{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:43:22Z","timestamp":1790707402324,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071090"],"award-info":[{"award-number":["82071090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10753-023-01910-6","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T13:02:06Z","timestamp":1696251726000},"page":"307-322","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages"],"prefix":"10.1007","volume":"47","author":[{"given":"Donghua","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youde","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"issue":"5","key":"1910_CR1","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.joen.2021.03.001","volume":"47","author":"HJ Van Hassel","year":"2021","unstructured":"Van Hassel, H.J. 2021. Reprint of: Physiology of the human dental pulp. Journal of Endodontics 47 (5): 690\u2013695. https:\/\/doi.org\/10.1016\/j.joen.2021.03.001.","journal-title":"Journal of Endodontics"},{"issue":"4","key":"1910_CR2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.dental.2023.03.013","volume":"39","author":"R Dal-Fabbro","year":"2023","unstructured":"Dal-Fabbro, R., W.B. Swanson, L.C. Capalbo, H. Sasaki, and M.C. Bottino. 2023. Next-generation biomaterials for dental pulp tissue immunomodulation. Dental Materials 39 (4): 333\u2013349. https:\/\/doi.org\/10.1016\/j.dental.2023.03.013.","journal-title":"Dental Materials"},{"issue":"5","key":"1910_CR3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.cytogfr.2015.07.001","volume":"26","author":"NA Nicola","year":"2015","unstructured":"Nicola, N.A., and J.J. Babon. 2015. Leukemia inhibitory factor (LIF). Cytokine & Growth Factor Reviews 26 (5): 533\u2013544. https:\/\/doi.org\/10.1016\/j.cytogfr.2015.07.001.","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"3","key":"1910_CR4","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/jbmr.1485","volume":"27","author":"IJ Poulton","year":"2012","unstructured":"Poulton, I.J., N.E. McGregor, S. Pompolo, E.C. Walker, and N.A. Sims. 2012. Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization. Journal of Bone and Mineral Research 27 (3): 586\u2013595. https:\/\/doi.org\/10.1002\/jbmr.1485.","journal-title":"Journal of Bone and Mineral Research"},{"issue":"4","key":"1910_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/humupd\/dmn010","volume":"14","author":"JS Fitzgerald","year":"2008","unstructured":"Fitzgerald, J.S., T.G. Poehlmann, E. Schleussner, and U.R. Markert. 2008. Trophoblast invasion: The role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3). Human Reproduction Update 14 (4): 335\u2013344. https:\/\/doi.org\/10.1093\/humupd\/dmn010.","journal-title":"Human Reproduction Update"},{"issue":"6","key":"1910_CR6","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/s0960-9822(09)00450-3","volume":"6","author":"M Sendtner","year":"1996","unstructured":"Sendtner, M., R. G\u00f6tz, B. Holtmann, J.L. Escary, Y. Masu, P. Carroll, et al. 1996. Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF. Current Biology 6 (6): 686\u2013694. https:\/\/doi.org\/10.1016\/s0960-9822(09)00450-3.","journal-title":"Current Biology"},{"issue":"13","key":"1910_CR7","doi-asserted-by":"publisher","first-page":"4319","DOI":"10.1182\/blood-2007-02-072587","volume":"110","author":"D Duluc","year":"2007","unstructured":"Duluc, D., Y. Delneste, F. Tan, M.-P. Moles, L. Grimaud, J. Lenoir, et al. 2007. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood 110 (13): 4319\u20134330. https:\/\/doi.org\/10.1182\/blood-2007-02-072587.","journal-title":"Blood"},{"issue":"2","key":"1910_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.immuni.2017.01.004","volume":"46","author":"HN Nguyen","year":"2017","unstructured":"Nguyen, H.N., E.H. Noss, F. Mizoguchi, C. Huppertz, K.S. Wei, G.F.M. Watts, et al. 2017. Autocrine loop involving IL-6 family member LIF, LIF receptor, and STAT4 drives sustained fibroblast production of inflammatory mediators. Immunity 46 (2): 220\u2013232. https:\/\/doi.org\/10.1016\/j.immuni.2017.01.004.","journal-title":"Immunity"},{"issue":"2","key":"1910_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1046\/j.1460-9568.2000.00922.x","volume":"12","author":"S Sugiura","year":"2000","unstructured":"Sugiura, S., R. Lahav, J. Han, S.Y. Kou, L.R. Banner, F. de Pablo, et al. 2000. Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitro. European Journal of Neuroscience 12 (2): 457\u2013466. https:\/\/doi.org\/10.1046\/j.1460-9568.2000.00922.x.","journal-title":"European Journal of Neuroscience"},{"key":"1910_CR10","doi-asserted-by":"publisher","unstructured":"Zhang, Y.S., D.E. Xin, Z. Wang, X. Song, Y. Sun, Q.C. Zou, et al. 2019. STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO Journal 38 (6):e99595. https:\/\/doi.org\/10.15252\/embj.201899595.","DOI":"10.15252\/embj.201899595"},{"issue":"3","key":"1910_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/cmi.2014.50","volume":"12","author":"A Dallagi","year":"2015","unstructured":"Dallagi, A., J. Girouard, J. Hamelin-Morrissette, R. Dadzie, L. Laurent, C. Vaillancourt, et al. 2015. The activating effect of IFN-\u03b3 on monocytes\/macrophages is regulated by the LIF-trophoblast-IL-10 axis via Stat1 inhibition and Stat3 activation. Cellular & Molecular Immunology 12 (3): 326\u2013341. https:\/\/doi.org\/10.1038\/cmi.2014.50.","journal-title":"Cellular & Molecular Immunology"},{"issue":"3","key":"1910_CR12","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.4049\/jimmunol.166.3.2049","volume":"166","author":"M Zhu","year":"2001","unstructured":"Zhu, M., K. Oishi, S.C. Lee, and P.H. Patterson. 2001. Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation. Journal of Immunology 166 (3): 2049\u20132054. https:\/\/doi.org\/10.4049\/jimmunol.166.3.2049.","journal-title":"Journal of Immunology"},{"issue":"1","key":"1910_CR13","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/s12974-018-1326-y","volume":"15","author":"SM Davis","year":"2018","unstructured":"Davis, S.M., L.A. Collier, E.D. Winford, C.C. Leonardo, C.T. Ajmo, E.A. Foran, et al. 2018. Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion. Journal of Neuroinflammation 15 (1): 288. https:\/\/doi.org\/10.1186\/s12974-018-1326-y.","journal-title":"Journal of Neuroinflammation"},{"issue":"1\u20132","key":"1910_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jneuroim.2008.07.015","volume":"204","author":"JJ Hendriks","year":"2008","unstructured":"Hendriks, J.J., H. Slaets, S. Carmans, H.E. de Vries, C.D. Dijkstra, P. Stinissen, et al. 2008. Leukemia inhibitory factor modulates production of inflammatory mediators and myelin phagocytosis by macrophages. Journal of Neuroimmunology 204 (1\u20132): 52\u201357. https:\/\/doi.org\/10.1016\/j.jneuroim.2008.07.015.","journal-title":"Journal of Neuroimmunology"},{"issue":"11","key":"1910_CR15","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/j.1365-2591.2010.01757.x","volume":"43","author":"KF Bruno","year":"2010","unstructured":"Bruno, K.F., J.A. Silva, T.A. Silva, A.C. Batista, A.H.G. Alencar, and C. Estrela. 2010. Characterization of inflammatory cell infiltrate in human dental pulpitis. International Endodontic Journal 43 (11): 1013\u20131021. https:\/\/doi.org\/10.1111\/j.1365-2591.2010.01757.x.","journal-title":"International Endodontic Journal"},{"issue":"9","key":"1910_CR16","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.joen.2021.06.015","volume":"47","author":"C Le Fournis","year":"2021","unstructured":"Le Fournis, C., C. Jeanneau, T. Giraud, I. El Karim, F.T. Lundy, and I. About. 2021. Fibroblasts control macrophage differentiation during pulp inflammation. Journal of Endodontics 47 (9): 1427\u20131434. https:\/\/doi.org\/10.1016\/j.joen.2021.06.015.","journal-title":"Journal of Endodontics"},{"key":"1910_CR17","doi-asserted-by":"publisher","unstructured":"Zaky, S.H., M. Shehabeldin, H. Ray, C. Sfeir, 2021. The role of inflammation modulation in dental pulp regeneration. European Cells & Materials 4 : 184\u2013193. https:\/\/doi.org\/10.22203\/eCM.v041a13.","DOI":"10.22203\/eCM.v041a13"},{"issue":"1","key":"1910_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.joen.2016.09.003","volume":"43","author":"Y He","year":"2017","unstructured":"He, Y., Y. Gan, J. Lu, Q. Feng, H. Wang, H. Guan, et al. 2017. Pulpal tissue inflammatory reactions after experimental pulpal exposure in mice. Journal of Endodontics 43 (1): 90\u201395. https:\/\/doi.org\/10.1016\/j.joen.2016.09.003.","journal-title":"Journal of Endodontics"},{"issue":"8","key":"1910_CR19","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.joen.2006.01.007","volume":"32","author":"L Ye","year":"2006","unstructured":"Ye, L., L. Peng, H. Tan, and X. Zhou. 2006. HGF enhanced proliferation and differentiation of dental pulp cells. Journal of Endodontics 32 (8): 736\u2013741. https:\/\/doi.org\/10.1016\/j.joen.2006.01.007.","journal-title":"Journal of Endodontics"},{"issue":"3","key":"1910_CR20","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","volume":"4","author":"Y Fan","year":"2013","unstructured":"Fan, Y., R. Mao, and J. Yang. 2013. NF-\u03baB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein & Cell 4 (3): 176\u2013185. https:\/\/doi.org\/10.1007\/s13238-013-2084-3.","journal-title":"Protein & Cell"},{"issue":"1","key":"1910_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","volume":"21","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov, S.I., and M. Karin. 2010. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine & Growth Factor Reviews 21 (1): 11\u201319. https:\/\/doi.org\/10.1016\/j.cytogfr.2009.11.005.","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"1","key":"1910_CR22","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/imr.12989","volume":"302","author":"RA Franklin","year":"2021","unstructured":"Franklin, R.A. 2021. Fibroblasts and macrophages: Collaborators in tissue homeostasis. Immunological Reviews 302 (1): 86\u2013103. https:\/\/doi.org\/10.1111\/imr.12989.","journal-title":"Immunological Reviews"},{"issue":"2","key":"1910_CR23","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.expneurol.2004.04.012","volume":"188","author":"BJ Kerr","year":"2004","unstructured":"Kerr, B.J., and P.H. Patterson. 2004. Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. Experimental Neurology 188 (2): 391\u2013407. https:\/\/doi.org\/10.1016\/j.expneurol.2004.04.012.","journal-title":"Experimental Neurology"},{"issue":"2","key":"1910_CR24","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1365-2249.2012.04601.x","volume":"169","author":"A Upadhyay","year":"2012","unstructured":"Upadhyay, A., D. Senyschyn, L. Santos, R. Gu, G.J. Carroll, and J.A. Jazayeri. 2012. K\/B\u00d7N serum transfer arthritis is delayed and less severe in leukaemia inhibitory factor (LIF)-deficient mice. Clinical and Experimental Immunology 169 (2): 71\u201378. https:\/\/doi.org\/10.1111\/j.1365-2249.2012.04601.x.","journal-title":"Clinical and Experimental Immunology"},{"issue":"2","key":"1910_CR25","first-page":"332","volume":"27","author":"MC Bell","year":"2000","unstructured":"Bell, M.C., and G.J. Carroll. 2000. Rheumatoid synovial fluid contains bioactive leukemia inhibitory factor with cartilage degrading activity\u2013Another target for chondroprotective intervention. Journal of Rheumatology 27 (2): 332\u2013338 (PMID:10685793).","journal-title":"Journal of Rheumatology"},{"issue":"2","key":"1910_CR26","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/labinvest.3700216","volume":"85","author":"MA Weber","year":"2005","unstructured":"Weber, M.A., S. Schnyder-Candrian, B. Schnyder, V. Quesniaux, V. Poli, C.L. Stewart, et al. 2005. Endogenous leukemia inhibitory factor attenuates endotoxin response. Laboratory Investigation 85 (2): 276\u2013284. https:\/\/doi.org\/10.1038\/labinvest.3700216.","journal-title":"Laboratory Investigation"},{"issue":"1","key":"1910_CR27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.4049\/jimmunol.182.1.613","volume":"182","author":"MA Nowell","year":"2009","unstructured":"Nowell, M.A., A.S. Williams, S.A. Carty, J. Scheller, A.J. Hayes, G.W. Jones, et al. 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182 (1): 613\u2013622. https:\/\/doi.org\/10.4049\/jimmunol.182.1.613.","journal-title":"Journal of Immunology"},{"issue":"5","key":"1910_CR28","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/75068","volume":"6","author":"R Atreya","year":"2000","unstructured":"Atreya, R., J. Mudter, S. Finotto, J. M\u00fcllberg, T. Jostock, S. Wirtz, et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo. Nature Medicine 6 (5): 583\u2013588. https:\/\/doi.org\/10.1038\/75068.","journal-title":"Nature Medicine"},{"issue":"2","key":"1910_CR29","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1172\/JCI1368","volume":"101","author":"Z Xing","year":"1998","unstructured":"Xing, Z., J. Gauldie, G. Cox, H. Baumann, M. Jordana, X.F. Lei, et al. 1998. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. Journal of Clinical Investigation 101 (2): 311\u2013320. https:\/\/doi.org\/10.1172\/JCI1368.","journal-title":"Journal of Clinical Investigation"},{"issue":"6","key":"1910_CR30","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/ni938","volume":"4","author":"H Yasukawa","year":"2003","unstructured":"Yasukawa, H., M. Ohishi, H. Mori, M. Murakami, T. Chinen, D. Aki, et al. 2003. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nature Immunology 4 (6): 551\u2013556. https:\/\/doi.org\/10.1038\/ni938.","journal-title":"Nature Immunology"},{"issue":"3","key":"1910_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","volume":"23","author":"C Garbers","year":"2012","unstructured":"Garbers, C., H.M. Hermanns, F. Schaper, G. M\u00fcller-Newen, J. Gr\u00f6tzinger, S. Rose-John, et al. 2012. Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine & Growth Factor Reviews 23 (3): 85\u201397. https:\/\/doi.org\/10.1016\/j.cytogfr.2012.04.001.","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"2","key":"1910_CR32","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.4049\/jimmunol.1002971","volume":"186","author":"CJ Greenhill","year":"2011","unstructured":"Greenhill, C.J., S. Rose-John, R. Lissilaa, W. Ferlin, M. Ernst, P.J. Hertzog, et al. 2011. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. Journal of Immunology 186 (2): 1199\u20131208. https:\/\/doi.org\/10.4049\/jimmunol.1002971.","journal-title":"Journal of Immunology"},{"issue":"4","key":"1910_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ccr.2009.02.015","volume":"15","author":"H Lee","year":"2009","unstructured":"Lee, H., A. Herrmann, J.H. Deng, M. Kujawski, G. Niu, Z. Li, et al. 2009. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15 (4): 283\u2013293. https:\/\/doi.org\/10.1016\/j.ccr.2009.02.015.","journal-title":"Cancer Cell"},{"issue":"11","key":"1910_CR34","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1101\/gad.1553707","volume":"21","author":"J Yang","year":"2007","unstructured":"Yang, J., X. Liao, M.K. Agarwal, L. Barnes, P.E. Auron, and G.R. Stark. 2007. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes & Development 21 (11): 1396\u20131408. https:\/\/doi.org\/10.1101\/gad.1553707.","journal-title":"Genes & Development"},{"issue":"15","key":"1910_CR35","doi-asserted-by":"publisher","first-page":"6696","DOI":"10.1523\/JNEUROSCI.22-15-06696.2002","volume":"22","author":"GK Tofaris","year":"2002","unstructured":"Tofaris, G.K., P.H. Patterson, K.R. Jessen, and R. Mirsky. 2002. Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. Journal of Neuroscience 22 (15): 6696\u20136703. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-15-06696.2002.","journal-title":"Journal of Neuroscience"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01910-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01910-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01910-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T07:14:26Z","timestamp":1705648466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-023-01910-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1910"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01910-6","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"6 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiment was approved by the Institutional Animal Care and Use Committee of Wuhan University (approval no: S07923020D).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All the authors have read the manuscript and agreed to submit the paper to the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}