{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:28:13Z","timestamp":1772119693930,"version":"3.50.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2021H026"],"award-info":[{"award-number":["LH2021H026"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s10753-024-01980-0","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T12:02:15Z","timestamp":1706788935000},"page":"1344-1355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u03b17nAChR Activation Combined with Endothelial Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis through the NF-\u03baB Pathway"],"prefix":"10.1007","volume":"47","author":[{"given":"Xiaoyun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enran","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wengang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"issue":"9","key":"1980_CR1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41574-022-00690-7","volume":"18","author":"D Tomic","year":"2022","unstructured":"Tomic, D., J.E. Shaw, and D.J. Magliano. 2022. The burden and risks of emerging complications of diabetes mellitus. Nature Reviews Endocrinology 18 (9): 525\u2013539. https:\/\/doi.org\/10.1038\/s41574-022-00690-7.","journal-title":"Nature Reviews. Endocrinology"},{"issue":"4","key":"1980_CR2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.tem.2020.01.007","volume":"31","author":"D Mauricio","year":"2020","unstructured":"Mauricio, D., N. Alonso, and M. Gratacos. 2020. Chronic diabetes complications: The need to move beyond classical concepts. Trends in Endocrinology and Metabolism 31 (4): 287\u2013295. https:\/\/doi.org\/10.1016\/j.tem.2020.01.007.","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"1","key":"1980_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.14336\/AD.2016.0627","volume":"8","author":"H Zheng","year":"2017","unstructured":"Zheng, H., J. Wu, Z. Jin, et al. 2017. Potential biochemical mechanisms of lung injury in diabetes. Aging and Disease 8 (1): 7\u201316. https:\/\/doi.org\/10.14336\/AD.2016.0627.","journal-title":"Aging and Disease"},{"key":"1980_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.ejphar.2017.11.011","volume":"818","author":"RA Ugan","year":"2018","unstructured":"Ugan, R.A., E. Cadirci, Z. Halici, et al. 2018. The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions. European Journal of Pharmacology 818: 457\u2013469. https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.011.","journal-title":"European Journal of Pharmacology"},{"key":"1980_CR5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.phrs.2018.10.008","volume":"137","author":"D Visca","year":"2018","unstructured":"Visca, D., P. Pignatti, A. Spanevello, et al. 2018. Relationship between diabetes and respiratory diseases-clinical and therapeutic aspects. Pharmacological Research 137: 230\u2013235. https:\/\/doi.org\/10.1016\/j.phrs.2018.10.008.","journal-title":"Pharmacological Research"},{"issue":"4","key":"1980_CR6","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s11154-020-09584-3","volume":"21","author":"H Xie","year":"2020","unstructured":"Xie, H., N. Yepuri, Q. Meng, et al. 2020. Therapeutic potential of alpha7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation. Reviews in Endocrine & Metabolic Disorders 21 (4): 431\u2013447. https:\/\/doi.org\/10.1007\/s11154-020-09584-3.","journal-title":"Reviews in Endocrine & Metabolic Disorders"},{"issue":"5","key":"1980_CR7","doi-asserted-by":"publisher","first-page":"3791","DOI":"10.3892\/mmr.2019.10016","volume":"19","author":"Z Shao","year":"2019","unstructured":"Shao, Z., Q. Li, S. Wang, et al. 2019. Protective effects of PNU282987 on sepsisinduced acute lung injury in mice. Molecular Medicine Reports 19 (5): 3791\u20133798. https:\/\/doi.org\/10.3892\/mmr.2019.10016.","journal-title":"Molecular Medicine Reports"},{"issue":"10","key":"1980_CR8","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1113\/JP275101","volume":"596","author":"C Bouzat","year":"2018","unstructured":"Bouzat, C., M. Lasala, B.E. Nielsen, et al. 2018. Molecular function of alpha7 nicotinic receptors as drug targets. Journal of Physiology 596 (10): 1847\u20131861. https:\/\/doi.org\/10.1113\/JP275101.","journal-title":"Journal of Physiology"},{"issue":"6","key":"1980_CR9","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.bbi.2005.03.015","volume":"19","author":"VA Pavlov","year":"2005","unstructured":"Pavlov, V.A., and K.J. Tracey. 2005. The cholinergic anti-inflammatory pathway. Brain, Behavior, and Immunity 19 (6): 493\u2013499. https:\/\/doi.org\/10.1016\/j.bbi.2005.03.015.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"7","key":"1980_CR10","doi-asserted-by":"publisher","first-page":"-","DOI":"10.3390\/biom10071057","volume":"10","author":"B Gausseres","year":"2020","unstructured":"Gausseres, B., J. Liu, E. Foppen, et al. 2020. The constitutive lack of alpha7 nicotinic receptor leads to metabolic disorders in mouse. Biomolecules 10 (7). PMID 32708537. https:\/\/doi.org\/10.3390\/biom10071057.","journal-title":"Biomolecules"},{"issue":"1","key":"1980_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00210-020-01957-4","volume":"394","author":"ME Youssef","year":"2021","unstructured":"Youssef, M.E., H.M. Abdelrazek, and Y.M. Moustafa. 2021. Cardioprotective role of GTS-21 by attenuating the TLR4\/NF-kappaB pathway in streptozotocin-induced diabetic cardiomyopathy in rats. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology 394 (1): 11\u201331. https:\/\/doi.org\/10.1007\/s00210-020-01957-4.","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"issue":"1","key":"1980_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/jpet.109.154633","volume":"332","author":"MB Marrero","year":"2010","unstructured":"Marrero, M.B., R. Lucas, C. Salet, et al. 2010. An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes. Journal of Pharmacology and Experimental Therapeutics 332 (1): 173\u2013180. https:\/\/doi.org\/10.1124\/jpet.109.154633.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"52","key":"1980_CR13","doi-asserted-by":"publisher","first-page":"20295","DOI":"10.1074\/jbc.RA118.004617","volume":"293","author":"D Gupta","year":"2018","unstructured":"Gupta, D., A.A. Lacayo, S.M. Greene, et al. 2018.\u00a0\u03b2-Cell mass restoration by alpha7 nicotinic acetylcholine receptor activation. Journal of Biological Chemistry 293 (52): 20295\u201320306. https:\/\/doi.org\/10.1074\/jbc.RA118.004617.","journal-title":"Journal of Biological Chemistry"},{"issue":"9","key":"1980_CR14","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1080\/14728222.2021.1988928","volume":"25","author":"JL Vincent","year":"2021","unstructured":"Vincent, J.L., C. Ince, and P. Pickkers. 2021. Endothelial dysfunction: A therapeutic target in bacterial sepsis? Expert Opinion on Therapeutic Targets 25 (9): 733\u2013748. https:\/\/doi.org\/10.1080\/14728222.2021.1988928.","journal-title":"Expert Opinion on Therapeutic Targets"},{"issue":"12","key":"1980_CR15","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1097\/CCM.0b013e3181f96f5f","volume":"38","author":"SK Cribbs","year":"2010","unstructured":"Cribbs, S.K., M.A. Matthay, and G.S. Martin. 2010. Stem cells in sepsis and acute lung injury. Critical Care Medicine 38 (12): 2379\u20132385. https:\/\/doi.org\/10.1097\/CCM.0b013e3181f96f5f.","journal-title":"Critical Care Medicine"},{"issue":"5","key":"1980_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1463-1326.2007.00754.x","volume":"10","author":"A Liew","year":"2008","unstructured":"Liew, A., J.H. McDermott, F. Barry, et al. 2008. Endothelial progenitor cells for the treatment of diabetic vasculopathy: Panacea or Pandora\u2019s box? Diabetes, Obesity & Metabolism 10 (5): 353\u2013366. https:\/\/doi.org\/10.1111\/j.1463-1326.2007.00754.x.","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"8","key":"1980_CR17","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1093\/eurheartj\/ehp078","volume":"30","author":"AM Leone","year":"2009","unstructured":"Leone, A.M., M. Valgimigli, M.B. Giannico, et al. 2009. From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells. European Heart Journal 30 (8): 890\u2013899. https:\/\/doi.org\/10.1093\/eurheartj\/ehp078.","journal-title":"European Heart Journal"},{"issue":"1","key":"1980_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00011-019-01299-9","volume":"69","author":"R Sun","year":"2020","unstructured":"Sun, R., J. Huang, and B. Sun. 2020. Mobilization of endothelial progenitor cells in sepsis. Inflammation Research 69 (1): 1\u20139. https:\/\/doi.org\/10.1007\/s00011-019-01299-9.","journal-title":"Inflammation Research"},{"issue":"4","key":"1980_CR19","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.molmed.2009.02.001","volume":"15","author":"G Krenning","year":"2009","unstructured":"Krenning, G., M.J. van Luyn, and M.C. Harmsen. 2009. Endothelial progenitor cell-based neovascularization: Implications for therapy. Trends in Molecular Medicine 15 (4): 180\u2013189. https:\/\/doi.org\/10.1016\/j.molmed.2009.02.001.","journal-title":"Trends in Molecular Medicine"},{"issue":"11","key":"1980_CR20","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s41419-021-04117-5","volume":"12","author":"W Ma","year":"2021","unstructured":"Ma, W., W. Zhang, B. Cui, et al. 2021. Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhibition. Cell Death & Disease 12 (11): 1056. https:\/\/doi.org\/10.1038\/s41419-021-04117-5.","journal-title":"Cell Death & Disease"},{"issue":"1","key":"1980_CR21","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s13054-019-2339-3","volume":"23","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y., P. Li, A.J. Goodwin, et al. 2019. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Critical Care 23 (1): 44. https:\/\/doi.org\/10.1186\/s13054-019-2339-3.","journal-title":"Critical Care"},{"issue":"5","key":"1980_CR22","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.ymthe.2018.02.020","volume":"26","author":"Y Zhou","year":"2018","unstructured":"Zhou, Y., P. Li, A.J. Goodwin, et al. 2018. Exosomes from endothelial progenitor cells improve the outcome of a murine model of sepsis. Molecular Therapy 26 (5): 1375\u20131384. https:\/\/doi.org\/10.1016\/j.ymthe.2018.02.020.","journal-title":"Molecular Therapy"},{"issue":"2","key":"1980_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jcyt.2015.11.009","volume":"18","author":"X Li","year":"2016","unstructured":"Li, X., C. Chen, L. Wei, et al. 2016. Exosomes derived from endothelial progenitor cells attenuate vascular repair and accelerate reendothelialization by enhancing endothelial function. Cytotherapy 18 (2): 253\u2013262. https:\/\/doi.org\/10.1016\/j.jcyt.2015.11.009.","journal-title":"Cytotherapy"},{"key":"1980_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110756","volume":"131","author":"S Bai","year":"2020","unstructured":"Bai, S., Q. Yin, T. Dong, et al. 2020. Endothelial progenitor cell-derived exosomes ameliorate endothelial dysfunction in a mouse model of diabetes. Biomedicine & Pharmacotherapy 131: 110756. https:\/\/doi.org\/10.1016\/j.biopha.2020.110756.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"7","key":"1980_CR25","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1097\/01.CCM.0000269034.86817.59","volume":"35","author":"N Rafat","year":"2007","unstructured":"Rafat, N., C. Hanusch, P.T. Brinkkoetter, et al. 2007. Increased circulating endothelial progenitor cells in septic patients: Correlation with survival. Critical Care Medicine 35 (7): 1677\u20131684. https:\/\/doi.org\/10.1097\/01.CCM.0000269034.86817.59.","journal-title":"Critical Care Medicine"},{"issue":"6","key":"1980_CR26","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1161\/ATVBAHA.114.302192","volume":"34","author":"KH Yiu","year":"2014","unstructured":"Yiu, K.H., and H.F. Tse. 2014. Specific role of impaired glucose metabolism and diabetes mellitus in endothelial progenitor cell characteristics and function. Arteriosclerosis, Thrombosis, and Vascular Biology 34 (6): 1136\u20131143. https:\/\/doi.org\/10.1161\/ATVBAHA.114.302192.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"4","key":"1980_CR27","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.2337\/db10-0875","volume":"60","author":"CV Desouza","year":"2011","unstructured":"Desouza, C.V., F.G. Hamel, K. Bidasee, et al. 2011. Role of inflammation and insulin resistance in endothelial progenitor cell dysfunction. Diabetes 60 (4): 1286\u20131294. https:\/\/doi.org\/10.2337\/db10-0875.","journal-title":"Diabetes"},{"issue":"4","key":"1980_CR28","doi-asserted-by":"publisher","first-page":"R118","DOI":"10.1186\/cc7968","volume":"13","author":"TH Luo","year":"2009","unstructured":"Luo, T.H., Y. Wang, Z.M. Lu, et al. 2009. The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes. Critical Care 13 (4): R118. https:\/\/doi.org\/10.1186\/cc7968.","journal-title":"Critical Care"},{"key":"1980_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.103975","volume":"129","author":"X Zhang","year":"2020","unstructured":"Zhang, X., G. Mao, Z. Zhang, et al. 2020. Activating alpha7nAChRs enhances endothelial progenitor cell function partially through the JAK2\/STAT3 signaling pathway. Microvascular Research 129: 103975. https:\/\/doi.org\/10.1016\/j.mvr.2020.103975.","journal-title":"Microvascular Research"},{"issue":"1","key":"1980_CR30","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1186\/s13287-020-01892-4","volume":"11","author":"X Chen","year":"2020","unstructured":"Chen, X., J. Chen, Y. Song, et al. 2020. Vagal alpha7nAChR signaling regulates alpha7nAChR(+)Sca1(+) cells during lung injury repair. Stem Cell Research & Therapy 11 (1): 375. https:\/\/doi.org\/10.1186\/s13287-020-01892-4.","journal-title":"Stem Cell Research & Therapy"},{"issue":"5","key":"1980_CR31","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.surg.2018.12.018","volume":"165","author":"T Jiang","year":"2019","unstructured":"Jiang, T., Y. Liu, Q. Meng, et al. 2019. Hydrogen sulfide attenuates lung ischemia-reperfusion injury through SIRT3-dependent regulation of mitochondrial function in type 2 diabetic rats. Surgery 165 (5): 1014\u20131026. https:\/\/doi.org\/10.1016\/j.surg.2018.12.018.","journal-title":"Surgery"},{"issue":"2","key":"1980_CR32","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/SHK.0000000000000911","volume":"49","author":"Y Ji","year":"2018","unstructured":"Ji, Y., G. Zhang, H. Zhu, et al. 2018. Indinavir plus methylprednisolone ameliorates experimental acute lung injury in vitro and in vivo. Shock 49 (2): 196\u2013204. https:\/\/doi.org\/10.1097\/SHK.0000000000000911.","journal-title":"Shock"},{"key":"1980_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108908","volume":"108","author":"Z Jin","year":"2022","unstructured":"Jin, Z., M.Y. Li, L. Tang, et al. 2022. Protective effect of ulinastatin on acute lung injury in diabetic sepsis rats. International Immunopharmacology 108: 108908. https:\/\/doi.org\/10.1016\/j.intimp.2022.108908.","journal-title":"International Immunopharmacology"},{"issue":"1","key":"1980_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41420-021-00431-1","volume":"7","author":"S Li","year":"2021","unstructured":"Li, S., D. Qi, J.N. Li, et al. 2021. Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3. Cell Death Discovery 7 (1): 63. https:\/\/doi.org\/10.1038\/s41420-021-00431-1.","journal-title":"Cell Death Discovery"},{"issue":"14","key":"1980_CR35","doi-asserted-by":"publisher","first-page":"-","DOI":"10.3390\/ijms22147552","volume":"22","author":"NM Pinheiro","year":"2021","unstructured":"Pinheiro, N.M., R. Banzato, I. Tiberio, et al. 2021. Acute lung injury in cholinergic-deficient mice supports anti-inflammatory role of alpha7 nicotinic acetylcholine receptor. International Journal of Molecular Sciences 22 (14). PMID 34299169. https:\/\/doi.org\/10.3390\/ijms22147552.","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"1980_CR36","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1111\/dom.14693","volume":"24","author":"Q Meng","year":"2022","unstructured":"Meng, Q., O.G. Chepurny, C.A. Leech, et al. 2022. The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db\/db mice. Diabetes, Obesity & Metabolism 24 (7): 1255\u20131266. https:\/\/doi.org\/10.1111\/dom.14693.","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"1","key":"1980_CR37","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s12931-020-01538-2","volume":"21","author":"RH Zhang","year":"2020","unstructured":"Zhang, R.H., J.B. Zhou, Y.H. Cai, et al. 2020. Non-linear association between diabetes mellitus and pulmonary function: A population-based study. Respiratory Research 21 (1): 292. https:\/\/doi.org\/10.1186\/s12931-020-01538-2.","journal-title":"Respiratory Research"},{"issue":"5","key":"1980_CR38","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2174\/138945012800399008","volume":"13","author":"P Filippini","year":"2012","unstructured":"Filippini, P., A. Cesario, M. Fini, et al. 2012. The yin and yang of non-neuronal alpha7-nicotinic receptors in inflammation and autoimmunity. Current Drug Targets 13 (5): 644\u2013655. https:\/\/doi.org\/10.2174\/138945012800399008.","journal-title":"Current Drug Targets"},{"issue":"5","key":"1980_CR39","doi-asserted-by":"publisher","first-page":"680","DOI":"10.2174\/138945012800398883","volume":"13","author":"HM Schuller","year":"2012","unstructured":"Schuller, H.M. 2012. Regulatory role of the alpha7nAChR in cancer. Current Drug Targets 13 (5): 680\u2013687. https:\/\/doi.org\/10.2174\/138945012800398883.","journal-title":"Current Drug Targets"},{"issue":"5","key":"1980_CR40","doi-asserted-by":"publisher","first-page":"671","DOI":"10.2174\/138945012800398847","volume":"13","author":"S Pillai","year":"2012","unstructured":"Pillai, S., and S. Chellappan. 2012. alpha7 nicotinic acetylcholine receptor subunit in angiogenesis and epithelial to mesenchymal transition. Current Drug Targets 13 (5): 671\u2013679. https:\/\/doi.org\/10.2174\/138945012800398847.","journal-title":"Current Drug Targets"},{"issue":"3","key":"1980_CR41","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.jaci.2012.04.002","volume":"130","author":"S Gundavarapu","year":"2012","unstructured":"Gundavarapu, S., J.A. Wilder, N.C. Mishra, et al. 2012. Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. J Allergy Clin Immunol 130 (3): 770\u2013780.e11. https:\/\/doi.org\/10.1016\/j.jaci.2012.04.002.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"1980_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2020.151950","volume":"225","author":"S Douaoui","year":"2020","unstructured":"Douaoui, S., R. Djidjik, M. Boubakeur, et al. 2020. GTS-21, an alpha7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function. Immunobiology 225 (3): 151950. https:\/\/doi.org\/10.1016\/j.imbio.2020.151950.","journal-title":"Immunobiology"},{"issue":"1","key":"1980_CR43","doi-asserted-by":"publisher","first-page":"401","DOI":"10.4049\/jimmunol.0901808","volume":"184","author":"X Su","year":"2010","unstructured":"Su, X., M.A. Matthay, and A.B. Malik. 2010. Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. The Journal of Immunology 184 (1): 401\u2013410. https:\/\/doi.org\/10.4049\/jimmunol.0901808.","journal-title":"The Journal of Immunology"},{"issue":"7","key":"1980_CR44","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1096\/fj.11-197384","volume":"26","author":"M Lafargue","year":"2012","unstructured":"Lafargue, M., L. Xu, M. Carles, et al. 2012. Stroke-induced activation of the alpha7 nicotinic receptor increases Pseudomonas aeruginosa lung injury. The FASEB Journal 26 (7): 2919\u20132929. https:\/\/doi.org\/10.1096\/fj.11-197384.","journal-title":"The FASEB Journal"},{"issue":"11","key":"1980_CR45","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1161\/STROKEAHA.115.008989","volume":"46","author":"O Engel","year":"2015","unstructured":"Engel, O., L. Akyuz, A.C. da Costa Goncalves, et al. 2015. Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke. Stroke 46 (11): 3232\u20133240. https:\/\/doi.org\/10.1161\/STROKEAHA.115.008989.","journal-title":"Stroke"},{"issue":"2","key":"1980_CR46","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1183\/09031936.00103408","volume":"33","author":"IA Giebelen","year":"2009","unstructured":"Giebelen, I.A., M. Leendertse, S. Florquin, et al. 2009. Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia. European Respiratory Journal 33 (2): 375\u2013381. https:\/\/doi.org\/10.1183\/09031936.00103408.","journal-title":"European Respiratory Journal"},{"issue":"9","key":"1980_CR47","doi-asserted-by":"publisher","first-page":"14666","DOI":"10.1002\/jcp.28220","volume":"234","author":"K Hajiasgharzadeh","year":"2019","unstructured":"Hajiasgharzadeh, K., S. Sadigh-Eteghad, B. Mansoori, et al. 2019. Alpha7 nicotinic acetylcholine receptors in lung inflammation and carcinogenesis: Friends or foes? Journal of Cellular Physiology 234 (9): 14666\u201314679. https:\/\/doi.org\/10.1002\/jcp.28220.","journal-title":"Journal of Cellular Physiology"},{"key":"1980_CR48","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.resp.2014.10.006","volume":"209","author":"D Mokra","year":"2015","unstructured":"Mokra, D., and P. Kosutova. 2015. Biomarkers in acute lung injury. Respiratory Physiology & Neurobiology 209: 52\u201358. https:\/\/doi.org\/10.1016\/j.resp.2014.10.006.","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"4","key":"1980_CR49","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1165\/rcmb.2014-0185OC","volume":"53","author":"T Kawasaki","year":"2015","unstructured":"Kawasaki, T., T. Nishiwaki, A. Sekine, et al. 2015. Vascular repair by tissue-resident endothelial progenitor cells in endotoxin-induced lung injury. American Journal of Respiratory Cell and Molecular Biology 53 (4): 500\u2013512. https:\/\/doi.org\/10.1165\/rcmb.2014-0185OC.","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"issue":"3","key":"1980_CR50","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/cvr\/cvn081","volume":"78","author":"A Zampetaki","year":"2008","unstructured":"Zampetaki, A., J.P. Kirton, and Q. Xu. 2008. Vascular repair by endothelial progenitor cells. Cardiovascular Research 78 (3): 413\u2013421. https:\/\/doi.org\/10.1093\/cvr\/cvn081.","journal-title":"Cardiovascular Research"},{"issue":"7","key":"1980_CR51","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1463-1326.2010.01210.x","volume":"12","author":"GP Fadini","year":"2010","unstructured":"Fadini, G.P., and A. Avogaro. 2010. Potential manipulation of endothelial progenitor cells in diabetes and its complications. Diabetes, Obesity & Metabolism 12 (7): 570\u2013583. https:\/\/doi.org\/10.1111\/j.1463-1326.2010.01210.x.","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"12","key":"1980_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000255","volume":"9","author":"Z Xing","year":"2020","unstructured":"Xing, Z., C. Zhao, H. Liu, et al. 2020. Endothelial progenitor cell-derived extracellular vesicles: A novel candidate for regenerative medicine and disease treatment. Advance Healthcare Materials 9 (12): e2000255. https:\/\/doi.org\/10.1002\/adhm.202000255.","journal-title":"Adv Healthc Mater"},{"issue":"12 Suppl","key":"1980_CR53","doi-asserted-by":"publisher","first-page":"S414","DOI":"10.1097\/01.ccm.0000186079.88909.94","volume":"33","author":"B Zingarelli","year":"2005","unstructured":"Zingarelli, B. 2005. Nuclear factor-kappaB. Critical Care Medicine 33 (12 Suppl): S414\u2013S416. https:\/\/doi.org\/10.1097\/01.ccm.0000186079.88909.94.","journal-title":"Critical Care Medicine"},{"issue":"Suppl 3","key":"1980_CR54","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/dom.12172","volume":"15","author":"MY Donath","year":"2013","unstructured":"Donath, M.Y. 2013. Targeting inflammation in the treatment of type 2 diabetes. Diabetes, Obesity & Metabolism 15 (Suppl 3): 193\u2013196. https:\/\/doi.org\/10.1111\/dom.12172.","journal-title":"Diabetes, Obesity & Metabolism"},{"issue":"3","key":"1980_CR55","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.trsl.2013.10.002","volume":"163","author":"CF Chian","year":"2014","unstructured":"Chian, C.F., C.H. Chiang, C.H. Chuang, et al. 2014. Inhibitor of nuclear factor-kappaB, SN50, attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model. Translational Research 163 (3): 211\u2013220. https:\/\/doi.org\/10.1016\/j.trsl.2013.10.002.","journal-title":"Translational Research"},{"issue":"6","key":"1980_CR56","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.2337\/db12-1374","volume":"62","author":"M Kassan","year":"2013","unstructured":"Kassan, M., S.K. Choi, M. Galan, et al. 2013. Enhanced NF-kappaB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes 62 (6): 2078\u20132087. https:\/\/doi.org\/10.2337\/db12-1374.","journal-title":"Diabetes"},{"issue":"3","key":"1980_CR57","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s00125-015-3817-z","volume":"59","author":"K Meyerovich","year":"2016","unstructured":"Meyerovich, K., M. Fukaya, L.F. Terra, et al. 2016. The non-canonical NF-kappaB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro. Diabetologia 59 (3): 512\u2013521. https:\/\/doi.org\/10.1007\/s00125-015-3817-z.","journal-title":"Diabetologia"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-01980-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-01980-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-01980-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T16:27:31Z","timestamp":1724430451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-01980-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1980"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-01980-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3410539\/v1","asserted-by":"object"}]},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"4 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"All animal protocols were approved by the Animal Ethics Committee of the Second Affiliated Hospital of Harbin Medical University (approval no. SYDW2021-009).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}