{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:10:40Z","timestamp":1781586640630,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82101022"],"award-info":[{"award-number":["82101022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870776"],"award-info":[{"award-number":["81870776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s10753-023-01856-9","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T18:42:29Z","timestamp":1687545749000},"page":"1997-2010","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["CKIP-1 Promotes P. gingivalis-Induced Inflammation of Periodontal Soft Tissues by Inhibiting Autophagy"],"prefix":"10.1007","volume":"46","author":[{"given":"Junhong","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hantao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengguo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"issue":"2","key":"1856_CR1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051x.1998.tb02419.x","volume":"25","author":"SS Socransky","year":"1998","unstructured":"Socransky, S.S., A.D. Haffajee, M.A. Cugini, C. Smith, and R.L. Kent Jr. 1998. Microbial complexes in subgingival plaque. Journal of Clinical Periodontology 25 (2): 134\u201344. https:\/\/doi.org\/10.1111\/j.1600-051x.1998.tb02419.x.","journal-title":"Journal of Clinical Periodontology"},{"issue":"10","key":"1856_CR2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nrmicro2873","volume":"10","author":"G Hajishengallis","year":"2012","unstructured":"Hajishengallis, G., R.P. Darveau, and M.A. Curtis. 2012. The keystone-pathogen hypothesis. Nature Reviews. Microbiology 10 (10): 717\u201325. https:\/\/doi.org\/10.1038\/nrmicro2873.","journal-title":"Nature Reviews. Microbiology"},{"issue":"1","key":"1856_CR3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis, G. 2015. Periodontitis: from microbial immune subversion to systemic inflammation. Nature Reviews. Immunology 15 (1): 30\u201344. https:\/\/doi.org\/10.1038\/nri3785.","journal-title":"Nature Reviews. Immunology"},{"issue":"7","key":"1856_CR4","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1128\/iai.64.7.2371-2380.1996","volume":"64","author":"SP Nair","year":"1996","unstructured":"Nair, S.P., S. Meghji, M. Wilson, K. Reddi, P. White, and B. Henderson. 1996. Bacterially induced bone destruction: mechanisms and misconceptions. Infection and Immunity 64 (7): 2371\u201380. https:\/\/doi.org\/10.1128\/iai.64.7.2371-2380.1996.","journal-title":"Infection and Immunity"},{"issue":"5","key":"1856_CR5","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1902\/jop.2015.150413","volume":"87","author":"Y Wang","year":"2016","unstructured":"Wang, Y., J. Gong, H. Zeng, R. Liu, B. Jin, L. Chen, et al. 2016. Lipopolysaccharide activates the unfolded protein response in human periodontal ligament fibroblasts. Journal of Periodontology 87 (5): e75\u2013e81. https:\/\/doi.org\/10.1902\/jop.2015.150413.","journal-title":"Journal of Periodontology"},{"issue":"4","key":"1856_CR6","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1902\/jop.2012.120177","volume":"84","author":"ACF Morandini","year":"2013","unstructured":"Morandini, A.C.F., P.P. Chaves Souza, E.S. Ramos-Junior, D.T. Brozoski, C.R. Sipert, C.A. Souza Costa, et al. 2013. Toll-like receptor 2 knockdown modulates interleukin (IL)-6 and IL-8 but not stromal derived factor-1 (SDF-1\/CXCL12) in human periodontal ligament and gingival fibroblasts. Journal of Periodontology 84 (4): 535\u201344. https:\/\/doi.org\/10.1902\/jop.2012.120177.","journal-title":"Journal of Periodontology"},{"issue":"10","key":"1856_CR7","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1002\/JPER.21-0290","volume":"93","author":"C Jiang","year":"2022","unstructured":"Jiang, C., S. Yao, Y. Guo, L. Ma, X. Wang, Y. Chen, et al. 2022. Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss. Journal of Periodontology 93 (10): 1525\u20131539. https:\/\/doi.org\/10.1002\/JPER.21-0290.","journal-title":"Journal of Periodontology"},{"issue":"4","key":"1856_CR8","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","volume":"147","author":"N Mizushima","year":"2011","unstructured":"Mizushima, N., and M. Komatsu. 2011. Autophagy: renovation of cells and tissues. Cell 147 (4): 728\u201341. https:\/\/doi.org\/10.1016\/j.cell.2011.10.026.","journal-title":"Cell"},{"issue":"2","key":"1856_CR9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1080\/15548627.2016.1234563","volume":"13","author":"YQ Tan","year":"2017","unstructured":"Tan, Y.Q., J. Zhang, and G. Zhou. 2017. Autophagy and its implication in human oral diseases. Autophagy 13 (2): 225\u201336. https:\/\/doi.org\/10.1080\/15548627.2016.1234563.","journal-title":"Autophagy"},{"issue":"12","key":"1856_CR10","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1007\/s00253-014-5721-8","volume":"98","author":"MU Awan","year":"2014","unstructured":"Awan, M.U., and Y. Deng. 2014. Role of autophagy and its significance in cellular homeostasis. Applied Microbiology and Biotechnology 98 (12): 5319\u201328. https:\/\/doi.org\/10.1007\/s00253-014-5721-8.","journal-title":"Applied Microbiology and Biotechnology"},{"issue":"1","key":"1856_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/jre.12810","volume":"56","author":"Y Yang","year":"2021","unstructured":"Yang, Y., Y. Huang, and W. Li. 2021. Autophagy and its significance in periodontal disease. Journal of Periodontal Research 56 (1): 18\u201326. https:\/\/doi.org\/10.1111\/jre.12810.","journal-title":"Journal of Periodontal Research"},{"issue":"2","key":"1856_CR12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/odi.13045","volume":"26","author":"M Jiang","year":"2020","unstructured":"Jiang, M., Z. Li, and G. Zhu. 2020. The role of autophagy in the pathogenesis of periodontal disease. Oral Diseases 26 (2): 259\u201369. https:\/\/doi.org\/10.1111\/odi.13045.","journal-title":"Oral Diseases"},{"issue":"1","key":"1856_CR13","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s10753-019-01111-0","volume":"43","author":"S He","year":"2020","unstructured":"He, S., Q. Zhou, B. Luo, B. Chen, L. Li, and F. Yan. 2020. Chloroquine and 3-methyladenine attenuates periodontal inflammation and bone loss in experimental periodontitis. Inflammation 43 (1): 220\u201330. https:\/\/doi.org\/10.1007\/s10753-019-01111-0.","journal-title":"Inflammation"},{"issue":"3","key":"1856_CR14","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/JPER.21-0178","volume":"93","author":"WJ Kim","year":"2022","unstructured":"Kim, W.J., S.Y. Park, O.S. Kim, H.S. Park, and J.Y. Jung. 2022. Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts. Journal of Periodontology 93 (3): 380\u201391. https:\/\/doi.org\/10.1002\/JPER.21-0178.","journal-title":"Journal of Periodontology"},{"issue":"19","key":"1856_CR15","doi-asserted-by":"publisher","first-page":"14295","DOI":"10.1074\/jbc.275.19.14295","volume":"275","author":"DG Bosc","year":"2000","unstructured":"Bosc, D.G., K.C. Graham, R.B. Saulnier, C. Zhang, D. Prober, R.D. Gietz, et al. 2000. Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. The Journal of Biological Chemistry 275 (19): 14295\u2013306. https:\/\/doi.org\/10.1074\/jbc.275.19.14295.","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"1856_CR16","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.arr.2012.07.002","volume":"12","author":"J Nie","year":"2013","unstructured":"Nie, J., L. Liu, F. He, X. Fu, W. Han, and L. Zhang. 2013. CKIP-1: a scaffold protein and potential therapeutic target integrating multiple signaling pathways and physiological functions. Ageing Research Reviews 12 (1): 276\u201381. https:\/\/doi.org\/10.1016\/j.arr.2012.07.002.","journal-title":"Ageing Research Reviews"},{"key":"1856_CR17","doi-asserted-by":"publisher","first-page":"100908","DOI":"10.1016\/j.arr.2019.05.002","volume":"53","author":"L Fu","year":"2019","unstructured":"Fu, L., and L. Zhang. 2019. Physiological functions of CKIP-1: from molecular mechanisms to therapy implications. Ageing Research Reviews 53: 100908. https:\/\/doi.org\/10.1016\/j.arr.2019.05.002.","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"1856_CR18","doi-asserted-by":"publisher","first-page":"112341","DOI":"10.1016\/j.yexcr.2020.112341","volume":"397","author":"L Li","year":"2020","unstructured":"Li, L., P. Xie, W. Lin, J. Liu, J. Chen, Z. Guo, et al. 2020. CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt\/mTOR signal pathway. Experimental Cell Research 397 (1): 112341. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112341.","journal-title":"Experimental Cell Research"},{"key":"1856_CR19","doi-asserted-by":"publisher","first-page":"6694050","DOI":"10.1155\/2021\/6694050","volume":"2021","author":"X Zhao","year":"2021","unstructured":"Zhao, X., J. Wang, P. Li, L. Tang, and Y. Bai. 2021. Casein kinase 2-interacting protein-1 alleviates high glucose-reduced autophagy, oxidative stress, and apoptosis in retinal pigment epithelial cells via activating the p62\/KEAP1\/NRF2 signaling pathway. Journal of Ophthalmology 2021: 6694050. https:\/\/doi.org\/10.1155\/2021\/6694050.","journal-title":"Journal of Ophthalmology"},{"issue":"2","key":"1856_CR20","doi-asserted-by":"publisher","first-page":"892","DOI":"10.18632\/aging.203848","volume":"14","author":"Y Yuan","year":"2022","unstructured":"Yuan, Y., J. Sun, H. Zhou, S. Wang, C. He, T. Chen, et al. 2022. The effect of QiangGuYin on osteoporosis through the AKT\/mTOR\/autophagy signaling pathway mediated by CKIP-1. Aging (Albany NY). 14 (2): 892\u2013906. https:\/\/doi.org\/10.18632\/aging.203848.","journal-title":"Aging (Albany NY)."},{"issue":"5","key":"1856_CR21","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1177\/00220345211054744","volume":"101","author":"X Huang","year":"2022","unstructured":"Huang, X., L. Ma, X. Wang, H. Wang, Y. Peng, X. Gao, H. Huang, Y. Chen, Y. Zhang, and Z. Cao. 2022. Ckip-1 Mediates P. gingivalis\u2013Suppressed Cementoblast Mineralization. Journal of Dental Research 101 (5): 599\u2013608. https:\/\/doi.org\/10.1177\/00220345211054744.","journal-title":"Journal of Dental Research"},{"issue":"8","key":"1856_CR22","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.7150\/ijbs.35419","volume":"15","author":"L Ma","year":"2019","unstructured":"Ma, L., X. Wang, H. Liu, C. Jiang, H. Liao, S. Xu, et al. 2019. CXXC5 mediates P. gingivalis-suppressed cementoblast functions partially via MAPK signaling network. International Journal of Biological Sciences 15 (8): 1685\u20131695. https:\/\/doi.org\/10.7150\/ijbs.35419.","journal-title":"International Journal of Biological Sciences"},{"key":"1856_CR23","doi-asserted-by":"publisher","first-page":"107399","DOI":"10.1016\/j.intimp.2021.107399","volume":"93","author":"K Ni","year":"2021","unstructured":"Ni, K., and Y. Hua. 2021. Hydrogen sulfide exacerbated periodontal inflammation and induced autophagy in experimental periodontitis. International Immunopharmacology 93: 107399. https:\/\/doi.org\/10.1016\/j.intimp.2021.107399.","journal-title":"International Immunopharmacology"},{"key":"1856_CR24","doi-asserted-by":"publisher","first-page":"476068","DOI":"10.1155\/2014\/476068","volume":"2014","author":"J Mysak","year":"2014","unstructured":"Mysak, J., S. Podzimek, P. Sommerova, Y. Lyuya-Mi, J. Bartova, T. Janatova, et al. 2014. Porphyromonas gingivalis: major periodontopathic pathogen overview. Journal of Immunology Research 2014: 476068. https:\/\/doi.org\/10.1155\/2014\/476068.","journal-title":"Journal of Immunology Research"},{"issue":"7","key":"1856_CR25","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/jcpe.12549","volume":"43","author":"Y An","year":"2016","unstructured":"An, Y., W. Liu, P. Xue, Y. Zhang, Q. Wang, and Y. Jin. 2016. Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment. Journal of Clinical Periodontology 43 (7): 618\u201325. https:\/\/doi.org\/10.1111\/jcpe.12549.","journal-title":"Journal of Clinical Periodontology"},{"key":"1856_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.lfs.2018.09.023","volume":"211","author":"J Liu","year":"2018","unstructured":"Liu, J., X. Wang, M. Zheng, and Q. Luan. 2018. Lipopolysaccharide from Porphyromonas gingivalis promotes autophagy of human gingival fibroblasts through the PI3K\/Akt\/mTOR signaling pathway. Life Sciences 211: 133\u20139. https:\/\/doi.org\/10.1016\/j.lfs.2018.09.023.","journal-title":"Life Sciences"},{"issue":"3","key":"1856_CR27","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4161\/auto.2828","volume":"2","author":"M Belanger","year":"2006","unstructured":"Belanger, M., P.H. Rodrigues, W.A. Dunn Jr, and A. Progulske-Fox. 2006. Autophagy: a highway for Porphyromonas gingivalis in endothelial cells. Autophagy 2 (3): 165\u201370. https:\/\/doi.org\/10.4161\/auto.2828.","journal-title":"Autophagy"},{"issue":"1","key":"1856_CR28","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1080\/21505594.2018.1454171","volume":"9","author":"K Lee","year":"2018","unstructured":"Lee, K., J.S. Roberts, C.H. Choi, K.R. Atanasova, and O. Yilmaz. 2018. Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells. Virulence 9 (1): 845\u201359. https:\/\/doi.org\/10.1080\/21505594.2018.1454171.","journal-title":"Virulence"},{"issue":"12","key":"1856_CR29","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1002\/JPER.19-0639","volume":"91","author":"HA Lee","year":"2020","unstructured":"Lee, H.A., M.H. Park, Y. Song, H.S. Na, and J. Chung. 2020. Role of Aggregatibacter actinomycetemcomitans-induced autophagy in inflammatory response. Journal of Periodontology 91 (12): 1682\u20131693. https:\/\/doi.org\/10.1002\/JPER.19-0639.","journal-title":"Journal of Periodontology"},{"issue":"16","key":"1856_CR30","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1097\/CM9.0000000000000951","volume":"133","author":"XG Tian","year":"2020","unstructured":"Tian, X.G., F.F. Gong, X. Li, F.H. Meng, Z. Zhou, and H.Z. Zhang. 2020. Inflammation-mediated age-dependent effects of casein kinase 2-interacting protein-1 on osteogenesis in mesenchymal stem cells. Chinese Medical Journal (Engl) 133 (16): 1935\u201342. https:\/\/doi.org\/10.1097\/CM9.0000000000000951.","journal-title":"Chinese Medical Journal (Engl)"},{"key":"1856_CR31","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cellsig.2017.02.015","volume":"33","author":"Y Chen","year":"2017","unstructured":"Chen, Y., W. Liu, Y. Wang, L. Zhang, J. Wei, X. Zhang, et al. 2017. Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization. Cellular Signalling 33: 107\u201321. https:\/\/doi.org\/10.1016\/j.cellsig.2017.02.015.","journal-title":"Cellular Signalling"},{"issue":"1","key":"1856_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.imlet.2013.04.001","volume":"152","author":"K Juhasz","year":"2013","unstructured":"Juhasz, K., A. Zvara, A.M. Lipp, B. Nimmervoll, A. Sonnleitner, Z. Balogi, et al. 2013. Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells. Immunology Letters 152 (1): 55\u201364. https:\/\/doi.org\/10.1016\/j.imlet.2013.04.001.","journal-title":"Immunology Letters"},{"key":"1856_CR33","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/1741-7015-10-122","volume":"10","author":"P Bullon","year":"2012","unstructured":"Bullon, P., M.D. Cordero, J.L. Quiles, C. Ramirez-Tortosa Mdel, A. Gonzalez-Alonso, S. Alfonsi, et al. 2012. Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation. BMC Medicine 10: 122. https:\/\/doi.org\/10.1186\/1741-7015-10-122.","journal-title":"BMC Medicine"},{"issue":"1","key":"1856_CR34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/omi.12153","volume":"32","author":"MH Park","year":"2017","unstructured":"Park, M.H., S.Y. Jeong, H.S. Na, and J. Chung. 2017. Porphyromonas gingivalis induces autophagy in THP-1-derived macrophages. Molecular Oral Microbiology 32 (1): 48\u201359. https:\/\/doi.org\/10.1111\/omi.12153.","journal-title":"Molecular Oral Microbiology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01856-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01856-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01856-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:29:56Z","timestamp":1697012996000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-023-01856-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1856"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01856-9","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"8 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"The Medical Ethics Committee of Wuhan University School of Stomatology (authorized B16\/2021) approved the collection of clinical specimens. The Ethics Committee for Animal Research, School and Hospital of Stomatology, Wuhan University, China (S07922090H) approved the Animal experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}