{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:14:03Z","timestamp":1792106043027,"version":"4.4.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:00Z","timestamp":1703894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study mainly explored the role of nicorandil in regulating ferroptosis and alleviating septic cardiomyopathy through toll-like receptor (TLR) 4\/solute carrier family 7 member 11 (SLC7A11) signaling pathway. Twenty-four male SD rats were randomly divided into control, Nic (nicorandil), LPS (lipopolysaccharide), and LPS + Nic groups and given echocardiography. A detection kit was applied to measure the levels of lactic dehydrogenase (LDH), cardiac troponin I (cTnI), and creatine kinase-MB (CK-MB); HE staining and the levels of glutathione (GSH), malondialdehyde (MDA), total iron, and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    of myocardial tissues were detected. Moreover, the expression of TLR4 and SLC7A11 were measured by qRT-PCR and the proteins regulating ferroptosis (TLR4, SLC7A11, GPX4, ACSL4, DMT1, Fpn, and TfR1) were checked by western blot. Myocardial cells (H9C2) were induced with lipopolysaccharide (LPS) and transfected with si-TLR4 or SLC7A11-OE. Then, the viability, ferroptosis, and TLR4\/SLC7A11 signaling pathway of cells were examined. Nicorandil could significantly increase left ventricular (LV) ejection fraction (LVEF) while reduce LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV). Also, it greatly reduced the levels of LDH, cTnI, and CK-MB; alleviated the pathological changes of myocardial injury; notably decreased MDA, total iron, and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    levels in myocardial tissues; and significantly increased GSH level. Besides, nicorandil obviously raised protein levels of GPX4, Fpn, and SLC7A11, and decreased protein levels of ACSL4, DMT1, TfR1, and TLR4. After knockdown of TLR4 or overexpression of SLC7A11, the inhibition effect of nicorandil on ferroptosis was strengthened in LPS-induced H9C2 cells. Therefore, nicorandil may regulate ferroptosis through TLR4\/SLC7A11 signaling, thereby alleviating septic cardiomyopathy.\n                  <\/jats:p>","DOI":"10.1007\/s10753-023-01954-8","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T06:01:50Z","timestamp":1703916110000},"page":"975-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Nicorandil Regulates Ferroptosis and Mitigates Septic Cardiomyopathy via TLR4\/SLC7A11 Signaling Pathway"],"prefix":"10.1007","volume":"47","author":[{"given":"Jin-shuai","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,30]]},"reference":[{"key":"1954_CR1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","volume":"392","author":"M Cecconi","year":"2018","unstructured":"Cecconi, M., L. Evans, M. Levy, and A. Rhodes. 2018. Sepsis and septic shock. Lancet 392: 75\u201387.","journal-title":"Lancet"},{"key":"1954_CR2","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/CCM.0b013e318174db05","volume":"36","author":"A Vieillard-Baron","year":"2008","unstructured":"Vieillard-Baron, A., V. Caille, C. Charron, G. Belliard, B. Page, and F. Jardin. 2008. Actual incidence of global left ventricular hypokinesia in adult septic shock. Critical Care Medicine 36: 1701\u20131706.","journal-title":"Critical Care Medicine"},{"key":"1954_CR3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1056\/NEJMp1707170","volume":"377","author":"K Reinhart","year":"2017","unstructured":"Reinhart, K., R. Daniels, N. Kissoon, F.R. Machado, R.D. Schachter, and S. Finfer. 2017. Recognizing sepsis as a global health priority \u2014 A WHO resolution. New England Journal of Medicine 377: 414\u2013417.","journal-title":"New England Journal of Medicine"},{"key":"1954_CR4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/QCO.0b013e32834536ce","volume":"24","author":"TM Balija","year":"2011","unstructured":"Balija, T.M., and S.F. Lowry. 2011. Lipopolysaccharide and sepsis-associated myocardial dysfunction. Current Opinion in Infectious Diseases 24: 248\u2013253.","journal-title":"Current Opinion in Infectious Diseases"},{"key":"1954_CR5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/SHK.0000000000000065","volume":"41","author":"A Zaky","year":"2014","unstructured":"Zaky, A., S. Deem, K. Bendjelid, and M.M. Treggiari. 2014. Characterization of cardiac dysfunction in sepsis: an ongoing challenge. Shock 41: 12\u201324.","journal-title":"Shock"},{"key":"1954_CR6","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.12659\/MSM.898457","volume":"22","author":"JB Meng","year":"2016","unstructured":"Meng, J.B., M.H. Hu, Z.Z. Lai, C.L. Ji, X.J. Xu, G. Zhang, et al. 2016. Levosimendan versus dobutamine in myocardial injury patients with septic shock: a randomized controlled trial. Medical Science Monitor 22: 1486\u20131496.","journal-title":"Medical Science Monitor"},{"key":"1954_CR7","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jcrc.2014.03.028","volume":"29","author":"E Antonucci","year":"2014","unstructured":"Antonucci, E., E. Fiaccadori, K. Donadello, F.S. Taccone, F. Franchi, and S. Scolletta. 2014. Myocardial depression in sepsis: from pathogenesis to clinical manifestations and treatment. Journal of Critical Care 29: 500\u2013511.","journal-title":"Journal of Critical Care"},{"key":"1954_CR8","first-page":"193","volume":"31","author":"X Liu","year":"2019","unstructured":"Liu, X., M. Wen, X. Li, L. Chen, J. Zeng, Y. Deng, et al. 2019. beta1 receptor blocker decreases the myocardial inflammation in the sepsis adult rats through inhibition of TLR4\/NF-KappaB signaling pathway. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 31: 193\u2013197.","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"1954_CR9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2018.11.055","volume":"217","author":"WX Zhang","year":"2019","unstructured":"Zhang, W.X., B.M. He, Y. Wu, J.F. Qiao, and Z.Y. Peng. 2019. Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. Life Sciences 217: 8\u201315.","journal-title":"Life Sciences"},{"key":"1954_CR10","first-page":"111","volume":"31","author":"LX Tang","year":"2018","unstructured":"Tang, L.X., L. Ding, and Z.W. Zhang. 2018. Research progress on pharmacodynamics, pharmacokinetics and clinical application of dexmedetomidine. Clinical Misdiagnosis & Mistherapy 31: 111\u2013116.","journal-title":"Clinical Misdiagnosis & Mistherapy"},{"key":"1954_CR11","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1039\/C8FO00688A","volume":"9","author":"N Zhou","year":"2018","unstructured":"Zhou, N., M.N. Zeng, K. Li, Y.Y. Yang, Z.Y. Bai, X.K. Zheng, et al. 2018. An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy. Food & Function 9: 4989\u20134997.","journal-title":"Food & Function"},{"key":"1954_CR12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4103\/ijp.IJP_298_19","volume":"51","author":"LA Ahmed","year":"2019","unstructured":"Ahmed, L.A. 2019. Nicorandil: a drug with ongoing benefits and different mechanisms in various diseased conditions. Indian Journal of Pharmacology 51: 296\u2013301.","journal-title":"Indian Journal of Pharmacology"},{"key":"1954_CR13","first-page":"419","volume":"20","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., W. Jiang, and X. Zhao. 2021. Efficacy of nicorandil in patients with sepsis-induced cardiomyopathy and its effects on prognosis. Chinese Journal of Multiple Organ Diseases in the Elderly 20: 419\u2013424.","journal-title":"Chinese Journal of Multiple Organ Diseases in the Elderly"},{"key":"1954_CR14","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1177\/15353702211013444","volume":"246","author":"F Chen","year":"2021","unstructured":"Chen, F., Z.Q. Chen, G.L. Zhong, and J.J. Zhu. 2021. Nicorandil inhibits TLR4\/MyD88\/NF-\u03baB\/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction. Experimental Biology and Medicine (Maywood, N.J.) 246: 1938\u20131947.","journal-title":"Experimental Biology and Medicine (Maywood, N.J.)"},{"key":"1954_CR15","first-page":"5822920","volume":"2021","author":"J Lu","year":"2021","unstructured":"Lu, J., F. Liu, X. Yu, L. Xu, and L. Zhang. 2021. The anti-inflammatory and antiapoptotic effects of nicorandil in antisepsis cardiomyopathy. Cardiovascular Therapeutics 2021: 5822920.","journal-title":"Cardiovascular Therapeutics"},{"key":"1954_CR16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2018.09.043","volume":"133","author":"T Hirschhorn","year":"2019","unstructured":"Hirschhorn, T., and B.R. Stockwell. 2019. The development of the concept of ferroptosis. Free Radical Biology & Medicine 133: 130\u2013143.","journal-title":"Free Radical Biology & Medicine"},{"key":"1954_CR17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2019.06.015","volume":"516","author":"X Chen","year":"2019","unstructured":"Chen, X., S. Xu, C. Zhao, and B. Liu. 2019. Role of TLR4\/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure. Biochemical and Biophysical Research Communications 516: 37\u201343.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"1954_CR18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11897-014-0247-z","volume":"12","author":"K Drosatos","year":"2015","unstructured":"Drosatos, K., A. Lymperopoulos, P.J. Kennel, N. Pollak, P.C. Schulze, and I.J. Goldberg. 2015. Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both? Current Heart Failure Reports 12: 130\u2013140.","journal-title":"Current Heart Failure Reports"},{"key":"1954_CR19","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.2147\/OTT.S248492","volume":"13","author":"B Yuan","year":"2020","unstructured":"Yuan, B., F. Liao, Z.Z. Shi, Y. Ren, X.L. Deng, T.T. Yang, et al. 2020. Dihydroartemisinin inhibits the proliferation, colony formation and induces ferroptosis of lung cancer cells by inhibiting PRIM2\/SLC7A11 axis. Oncotargets and Therapy 13: 10829\u201310840.","journal-title":"Oncotargets and Therapy"},{"key":"1954_CR20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s10815-022-02443-x","volume":"39","author":"SRA El-Khalik","year":"2022","unstructured":"El-Khalik, S.R.A., R.R. Ibrahim, M.T.A. Ghafar, D. Shatat, and O.S. El-Deeb. 2022. Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: Identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers. Journal of Assisted Reproduction and Genetics 39: 1115\u20131124.","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"1954_CR21","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.biopha.2018.07.014","volume":"106","author":"Q Su","year":"2018","unstructured":"Su, Q., X. Lv, Y. Sun, Z. Ye, B. Kong, and Z. Qin. 2018. Role of TLR4\/MyD88\/NF-\u03baB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil. Biomedicine & Pharmacotherapy 106: 776\u2013784.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1954_CR22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","volume":"25","author":"P Liu","year":"2020","unstructured":"Liu, P., Y. Feng, H. Li, X. Chen, G. Wang, S. Xu, et al. 2020. Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis. Cellular & Molecular Biology Letters 25: 10.","journal-title":"Cellular & Molecular Biology Letters"},{"key":"1954_CR23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.21037\/apm-21-3936","volume":"11","author":"S Li","year":"2022","unstructured":"Li, S., L. Zhao, B. Zhang, Y. Yuan, H. Cao, and Z. Yu. 2022. Ultrasound cardiogram-based diagnosis of cardiac hypertrophy from hypertension and analysis of its relationship with expression of autophagy-related protein. Annals of Palliative Medicine 11: 684\u2013694.","journal-title":"Annals of Palliative Medicine"},{"key":"1954_CR24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40560-016-0148-1","volume":"4","author":"Y Kakihana","year":"2016","unstructured":"Kakihana, Y., T. Ito, M. Nakahara, K. Yamaguchi, and T. Yasuda. 2016. Sepsis-induced myocardial dysfunction: Pathophysiology and management. Journal of Intensive Care 4: 22.","journal-title":"Journal of Intensive Care"},{"key":"1954_CR25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/sj.bjp.0703267","volume":"130","author":"RG Bogle","year":"2000","unstructured":"Bogle, R.G., P.G. McLean, A. Ahluwalia, and P. Vallance. 2000. Impaired vascular sensitivity to nitric oxide in the coronary microvasculature after endotoxaemia. British Journal of Pharmacology 130: 118\u2013124.","journal-title":"British Journal of Pharmacology"},{"issue":"44\u201347","key":"1954_CR26","first-page":"51","volume":"29","author":"J Zheng","year":"2019","unstructured":"Zheng, J., Y.L. Wu, M. Wang, L. Xu, H.B. Yu, and M. He. 2019. Clinical effect of levosimendan combined with traditional Chinese medicine on treatment of severe sepsis patients with myocardial injury. Chinese Journal of Nosocomiology 29 (44\u201347): 51.","journal-title":"Chinese Journal of Nosocomiology"},{"key":"1954_CR27","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"X Fang","year":"2019","unstructured":"Fang, X., H. Wang, D. Han, E. Xie, X. Yang, J. Wei, et al. 2019. Ferroptosis as a target for protection against cardiomyopathy. Proceedings of the National Academy of Sciences 116: 2672\u20132680.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"1954_CR28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2020.08.009","volume":"160","author":"N Li","year":"2020","unstructured":"Li, N., W. Wang, H. Zhou, Q. Wu, M. Duan, C. Liu, et al. 2020. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radical Biology & Medicine 160: 303\u2013318.","journal-title":"Free Radical Biology & Medicine"},{"key":"1954_CR29","first-page":"1959","volume":"57","author":"GD Cao","year":"2022","unstructured":"Cao, G.D., F.F. Deng, Y.H. Zhao, Y.C. Zeng, L. Lin, L.C. Guo, et al. 2022. H2S attenuates sepsis-induced cardiomyopathy by regulating the Xc-\/GPX4 pathway in ferroptosis. Acta Universitatis Medicinalis Anhui 57: 1959\u20131964.","journal-title":"Acta Universitatis Medicinalis Anhui"},{"key":"1954_CR30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.arcmed.2018.12.006","volume":"49","author":"Y Xing","year":"2018","unstructured":"Xing, Y., C. Liu, H. Wang, X. Zhang, Y. Wang, X. Yue, et al. 2018. Protective effects of nicorandil on cardiac function and left ventricular remodeling in a rat model of ischemic heart failure. Archives of Medical Research 49: 583\u2013587.","journal-title":"Archives of Medical Research"},{"key":"1954_CR31","doi-asserted-by":"crossref","first-page":"472","DOI":"10.2174\/1389201018666170623125842","volume":"18","author":"M Kruska","year":"2017","unstructured":"Kruska, M., I. El-Battrawy, M. Behnes, M. Borggrefe, and I. Akin. 2017. Biomarkers in cardiomyopathies and prediction of sudden cardiac death. Current Pharmaceutical Biotechnology 18: 472\u2013481.","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"1954_CR32","volume":"11","author":"Z Yang","year":"2016","unstructured":"Yang, Z., A. Qdaisat, Z. Hu, E.A. Wagar, C. Reyes-Gibby, Q.H. Meng, et al. 2016. Cardiac troponin is a predictor of septic shock mortality in cancer patients in an emergency department: A retrospective cohort study. PLoS ONE 11: e0153492.","journal-title":"PLoS ONE"},{"key":"1954_CR33","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/01.CCM.0000162561.82012.E9","volume":"33","author":"A Roch","year":"2005","unstructured":"Roch, A., J. Allardet-Servent, P. Michelet, C. Oddoze, J.M. Forel, K. Barrau, et al. 2005. NH2 terminal pro-brain natriuretic peptide plasma level as an early marker of prognosis and cardiac dysfunction in septic shock patients. Critical Care Medicine 33: 1001\u20131007.","journal-title":"Critical Care Medicine"},{"key":"1954_CR34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194623","volume":"13","author":"N Kawakita","year":"2018","unstructured":"Kawakita, N., K. Ejiri, T. Miyoshi, K. Kohno, M. Nakahama, M. Doi, et al. 2018. Protective effect of nicorandil on myocardial injury following percutaneous coronary intervention in older patients with stable coronary artery disease: Secondary analysis of a randomized, controlled trial (RINC). PLoS ONE 13: e0194623.","journal-title":"PLoS ONE"},{"key":"1954_CR35","doi-asserted-by":"crossref","first-page":"9395","DOI":"10.3390\/ijms23169395","volume":"23","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y., Y. Lu, and L. Jin. 2022. Iron metabolism and ferroptosis in physiological and pathological pregnancy. International Journal of Molecular Sciences 23: 9395.","journal-title":"International Journal of Molecular Sciences"},{"key":"1954_CR36","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang, D., A.M. Minikes, and X. Jiang. 2022. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Molecular Cell 82: 2215\u20132227.","journal-title":"Molecular Cell"},{"key":"1954_CR37","first-page":"16","volume":"45","author":"WB Zhou","year":"2018","unstructured":"Zhou, W.B., C.F. Kong, G.W. Qin, Y.Y. Wang, X. Liu, and X.F. Wang. 2018. Research progress on the mechanism of ferroptosis. Sheng Wu Hua Xue Yu Sheng Wu Li Jin Zhan 45: 16\u201322.","journal-title":"Sheng Wu Hua Xue Yu Sheng Wu Li Jin Zhan"},{"key":"1954_CR38","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli, J.P., M. Schneider, B. Proneth, Y.Y. Tyurina, V.A. Tyurin, V.J. Hammond, et al. 2014. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nature Cell Biology 16: 1180\u20131191.","journal-title":"Nature Cell Biology"},{"key":"1954_CR39","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1111\/jcmm.12659","volume":"19","author":"L Liu","year":"2015","unstructured":"Liu, L., Y. Wang, Z.Y. Cao, M.M. Wang, X.M. Liu, T. Gao, et al. 2015. Up-regulated TLR4 in cardiomyocytes exacerbates heart failure after long-term myocardial infarction. Journal of Cellular and Molecular Medicine 19: 2728\u20132740.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"1954_CR40","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1159\/000490866","volume":"47","author":"Q Su","year":"2018","unstructured":"Su, Q., L. Li, Y. Sun, H. Yang, Z. Ye, and J. Zhao. 2018. Effects of the TLR4\/Myd88\/NF-kappaB signaling pathway on NLRP3 inflammasome in coronary microembolization-induced myocardial injury. Cellular Physiology and Biochemistry 47: 1497\u20131508.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"1954_CR41","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S.J., K.M. Lemberg, M.R. Lamprecht, R. Skouta, E.M. Zaitsev, C.E. Gleason, et al. 2012. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell 149: 1060\u20131072.","journal-title":"Cell"},{"key":"1954_CR42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.celrep.2016.09.022","volume":"17","author":"SJ Wang","year":"2016","unstructured":"Wang, S.J., D. Li, Y. Ou, L. Jiang, Y. Chen, Y. Zhao, et al. 2016. Acetylation is crucial for p53-mediated ferroptosis and tumor suppression. Cell Reports 17: 366\u2013373.","journal-title":"Cell Reports"}],"updated-by":[{"DOI":"10.1007\/s10753-026-02625-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000}}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01954-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01954-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-023-01954-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:43:30Z","timestamp":1791996210000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-023-01954-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,30]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1954"],"URL":"https:\/\/doi.org\/10.1007\/s10753-023-01954-8","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,30]]},"assertion":[{"value":"16 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10753-026-02625-0","URL":"https:\/\/doi.org\/10.1007\/s10753-026-02625-0","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This experiment was approved by the animal ethics committee of People\u2019s Hospital of Xinjiang Uygur Autonomous Region (KY2023031381).","order":1,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"DECLARATIONS"}}]}}