{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:11:15Z","timestamp":1792123875319,"version":"4.4.0"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psoriasis has emerged as a systemic disease characterized by skin and joint manifestations as well as systemic inflammation and cardiovascular comorbidities. Many progresses have been made in the comprehension of the immunological mechanisms involved in the exacerbation of psoriatic plaques, and initial studies have investigated the mechanisms that lead to extracutaneous disease manifestations, including endothelial disfunction and cardiovascular disease. In the past decade, the involvement of gut dysbiosis in the development of pathologies with inflammatory and autoimmune basis has clearly emerged. More recently, a major role for the skin microbiota in establishing the immunological tolerance in early life and as a source of antigens leading to cross-reactive responses towards self-antigens in adult life has also been evidenced. Gut microbiota can indeed be involved in shaping the immune and inflammatory response at systemic level and in fueling inflammation in the cutaneous and vascular compartments. Here, we summarized the microbiota-mediated mechanisms that, in the skin and gut, may promote and modulate local or systemic inflammation involved in psoriatic disease and endothelial dysfunction. We also analyze the emerging strategies for correcting dysbiosis or modulating skin and gut microbiota composition to integrate systemically existing pharmacological therapies for psoriatic disease. The possibility of merging systemic treatment and tailored microbial modifying therapies could increase the efficacy of the current treatments and potentially lower the effect on patient\u2019s life quality.<\/jats:p>","DOI":"10.1007\/s10753-023-01915-1","type":"journal-article","created":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T23:09:17Z","timestamp":1699830557000},"page":"13-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Use of Microbial Modifying Therapies to Prevent Psoriasis Exacerbation and Associated Cardiovascular Comorbidity"],"prefix":"10.1007","volume":"47","author":[{"given":"Eva","family":"Reali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Caliceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Lorenzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"1915_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","volume":"32","author":"MA Lowes","year":"2014","unstructured":"Lowes, M.A., M. Suarez-Farinas, and J.G. Krueger. 2014. Immunology of psoriasis. Annual Review of Immunology. 32: 227\u2013255. https:\/\/doi.org\/10.1146\/annurev-immunol-032713-120225.","journal-title":"Annual review of immunology."},{"issue":"5","key":"1915_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s40257-013-0032-x","volume":"14","author":"WH Boehncke","year":"2013","unstructured":"Boehncke, W.H., and A. Menter. 2013. Burden of disease: Psoriasis and psoriatic arthritis. American Journal of Clinical Dermatology. 14 (5): 377\u2013388. https:\/\/doi.org\/10.1007\/s40257-013-0032-x.","journal-title":"American journal of clinical dermatology."},{"issue":"9997","key":"1915_CR3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/s0140-6736(14)61909-7","volume":"386","author":"WH Boehncke","year":"2015","unstructured":"Boehncke, W.H., and M.P. Sch\u00f6n. 2015. Psoriasis. Lancet (London, England). 386 (9997): 983\u2013994. https:\/\/doi.org\/10.1016\/s0140-6736(14)61909-7.","journal-title":"Lancet (London, England)."},{"key":"1915_CR4","doi-asserted-by":"publisher","unstructured":"Reali, E., and N.C. Brembilla. 2019. Editorial: Immunology of psoriatic disease. Frontiers in Immunology. 10. https:\/\/doi.org\/10.3389\/fimmu.2019.00657.","DOI":"10.3389\/fimmu.2019.00657"},{"issue":"1","key":"1915_CR5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s12016-018-8668-1","volume":"54","author":"C Conrad","year":"2018","unstructured":"Conrad, C., and M. Gilliet. 2018. Psoriasis: From pathogenesis to targeted therapies. Clinical Reviews in Allergy and Immunology. 54 (1): 102\u2013113. https:\/\/doi.org\/10.1007\/s12016-018-8668-1.","journal-title":"Clinical Reviews in Allergy and Immunology"},{"issue":"1","key":"1915_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/eji.201344277","volume":"45","author":"R Lande","year":"2015","unstructured":"Lande, R., G. Chamilos, D. Ganguly, O. Demaria, L. Frasca, S. Durr, et al. 2015. Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA. European Journal of Immunology. 45 (1): 203\u2013213. https:\/\/doi.org\/10.1002\/eji.201344277.","journal-title":"European journal of immunology."},{"issue":"9","key":"1915_CR7","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1084\/jem.20090480","volume":"206","author":"D Ganguly","year":"2009","unstructured":"Ganguly, D., G. Chamilos, R. Lande, J. Gregorio, S. Meller, V. Facchinetti, et al. 2009. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. The Journal of Experimental Medicine. 206 (9): 1983\u20131994. https:\/\/doi.org\/10.1084\/jem.20090480.","journal-title":"The Journal of experimental medicine."},{"key":"1915_CR8","doi-asserted-by":"publisher","unstructured":"Ferrari, D., F. Casciano, P. Secchiero, and E. Reali. 2021. Purinergic signaling and inflammasome activation in psoriasis pathogenesis.\u00a0International Journal of Molecular Sciences. 22 (17). https:\/\/doi.org\/10.3390\/ijms22179449.","DOI":"10.3390\/ijms22179449"},{"issue":"1","key":"1915_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/jid.2008.194","volume":"129","author":"LC Zaba","year":"2009","unstructured":"Zaba, L.C., J. Fuentes-Duculan, N.J. Eungdamrong, M.V. Abello, I. Novitskaya, K.C. Pierson, et al. 2009. Psoriasis is characterized by accumulation of immunostimulatory and Th1\/Th17 cell-polarizing myeloid dendritic cells. The Journal of Investigative Dermatology. 129 (1): 79\u201388. https:\/\/doi.org\/10.1038\/jid.2008.194.","journal-title":"The Journal of investigative dermatology."},{"key":"1915_CR10","doi-asserted-by":"publisher","unstructured":"Zaba, L.C., J. Fuentes-Duculan, N.J. Eungdamrong, L.M. Johnson-Huang, K.E. Nograles, T.R. White, et al. 2010. Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis. The Journal of Allergy and Clinical Immunology. 125 (6): 1261\u20138 e9. https:\/\/doi.org\/10.1016\/j.jaci.2010.03.018.","DOI":"10.1016\/j.jaci.2010.03.018"},{"issue":"7162","key":"1915_CR11","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nature06116","volume":"449","author":"R Lande","year":"2007","unstructured":"Lande, R., J. Gregorio, V. Facchinetti, B. Chatterjee, Y.H. Wang, B. Homey, et al. 2007. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 449 (7162): 564\u2013569. https:\/\/doi.org\/10.1038\/nature06116.","journal-title":"Nature"},{"issue":"8","key":"1915_CR12","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson, K.V., and M. Deng. 2019. The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nature Reviews Immunology. 19 (8): 477\u2013489. https:\/\/doi.org\/10.1038\/s41577-019-0165-0.","journal-title":"Nature Reviews Immunology"},{"issue":"3","key":"1915_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jdermsci.2020.03.001","volume":"98","author":"D Wang","year":"2020","unstructured":"Wang, D., B. Duncan, X. Li, and J. Shi. 2020. The role of NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases. Journal of Dermatological Science 98 (3): 146\u2013151. https:\/\/doi.org\/10.1016\/j.jdermsci.2020.03.001.","journal-title":"Journal of Dermatological Science"},{"key":"1915_CR14","doi-asserted-by":"publisher","first-page":"7692024","DOI":"10.1155\/2016\/7692024","volume":"2016","author":"M Diani","year":"2016","unstructured":"Diani, M., G. Altomare, and E. Reali. 2016. T helper cell subsets in clinical manifestations of psoriasis. Journal of Immunology Research. 2016: 7692024. https:\/\/doi.org\/10.1155\/2016\/7692024.","journal-title":"Journal of immunology research."},{"issue":"8","key":"1915_CR15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1517\/13543784.2013.806483","volume":"22","author":"A Chiricozzi","year":"2013","unstructured":"Chiricozzi, A., and J.G. Krueger. 2013. IL-17 targeted therapies for psoriasis. Expert Opinion On Investigational Drugs. 22 (8): 993\u20131005. https:\/\/doi.org\/10.1517\/13543784.2013.806483.","journal-title":"Expert opinion on investigational drugs."},{"issue":"2","key":"1915_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090284","volume":"9","author":"A Chiricozzi","year":"2014","unstructured":"Chiricozzi, A., K.E. Nograles, L.M. Johnson-Huang, J. Fuentes-Duculan, I. Cardinale, K.M. Bonifacio, et al. 2014. IL-17 induces an expanded range of downstream genes in reconstituted human epidermis model. PLoS ONE. 9 (2): e90284. https:\/\/doi.org\/10.1371\/journal.pone.0090284.","journal-title":"PLoS ONE"},{"issue":"5","key":"1915_CR17","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1002\/eji.200535503","volume":"36","author":"K Wolk","year":"2006","unstructured":"Wolk, K., E. Witte, E. Wallace, W.D. Docke, S. Kunz, K. Asadullah, et al. 2006. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis. European Journal of Immunology. 36 (5): 1309\u20131323. https:\/\/doi.org\/10.1002\/eji.200535503.","journal-title":"European journal of immunology."},{"issue":"4","key":"1915_CR18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.it.2012.11.005","volume":"34","author":"MA Lowes","year":"2013","unstructured":"Lowes, M.A., C.B. Russell, D.A. Martin, J.E. Towne, and J.G. Krueger. 2013. The IL-23\/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends in Immunology. 34 (4): 174\u2013181. https:\/\/doi.org\/10.1016\/j.it.2012.11.005.","journal-title":"Trends in immunology."},{"issue":"5","key":"1915_CR19","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/j.1365-2133.2008.08769.x","volume":"159","author":"KE Nograles","year":"2008","unstructured":"Nograles, K.E., L.C. Zaba, E. Guttman-Yassky, J. Fuentes-Duculan, M. Suarez-Farinas, I. Cardinale, et al. 2008. Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. The British Journal of Dermatology. 159 (5): 1092\u20131102. https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08769.x.","journal-title":"The British journal of dermatology."},{"issue":"10","key":"1915_CR20","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1111\/jdv.14433","volume":"31","author":"G Girolomoni","year":"2017","unstructured":"Girolomoni, G., R. Strohal, L. Puig, H. Bachelez, J. Barker, W.H. Boehncke, et al. 2017. The role of IL-23 and the IL-23\/TH 17 immune axis in the pathogenesis and treatment of psoriasis. Journal of the European Academy of Dermatology and Venereology: JEADV. 31 (10): 1616\u20131626. https:\/\/doi.org\/10.1111\/jdv.14433.","journal-title":"Journal of the European Academy of Dermatology and Venereology : JEADV."},{"issue":"12","key":"1915_CR21","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.autrev.2015.08.003","volume":"14","author":"MS Chimenti","year":"2015","unstructured":"Chimenti, M.S., P. Triggianese, M. Nuccetelli, C. Terracciano, A. Crisanti, M.D. Guarino, et al. 2015. Auto-reactions, autoimmunity and psoriatic arthritis. Autoimmunity Reviews. 14 (12): 1142\u20131146. https:\/\/doi.org\/10.1016\/j.autrev.2015.08.003.","journal-title":"Autoimmunity reviews."},{"issue":"4","key":"1915_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.coi.2008.06.008","volume":"20","author":"M Gilliet","year":"2008","unstructured":"Gilliet, M., and R. Lande. 2008. Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Current Opinion in Immunology. 20 (4): 401\u2013407. https:\/\/doi.org\/10.1016\/j.coi.2008.06.008.","journal-title":"Current Opinion in Immunology"},{"key":"1915_CR23","doi-asserted-by":"publisher","unstructured":"Cheuk, S., M. Wik\u00e9n, L. Blomqvist, S. Nyl\u00e9n, T. Talme, M. St\u00e5hle, et al. 2014. Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis. Journal of Immunology (Baltimore, Md : 1950). 192 (7): 3111\u201320. https:\/\/doi.org\/10.4049\/jimmunol.1302313.","DOI":"10.4049\/jimmunol.1302313"},{"key":"1915_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.02.030","author":"I Gallais Serezal","year":"2018","unstructured":"Gallais Serezal, I., C. Classon, S. Cheuk, M. Barrientos-Somarribas, E. Wadman, E. Martini, et al. 2018. Resident T cells in resolved psoriasis steer tissue responses that stratify clinical outcome. The Journal of Investigative Dermatology. https:\/\/doi.org\/10.1016\/j.jid.2018.02.030.","journal-title":"The Journal of investigative dermatology."},{"key":"1915_CR25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.clim.2017.04.001","volume":"180","author":"M Diani","year":"2017","unstructured":"Diani, M., M. Galasso, C. Cozzi, F. Sgambelluri, A. Altomare, C. Cigni, et al. 2017. Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease. Clinical Immunology. 180: 84\u201394. https:\/\/doi.org\/10.1016\/j.clim.2017.04.001.","journal-title":"Clinical immunology."},{"key":"1915_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jaut.2016.03.019","volume":"70","author":"F Sgambelluri","year":"2016","unstructured":"Sgambelluri, F., M. Diani, A. Altomare, E. Frigerio, L. Drago, F. Granucci, et al. 2016. A role for CCR5(+)CD4 T cells in cutaneous psoriasis and for CD103(+) CCR4(+) CD8 Teff cells in the associated systemic inflammation. Journal of Autoimmunity. 70: 80\u201390. https:\/\/doi.org\/10.1016\/j.jaut.2016.03.019.","journal-title":"Journal of autoimmunity."},{"key":"1915_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/ptt.S320016","volume":"11","author":"M Teklu","year":"2021","unstructured":"Teklu, M., P.M. Parel, and N.N. Mehta. 2021. Psoriasis and cardiometabolic diseases: The impact of inflammation on vascular health. Psoriasis (Auckl). 11: 99\u2013108. https:\/\/doi.org\/10.2147\/ptt.S320016.","journal-title":"Psoriasis (Auckl)."},{"issue":"8","key":"1915_CR28","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1600-0625.2010.01095.x","volume":"19","author":"J Garbaraviciene","year":"2010","unstructured":"Garbaraviciene, J., S. Diehl, D. Varwig, M. Bylaite, H. Ackermann, R.J. Ludwig, et al. 2010. Platelet P-selectin reflects a state of cutaneous inflammation: Possible application to monitor treatment efficacy in psoriasis. Experimental Dermatology. 19 (8): 736\u2013741. https:\/\/doi.org\/10.1111\/j.1600-0625.2010.01095.x.","journal-title":"Experimental dermatology."},{"issue":"8","key":"1915_CR29","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/j.1365-2230.2011.04131.x","volume":"36","author":"A Kanelleas","year":"2011","unstructured":"Kanelleas, A., C. Liapi, A. Katoulis, P. Stavropoulos, G. Avgerinou, S. Georgala, et al. 2011. The role of inflammatory markers in assessing disease severity and response to treatment in patients with psoriasis treated with etanercept. Clinical and Experimental Dermatology. 36 (8): 845\u2013850. https:\/\/doi.org\/10.1111\/j.1365-2230.2011.04131.x.","journal-title":"Clinical and experimental dermatology."},{"issue":"2","key":"1915_CR30","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/j.1365-2133.2008.08628.x","volume":"159","author":"B Strober","year":"2008","unstructured":"Strober, B., C. Teller, P. Yamauchi, J.L. Miller, M. Hooper, Y.C. Yang, et al. 2008. Effects of etanercept on C-reactive protein levels in psoriasis and psoriatic arthritis. The British Journal of Dermatology. 159 (2): 322\u2013330. https:\/\/doi.org\/10.1111\/j.1365-2133.2008.08628.x.","journal-title":"The British journal of dermatology."},{"issue":"9","key":"1915_CR31","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1001\/archdermatol.2011.119","volume":"147","author":"NN Mehta","year":"2011","unstructured":"Mehta, N.N., Y. Yu, B. Saboury, N. Foroughi, P. Krishnamoorthy, A. Raper, et al. 2011. Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET\/CT): A pilot study. Archives of Dermatology. 147 (9): 1031\u20131039. https:\/\/doi.org\/10.1001\/archdermatol.2011.119.","journal-title":"Archives of dermatology."},{"key":"1915_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.909760","volume":"13","author":"DM Schwartz","year":"2022","unstructured":"Schwartz, D.M., P. Parel, H. Li, A.V. Sorokin, A.R. Berg, M. Chen, et al. 2022. PET\/CT-based characterization of 18F-FDG uptake in various tissues reveals novel potential contributions to coronary artery disease in psoriatic arthritis. Frontiers in Immunology. 13: 909760. https:\/\/doi.org\/10.3389\/fimmu.2022.909760.","journal-title":"Frontiers in immunology."},{"issue":"32","key":"1915_CR33","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1093\/eurheartj\/ehs141","volume":"34","author":"P Rizzo","year":"2013","unstructured":"Rizzo, P., L. Miele, and R. Ferrari. 2013. The Notch pathway: A crossroad between the life and death of the endothelium. European Heart Journal. 34 (32): 2504\u20132509. https:\/\/doi.org\/10.1093\/eurheartj\/ehs141.","journal-title":"European Heart Journal"},{"key":"1915_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.864185","volume":"9","author":"P Anyfanti","year":"2022","unstructured":"Anyfanti, P., A. Margouta, K. Goulas, M. Gavriilaki, E. Lazaridou, A. Patsatsi, et al. 2022. Endothelial dysfunction in psoriasis: An updated review. Frontiers in Medicine\u00a0(Lausanne). 9: 864185. https:\/\/doi.org\/10.3389\/fmed.2022.864185.","journal-title":"Front Med (Lausanne)."},{"key":"1915_CR35","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3389\/fimmu.2018.00579","volume":"9","author":"WH Boehncke","year":"2018","unstructured":"Boehncke, W.H. 2018. Systemic inflammation and cardiovascular comorbidity in psoriasis patients: Causes and consequences. Frontiers in Immunology. 9: 579. https:\/\/doi.org\/10.3389\/fimmu.2018.00579.","journal-title":"Frontiers in immunology."},{"key":"1915_CR36","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3899\/jrheum.190114","volume":"95","author":"L Eder","year":"2019","unstructured":"Eder, L., A. Dey, A.A. Joshi, W.H. Boehncke, N.N. Mehta, and A. Szentpetery. 2019. Cardiovascular diseases in psoriasis and psoriatic arthritis. Journal of Rheumatology. Supplement 95: 20\u201327. https:\/\/doi.org\/10.3899\/jrheum.190114.","journal-title":"Journal of Rheumatology. Supplement"},{"issue":"5","key":"1915_CR37","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1136\/annrheumdis-2012-201497","volume":"72","author":"L Eder","year":"2013","unstructured":"Eder, L., J. Jayakar, S. Shanmugarajah, A. Thavaneswaran, D. Pereira, V. Chandran, et al. 2013. The burden of carotid artery plaques is higher in patients with psoriatic arthritis compared with those with psoriasis alone. Annals of the Rheumatic Diseases. 72 (5): 715\u2013720. https:\/\/doi.org\/10.1136\/annrheumdis-2012-201497.","journal-title":"Annals of the rheumatic diseases."},{"key":"1915_CR38","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2014.13968","volume":"144","author":"WH Boehncke","year":"2014","unstructured":"Boehncke, W.H., and S. Boehncke. 2014. More than skin-deep: The many dimensions of the psoriatic disease. Swiss Medical Weekly. 144: w13968. https:\/\/doi.org\/10.4414\/smw.2014.13968.","journal-title":"Swiss medical weekly."},{"issue":"4","key":"1915_CR39","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1600-0625.2011.01261.x","volume":"20","author":"WH Boehncke","year":"2011","unstructured":"Boehncke, W.H., S. Boehncke, A.M. Tobin, and B. Kirby. 2011. The \u2018psoriatic march\u2019: A concept of how severe psoriasis may drive cardiovascular comorbidity. Experimental Dermatology. 20 (4): 303\u2013307. https:\/\/doi.org\/10.1111\/j.1600-0625.2011.01261.x.","journal-title":"Experimental dermatology."},{"key":"1915_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8634-3","author":"WH Boehncke","year":"2017","unstructured":"Boehncke, W.H., and N.C. Brembilla. 2017. Unmet needs in the field of psoriasis: Pathogenesis and treatment. Clinical Reviews in Allergy & Immunology. https:\/\/doi.org\/10.1007\/s12016-017-8634-3.","journal-title":"Clinical reviews in allergy & immunology."},{"issue":"3","key":"1915_CR41","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3899\/jrheum.101124","volume":"38","author":"WH Boehncke","year":"2011","unstructured":"Boehncke, W.H., D.D. Gladman, and V. Chandran. 2011. Cardiovascular comorbidities in psoriasis and psoriatic arthritis: Pathogenesis, consequences for patient management, and future research agenda: A report from the GRAPPA 2009 annual meeting. The Journal of Rheumatology. 38 (3): 567\u2013571. https:\/\/doi.org\/10.3899\/jrheum.101124.","journal-title":"The Journal of rheumatology."},{"issue":"3","key":"1915_CR42","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/jdv.12222","volume":"28","author":"WH Boehncke","year":"2014","unstructured":"Boehncke, W.H., B. Kirby, O. Fitzgerald, and P.C. van de Kerkhof. 2014. New developments in our understanding of psoriatic arthritis and their impact on the diagnosis and clinical management of the disease. Journal of the European Academy of Dermatology and Venereology: JEADV. 28 (3): 264\u2013270. https:\/\/doi.org\/10.1111\/jdv.12222.","journal-title":"Journal of the European Academy of Dermatology and Venereology : JEADV."},{"issue":"12","key":"1915_CR43","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1161\/atvbaha.114.304108","volume":"34","author":"S Karbach","year":"2014","unstructured":"Karbach, S., A.L. Croxford, M. Oelze, R. Sch\u00fcler, D. Minwegen, J. Wegner, et al. 2014. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 34 (12): 2658\u20132668. https:\/\/doi.org\/10.1161\/atvbaha.114.304108.","journal-title":"Arteriosclerosis, thrombosis, and vascular biology."},{"issue":"8","key":"1915_CR44","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1038\/jid.2012.112","volume":"132","author":"Y Wang","year":"2012","unstructured":"Wang, Y., H. Gao, C.M. Loyd, W. Fu, D. Diaconu, S. Liu, et al. 2012. Chronic skin-specific inflammation promotes vascular inflammation and thrombosis. The Journal of Investigative Dermatology. 132 (8): 2067\u20132075. https:\/\/doi.org\/10.1038\/jid.2012.112.","journal-title":"The Journal of investigative dermatology."},{"issue":"1","key":"1915_CR45","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jaad.2016.07.042","volume":"76","author":"JJ Wu","year":"2017","unstructured":"Wu, J.J., A. Gu\u00e9rin, M. Sundaram, K. Dea, M. Cloutier, and P. Mulani. 2017. Cardiovascular event risk assessment in psoriasis patients treated with tumor necrosis factor-\u03b1 inhibitors versus methotrexate. Journal of the American Academy of Dermatology. 76 (1): 81\u201390. https:\/\/doi.org\/10.1016\/j.jaad.2016.07.042.","journal-title":"Journal of the American Academy of Dermatology."},{"issue":"1","key":"1915_CR46","doi-asserted-by":"publisher","first-page":"10870","DOI":"10.1038\/s41598-019-47310-5","volume":"9","author":"M Diani","year":"2019","unstructured":"Diani, M., F. Casciano, L. Marongiu, M. Longhi, A. Altomare, P.D. Pigatto, et al. 2019. Increased frequency of activated CD8(+) T cell effectors in patients with psoriatic arthritis. Scientific Reports. 9 (1): 10870. https:\/\/doi.org\/10.1038\/s41598-019-47310-5.","journal-title":"Scientific reports."},{"key":"1915_CR47","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3389\/fimmu.2018.01390","volume":"9","author":"F Casciano","year":"2018","unstructured":"Casciano, F., P.D. Pigatto, P. Secchiero, R. Gambari, and E. Reali. 2018. T cell hierarchy in the pathogenesis of psoriasis and associated cardiovascular comorbidities. Frontiers in Immunology. 9: 1390. https:\/\/doi.org\/10.3389\/fimmu.2018.01390.","journal-title":"Frontiers in immunology."},{"issue":"8","key":"1915_CR48","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/eurheartj\/ehs263","volume":"34","author":"T Simon","year":"2013","unstructured":"Simon, T., S. Taleb, N. Danchin, L. Laurans, B. Rousseau, S. Cattan, et al. 2013. Circulating levels of interleukin-17 and cardiovascular outcomes in patients with acute myocardial infarction. European Heart Journal. 34 (8): 570\u2013577. https:\/\/doi.org\/10.1093\/eurheartj\/ehs263.","journal-title":"European Heart Journal"},{"key":"1915_CR49","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.3389\/fimmu.2019.03096","volume":"10","author":"E von Stebut","year":"2019","unstructured":"von Stebut, E., W.H. Boehncke, K. Ghoreschi, T. Gori, Z. Kaya, D. Thaci, et al. 2019. IL-17A in Psoriasis and beyond: Cardiovascular and metabolic implications. Frontiers in Immunology. 10: 3096. https:\/\/doi.org\/10.3389\/fimmu.2019.03096.","journal-title":"Frontiers in immunology."},{"issue":"3","key":"1915_CR50","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","volume":"16","author":"AL Byrd","year":"2018","unstructured":"Byrd, A.L., Y. Belkaid, and J.A. Segre. 2018. The human skin microbiome. Nature Reviews Microbiology. 16 (3): 143\u2013155. https:\/\/doi.org\/10.1038\/nrmicro.2017.157.","journal-title":"Nature Reviews Microbiology"},{"key":"1915_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.008","author":"A Weckel","year":"2023","unstructured":"Weckel, A., M.O. Dhariwala, K. Ly, V.M. Tran, O.T. Ojewumi, J.B. Riggs, et al. 2023. Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup. Immunity. https:\/\/doi.org\/10.1016\/j.immuni.2023.03.008.","journal-title":"Immunity"},{"issue":"6","key":"1915_CR52","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41590-023-01500-6","volume":"24","author":"Q Liu","year":"2023","unstructured":"Liu, Q., R. Ranallo, C. Rios, E.A. Grice, K. Moon, and R.L. Gallo. 2023. Crosstalk between skin microbiota and immune system in health and disease. Nature Immunology. 24 (6): 895\u2013898. https:\/\/doi.org\/10.1038\/s41590-023-01500-6.","journal-title":"Nature Immunology"},{"issue":"11","key":"1915_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2022.103169","volume":"21","author":"B Kapoor","year":"2022","unstructured":"Kapoor, B., M. Gulati, P. Rani, and R. Gupta. 2022. Psoriasis: Interplay between dysbiosis and host immune system. Autoimmunity Reviews. 21 (11): 103169. https:\/\/doi.org\/10.1016\/j.autrev.2022.103169.","journal-title":"Autoimmunity Reviews"},{"issue":"1","key":"1915_CR54","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.1038\/s41467-019-12253-y","volume":"10","author":"N Fyhrquist","year":"2019","unstructured":"Fyhrquist, N., G. Muirhead, S. Prast-Nielsen, M. Jeanmougin, P. Olah, T. Skoog, et al. 2019. Microbe-host interplay in atopic dermatitis and psoriasis. Nature Communications. 10 (1): 4703. https:\/\/doi.org\/10.1038\/s41467-019-12253-y.","journal-title":"Nature Communications"},{"key":"1915_CR55","doi-asserted-by":"publisher","unstructured":"Olejniczak-Staruch, I., M. Ci\u0105\u017cy\u0144ska, D. Sobolewska-Sztychny, J. Narbutt, M. Skibi\u0144ska, and A. Lesiak. 2021. Alterations of the skin and gut microbiome in psoriasis and psoriatic arthritis.\u00a0International Journal of Molecular Sciences. 22 (8). https:\/\/doi.org\/10.3390\/ijms22083998.","DOI":"10.3390\/ijms22083998"},{"key":"1915_CR56","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12948-016-0038-z","volume":"14","author":"L Drago","year":"2016","unstructured":"Drago, L., R. De Grandi, G. Altomare, P. Pigatto, O. Rossi, and M. Toscano. 2016. Skin microbiota of first cousins affected by psoriasis and atopic dermatitis.\u00a0Clinical and Molecular Allergy. 14: 2. https:\/\/doi.org\/10.1186\/s12948-016-0038-z.","journal-title":"Clin Mol Allergy."},{"key":"1915_CR57","doi-asserted-by":"publisher","unstructured":"Nickoloff, B.J., R.S. Mitra, J. Green, Y. Shimizu, C. Thompson, and L.A. Turka. 1993. Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: Relevance to psoriasis. Journal of Dermatological Science. 6 (2): 127\u201333. https:\/\/doi.org\/10.1016\/0923-1811(93)90002-7.","DOI":"10.1016\/0923-1811(93)90002-7"},{"issue":"3","key":"1915_CR58","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/1523-1747.ep12468941","volume":"100","author":"DY Leung","year":"1993","unstructured":"Leung, D.Y., P. Walsh, R. Giorno, and D.A. Norris. 1993. A potential role for superantigens in the pathogenesis of psoriasis. The Journal of Investigative Dermatology. 100 (3): 225\u2013228. https:\/\/doi.org\/10.1111\/1523-1747.ep12468941.","journal-title":"The Journal of Investigative Dermatology"},{"issue":"13","key":"1915_CR59","doi-asserted-by":"publisher","first-page":"6955","DOI":"10.3390\/ijms23136955","volume":"23","author":"S Zhou","year":"2022","unstructured":"Zhou, S., and Z. Yao. 2022. Roles of infection in psoriasis. International Journal of Molecular Sciences. 23 (13): 6955.","journal-title":"International Journal of Molecular Sciences."},{"issue":"3","key":"1915_CR60","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0167-5699(95)80132-4","volume":"16","author":"H Valdimarsson","year":"1995","unstructured":"Valdimarsson, H., B.S. Baker, I. Jonsdottir, A. Powles, and L. Fry. 1995. Psoriasis: A T-cell-mediated autoimmune disease induced by streptococcal superantigens? Immunology Today. 16 (3): 145\u2013149.","journal-title":"Immunology today."},{"issue":"Suppl 1","key":"1915_CR61","first-page":"21","volume":"107","author":"H Valdimarsson","year":"1997","unstructured":"Valdimarsson, H., H. Sigmundsdottir, and I. Jonsdottir. 1997. Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin? Clinical and Experimental Immunology. 107 (Suppl 1): 21\u201324.","journal-title":"Clinical and experimental immunology."},{"issue":"10","key":"1915_CR62","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.it.2009.07.008","volume":"30","author":"H Valdimarsson","year":"2009","unstructured":"Valdimarsson, H., R.H. Thorleifsdottir, S.L. Sigurdardottir, J.E. Gudjonsson, and A. Johnston. 2009. Psoriasis\u2013as an autoimmune disease caused by molecular mimicry. Trends in Immunology. 30 (10): 494\u2013501. https:\/\/doi.org\/10.1016\/j.it.2009.07.008.","journal-title":"Trends in immunology."},{"key":"1915_CR63","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3389\/fmicb.2018.01459","volume":"9","author":"I Salem","year":"2018","unstructured":"Salem, I., A. Ramser, N. Isham, and M.A. Ghannoum. 2018. The gut microbiome as a major regulator of the gut-skin axis. Frontiers in Microbiology 9: 1459. https:\/\/doi.org\/10.3389\/fmicb.2018.01459.","journal-title":"Frontiers in Microbiology"},{"key":"1915_CR64","doi-asserted-by":"publisher","unstructured":"Polak, K., B. Bergler-Czop, M. Szczepanek, K. Wojciechowska, A. Fr\u0105tczak, and N. Kiss. 2021. Psoriasis and gut microbiome-current state of art.\u00a0International Journal of Molecular Sciences. 22 (9). https:\/\/doi.org\/10.3390\/ijms22094529.","DOI":"10.3390\/ijms22094529"},{"key":"1915_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.571319","volume":"11","author":"S Yegorov","year":"2020","unstructured":"Yegorov, S., D. Babenko, S. Kozhakhmetov, L. Akhmaltdinova, I. Kadyrova, A. Nurgozhina, et al. 2020. Psoriasis is associated with elevated gut IL-1\u03b1 and intestinal microbiome alterations. Frontiers in Immunology. 11: 571319. https:\/\/doi.org\/10.3389\/fimmu.2020.571319.","journal-title":"Frontiers in Immunology"},{"key":"1915_CR66","doi-asserted-by":"publisher","unstructured":"Okada, K., Y. Matsushima, K. Mizutani, and K. Yamanaka. 2020. The role of gut microbiome in psoriasis: Oral administration of Staphylococcus aureus and Streptococcus danieliae exacerbates skin inflammation of imiquimod-induced psoriasis-like dermatitis.\u00a0International Journal of Molecular Sciences. 21 (9). https:\/\/doi.org\/10.3390\/ijms21093303.","DOI":"10.3390\/ijms21093303"},{"key":"1915_CR67","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2147\/jir.S292544","volume":"14","author":"M Sikora","year":"2021","unstructured":"Sikora, M., A. Stec, M. Chrabaszcz, J. Giebultowicz, E. Samborowska, R. Jazwiec, et al. 2021. Clinical implications of intestinal barrier damage in psoriasis. Journal of Inflammation Research. 14: 237\u2013243. https:\/\/doi.org\/10.2147\/jir.S292544.","journal-title":"Journal of Inflammation Research"},{"issue":"1","key":"1915_CR68","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41577-022-00727-y","volume":"23","author":"E Miyauchi","year":"2023","unstructured":"Miyauchi, E., C. Shimokawa, A. Steimle, M.S. Desai, and H. Ohno. 2023. The impact of the gut microbiome on extra-intestinal autoimmune diseases. Nature Reviews Immunology. 23 (1): 9\u201323. https:\/\/doi.org\/10.1038\/s41577-022-00727-y.","journal-title":"Nature Reviews Immunology"},{"key":"1915_CR69","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01202","volume":"2","author":"JU Scher","year":"2013","unstructured":"Scher, J.U., A. Sczesnak, R.S. Longman, N. Segata, C. Ubeda, C. Bielski, et al. 2013. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. eLife. 2: e01202. https:\/\/doi.org\/10.7554\/eLife.01202.","journal-title":"eLife"},{"issue":"5","key":"1915_CR70","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1136\/annrheumdis-2018-214514","volume":"78","author":"D Alpizar-Rodriguez","year":"2019","unstructured":"Alpizar-Rodriguez, D., T.R. Lesker, A. Gronow, B. Gilbert, E. Raemy, C. Lamacchia, et al. 2019. Prevotella copri in individuals at risk for rheumatoid arthritis. Annals of the Rheumatic Diseases. 78 (5): 590\u2013593. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214514.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1915_CR71","doi-asserted-by":"publisher","unstructured":"Montico, G., F. Mingozzi, F. Casciano, G. Protti, L. Gornati, E. Marzola, et al. 2023. CCR4(+) CD8(+) T cells clonally expand to differentiated effectors in murine psoriasis and in human psoriatic arthritis. European Journal of Immunology. e2149702. https:\/\/doi.org\/10.1002\/eji.202149702.","DOI":"10.1002\/eji.202149702"},{"issue":"1","key":"1915_CR72","doi-asserted-by":"publisher","first-page":"12754","DOI":"10.1038\/s41598-020-69537-3","volume":"10","author":"I Dei-Cas","year":"2020","unstructured":"Dei-Cas, I., F. Giliberto, L. Luce, H. Dopazo, and A. Penas-Steinhardt. 2020. Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: Development of a new Psoriasis-Microbiome Index. Scientific Reports. 10 (1): 12754. https:\/\/doi.org\/10.1038\/s41598-020-69537-3.","journal-title":"Scientific Reports."},{"key":"1915_CR73","doi-asserted-by":"publisher","unstructured":"Magne, F., M. Gotteland, L. Gauthier, A. Zazueta, S. Pesoa, P. Navarrete, et al. 2020. The Firmicutes\/Bacteroidetes ratio: A relevant marker of gut dysbiosis in obese patients? Nutrients. 12 (5). https:\/\/doi.org\/10.3390\/nu12051474.","DOI":"10.3390\/nu12051474"},{"key":"1915_CR74","doi-asserted-by":"publisher","first-page":"4634172","DOI":"10.1155\/2020\/4634172","volume":"2020","author":"Y Liu","year":"2020","unstructured":"Liu, Y., and M. Dai. 2020. Trimethylamine N-oxide generated by the gut microbiota is associated with vascular inflammation: New insights into atherosclerosis. Mediators of Inflammation. 2020: 4634172. https:\/\/doi.org\/10.1155\/2020\/4634172.","journal-title":"Mediators of Inflammation"},{"key":"1915_CR75","doi-asserted-by":"publisher","unstructured":"Canyelles, M., M. Tondo, L. Ced\u00f3, M. Farr\u00e0s, J.C. Escol\u00e0-Gil, and F. Blanco-Vaca. 2018. Trimethylamine N-oxide: A link among diet, gut microbiota, gene regulation of liver and intestine cholesterol homeostasis and HDL function.\u00a0International Journal of Molecular Sciences. 19 (10). https:\/\/doi.org\/10.3390\/ijms19103228.","DOI":"10.3390\/ijms19103228"},{"issue":"3","key":"1915_CR76","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.jfda.2016.06.003","volume":"25","author":"YH Chen","year":"2017","unstructured":"Chen, Y.H., C.S. Wu, Y.H. Chao, C.C. Lin, H.Y. Tsai, Y.R. Li, et al. 2017. Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice. Journal of Food and Drug Analysis. 25 (3): 559\u2013566. https:\/\/doi.org\/10.1016\/j.jfda.2016.06.003.","journal-title":"Journal of Food and Drug Analysis"},{"key":"1915_CR77","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3899\/jrheum.180134","volume":"94","author":"JU Scher","year":"2018","unstructured":"Scher, J.U. 2018. The microbiome in psoriasis and psoriatic arthritis: Joints. Journal of Rheumatology. Supplement. 94: 32\u201335. https:\/\/doi.org\/10.3899\/jrheum.180134.","journal-title":"Journal of Rheumatology. Supplement"},{"issue":"1","key":"1915_CR78","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/art.38892","volume":"67","author":"JU Scher","year":"2015","unstructured":"Scher, J.U., C. Ubeda, A. Artacho, M. Attur, S. Isaac, S.M. Reddy, et al. 2015. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis & Rhematology. 67 (1): 128\u2013139. https:\/\/doi.org\/10.1002\/art.38892.","journal-title":"Arthritis & Rhematology"},{"key":"1915_CR79","unstructured":"Joint FAO\/WHO Working Group. 2002. Drafting Guidelines for the Evaluation of Probiotics in Food: Guidelines for the evaluation of probiotics in food. London, ON, Canada.\u00a0http:\/\/www.who.int\/foodsafety\/publications\/fs_management\/probiotics2\/en\/"},{"key":"1915_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2022.101599","volume":"59","author":"F Strati","year":"2022","unstructured":"Strati, F., G. Lattanzi, C. Amoroso, and F. Facciotti. 2022. Microbiota-targeted therapies in inflammation resolution. Seminars in Immunology. 59: 101599. https:\/\/doi.org\/10.1016\/j.smim.2022.101599.","journal-title":"Seminars in Immunology"},{"key":"1915_CR81","doi-asserted-by":"publisher","first-page":"8424","DOI":"10.1038\/ncomms9424","volume":"6","author":"P Zanvit","year":"2015","unstructured":"Zanvit, P., J.E. Konkel, X. Jiao, S. Kasagi, D. Zhang, R. Wu, et al. 2015. Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. Nature Communications. 6: 8424. https:\/\/doi.org\/10.1038\/ncomms9424.","journal-title":"Nature communications."},{"key":"1915_CR82","doi-asserted-by":"publisher","unstructured":"Dargahi, N., J. Johnson, O. Donkor, T. Vasiljevic, and V. Apostolopoulos. 2019. Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases? Maturitas. 119: 25\u201338. https:\/\/doi.org\/10.1016\/j.maturitas.2018.11.002.","DOI":"10.1016\/j.maturitas.2018.11.002"},{"key":"1915_CR83","doi-asserted-by":"publisher","unstructured":"Schiweck, C., S.E. Thanarajah, M. Aichholzer, S. Matura, A. Reif, E. Vrieze, et al. 2022. Regulation of CD4(+) and CD8(+) T cell biology by short-chain fatty acids and its relevance for autoimmune pathology.\u00a0International Journal of Molecular Sciences. 23 (15). https:\/\/doi.org\/10.3390\/ijms23158272.","DOI":"10.3390\/ijms23158272"},{"key":"1915_CR84","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","volume":"10","author":"D Parada Venegas","year":"2019","unstructured":"Parada Venegas, D., M.K. De la Fuente, G. Landskron, M.J. Gonz\u00e1lez, R. Quera, G. Dijkstra, et al. 2019. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology. 10: 277. https:\/\/doi.org\/10.3389\/fimmu.2019.00277.","journal-title":"Frontiers in Immunology"},{"key":"1915_CR85","doi-asserted-by":"publisher","unstructured":"Portincasa, P., L. Bonfrate, M. Vacca, M. De Angelis, I. Farella, E. Lanza, et al. 2022. Gut microbiota and short chain fatty acids: Implications in glucose homeostasis. International Journal of Molecular Sciences. 23 (3). https:\/\/doi.org\/10.3390\/ijms23031105.","DOI":"10.3390\/ijms23031105"},{"issue":"3","key":"1915_CR86","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/jmf.2007.0144","volume":"11","author":"CW Park","year":"2008","unstructured":"Park, C.W., M. Youn, Y.M. Jung, H. Kim, Y. Jeong, H.K. Lee, et al. 2008. New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse. Journal of Medicinal Food. 11 (3): 405\u2013412. https:\/\/doi.org\/10.1089\/jmf.2007.0144.","journal-title":"Journal of Medicinal Food"},{"issue":"2","key":"1915_CR87","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1111\/jam.12229","volume":"115","author":"JY Kim","year":"2013","unstructured":"Kim, J.Y., B.K. Park, H.J. Park, Y.H. Park, B.O. Kim, and S. Pyo. 2013. Atopic dermatitis-mitigating effects of new Lactobacillus strain, Lactobacillus sakei probio 65 isolated from kimchi. Journal of Applied Microbiology. 115 (2): 517\u2013526. https:\/\/doi.org\/10.1111\/jam.12229.","journal-title":"Journal of Applied Microbiology"},{"issue":"9","key":"1915_CR88","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1002\/eji.200425139","volume":"34","author":"L Chapat","year":"2004","unstructured":"Chapat, L., K. Chemin, B. Dubois, R. Bourdet-Sicard, and D. Kaiserlian. 2004. Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation. European Journal of Immunology. 34 (9): 2520\u20132528. https:\/\/doi.org\/10.1002\/eji.200425139.","journal-title":"European Journal of Immunology"},{"issue":"3","key":"1915_CR89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004903","volume":"4","author":"F Hacini-Rachinel","year":"2009","unstructured":"Hacini-Rachinel, F., H. Gheit, J.B. Le Luduec, F. Dif, S. Nancey, and D. Kaiserlian. 2009. Oral probiotic control skin inflammation by acting on both effector and regulatory T cells. PLoS ONE. 4 (3): e4903. https:\/\/doi.org\/10.1371\/journal.pone.0004903.","journal-title":"PLoS ONE"},{"key":"1915_CR90","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3389\/fmicb.2018.01021","volume":"9","author":"IA Rather","year":"2018","unstructured":"Rather, I.A., V.K. Bajpai, Y.S. Huh, Y.K. Han, E.A. Bhat, J. Lim, et al. 2018. Probiotic Lactobacillus sakei proBio-65 extract ameliorates the severity of imiquimod induced psoriasis-like skin inflammation in a mouse model. Frontiers in Microbiology. 9: 1021. https:\/\/doi.org\/10.3389\/fmicb.2018.01021.","journal-title":"Frontiers in Microbiology"},{"issue":"4","key":"1915_CR91","doi-asserted-by":"publisher","first-page":"325","DOI":"10.4161\/gmic.25487","volume":"4","author":"D Groeger","year":"2013","unstructured":"Groeger, D., L. O\u2019Mahony, E.F. Murphy, J.F. Bourke, T.G. Dinan, B. Kiely, et al. 2013. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. Gut Microbes. 4 (4): 325\u2013339. https:\/\/doi.org\/10.4161\/gmic.25487.","journal-title":"Gut Microbes."},{"key":"1915_CR92","doi-asserted-by":"publisher","unstructured":"Ma, J., J. Zhang, Q. Li, Z. Shi, H. Wu, H. Zhang, et al. 2019. Oral administration of a mixture of probiotics protects against food allergy via induction of CD103+ dendritic cells and modulates the intestinal microbiota. Journal of Functional Foods. 55: 65\u201375. https:\/\/doi.org\/10.1016\/j.jff.2019.02.010.","DOI":"10.1016\/j.jff.2019.02.010"},{"issue":"7480","key":"1915_CR93","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nature12721","volume":"504","author":"Y Furusawa","year":"2013","unstructured":"Furusawa, Y., Y. Obata, S. Fukuda, T.A. Endo, G. Nakato, D. Takahashi, et al. 2013. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 504 (7480): 446\u2013450. https:\/\/doi.org\/10.1038\/nature12721.","journal-title":"Nature"},{"issue":"3","key":"1915_CR94","doi-asserted-by":"publisher","first-page":"173","DOI":"10.5483\/bmbrep.2014.47.3.272","volume":"47","author":"S Kim","year":"2014","unstructured":"Kim, S., J.H. Kim, B.O. Park, and Y.S. Kwak. 2014. Perspectives on the therapeutic potential of short-chain fatty acid receptors. BMB Reports. 47 (3): 173\u2013178. https:\/\/doi.org\/10.5483\/bmbrep.2014.47.3.272.","journal-title":"BMB Reports"},{"key":"1915_CR95","doi-asserted-by":"publisher","unstructured":"Haase, S., J. M\u00e4urer, A. Duscha, D.H. Lee, A. Balogh, R. Gold, et al. 2021. Propionic acid rescues high-fat diet enhanced immunopathology in autoimmunity via effects on Th17 responses. Frontiers in Immunology.\u00a012: 701626.\u00a0https:\/\/doi.org\/10.3389\/fimmu.2021.701626.","DOI":"10.3389\/fimmu.2021.701626"},{"issue":"12","key":"1915_CR96","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.2340\/00015555-3305","volume":"99","author":"V Navarro-L\u00f3pez","year":"2019","unstructured":"Navarro-L\u00f3pez, V., A. Mart\u00ednez-Andr\u00e9s, A. Ram\u00edrez-Bosc\u00e1, B. Ruzafa-Costas, E. N\u00fa\u00f1ez-Delegido, M.A. Carri\u00f3n-Guti\u00e9rrez, et al. 2019. Efficacy and safety of oral administration of a mixture of probiotic strains in patients with psoriasis: A randomized controlled clinical trial. Acta Dermato Venereologica. 99 (12): 1078\u20131084. https:\/\/doi.org\/10.2340\/00015555-3305.","journal-title":"Acta Dermato Venereologica"},{"issue":"2","key":"1915_CR97","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jtcme.2021.09.006","volume":"13","author":"S Panyod","year":"2023","unstructured":"Panyod, S., W.K. Wu, C.C. Chen, M.S. Wu, C.T. Ho, and L.Y. Sheen. 2023. Modulation of gut microbiota by foods and herbs to prevent cardiovascular diseases. Journal of Traditional & Complementary Medicine. 13 (2): 107\u2013118. https:\/\/doi.org\/10.1016\/j.jtcme.2021.09.006.","journal-title":"Journal of Traditional & Complementary Medicine"},{"key":"1915_CR98","doi-asserted-by":"publisher","unstructured":"Luo, X., Z. Han, Q. Kong, Y. Wang, H. Mou, and X. Duan. 2023. Clostridium butyricum prevents dysbiosis and the rise in blood pressure in spontaneously hypertensive rats.\u00a0International Journal of Molecular Sciences. 24 (5). https:\/\/doi.org\/10.3390\/ijms24054955.","DOI":"10.3390\/ijms24054955"},{"issue":"1","key":"1915_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3920\/bm2022.0030","volume":"14","author":"J \u0160t\u0161epetova","year":"2023","unstructured":"\u0160t\u0161epetova, J., M. R\u00e4tsep, O. Gerulis, A. J\u00f5esaar, M. Mikelsaar, and E. Songisepp. 2023. Impact of Lactiplantibacillus plantarum Inducia on metabolic and antioxidative response in cholesterol and BMI variable indices: Randomised, double-blind, placebo-controlled trials. Beneficial Microorganisms. 14 (1): 1\u201315. https:\/\/doi.org\/10.3920\/bm2022.0030.","journal-title":"Benef Microbes."},{"key":"1915_CR100","doi-asserted-by":"publisher","unstructured":"Ghorbani, Z., A. Kazemi,\u00a0T.U.P Bartolomaeus, F. Martami, M. Noormohammadi, A. Salari, et al. 2023. The effect of probiotic and synbiotic supplementation on lipid parameters among patients with cardiometabolic risk factors: A systematic review and meta-analysis of clinical trials.\u00a0Cardiovascular Research. 119 (4): 933\u201356. https:\/\/doi.org\/10.1093\/cvr\/cvac128.","DOI":"10.1093\/cvr\/cvac128"},{"key":"1915_CR101","doi-asserted-by":"publisher","unstructured":"de Luna Freire, M.O., L.C.P. do Nascimento, K.\u00c1.R de Oliveira, A.M. de Oliveira, L.M. Dos Santos, T.H. Napole\u00e3o, et al. 2023. Limosilactobacillus fermentum strains with claimed probiotic properties exert anti-oxidant and anti-inflammatory properties and prevent cardiometabolic disorder in female rats fed a high-fat diet.\u00a0Probiotics and Antimicrobial Proteins. 15 (3): 601\u201313. https:\/\/doi.org\/10.1007\/s12602-021-09878-1.","DOI":"10.1007\/s12602-021-09878-1"},{"key":"1915_CR102","doi-asserted-by":"publisher","unstructured":"Jia, B., Y. Zou, X. Han, J.-W. Bae, and C.O. Jeon. 2023. Gut microbiome-mediated mechanisms for reducing cholesterol levels: Implications for ameliorating cardiovascular disease. Trends in Microbiology. 31(1):76\u201391. https:\/\/doi.org\/10.1016\/j.tim.2022.08.003.","DOI":"10.1016\/j.tim.2022.08.003"},{"key":"1915_CR103","doi-asserted-by":"publisher","unstructured":"Oniszczuk, A., T. Oniszczuk, M. Gancarz, and J. Szyma\u0144ska. 2021. Role of gut microbiota, probiotics and prebiotics in the cardiovascular diseases. Molecules. 26(4). https:\/\/doi.org\/10.3390\/molecules26041172.","DOI":"10.3390\/molecules26041172"},{"issue":"10","key":"1915_CR104","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3760\/cma.j.issn.0578-1426.2019.10.011","volume":"58","author":"G Yin","year":"2019","unstructured":"Yin, G., J.F. Li, Y.F. Sun, X. Ding, J.Q. Zeng, T. Zhang, et al. 2019. Fecal microbiota transplantation as a novel therapy for severe psoriasis. Zhonghua Nei Ke Za Zhi. 58 (10): 782\u2013785. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1426.2019.10.011.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"1915_CR105","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.761978","volume":"8","author":"C Sun","year":"2021","unstructured":"Sun, C., L. Chen, H. Yang, H. Sun, Z. Xie, B. Zhao, et al. 2021. Involvement of gut microbiota in the development of psoriasis vulgaris. Frontiers in Nutrition. 8: 761978. https:\/\/doi.org\/10.3389\/fnut.2021.761978.","journal-title":"Frontiers in Nutrition"},{"issue":"9","key":"1915_CR106","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1136\/annrheumdis-2020-219511","volume":"80","author":"MS Kragsnaes","year":"2021","unstructured":"Kragsnaes, M.S., J. Kjeldsen, H.C. Horn, H.L. Munk, J.K. Pedersen, S.A. Just, et al. 2021. Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: An exploratory randomised placebo-controlled trial. Annals of the Rheumatic Diseases. 80 (9): 1158\u20131167. https:\/\/doi.org\/10.1136\/annrheumdis-2020-219511.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1915_CR107","doi-asserted-by":"publisher","first-page":"17057","DOI":"10.1038\/nmicrobiol.2017.57","volume":"2","author":"PW O'Toole","year":"2017","unstructured":"O\u2019Toole, P.W., J.R. Marchesi, and C. Hill. 2017. Next-generation probiotics: The spectrum from probiotics to live biotherapeutics. Nature Microbiology. 2: 17057. https:\/\/doi.org\/10.1038\/nmicrobiol.2017.57.","journal-title":"Nature Microbiology"},{"key":"1915_CR108","doi-asserted-by":"publisher","unstructured":"Olas, B. 2020. Probiotics, prebiotics and synbiotics-a promising strategy in prevention and treatment of cardiovascular diseases?\u00a0International Journal of Molecular Sciences. 21 (24). https:\/\/doi.org\/10.3390\/ijms21249737.","DOI":"10.3390\/ijms21249737"},{"key":"1915_CR109","doi-asserted-by":"publisher","first-page":"5633403","DOI":"10.1155\/2022\/5633403","volume":"2022","author":"H Zhang","year":"2022","unstructured":"Zhang, H., Y. Duan, F. Cai, D. Cao, L. Wang, Z. Qiao, et al. 2022. Next-generation probiotics: Microflora intervention to human diseases. BioMed Research International. 2022: 5633403. https:\/\/doi.org\/10.1155\/2022\/5633403.","journal-title":"BioMed Research International"},{"key":"1915_CR110","doi-asserted-by":"publisher","unstructured":"Effendi, R., M. Anshory, H. Kalim, R.F. Dwiyana, O. Suwarsa, L.M. Pardo, et al. 2022. Akkermansia muciniphila and Faecalibacterium prausnitzii in immune-related diseases. Microorganisms. 10(12). https:\/\/doi.org\/10.3390\/microorganisms10122382.","DOI":"10.3390\/microorganisms10122382"},{"key":"1915_CR111","doi-asserted-by":"publisher","first-page":"16643","DOI":"10.1038\/srep16643","volume":"5","author":"M Schneeberger","year":"2015","unstructured":"Schneeberger, M., A. Everard, A.G. G\u00f3mez-Valad\u00e9s, S. Matamoros, S. Ram\u00edrez, N.M. Delzenne, et al. 2015. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Science and Reports. 5: 16643. https:\/\/doi.org\/10.1038\/srep16643.","journal-title":"Science and Reports"},{"issue":"9","key":"1915_CR112","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/ecco-jcc\/jjw070","volume":"10","author":"H Eppinga","year":"2016","unstructured":"Eppinga, H., C.J. Sperna Weiland, H.B. Thio, C.J. van der Woude, T.E. Nijsten, M.P. Peppelenbosch, et al. 2016. Similar depletion of protective Faecalibacterium prausnitzii in psoriasis and inflammatory bowel disease, but not in hidradenitis suppurativa. Journal of Crohn\u2019s & Colitis. 10 (9): 1067\u20131075. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjw070.","journal-title":"Journal of Crohn's & Colitis"},{"key":"1915_CR113","doi-asserted-by":"publisher","unstructured":"Caliceti, C., M. Malaguti, L. Marracino, M.C. Barbalace, P. Rizzo, and S. Hrelia. 2022. Agri-food waste from apple, pear, and sugar beet as a source of protective bioactive molecules for endothelial dysfunction and its major complications. Antioxidants (Basel). 11 (9). https:\/\/doi.org\/10.3390\/antiox11091786.","DOI":"10.3390\/antiox11091786"},{"issue":"3","key":"1915_CR114","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/exd.12333","volume":"23","author":"S Leon Carrion","year":"2014","unstructured":"Leon Carrion, S., C.H. Sutter, and T.R. Sutter. 2014. Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation. Experimental Dermatology. 23 (3): 211\u2013214. https:\/\/doi.org\/10.1111\/exd.12333.","journal-title":"Experimental Dermatology"},{"issue":"1","key":"1915_CR115","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jid.2020.04.031","volume":"141","author":"A Schwarz","year":"2021","unstructured":"Schwarz, A., R. Philippsen, and T. Schwarz. 2021. Induction of regulatory T cells and correction of cytokine disbalance by short-chain fatty acids: Implications for psoriasis therapy. The Journal of Investigative Dermatology. 141 (1): 95\u2013104.e2. https:\/\/doi.org\/10.1016\/j.jid.2020.04.031.","journal-title":"The Journal of Investigative Dermatology"},{"key":"1915_CR116","doi-asserted-by":"publisher","unstructured":"Wegh, C.A.M., S.Y. Geerlings, J. Knol, G. Roeselers, and C. Belzer. 2019. Postbiotics and their potential applications in early life nutrition and beyond.\u00a0International Journal of Molecular Sciences. 20 (19). https:\/\/doi.org\/10.3390\/ijms20194673.","DOI":"10.3390\/ijms20194673"},{"key":"1915_CR117","doi-asserted-by":"publisher","unstructured":"Vinderola, G., M.E. Sanders, and S. Salminen. 2022. The concept of postbiotics. Foods. 11 (8). https:\/\/doi.org\/10.3390\/foods11081077.","DOI":"10.3390\/foods11081077"},{"key":"1915_CR118","doi-asserted-by":"publisher","unstructured":"Marracino, L., . Punzo, P. Severi, R. Nganwouo Tchoutang, C. Vargas-De-la-Cruz, F. Fortini, et al. 2022. Fermentation of Vaccinium floribundum berries with Lactiplantibacillus plantarum reduces oxidative stress in endothelial cells and modulates macrophages function. Nutrients. 14 (8). https:\/\/doi.org\/10.3390\/nu14081560.","DOI":"10.3390\/nu14081560"},{"issue":"2","key":"1915_CR119","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/fermentation5020041","volume":"5","author":"V Lolou","year":"2019","unstructured":"Lolou, V., and M.I. Panayiotidis. 2019. Functional role of probiotics and prebiotics on skin health and disease. Fermentation. 5 (2): 41.","journal-title":"Fermentation."}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01915-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01915-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01915-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T02:18:13Z","timestamp":1705630693000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-023-01915-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":119,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1915"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01915-1","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"24 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests or other interests that might be perceived to influence the results and\/or discussion reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}