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Epithelial-mesenchymal transition (EMT) is an essential player in these alterations. Scutellarin is isolated from <jats:italic>Erigeron breviscapus<\/jats:italic>. Its vascular relaxative, myocardial protective, and anti-inflammatory effects have been well established. This study was designed to detect the biological roles of scutellarin in asthma and its related mechanisms. The asthma-like conditions were induced by ovalbumin challenges. The airway resistance and dynamic compliance were recorded as the results of AHR. Bronchoalveolar lavage fluid (BALF) was collected and processed for differential cell counting. Hematoxylin and eosin staining, periodic acid-Schiff staining, and Masson staining were conducted to examine histopathological changes. The levels of asthma-related cytokines were measured by enzyme-linked immunosorbent assay. For <jats:italic>in vitro<\/jats:italic> analysis, the 16HBE cells were stimulated with 10 ng\/mL transforming growth beta-1 (TGF-\u03b21). Cell migration was estimated by Transwell assays and wound healing assays. E-cadherin, N-cadherin, and \u03b1-smooth muscle actin (\u03b1-SMA) were analyzed by western blotting, real-time quantitative polymerase chain reaction, immunofluorescence staining, and immunohistochemistry staining. The underlying mechanisms of the mitogen-activated protein kinase (MAPK) and Smad pathways were investigated by western blotting. In an ovalbumin-induced asthmatic mouse model, scutellarin suppressed inflammation and inflammatory cell infiltration into the lungs and attenuated AHR and airway remodeling. Additionally, scutellarin inhibited airway EMT (upregulated E-cadherin level and downregulated N-cadherin and \u03b1-SMA) in ovalbumin-challenged asthmatic mice. For <jats:italic>in vitro<\/jats:italic> analysis, scutellarin prevented the TGF-\u03b21-induced migration and EMT in 16HBE cells. Mechanistically, scutellarin inhibits the phosphorylation of Smad2, Smad3, ERK, JNK, and p38 <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. In conclusion, scutellarin can inactivate the Smad\/MAPK pathways to suppress the TGF-\u03b21-stimulated epithelial fibrosis and EMT and relieve airway inflammation and remodeling in asthma. This study provides a potential therapeutic strategy for asthma.<\/jats:p>","DOI":"10.1007\/s10753-023-01947-7","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T19:05:08Z","timestamp":1704222308000},"page":"853-873","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-\u03b2-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2\/3 Signaling Pathways"],"prefix":"10.1007","volume":"47","author":[{"given":"Minfang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"issue":"1","key":"1947_CR1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12931-023-02475-6","volume":"24","author":"Z Wang","year":"2023","unstructured":"Wang, Z., Y. 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