{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:36:07Z","timestamp":1792694167914,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s10753-024-01972-0","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T03:02:13Z","timestamp":1707188533000},"page":"1229-1247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["FSTL1 Accelerates Nucleus Pulposus Cell Senescence and Intervertebral Disc Degeneration Through TLR4\/NF-\u03baB Pathway"],"prefix":"10.1007","volume":"47","author":[{"given":"Xu","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Yu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Liang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"1972_CR1","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","volume":"391","author":"J Hartvigsen","year":"2018","unstructured":"Hartvigsen, J., M.J. Hancock, A. Kongsted, Q. Louw, M.L. Ferreira, S. Genevay, et al. 2018. What low back pain is and why we need to pay attention. Lancet 391: 2356\u20132367.","journal-title":"Lancet"},{"key":"1972_CR2","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1016\/S0140-6736(20)32340-0","volume":"396","author":"A Cieza","year":"2021","unstructured":"Cieza, A., K. Causey, K. Kamenov, S.W. Hanson, S. Chatterji, and T. Vos. 2021. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet 396: 2006\u20132017.","journal-title":"Lancet"},{"key":"1972_CR3","doi-asserted-by":"crossref","unstructured":"Raj, PP.\u00a02008. Intervertebral disc: anatomy-physiology-pathophysiology-treatment. Pain practice : the official journal of World Institute of Pain 8:18\u201344.","DOI":"10.1111\/j.1533-2500.2007.00171.x"},{"key":"1972_CR4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","volume":"54","author":"W Zhang","year":"2022","unstructured":"Zhang, W., G. Li, R. Luo, J. Lei, Y. Song, B. Wang, et al. 2022. Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis. Experimental & Molecular Medicine 54: 129\u2013142.","journal-title":"Experimental & Molecular Medicine"},{"key":"1972_CR5","first-page":"146","volume":"6","author":"Y Liu","year":"2021","unstructured":"Liu, Y., J. Du, P. Peng, R. Cheng, J. Lin, C. Xu, et al. 2021. Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy. Bioact Mater 6: 146\u2013157.","journal-title":"Bioact Mater"},{"key":"1972_CR6","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1016\/j.ymthe.2022.05.021","volume":"30","author":"J Wu","year":"2022","unstructured":"Wu, J., Y. Chen, Z. Liao, H. Liu, S. Zhang, D. Zhong, et al. 2022. Self-amplifying loop of NF-kappaB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration. Molecular Therapy 30: 3241\u20133256.","journal-title":"Molecular Therapy"},{"key":"1972_CR7","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/s12276-022-00811-2","volume":"54","author":"W Zhou","year":"2022","unstructured":"Zhou, W., Y. Shi, H. Wang, L. Chen, C. Yu, X. Zhang, et al. 2022. Exercise-induced FNDC5\/irisin protects nucleus pulposus cells against senescence and apoptosis by activating autophagy. Experimental & Molecular Medicine 54: 1038\u20131048.","journal-title":"Experimental & Molecular Medicine"},{"key":"1972_CR8","first-page":"29","volume":"15","author":"L Luo","year":"2022","unstructured":"Luo, L., J. Gong, Z. Wang, Y. Liu, J. Cao, J. Qin, et al. 2022. Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration. Bioact Mater 15: 29\u201343.","journal-title":"Bioact Mater"},{"key":"1972_CR9","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.joca.2023.01.006","volume":"31","author":"S Li","year":"2023","unstructured":"Li, S., X. Pan, Y. Wu, Y. Tu, W. Hong, J. Ren, et al. 2023. IL-37 alleviates intervertebral disc degeneration via the IL-1R8\/NF-kappaB pathway. Osteoarthritis Cartilage 31: 588\u2013599.","journal-title":"Osteoarthritis Cartilage"},{"key":"1972_CR10","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","volume":"17","author":"R He","year":"2021","unstructured":"He, R., Z. Wang, M. Cui, S. Liu, W. Wu, M. Chen, et al. 2021. HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. Autophagy 17: 3338\u20133360.","journal-title":"Autophagy"},{"key":"1972_CR11","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nature15372","volume":"525","author":"K Wei","year":"2015","unstructured":"Wei, K., V. Serpooshan, C. Hurtado, M. Diez-Cunado, M. Zhao, S. Maruyama, et al. 2015. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 525: 479\u2013485.","journal-title":"Nature"},{"key":"1972_CR12","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1136\/annrheumdis-2013-204822","volume":"74","author":"Y Chaly","year":"2015","unstructured":"Chaly, Y., H.C. Blair, S.M. Smith, D.S. Bushnell, A.D. Marinov, B.T. Campfield, et al. 2015. Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells. Annals of the Rheumatic Diseases 74: 1467\u20131473.","journal-title":"Annals of the Rheumatic Diseases"},{"key":"1972_CR13","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1136\/gutjnl-2021-325150","volume":"71","author":"J Rao","year":"2022","unstructured":"Rao, J., H. Wang, M. Ni, Z. Wang, Z. Wang, S. Wei, et al. 2022. FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2. Gut 71: 2539\u20132550.","journal-title":"Gut"},{"key":"1972_CR14","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1002\/pro.3696","volume":"28","author":"X Li","year":"2019","unstructured":"Li, X., L. Li, Y. Chang, W. Ning, and X. Liu. 2019. Structural and functional study of FK domain of Fstl1. Protein Science 28: 1819\u20131829.","journal-title":"Protein Science"},{"key":"1972_CR15","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1161\/CIRCULATIONAHA.112.115089","volume":"126","author":"Y Ogura","year":"2012","unstructured":"Ogura, Y., N. Ouchi, K. Ohashi, R. Shibata, Y. Kataoka, T. Kambara, et al. 2012. Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models. Circulation 126: 1728\u20131738.","journal-title":"Circulation"},{"key":"1972_CR16","doi-asserted-by":"publisher","first-page":"618","DOI":"10.2174\/1574888X14666190628103528","volume":"14","author":"RD May","year":"2019","unstructured":"May, R.D., D.A. Frauchiger, C.E. Albers, A. Tekari, L.M. Benneker, F.M. Klenke, et al. 2019. Application of cytokines of the bone morphogenetic protein (BMP) family in spinal fusion - effects on the bone, intervertebral disc and mesenchymal stromal cells. Current Stem Cell Research & Therapy 14: 618\u2013643.","journal-title":"Current Stem Cell Research & Therapy"},{"key":"1972_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s12026-014-8526-z","volume":"59","author":"Y Chaly","year":"2014","unstructured":"Chaly, Y., B. Hostager, S. Smith, and R. Hirsch. 2014. Follistatin-like protein 1 and its role in inflammation and inflammatory diseases. Immunologic Research 59: 266\u2013272.","journal-title":"Immunologic Research"},{"key":"1972_CR18","doi-asserted-by":"publisher","first-page":"144339","DOI":"10.1016\/j.gene.2020.144339","volume":"732","author":"C Xu","year":"2020","unstructured":"Xu, C., T. Jiang, S. Ni, C. Chen, C. Li, C. Zhuang, et al. 2020. FSTL1 promotes nitric oxide-induced chondrocyte apoptosis via activating the SAPK\/JNK\/caspase3 signaling pathway. Gene 732: 144339.","journal-title":"Gene"},{"key":"1972_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13075-015-0605-6","volume":"17","author":"S Ni","year":"2015","unstructured":"Ni, S., K. Miao, X. Zhou, N. Xu, C. Li, R. Zhu, et al. 2015. The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-kappaB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation. Arthritis Research & Therapy 17: 91.","journal-title":"Arthritis Research & Therapy"},{"key":"1972_CR20","doi-asserted-by":"publisher","first-page":"R193","DOI":"10.1186\/ar3522","volume":"13","author":"Y Wang","year":"2011","unstructured":"Wang, Y., D. Li, N. Xu, W. Tao, R. Zhu, R. Sun, et al. 2011. Follistatin-like protein 1: A serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis. Arthritis Research & Therapy 13: R193.","journal-title":"Arthritis Research & Therapy"},{"key":"1972_CR21","doi-asserted-by":"crossref","unstructured":"Mao, H., D. Geng, X. Wu, Y. Gu, T. Du, Z. Yu, et al.\u00a02022. CB2R attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through AMPK\/GSK3\u03b2 pathway. Aging and disease 13.","DOI":"10.14336\/AD.2021.1025"},{"key":"1972_CR22","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s13287-021-02362-1","volume":"12","author":"Y Sun","year":"2021","unstructured":"Sun, Y., W. Zhang, and X. Li. 2021. Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration. Stem Cell Research & Therapy 12: 286.","journal-title":"Stem Cell Research & Therapy"},{"key":"1972_CR23","doi-asserted-by":"publisher","first-page":"10703","DOI":"10.18632\/aging.202850","volume":"13","author":"J Ding","year":"2021","unstructured":"Ding, J., R. Zhang, H. Li, Q. Ji, X. Cheng, R.F. Thorne, et al. 2021. ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration. Aging 13: 10703\u201310723.","journal-title":"Aging"},{"key":"1972_CR24","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s42764-022-00087-w","volume":"4","author":"X Xu","year":"2022","unstructured":"Xu, X., S. Nowsheen, and M. Deng. 2022. Exploring the DNA damage response pathway for synthetic lethality. Genome Instability & Disease 4: 98\u2013120.","journal-title":"Genome Instability & Disease"},{"key":"1972_CR25","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","volume":"169","author":"S He","year":"2017","unstructured":"He, S., and N.E. Sharpless. 2017. Senescence in Health and Disease. Cell 169: 1000\u20131011.","journal-title":"Cell"},{"key":"1972_CR26","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1101\/gad.343129.120","volume":"34","author":"J Birch","year":"2020","unstructured":"Birch, J., and J. Gil. 2020. Senescence and the SASP: Many therapeutic avenues. Genes & development 34: 1565\u20131576.","journal-title":"Genes & development"},{"key":"1972_CR27","doi-asserted-by":"publisher","first-page":"6891","DOI":"10.1080\/21655979.2021.1973781","volume":"12","author":"Z Li","year":"2021","unstructured":"Li, Z., C. Sun, M. Chen, and B. Wang. 2021. Lumican silencing alleviates tumor necrosis factor-\u03b1-induced nucleus pulposus cell inflammation and senescence by inhibiting apoptosis signal regulating kinase 1\/p38 signaling pathway via inactivating Fas ligand expression. Bioengineered 12: 6891\u20136901.","journal-title":"Bioengineered"},{"key":"1972_CR28","doi-asserted-by":"crossref","unstructured":"Guo, Q., X. Chen, J. Chen, G. Zheng, C. Xie, H. Wu, et al.\u00a02021. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-\u03baB signaling pathway. Cell Death & Disease 12.","DOI":"10.1038\/s41419-020-03341-9"},{"key":"1972_CR29","doi-asserted-by":"publisher","first-page":"5051","DOI":"10.1038\/s41467-018-07360-1","volume":"9","author":"ML Ji","year":"2018","unstructured":"Ji, M.L., H. Jiang, X.J. Zhang, P.L. Shi, C. Li, H. Wu, et al. 2018. Preclinical development of a microRNA-based therapy for intervertebral disc degeneration. Nature Communications 9: 5051.","journal-title":"Nature Communications"},{"key":"1972_CR30","doi-asserted-by":"publisher","first-page":"106465","DOI":"10.1016\/j.intimp.2020.106465","volume":"83","author":"W Li","year":"2020","unstructured":"Li, W., M. Alahdal, Z. Deng, J. Liu, Z. Zhao, X. Cheng, et al. 2020. Molecular functions of FSTL1 in the osteoarthritis. International Immunopharmacology 83: 106465.","journal-title":"International Immunopharmacology"},{"key":"1972_CR31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","volume":"168","author":"Q Zhang","year":"2017","unstructured":"Zhang, Q., M.J. Lenardo, and D. Baltimore. 2017. 30 years of NF-\u03baB: A blossoming of relevance to human pathobiology. Cell 168: 37\u201357.","journal-title":"Cell"},{"key":"1972_CR32","doi-asserted-by":"publisher","first-page":"114060","DOI":"10.1016\/j.expneurol.2022.114060","volume":"353","author":"X Xiao","year":"2022","unstructured":"Xiao, X., H. Zhang, W. Ning, Z. Yang, Y. Wang, and T. Zhang. 2022. Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4\/MyD88\/NF-kappaB pathway in CUMS mice. Experimental Neurology 353: 114060.","journal-title":"Experimental Neurology"},{"key":"1972_CR33","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.matbio.2019.02.004","volume":"82","author":"EJ Novais","year":"2019","unstructured":"Novais, E.J., B.O. Diekman, I.M. Shapiro, and M.V. Risbud. 2019. p16(Ink4a) deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix biology\u202f: Journal of the International Society for Matrix Biology 82: 54\u201370.","journal-title":"Matrix biology : Journal of the International Society for Matrix Biology"},{"key":"1972_CR34","doi-asserted-by":"crossref","unstructured":"Silwal, P.,\u00a0A.M. Nguyen-Thai, H.A. Mohammad, Y. Wang, P.D. Robbins, J.Y. Lee, et al. 2023. Cellular senescence in intervertebral disc aging and degeneration: molecular mechanisms and potential therapeutic opportunities. Biomolecules 13.","DOI":"10.3390\/biom13040686"},{"key":"1972_CR35","doi-asserted-by":"publisher","first-page":"571","DOI":"10.7150\/ijbs.70211","volume":"19","author":"WN Xu","year":"2023","unstructured":"Xu, W.N., C. Liu, H.L. Zheng, H.X. Xu, R.Z. Yang, S.D. Jiang, et al. 2023. Sesn2 serves as a regulator between mitochondrial unfolded protein response and mitophagy in intervertebral disc degeneration. International Journal of Biological Sciences 19: 571\u2013592.","journal-title":"International Journal of Biological Sciences"},{"key":"1972_CR36","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","volume":"54","author":"Q Xiang","year":"2022","unstructured":"Xiang, Q., Y. Zhao, J. Lin, S. Jiang, and W. Li. 2022. The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights. Experimental & Molecular Medicine 54: 1067\u20131075.","journal-title":"Experimental & Molecular Medicine"},{"key":"1972_CR37","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41413-020-0087-2","volume":"8","author":"F Chen","year":"2020","unstructured":"Chen, F., G. Jiang, H. Liu, Z. Li, Y. Pei, H. Wang, et al. 2020. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1beta\/NF-kappaB-NLRP3 inflammasome positive feedback loop. Bone Res 8: 10.","journal-title":"Bone Res"},{"key":"1972_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13075-023-03093-9","volume":"25","author":"C Liu","year":"2023","unstructured":"Liu, C., X. Gao, J. Lou, H. Li, Y. Chen, M. Chen, et al. 2023. Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1. Arthritis Research & Therapy 25: 117.","journal-title":"Arthritis Research & Therapy"},{"key":"1972_CR39","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s13287-022-03031-7","volume":"13","author":"YY Zhang","year":"2022","unstructured":"Zhang, Y.Y., Z.L. Hu, Y.H. Qi, H.Y. Li, X. Chang, X.X. Gao, et al. 2022. Pretreatment of nucleus pulposus mesenchymal stem cells with appropriate concentration of H(2)O(2) enhances their ability to treat intervertebral disc degeneration. Stem Cell Research & Therapy 13: 340.","journal-title":"Stem Cell Research & Therapy"},{"key":"1972_CR40","doi-asserted-by":"publisher","first-page":"e12941","DOI":"10.1111\/cpr.12941","volume":"54","author":"K Zhao","year":"2021","unstructured":"Zhao, K., R. An, Q. Xiang, G. Li, K. Wang, Y. Song, et al. 2021. Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration. Cell Proliferation 54: e12941.","journal-title":"Cell Proliferation"},{"key":"1972_CR41","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1002\/cbin.12062","volume":"47","author":"W Sun","year":"2023","unstructured":"Sun, W., X. Yang, L. Chen, L. Guo, H. Huang, X. Liu, et al. 2023. FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation. Cell Biology International 47: 1716\u20131727.","journal-title":"Cell Biology International"},{"key":"1972_CR42","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00011-021-01475-w","volume":"70","author":"Y Wang","year":"2021","unstructured":"Wang, Y., D. Zhang, T. Liu, J.F. Wang, J.X. Wu, J.P. Zhao, et al. 2021. FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3\/IL-1beta signaling pathway in mice and macrophages. Inflammation Research 70: 777\u2013787.","journal-title":"Inflammation Research"},{"key":"1972_CR43","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.apsb.2022.12.001","volume":"13","author":"SB Yoon","year":"2023","unstructured":"Yoon, S.B., H. Hong, H.J. Lim, J.H. Choi, Y.P. Choi, S.W. Seo, et al. 2023. A novel IRAK4\/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR\/MYD88-mediated NF-kappaB pathway. Acta Pharm Sin B 13: 1093\u20131109.","journal-title":"Acta Pharm Sin B"},{"key":"1972_CR44","doi-asserted-by":"publisher","first-page":"6163","DOI":"10.1002\/jmv.27212","volume":"93","author":"T Tang","year":"2021","unstructured":"Tang, T., Y. Guo, X. Xu, L. Zhao, X. Shen, L. Sun, et al. 2021. BoDV-1 infection induces neuroinflammation by activating the TLR4\/MyD88\/IRF5 signaling pathway, leading to learning and memory impairment in rats. Journal of Medical Virology 93: 6163\u20136171.","journal-title":"Journal of Medical Virology"},{"key":"1972_CR45","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.cellsig.2016.05.018","volume":"28","author":"HJ Kim","year":"2016","unstructured":"Kim, H.J., W.Y. Kang, S.J. Seong, S.Y. Kim, M.S. Lim, and Y.R. Yoon. 2016. Follistatin-like 1 promotes osteoclast formation via RANKL-mediated NF-kappaB activation and M-CSF-induced precursor proliferation. Cellular Signalling 28: 1137\u20131144.","journal-title":"Cellular Signalling"},{"key":"1972_CR46","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.7150\/ijbs.56823","volume":"17","author":"S Xie","year":"2021","unstructured":"Xie, S., C. Zhao, W. Chen, G. Li, Z. Xiong, X. Tang, et al. 2021. Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling. International Journal of Biological Sciences 17: 2367\u20132379.","journal-title":"International Journal of Biological Sciences"},{"key":"1972_CR47","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1152\/physrev.00028.2017","volume":"98","author":"JW Lowery","year":"2018","unstructured":"Lowery, J.W., and V. Rosen. 2018. The BMP Pathway and Its Inhibitors in the Skeleton. Physiological Reviews 98: 2431\u20132452.","journal-title":"Physiological Reviews"},{"key":"1972_CR48","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1038\/boneres.2016.9","volume":"4","author":"M Wu","year":"2016","unstructured":"Wu, M., G. Chen, and Y.P. Li. 2016. TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res 4: 16009.","journal-title":"Bone Res"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-01972-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-01972-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-01972-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T20:27:38Z","timestamp":1724444858000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-01972-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1972"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-01972-0","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}