{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:29:13Z","timestamp":1793158153532,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270754"],"award-info":[{"award-number":["32270754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s10753-023-01912-4","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T09:05:36Z","timestamp":1696842336000},"page":"333-345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Manganese Exacerbates ConA-Induced Liver Inflammation via the cGAS-STING Signaling Pathway"],"prefix":"10.1007","volume":"47","author":[{"given":"Kaidireya","family":"Saimaier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanxing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-9785","authenticated-orcid":false,"given":"Changsheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,8]]},"reference":[{"key":"1912_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-nutr-071714-034419","volume":"35","author":"KJ Horning","year":"2015","unstructured":"Horning, K.J., S.W. Caito, K.G. Tipps, A.B. Bowman, and M. Aschner. 2015. Manganese is essential for neuronal health. Annual Review of Nutrition 35: 71\u2013108.","journal-title":"Annual Review of Nutrition"},{"key":"1912_CR2","first-page":"213","volume":"20","author":"CL Keen","year":"1999","unstructured":"Keen, C.L., J.L. Ensunsa, M.H. Watson, D.L. Baly, S.M. Donovan, M.H. Monaco, et al. 1999. Nutritional aspects of manganese from experimental studies. Neurotoxicology 20: 213\u2013223.","journal-title":"Neurotoxicology"},{"key":"1912_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jat.4214","volume":"42","author":"D Gandhi","year":"2022","unstructured":"Gandhi, D., A.P. Rudrashetti, and S. Rajasekaran. 2022. The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions. Journal of Applied Toxicology 42: 103\u2013129.","journal-title":"Journal of Applied Toxicology"},{"key":"1912_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s40572-015-0056-x","volume":"2","author":"SL O'Neal","year":"2015","unstructured":"O\u2019Neal, S.L., and W. Zheng. 2015. Manganese toxicity upon overexposure: A decade in review. Current Environmental Health Reports 2: 315\u2013328.","journal-title":"Current Environmental Health Reports"},{"key":"1912_CR5","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1248\/bpb.25.426","volume":"25","author":"A Nakayama","year":"2002","unstructured":"Nakayama, A., H. Fukuda, M. Ebara, H. Hamasaki, K. Nakajima, and H. Sakurai. 2002. A new diagnostic method for chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma based on serum metallothionein, copper, and zinc levels. Biological and Pharmaceutical Bulletin 25: 426\u2013431.","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"1912_CR6","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1093\/clinchem\/20.9.1141","volume":"20","author":"J Versieck","year":"1974","unstructured":"Versieck, J., F. Barbier, A. Speecke, and J. Hoste. 1974. Manganese, copper, and zinc concentrations in serum and packed blood cells during acute hepatitis, chronic hepatitis, and posthepatitic cirrhosis. Clinical Chemistry 20: 1141\u20131145.","journal-title":"Clinical Chemistry"},{"key":"1912_CR7","doi-asserted-by":"publisher","first-page":"22222","DOI":"10.1007\/s11356-022-23630-4","volume":"30","author":"J Liu","year":"2023","unstructured":"Liu, J., L. Tan, Z. Liu, and R. Shi. 2023. Blood and urine manganese exposure in non-alcoholic fatty liver disease and advanced liver fibrosis: An observational study. Environmental Science and Pollution Research International 30: 22222\u201322231.","journal-title":"Environmental Science and Pollution Research International"},{"key":"1912_CR8","doi-asserted-by":"publisher","first-page":"14079","DOI":"10.1523\/JNEUROSCI.2329-14.2014","volume":"34","author":"D Leyva-Illades","year":"2014","unstructured":"Leyva-Illades, D., P. Chen, C.E. Zogzas, S. Hutchens, J.M. Mercado, C.D. Swaim, et al. 2014. SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity. Journal of Neuroscience 34: 14079\u201314095.","journal-title":"Journal of Neuroscience"},{"key":"1912_CR9","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ajhg.2012.01.017","volume":"90","author":"M Quadri","year":"2012","unstructured":"Quadri, M., A. Federico, T. Zhao, G.J. Breedveld, C. Battisti, C. Delnooz, et al. 2012. Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. American Journal of Human Genetics 90: 467\u2013477.","journal-title":"American Journal of Human Genetics"},{"key":"1912_CR10","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1038\/s41467-021-24563-1","volume":"12","author":"LD Ward","year":"2021","unstructured":"Ward, L.D., H.C. Tu, C.B. Quenneville, S. Tsour, A.O. Flynn-Carroll, M.M. Parker, et al. 2021. GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms. Nature Communications 12: 4571.","journal-title":"Nature Communications"},{"key":"1912_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.jtemb.2011.07.001","volume":"25","author":"MN Rashed","year":"2011","unstructured":"Rashed, M.N. 2011. The role of trace elements on hepatitis virus infections: A review. Journal of Trace Elements in Medicine and Biology 25: 181\u2013187.","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"1912_CR12","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev-pathol-020117-043534","volume":"13","author":"GJ Webb","year":"2018","unstructured":"Webb, G.J., G.M. Hirschfield, E.L. Krawitt, and M.E. Gershwin. 2018. Cellular and molecular mechanisms of autoimmune hepatitis. Annual Review of Pathology: Mechanisms of Disease 13: 247\u2013292.","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"key":"1912_CR13","doi-asserted-by":"publisher","first-page":"879","DOI":"10.4254\/wjh.v13.i8.879","volume":"13","author":"JH Fan","year":"2021","unstructured":"Fan, J.H., G.F. Liu, X.D. Lv, R.Z. Zeng, L.L. Zhan, and X.P. Lv. 2021. Pathogenesis of autoimmune hepatitis. World Journal of Hepatology 13: 879\u2013886.","journal-title":"World Journal of Hepatology"},{"key":"1912_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jaut.2018.10.020","volume":"95","author":"A Floreani","year":"2018","unstructured":"Floreani, A., P. Restrepo-Jim\u00e9nez, M.F. Secchi, S. De Martin, P.S.C. Leung, E. Krawitt, et al. 2018. Etiopathogenesis of autoimmune hepatitis. Journal of Autoimmunity 95: 133\u2013143.","journal-title":"Journal of Autoimmunity"},{"key":"1912_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0021-9258(18)86844-2","volume":"28","author":"DB Jones","year":"1916","unstructured":"Jones, D.B., and C.O. Johns. 1916. Some proteins from the jack bean, Canavalia Ensiformis. Journal of Biological Chemistry 28: 67\u201375.","journal-title":"Journal of Biological Chemistry"},{"key":"1912_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1172\/JCI115836","volume":"90","author":"G Tiegs","year":"1992","unstructured":"Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. The Journal of Clinical Investigation 90: 196\u2013203.","journal-title":"The Journal of Clinical Investigation"},{"key":"1912_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1515\/biol-2022-0013","volume":"17","author":"Y Liu","year":"2022","unstructured":"Liu, Y., H. Hao, and T. Hou. 2022. Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook. Open Life Sciences 17: 91\u2013101.","journal-title":"Open Life Sciences"},{"key":"1912_CR18","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","volume":"111","author":"S Kusters","year":"1996","unstructured":"Kusters, S., F. Gantner, G. Kunstle, and G. Tiegs. 1996. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111: 462\u2013471.","journal-title":"Gastroenterology"},{"key":"1912_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/15287398709531053","volume":"22","author":"B Srisuchart","year":"1987","unstructured":"Srisuchart, B., M.J. Taylor, and R.P. Sharma. 1987. Alteration of humoral and cellular immunity in manganese chloride-treated mice. Journal of Toxicology and Environment Health 22: 91\u201399.","journal-title":"Journal of Toxicology and Environment Health"},{"key":"1912_CR20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","volume":"48","author":"C Wang","year":"2018","unstructured":"Wang, C., Y. Guan, M. Lv, R. Zhang, Z. Guo, X. Wei, et al. 2018. Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and Is required for the host defense against DNA viruses. Immunity 48: 675-687.e7.","journal-title":"Immunity"},{"key":"1912_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29013","volume":"95","author":"R Zhang","year":"2023","unstructured":"Zhang, R., W. Yang, H. Zhu, J. Zhai, M. Xue, and C. Zheng. 2023. NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1. Journal of Medical Virology 95: e29013.","journal-title":"Journal of Medical Virology"},{"key":"1912_CR22","doi-asserted-by":"crossref","unstructured":"Xu, H., C. Su, A. Pearson, C.H. Mody, and C. Zheng. 2017. Herpes Simplex Virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-\u03baB activation. Journal of Virology 91: e00025-17.","DOI":"10.1128\/JVI.00025-17"},{"key":"1912_CR23","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2174\/1570159X19666210924110144","volume":"20","author":"K Chen","year":"2022","unstructured":"Chen, K., C. Lai, Y. Su, W.D. Bao, L.N. Yang, P.P. Xu, et al. 2022. cGAS-STING-mediated IFN-I response in host defense and neuroinflammatory diseases. Current Neuropharmacology 20: 362\u2013371.","journal-title":"Current Neuropharmacology"},{"key":"1912_CR24","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/0016-5085(95)90139-6","volume":"108","author":"L Garc\u00eda-Buey","year":"1995","unstructured":"Garc\u00eda-Buey, L., C. Garc\u00eda-Monz\u00f3n, S. Rodriguez, M.J. Borque, A. Garc\u00eda-S\u00e1nchez, R. Iglesias, et al. 1995. Latent autoimmune hepatitis triggered during interferon therapy in patients with chronic hepatitis C. Gastroenterology 108: 1770\u20131777.","journal-title":"Gastroenterology"},{"key":"1912_CR25","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S1665-2681(19)30792-6","volume":"14","author":"A Villamil","year":"2015","unstructured":"Villamil, A., E. Mullen, P. Casciato, and A. Gadano. 2015. Interferon beta 1a-induced severe autoimmune hepatitis in patients with multiple sclerosis: Report of two cases and review of the literature. Annals of Hepatology 14: 273\u2013280.","journal-title":"Annals of Hepatology"},{"key":"1912_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108411","volume":"102","author":"J Hao","year":"2022","unstructured":"Hao, J., W. Sun, and H. Xu. 2022. Pathogenesis of concanavalin A induced autoimmune hepatitis in mice. International Immunopharmacology 102: 108411.","journal-title":"International Immunopharmacology"},{"key":"1912_CR27","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","volume":"21","author":"A Decout","year":"2021","unstructured":"Decout, A., J.D. Katz, S. Venkatraman, and A. Ablasser. 2021. The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nature Reviews Immunology 21: 548\u2013569.","journal-title":"Nature Reviews Immunology"},{"key":"1912_CR28","first-page":"93","volume":"22","author":"SI Grivennikov","year":"2005","unstructured":"Grivennikov, S.I., A.V. Tumanov, D.J. Liepinsh, A.A. Kruglov, B.I. Marakusha, A.N. Shakhov, et al. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: Protective and deleterious effects. Immunity 22: 93\u2013104.","journal-title":"Immunity"},{"key":"1912_CR29","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1084\/jem.179.5.1529","volume":"179","author":"H Mizuhara","year":"1994","unstructured":"Mizuhara, H., E. O\u2019Neill, N. Seki, T. Ogawa, C. Kusunoki, K. Otsuka, et al. 1994. T cell activation-associated hepatic injury: Mediation by tumor necrosis factors and protection by interleukin 6. Journal of Experimental Medicine 179: 1529\u20131537.","journal-title":"Journal of Experimental Medicine"},{"key":"1912_CR30","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","volume":"59","author":"C Brenner","year":"2013","unstructured":"Brenner, C., L. Galluzzi, O. Kepp, and G. Kroemer. 2013. Decoding cell death signals in liver inflammation. Journal of Hepatology 59: 583\u2013594.","journal-title":"Journal of Hepatology"},{"key":"1912_CR31","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.jhep.2007.06.022","volume":"47","author":"B Knight","year":"2007","unstructured":"Knight, B., R. Lim, G.C. Yeoh, and J.K. Olynyk. 2007. Interferon-gamma exacerbates liver damage, the hepatic progenitor cell response and fibrosis in a mouse model of chronic liver injury. Journal of Hepatology 47: 826\u2013833.","journal-title":"Journal of Hepatology"},{"key":"1912_CR32","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1073\/pnas.91.2.614","volume":"91","author":"T Toyonaga","year":"1994","unstructured":"Toyonaga, T., O. Hino, S. Sugai, S. Wakasugi, K. Abe, M. Shichiri, et al. 1994. Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver. Proceedings of the National Academy of Sciences of the United States of America 91: 614\u2013618.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"1912_CR33","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/hep.20447","volume":"40","author":"T Miyagi","year":"2004","unstructured":"Miyagi, T., T. Takehara, T. Tatsumi, T. Suzuki, M. Jinushi, Y. Kanazawa, et al. 2004. Concanavalin a injection activates intrahepatic innate immune cells to provoke an antitumor effect in murine liver. Hepatology 40: 1190\u20131196.","journal-title":"Hepatology"},{"key":"1912_CR34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri3581","volume":"14","author":"LB Ivashkiv","year":"2014","unstructured":"Ivashkiv, L.B., and L.T. Donlin. 2014. Regulation of type I interferon responses. Nature Reviews Immunology 14: 36\u201349.","journal-title":"Nature Reviews Immunology"},{"key":"1912_CR35","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00018-021-04072-6","volume":"79","author":"C Su","year":"2021","unstructured":"Su, C., Y.D. Tang, and C. Zheng. 2021. DExD\/H-box helicases: Multifunctional regulators in antiviral innate immunity. Cellular and Molecular Life Sciences 79: 2.","journal-title":"Cellular and Molecular Life Sciences"},{"key":"1912_CR36","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1136\/gut.2006.092064","volume":"56","author":"S Berardi","year":"2007","unstructured":"Berardi, S., F. Lodato, A. Gramenzi, A. D\u2019Errico, M. Lenzi, A. Bontadini, et al. 2007. High incidence of allograft dysfunction in liver transplanted patients treated with pegylated-interferon alpha-2b and ribavirin for hepatitis C recurrence: Possible de novo autoimmune hepatitis? Gut 56: 237\u2013242.","journal-title":"Gut"},{"key":"1912_CR37","doi-asserted-by":"crossref","unstructured":"Hong, Z., J. Mei, H. Guo, J. Zhu, and C. Wang. 2022. Intervention of cGAS\u2012STING signaling in sterile inflammatory diseases. Journal of Molecular Cell Biology 14: mjac005.","DOI":"10.1093\/jmcb\/mjac005"},{"key":"1912_CR38","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/s41423-021-00669-w","volume":"18","author":"R Zhang","year":"2021","unstructured":"Zhang, R., C. Wang, Y. Guan, X. Wei, M. Sha, M. Yi, et al. 2021. Manganese salts function as potent adjuvants. Cellular & Molecular Immunology 18: 1222\u20131234.","journal-title":"Cellular & Molecular Immunology"},{"key":"1912_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.682736","volume":"12","author":"D Xu","year":"2021","unstructured":"Xu, D., Y. Tian, Q. Xia, and B. Ke. 2021. The cGAS-STING pathway: Novel perspectives in liver diseases. Frontiers in Immunology 12: 682736.","journal-title":"Frontiers in Immunology"},{"key":"1912_CR40","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/s41581-022-00589-6","volume":"18","author":"S Skopelja-Gardner","year":"2022","unstructured":"Skopelja-Gardner, S., J. An, and K.B. Elkon. 2022. Role of the cGAS-STING pathway in systemic and organ-specific diseases. Nature Reviews Nephrology 18: 558\u2013572.","journal-title":"Nature Reviews Nephrology"},{"key":"1912_CR41","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","volume":"20","author":"M Motwani","year":"2019","unstructured":"Motwani, M., S. Pesiridis, and K.A. Fitzgerald. 2019. DNA sensing by the cGAS-STING pathway in health and disease. Nature Reviews Genetics 20: 657\u2013674.","journal-title":"Nature Reviews Genetics"},{"key":"1912_CR42","doi-asserted-by":"publisher","first-page":"12814","DOI":"10.1128\/JVI.02355-13","volume":"87","author":"S Wang","year":"2013","unstructured":"Wang, S., K. Wang, R. Lin, and C. Zheng. 2013. Herpes simplex virus 1 serine\/threonine kinase US3 hyperphosphorylates IRF3 and inhibits beta interferon production. Journal of Virology 87: 12814\u201312827.","journal-title":"Journal of Virology"},{"key":"1912_CR43","doi-asserted-by":"publisher","first-page":"51","DOI":"10.7326\/0003-4819-116-1-51","volume":"116","author":"T Papo","year":"1992","unstructured":"Papo, T., P. Marcellin, J. Bernuau, F. Durand, T. Poynard, and J.P. Benhamou. 1992. Autoimmune chronic hepatitis exacerbated by alpha-interferon. Annals of Internal Medicine 116: 51\u201353.","journal-title":"Annals of Internal Medicine"},{"key":"1912_CR44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264307","volume":"17","author":"MM Tana","year":"2022","unstructured":"Tana, M.M., A. Klepper, A. Lyden, A.O. Pisco, M. Phelps, B. McGee, et al. 2022. Transcriptomic profiling of blood from autoimmune hepatitis patients reveals potential mechanisms with implications for management. PLoS ONE 17: e0264307.","journal-title":"PLoS ONE"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01912-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01912-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01912-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T08:08:55Z","timestamp":1705651735000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-023-01912-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,8]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1912"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01912-4","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,8]]},"assertion":[{"value":"9 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted following the line of legislation and ethical guidelines of the People\u2019s Republic of China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"This is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Participation and Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}