},{"issue":"1","key":"1822_CR28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s12975-017-0559-x","volume":"9","author":"Z Wang","year":"2018","unstructured":"Wang, Z., F. Zhou, Y. Dou, X. Tian, C. Liu, H. Li, H. Shen, and G. Chen. 2018. Melatonin alleviates intracerebral hemorrhage-induced secondary brain injury in rats via suppressing apoptosis, inflammation, oxidative stress, DNA damage, and mitochondria injury. Translational Stroke Research 9 (1): 74\u201391.","journal-title":"Translational stroke research"},{"key":"1822_CR29","doi-asserted-by":"crossref","unstructured":"Lv, W.J., C. Liu, L.Z. Yu, J.H. Zhou, Y. Li, Y. Xiong, A. Guo, L.M. Chao, Q. Qu, G.W. Wei, X.G. Tang, Y.L. Yin, and S.N. Guo. 2020. Melatonin alleviates neuroinflammation and metabolic disorder in DSS-induced depression rats. Oxidative Medicine and Cellular Longevity\u00a02020\u00a0(1241894).","DOI":"10.1155\/2020\/1241894"},{"key":"1822_CR30","doi-asserted-by":"crossref","unstructured":"Zhang, L., X. Wang, W. Yu, J. Ying, P. Fang, Q. Zheng, X. Feng, J. Hu, F. Xiao, S. Chen, G. Wei, Y. Lin, X. Liu, D. Yang, Y. Fang, G. Xu, and F. Hua. 2022. CB2R activation regulates TFEB-mediated autophagy and affects lipid metabolism and inflammation of astrocytes in POCD. Frontiers in Immunology 13 (836494).","DOI":"10.3389\/fimmu.2022.836494"},{"key":"1822_CR31","doi-asserted-by":"crossref","unstructured":"Tan, X.X., L.L. Qiu, and J. Sun. 2021. Research progress on the role of inflammatory mechanisms in the development of postoperative cognitive dysfunction. BioMed Research International\u00a02021\u00a0(3883204).","DOI":"10.1155\/2021\/3883204"},{"issue":"2","key":"1822_CR32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","volume":"20","author":"T Gong","year":"2020","unstructured":"Gong, T., L. Liu, W. Jiang, and R. Zhou. 2020. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nature reviews Immunology 20 (2): 95\u2013112.","journal-title":"Nature reviews Immunology"},{"issue":"1","key":"1822_CR33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/imr.12285","volume":"265","author":"M Haneklaus","year":"2015","unstructured":"Haneklaus, M., and L.A. O\u2019Neill. 2015. NLRP3 at the interface of metabolism and inflammation. Immunological Reviews 265 (1): 53\u201362.","journal-title":"Immunological reviews"},{"key":"1822_CR34","doi-asserted-by":"crossref","unstructured":"Ma, S., J. Chen, J. Feng, R. Zhang, M. Fan, D. Han, X. Li, C. Li, J. Ren, Y. Wang, and F. Cao. 2018. Melatonin ameliorates the progression of atherosclerosis via mitophagy activation and NLRP3 inflammasome inhibition. Oxidative Medicine and Cellular Longevity\u00a02018\u00a0(9286458).","DOI":"10.1155\/2018\/9286458"},{"issue":"4","key":"1822_CR35","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/jpi.12322","volume":"60","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y., X. Li, J.J. Grailer, N. Wang, M. Wang, J. Yao, R. Zhong, G.F. Gao, P.A. Ward, D.X. Tan, and X. Li. 2016. Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. Journal of Pineal Research 60 (4): 405\u2013414.","journal-title":"Journal of pineal research"},{"issue":"8","key":"1822_CR36","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/ni.3772","volume":"18","author":"IS Afonina","year":"2017","unstructured":"Afonina, I.S., Z. Zhong, M. Karin, and R. Beyaert. 2017. Limiting inflammation-the negative regulation of NF-\u03baB and the NLRP3 inflammasome. Nature Immunology 18 (8): 861\u2013869.","journal-title":"Nature immunology"},{"issue":"3","key":"1822_CR37","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden, M.S., and S. Ghosh. 2008. Shared principles in NF-kappaB signaling. Cell 132 (3): 344\u2013362.","journal-title":"Cell"},{"issue":"6411","key":"1822_CR38","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1126\/science.aat0473","volume":"362","author":"NJ Allen","year":"2018","unstructured":"Allen, N.J., and D.A. Lyons. 2018. Glia as architects of central nervous system formation and function. Science (New York, NY) 362 (6411): 181\u2013185.","journal-title":"Science (New York, NY)"},{"issue":"5","key":"1822_CR39","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/dneu.22737","volume":"81","author":"J Bittern","year":"2021","unstructured":"Bittern, J., N. Pogodalla, H. Ohm, L. Br\u00fcser, R. Kottmeier, S. Schirmeier, and C. Kl\u00e4mbt. 2021. Neuron-glia interaction in the Drosophila nervous system. Developmental Neurobiology 81 (5): 438\u2013452.","journal-title":"Developmental neurobiology"},{"issue":"5","key":"1822_CR40","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41593-022-01049-x","volume":"25","author":"M Armbruster","year":"2022","unstructured":"Armbruster, M., S. Naskar, J.P. Garcia, M. Sommer, E. Kim, Y. Adam, P.G. Haydon, E.S. Boyden, A.E. Cohen, and C.G. Dulla. 2022. Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes. Nature Neuroscience 25 (5): 607\u2013616.","journal-title":"Nature neuroscience"},{"key":"1822_CR41","doi-asserted-by":"crossref","unstructured":"Banerjee, S., and M.A. Bhat. 2007. Neuron-glial interactions in blood-brain barrier formation. Annual Review of Neuroscience 30 (235\u2013258).","DOI":"10.1146\/annurev.neuro.30.051606.094345"},{"key":"1822_CR42","doi-asserted-by":"crossref","unstructured":"Kotekar, N., A. Shenkar, and R. Nagaraj. 2018. Postoperative cognitive dysfunction - current preventive strategies. Clinical Interventions in Aging 13 (2267\u20132273).","DOI":"10.2147\/CIA.S133896"},{"issue":"8","key":"1822_CR43","first-page":"119","volume":"111","author":"I Rundshagen","year":"2014","unstructured":"Rundshagen, I. 2014. Postoperative cognitive dysfunction. DeutsChes Arzteblatt International 111 (8): 119\u2013125.","journal-title":"Deutsches Arzteblatt international"},{"key":"1822_CR44","doi-asserted-by":"crossref","unstructured":"Lin, X., Y. Chen, P. Zhang, G. Chen, Y. Zhou, and X. Yu. 2020. The potential mechanism of postoperative cognitive dysfunction in older people. Experimental Gerontology 130 (110791).","DOI":"10.1016\/j.exger.2019.110791"},{"issue":"1","key":"1822_CR45","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12974-020-01778-5","volume":"17","author":"WT O'Brien","year":"2020","unstructured":"O\u2019Brien, W.T., L. Pham, G.F. Symons, M. Monif, S.R. Shultz, and S.J. McDonald. 2020. The NLRP3 inflammasome in traumatic brain injury: Potential as a biomarker and therapeutic target. Journal of Neuroinflammation 17 (1): 104.","journal-title":"Journal of neuroinflammation"},{"issue":"7434","key":"1822_CR46","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka, M.T., M.P. Kummer, A. Stutz, A. Delekate, S. Schwartz, A. Vieira-Saecker, A. Griep, D. Axt, A. Remus, T.C. Tzeng, E. Gelpi, A. Halle, M. Korte, E. Latz, and D.T. Golenbock. 2013. NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature 493 (7434): 674\u2013678.","journal-title":"Nature"},{"issue":"1","key":"1822_CR47","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12974-018-1137-1","volume":"15","author":"Z Wang","year":"2018","unstructured":"Wang, Z., S. Meng, L. Cao, Y. Chen, Z. Zuo, and S. Peng. 2018. Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment. Journal of Neuroinflammation 15 (1): 109.","journal-title":"Journal of neuroinflammation"},{"key":"1822_CR48","doi-asserted-by":"crossref","unstructured":"Wei, P., F. Yang, Q. Zheng, W. Tang, and J. Li. 2019. The potential role of the NLRP3 inflammasome activation as a link between mitochondria ROS generation and neuroinflammation in postoperative cognitive dysfunction. Frontiers in Cellular Neuroscience 13 (73).","DOI":"10.3389\/fncel.2019.00073"},{"issue":"11","key":"1822_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079624","volume":"8","author":"L Peng","year":"2013","unstructured":"Peng, L., L. Xu, and W. Ouyang. 2013. Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): A meta-analysis. PLoS ONE 8 (11): e79624.","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"1822_CR50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","volume":"160","author":"Y Yan","year":"2015","unstructured":"Yan, Y., W. Jiang, L. Liu, X. Wang, C. Ding, Z. Tian, and R. Zhou. 2015. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell 160 (1\u20132): 62\u201373.","journal-title":"Cell"},{"key":"1822_CR51","doi-asserted-by":"crossref","unstructured":"Vasey, C., J. McBride, and K. Penta. 2021. Circadian rhythm dysregulation and restoration: the role of melatonin. Nutrients 13 (10).","DOI":"10.3390\/nu13103480"},{"key":"1822_CR52","doi-asserted-by":"crossref","unstructured":"Liu, Z., L. Gan, T. Zhang, Q. Ren, and C. Sun. 2018. Melatonin alleviates adipose inflammation through elevating \u03b1-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. Journal of Pineal Research 64 (1).","DOI":"10.1111\/jpi.12455"},{"key":"1822_CR53","doi-asserted-by":"crossref","unstructured":"Chitimus, D.M., M.R. Popescu, S.E. Voiculescu, A.M. Panaitescu, B. Pavel, L. Zagrean, and A.M. Zagrean. 2020. Melatonin\u2019s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules 10 (9).","DOI":"10.3390\/biom10091211"},{"key":"1822_CR54","doi-asserted-by":"crossref","unstructured":"Arioz, B.I., B. Tastan, E. Tarakcioglu, K.U. Tufekci, M. Olcum, N. Ersoy, A. Bagriyanik, K. Genc, and S. Genc. 2019. melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1\/Nrf2 pathway. Frontiers in Immunology 10 (1511).","DOI":"10.3389\/fimmu.2019.01511"},{"key":"1822_CR55","doi-asserted-by":"crossref","unstructured":"Zhang, Y., X. Liu, X. Bai, Y. Lin, Z. Li, J. Fu, M. Li, T. Zhao, H. Yang, R. Xu, J. Li, J. Ju, B. Cai, C. Xu, and B. Yang. 2018. Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\/miR-223\/NLRP3 axis. Journal of Pineal Research 64(2).","DOI":"10.1111\/jpi.12449"},{"issue":"10","key":"1822_CR56","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.tplants.2015.07.005","volume":"20","author":"Y Shen","year":"2015","unstructured":"Shen, Y., W. Wei, and D.X. Zhou. 2015. Histone acetylation enzymes coordinate metabolism and gene expression. Trends in Plant Science 20 (10): 614\u2013621.","journal-title":"Trends in plant science"},{"issue":"5","key":"1822_CR57","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","volume":"23","author":"M Shvedunova","year":"2022","unstructured":"Shvedunova, M., and A. Akhtar. 2022. Modulation of cellular processes by histone and non-histone protein acetylation. NAture Reviews Molecular Cell Biology 23 (5): 329\u2013349.","journal-title":"Nature reviews Molecular cell biology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01822-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01822-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01822-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T03:13:53Z","timestamp":1689822833000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-023-01822-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1822"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01822-5","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"assertion":[{"value":"1 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"All experimental procedures were carried out in accordance with the Chinese Guidelines of Animal Care and Welfare, the animal study was reviewed and approved by Medical Animal Experiment Center of Nanchang University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All authors have read and agreed with the final paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}