{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:25:21Z","timestamp":1789986321871,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81891012"],"award-info":[{"award-number":["81891012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDRC0041"],"award-info":[{"award-number":["2021JDRC0041"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan TCM Science and Technology Industry Innovation Team","award":["2022C001"],"award-info":[{"award-number":["2022C001"]}]},{"name":"Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine","award":["ZYYCXTD-D-202209"],"award-info":[{"award-number":["ZYYCXTD-D-202209"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s10753-024-01984-w","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T10:02:39Z","timestamp":1708682559000},"page":"1403-1422","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Phillygenin Inhibits TGF-\u03b21-induced Hepatic Stellate Cell Activation and Inflammation: Regulation of the Bax\/Bcl-2 and Wnt\/\u03b2-catenin Pathways"],"prefix":"10.1007","volume":"47","author":[{"given":"Cheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"3","key":"1984_CR1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","volume":"18","author":"T Kisseleva","year":"2021","unstructured":"Kisseleva, T., and D. Brenner. 2021. Molecular and cellular mechanisms of liver fibrosis and its regression. Nature Reviews Gastroenterology & Hepatology 18 (3): 151\u2013166.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"issue":"1","key":"1984_CR2","doi-asserted-by":"publisher","first-page":"e1499","DOI":"10.1002\/wsbm.1499","volume":"13","author":"J Berumen","year":"2021","unstructured":"Berumen, J., J. Baglieri, T. Kisseleva, and K. Mekeel. 2021. Liver fibrosis: Pathophysiology and clinical implications. WIREs Mechanisms of Disease 13 (1): e1499.","journal-title":"WIREs Mechanisms of Disease"},{"issue":"10","key":"1984_CR3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41575-023-00821-z","volume":"20","author":"B Cogliati","year":"2023","unstructured":"Cogliati, B., C.N. Yashaswini, S. Wang, D. Sia, and S.L. Friedman. 2023. Friend or foe? The elusive role of hepatic stellate cells in liver cancer. Nature Reviews Gastroenterology & Hepatology 20 (10): 647\u2013661.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"1984_CR4","doi-asserted-by":"publisher","first-page":"113869","DOI":"10.1016\/j.addr.2021.113869","volume":"176","author":"S Kumar","year":"2021","unstructured":"Kumar, S., Q. Duan, R. Wu, E.N. Harris, and Q. Su. 2021. Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis. Advanced Drug Delivery Reviews 176: 113869.","journal-title":"Advanced Drug Delivery Reviews"},{"key":"1984_CR5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","volume":"121","author":"T Higashi","year":"2017","unstructured":"Higashi, T., S.L. Friedman, and Y. Hoshida. 2017. Hepatic stellate cells as key target in liver fibrosis. Advanced Drug Delivery Reviews 121: 27\u201342.","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"1","key":"1984_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1152\/physrev.00013.2007","volume":"88","author":"SL Friedman","year":"2008","unstructured":"Friedman, S.L. 2008. Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver. Physiological Reviews 88 (1): 125\u2013172.","journal-title":"Physiological Reviews"},{"issue":"7","key":"1984_CR7","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","volume":"14","author":"T Tsuchida","year":"2017","unstructured":"Tsuchida, T., and S.L. Friedman. 2017. Mechanisms of hepatic stellate cell activation. Nature Reviews Gastroenterology & Hepatology 14 (7): 397\u2013411.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"1984_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","volume":"65","author":"M Parola","year":"2019","unstructured":"Parola, M., and M. Pinzani. 2019. Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. Molecular Aspects of Medicine 65: 37\u201355.","journal-title":"Molecular Aspects of Medicine"},{"issue":"4","key":"1984_CR9","doi-asserted-by":"publisher","first-page":"337","DOI":"10.33549\/physiolres.932289","volume":"61","author":"Y Guo","year":"2012","unstructured":"Guo, Y., L. Xiao, L. Sun, and F. Liu. 2012. Wnt\/beta-catenin signaling: A promising new target for fibrosis diseases. Physiological Research 61 (4): 337\u2013346.","journal-title":"Physiological Research"},{"issue":"11","key":"1984_CR10","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1111\/exd.12255","volume":"22","author":"C Dees","year":"2013","unstructured":"Dees, C., and J.H. Distler. 2013. Canonical Wnt signalling as a key regulator of fibrogenesis - implications for targeted therapies? Experimental Dermatology 22 (11): 710\u2013713.","journal-title":"Experimental Dermatology"},{"key":"1984_CR11","doi-asserted-by":"publisher","first-page":"101063","DOI":"10.1016\/j.arr.2020.101063","volume":"60","author":"HH Hu","year":"2020","unstructured":"Hu, H.H., G. Cao, X.Q. Wu, N.D. Vaziri, and Y.Y. Zhao. 2020. Wnt signaling pathway in aging-related tissue fibrosis and therapies. Ageing Research Reviews 60: 101063.","journal-title":"Ageing Research Reviews"},{"issue":"3","key":"1984_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41581-020-00343-w","volume":"17","author":"SJ Schunk","year":"2021","unstructured":"Schunk, S.J., J. Floege, D. Fliser, and T. Speer. 2021. WNT-\u03b2-catenin signalling - a versatile player in kidney injury and repair. Nature Reviews Nephrology 17 (3): 172\u2013184.","journal-title":"Nature Reviews Nephrology"},{"issue":"10","key":"1984_CR13","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.3390\/ijms19103103","volume":"19","author":"K Nishikawa","year":"2018","unstructured":"Nishikawa, K., Y. Osawa, and K. Kimura. 2018. Wnt\/\u03b2-Catenin Signaling as a Potential Target for the Treatment of Liver Cirrhosis Using Antifibrotic Drugs. International Journal of Molecular Sciences 19 (10): 3103.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"1984_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jhep.2006.03.016","volume":"45","author":"F Jiang","year":"2006","unstructured":"Jiang, F., C.J. Parsons, and B. Stefanovic. 2006. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. Journal of Hepatology 45 (3): 401\u2013409.","journal-title":"Journal of Hepatology"},{"key":"1984_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115410","volume":"166","author":"C Wang","year":"2023","unstructured":"Wang, C., R. Wu, S. Zhang, L. Gong, K. Fu, C. Yao, C. Peng, and Y. Li. 2023. A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives. Biomedicine & Pharmacotherapy 166: 115410.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1984_CR16","doi-asserted-by":"publisher","first-page":"7964318","DOI":"10.1155\/2018\/7964318","volume":"2018","author":"W Song","year":"2018","unstructured":"Song, W., J. Wu, L. Yu, and Z. Peng. 2018. Evaluation of the Pharmacokinetics and Hepatoprotective Effects of Phillygenin in Mouse. BioMed Research International 2018: 7964318.","journal-title":"BioMed Research International"},{"key":"1984_CR17","doi-asserted-by":"publisher","first-page":"154235","DOI":"10.1016\/j.phymed.2022.154235","volume":"103","author":"W Zhou","year":"2022","unstructured":"Zhou, W., X. Yan, Y. Zhai, H. Liu, L. Guan, Y. Qiao, J. Jiang, and L. Peng. 2022. Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy. Phytomedicine 103: 154235.","journal-title":"Phytomedicine"},{"key":"1984_CR18","doi-asserted-by":"publisher","first-page":"113481","DOI":"10.1016\/j.ecoenv.2022.113481","volume":"236","author":"J Guo","year":"2022","unstructured":"Guo, J., W.R. Yan, J.K. Tang, X. Jin, H.H. Xue, T. Wang, L.W. Zhang, Q.Y. Sun, and Z.X. Liang. 2022. Dietary phillygenin supplementation ameliorates aflatoxin B(1)-induced oxidative stress, inflammation, and apoptosis in chicken liver. Ecotoxicology and Environmental Safety 236: 113481.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"1984_CR19","doi-asserted-by":"publisher","first-page":"113275","DOI":"10.1016\/j.jep.2020.113275","volume":"262","author":"N Hu","year":"2020","unstructured":"Hu, N., C. Guo, X. Dai, C. Wang, L. Gong, L. Yu, C. Peng, and Y. Li. 2020. Forsythiae Fructuse water extract attenuates liver fibrosis via TLR4\/MyD88\/NF-\u03baB and TGF-\u03b2\/smads signaling pathways. Journal of Ethnopharmacology 262: 113275.","journal-title":"Journal of Ethnopharmacology"},{"key":"1984_CR20","doi-asserted-by":"publisher","first-page":"112361","DOI":"10.1016\/j.jep.2019.112361","volume":"248","author":"N Hu","year":"2020","unstructured":"Hu, N., C. Wang, X. Dai, M. Zhou, L. Gong, L. Yu, C. Peng, and Y. Li. 2020. Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4\/MyD88\/NF-\u03baB signaling pathway. Journal of Ethnopharmacology 248: 112361.","journal-title":"Journal of Ethnopharmacology"},{"key":"1984_CR21","doi-asserted-by":"publisher","first-page":"756924","DOI":"10.3389\/fphar.2021.756924","volume":"12","author":"C Wang","year":"2021","unstructured":"Wang, C., C. Ma, K. Fu, L.H. Gong, Y.F. Zhang, H.L. Zhou, and Y.X. Li. 2021. Phillygenin Attenuates Carbon Tetrachloride-Induced Liver Fibrosis via Modulating Inflammation and Gut Microbiota. Frontiers in Pharmacology 12: 756924.","journal-title":"Frontiers in Pharmacology"},{"key":"1984_CR22","doi-asserted-by":"publisher","first-page":"115478","DOI":"10.1016\/j.jep.2022.115478","volume":"296","author":"C Wang","year":"2022","unstructured":"Wang, C., C. Ma, K. Fu, Y. Liu, L. Gong, C. Peng, and Y. Li. 2022. Hepatoprotective effect of phillygenin on carbon tetrachloride-induced liver fibrosis and its effects on short chain fatty acid and bile acid metabolism. Journal of Ethnopharmacology 296: 115478.","journal-title":"Journal of Ethnopharmacology"},{"key":"1984_CR23","doi-asserted-by":"publisher","first-page":"114264","DOI":"10.1016\/j.biopha.2023.114264","volume":"159","author":"C Ma","year":"2023","unstructured":"Ma, C., C. Wang, Y. Zhang, Y. Li, K. Fu, L. Gong, H. Zhou, and Y. Li. 2023. Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p. Biomedicine & Pharmacotherapy 159: 114264.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1984_CR24","doi-asserted-by":"crossref","unstructured":"Kim, K.K., D. Sheppard, H.A. Chapman. 2018. TGF-\u03b21 Signaling and Tissue Fibrosis. Cold Spring Harb Perspect Biol 10(4).","DOI":"10.1101\/cshperspect.a022293"},{"key":"1984_CR25","doi-asserted-by":"publisher","first-page":"155288","DOI":"10.1016\/j.cyto.2020.155288","volume":"136","author":"F Peng","year":"2020","unstructured":"Peng, F., Y. Tian, J. Ma, Z. Xu, S. Wang, M. Tang, J. Lei, G. Gong, and Y. Jiang. 2020. CAT1 silencing inhibits TGF-\u03b21-induced mouse hepatic stellate cell activation in vitro and hepatic fibrosis in vivo. Cytokine 136: 155288.","journal-title":"Cytokine"},{"key":"1984_CR26","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.toxlet.2022.04.004","volume":"362","author":"J Liao","year":"2022","unstructured":"Liao, J., Z. Zhang, Q. Yuan, L. Luo, and X. Hu. 2022. The mouse Anxa6\/miR-9-5p\/Anxa2 axis modulates TGF-\u03b21-induced mouse hepatic stellate cell (mHSC) activation and CCl(4)-caused liver fibrosis. Toxicology Letters 362: 38\u201349.","journal-title":"Toxicology Letters"},{"issue":"1","key":"1984_CR27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1080\/08923973.2018.1547742","volume":"41","author":"B Du","year":"2019","unstructured":"Du, B., L. Zhang, Y. Sun, G. Zhang, J. Yao, M. Jiang, L. Pan, and C. Sun. 2019. Phillygenin exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. Immunopharmacology and Immunotoxicology 41 (1): 76\u201385.","journal-title":"Immunopharmacology and Immunotoxicology"},{"issue":"3","key":"1984_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/MOG.0b013e3283279668","volume":"25","author":"J Jiao","year":"2009","unstructured":"Jiao, J., S.L. Friedman, and C. Aloman. 2009. Hepatic fibrosis. Current Opinion in Gastroenterology 25 (3): 223\u2013229.","journal-title":"Current Opinion in Gastroenterology"},{"issue":"5","key":"1984_CR29","first-page":"940","volume":"23","author":"MJ Arthur","year":"1999","unstructured":"Arthur, M.J., J.P. Iredale, and D.A. Mann. 1999. Tissue inhibitors of metalloproteinases: Role in liver fibrosis and alcoholic liver disease. Alcoholism, Clinical and Experimental Research 23 (5): 940\u2013943.","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"3","key":"1984_CR30","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1055\/s-2001-17554","volume":"21","author":"M Pinzani","year":"2001","unstructured":"Pinzani, M., and F. Marra. 2001. Cytokine receptors and signaling in hepatic stellate cells. Seminars in Liver Disease 21 (3): 397\u2013416.","journal-title":"Seminars in Liver Disease"},{"issue":"1","key":"1984_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1172\/JCI88881","volume":"127","author":"Y Koyama","year":"2017","unstructured":"Koyama, Y., and D.A. Brenner. 2017. Liver inflammation and fibrosis. The Journal of Clinical Investigation 127 (1): 55\u201364.","journal-title":"The Journal of Clinical Investigation"},{"issue":"10","key":"1984_CR32","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","volume":"20","author":"L Hammerich","year":"2023","unstructured":"Hammerich, L., and F. Tacke. 2023. Hepatic inflammatory responses in liver fibrosis. Nature Reviews Gastroenterology & Hepatology 20 (10): 633\u2013646.","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"1984_CR33","first-page":"9938392","volume":"2022","author":"M Zhou","year":"2022","unstructured":"Zhou, M., X. Zhao, L. Liao, Y. Deng, M. Liu, J. Wang, X. Xue, and Y. Li. 2022. Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS. Oxidative Medicine and Cellular Longevity 2022: 9938392.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"4","key":"1984_CR34","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1007\/s10753-023-01826-1","volume":"46","author":"C Wang","year":"2023","unstructured":"Wang, C., Y. Liu, L. Gong, X. Xue, K. Fu, C. Ma, and Y. Li. 2023. Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt\/\u03b2-Catenin Signaling Pathway. Inflammation 46 (4): 1543\u20131560.","journal-title":"Inflammation"},{"issue":"1","key":"1984_CR35","doi-asserted-by":"publisher","first-page":"a041231","DOI":"10.1101\/cshperspect.a041231","volume":"15","author":"R Schuster","year":"2023","unstructured":"Schuster, R., F. Younesi, M. Ezzo, and B. Hinz. 2023. The Role of Myofibroblasts in Physiological and Pathological Tissue Repair. Cold Spring Harbor Perspectives in Biology 15 (1): a041231.","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"1","key":"1984_CR36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","volume":"16","author":"B Hinz","year":"2020","unstructured":"Hinz, B., and D. Lagares. 2020. Evasion of apoptosis by myofibroblasts: A hallmark of fibrotic diseases. Nature Reviews Rheumatology 16 (1): 11\u201331.","journal-title":"Nature Reviews Rheumatology"},{"issue":"6","key":"1984_CR37","doi-asserted-by":"publisher","first-page":"a041046","DOI":"10.1101\/cshperspect.a041046","volume":"14","author":"DR Green","year":"2022","unstructured":"Green, D.R. 2022. The Mitochondrial Pathway of Apoptosis Part II: The BCL-2 Protein Family. Cold Spring Harbor Perspectives in Biology 14 (6): a041046.","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"22","key":"1984_CR38","doi-asserted-by":"publisher","first-page":"5021","DOI":"10.1158\/1078-0432.CCR-15-0364","volume":"21","author":"CJ Gibson","year":"2015","unstructured":"Gibson, C.J., and M.S. Davids. 2015. BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis. Clinical Cancer Research 21 (22): 5021\u20135029.","journal-title":"Clinical Cancer Research"},{"issue":"1","key":"1984_CR39","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbrc.2017.06.190","volume":"500","author":"F Edlich","year":"2018","unstructured":"Edlich, F. 2018. BCL-2 proteins and apoptosis: Recent insights and unknowns. Biochemical and Biophysical Research Communications 500 (1): 26\u201334.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"1984_CR40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1176\/appi.ajp.161.1.109","volume":"161","author":"LF Jarskog","year":"2004","unstructured":"Jarskog, L.F., E.S. Selinger, J.A. Lieberman, and J.H. Gilmore. 2004. Apoptotic proteins in the temporal cortex in schizophrenia: High Bax\/Bcl-2 ratio without caspase-3 activation. American Journal of Psychiatry 161 (1): 109\u2013115.","journal-title":"American Journal of Psychiatry"},{"issue":"2","key":"1984_CR41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41575-018-0075-9","volume":"16","author":"MJ Perugorria","year":"2019","unstructured":"Perugorria, M.J., P. Olaizola, I. Labiano, A. Esparza-Baquer, M. Marzioni, J.J.G. Marin, L. Bujanda, and J.M. Banales. 2019. Wnt-\u03b2-catenin signalling in liver development, health and disease. Nature Reviews. Gastroenterology & Hepatology 16 (2): 121\u2013136.","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"1","key":"1984_CR42","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.canlet.2013.09.020","volume":"343","author":"JM Lee","year":"2014","unstructured":"Lee, J.M., J. Yang, P. Newell, S. Singh, A. Parwani, S.L. Friedman, K.N. Nejak-Bowen, and S.P. Monga. 2014. \u03b2-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation. Cancer Letters 343 (1): 90\u201397.","journal-title":"Cancer Letters"},{"issue":"12","key":"1984_CR43","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","volume":"95","author":"CG Miao","year":"2013","unstructured":"Miao, C.G., Y.Y. Yang, X. He, C. Huang, Y. Huang, L. Zhang, X.W. Lv, Y. Jin, and J. Li. 2013. Wnt signaling in liver fibrosis: Progress, challenges and potential directions. Biochimie 95 (12): 2326\u20132335.","journal-title":"Biochimie"},{"issue":"1","key":"1984_CR44","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","volume":"7","author":"J Liu","year":"2022","unstructured":"Liu, J., Q. Xiao, J. Xiao, C. Niu, Y. Li, X. Zhang, Z. Zhou, G. Shu, and G. Yin. 2022. Wnt\/\u03b2-catenin signalling: Function, biological mechanisms, and therapeutic opportunities. Signal Transduction and Targeted Therapy 7 (1): 3.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"6","key":"1984_CR45","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"R Nusse","year":"2017","unstructured":"Nusse, R., and H. Clevers. 2017. Wnt\/\u03b2-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169 (6): 985\u2013999.","journal-title":"Cell"},{"issue":"1","key":"1984_CR46","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ydbio.2013.08.007","volume":"383","author":"A Koehler","year":"2013","unstructured":"Koehler, A., J. Schlupf, M. Schneider, B. Kraft, C. Winter, and J. Kashef. 2013. Loss of Xenopus cadherin-11 leads to increased Wnt\/\u03b2-catenin signaling and up-regulation of target genes c-myc and cyclin D1 in neural crest. Developmental Biology 383 (1): 132\u2013145.","journal-title":"Developmental Biology"},{"key":"1984_CR47","doi-asserted-by":"publisher","first-page":"104733","DOI":"10.1016\/j.yexmp.2021.104733","volume":"124","author":"H Ahmed","year":"2022","unstructured":"Ahmed, H., M.I. Umar, S. Imran, F. Javaid, S.K. Syed, R. Riaz, and W. Hassan. 2022. TGF-\u03b21 signaling can worsen NAFLD with liver fibrosis backdrop. Experimental and Molecular Pathology 124: 104733.","journal-title":"Experimental and Molecular Pathology"},{"issue":"11","key":"1984_CR48","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1248\/bpb.b20-00258","volume":"43","author":"Y Xiong","year":"2020","unstructured":"Xiong, Y., H. Lu, and H. Xu. 2020. Galangin Reverses Hepatic Fibrosis by Inducing HSCs Apoptosis via the PI3K\/Akt, Bax\/Bcl-2, and Wnt\/\u03b2-Catenin Pathway in LX-2 Cells. Biological &\/and Pharmaceutical Bulletin 43 (11): 1634\u20131642.","journal-title":"Biological &\/and Pharmaceutical Bulletin"},{"key":"1984_CR49","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.intimp.2018.08.005","volume":"63","author":"C Zhang","year":"2018","unstructured":"Zhang, C., X.Q. Liu, H.N. Sun, X.M. Meng, Y.W. Bao, H.P. Zhang, F.M. Pan, and C. Zhang. 2018. Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt\/\u03b2-catenin signaling pathway, c-Myc and cyclin D1. International Immunopharmacology 63: 183\u2013190.","journal-title":"International Immunopharmacology"},{"issue":"1","key":"1984_CR50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13027-022-00432-4","volume":"17","author":"Z Liu","year":"2022","unstructured":"Liu, Z., S. Zhou, Y. Zhang, and M. Zhao. 2022. Rat bone marrow mesenchymal stem cells (BMSCs) inhibit liver fibrosis by activating GSK3\u03b2 and inhibiting the Wnt3a\/\u03b2-catenin pathway. Infectious Agents and Cancer 17 (1): 17.","journal-title":"Infect Agent Cancer"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-01984-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-01984-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-01984-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T20:29:01Z","timestamp":1724444941000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-01984-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1984"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-01984-w","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]},"assertion":[{"value":"14 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The whole experimental scheme was approved by the Animal Experiment Ethics Committee of Chengdu University of traditional Chinese medicine and carried out under its supervision (Permit number: SYXK 2020-124).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All authors have read the manuscript and authorized its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}