{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:07:16Z","timestamp":1791846436307,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2021A1515010876"],"award-info":[{"award-number":["2021A1515010876"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2023A1515012257"],"award-info":[{"award-number":["2023A1515012257"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["82100995"],"award-info":[{"award-number":["82100995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["82170939"],"award-info":[{"award-number":["82170939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Projects in Guangzhou","award":["SL2023A04J01702"],"award-info":[{"award-number":["SL2023A04J01702"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2023A1515010327"],"award-info":[{"award-number":["2023A1515010327"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"International Cooperation Project of Science and Technology in Guangdong Province","award":["2023A0505050158"],"award-info":[{"award-number":["2023A0505050158"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10753-024-02024-3","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T13:01:34Z","timestamp":1714741294000},"page":"2041-2056","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2"],"prefix":"10.1007","volume":"47","author":[{"given":"Yiyang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peimeng","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"issue":"Suppl 1","key":"2024_CR1","first-page":"S173","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou, P.N., M. Sanz, N. Buduneli, T. Dietrich, M. Feres, D.H. Fine, et al. 2018. Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. Journal of Periodontology 89 (Suppl 1): S173\u2013S182.","journal-title":"Journal of Periodontology"},{"issue":"Suppl 20","key":"2024_CR2","first-page":"S219","volume":"45","author":"S Jepsen","year":"2018","unstructured":"Jepsen, S., J.G. Caton, J.M. Albandar, N.F. Bissada, P. Bouchard, P. Cortellini, et al. 2018. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Clinical Periodontology 45 (Suppl 20): S219\u2013S229.","journal-title":"Journal of Clinical Periodontology"},{"issue":"7","key":"2024_CR3","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrmicro2337","volume":"8","author":"RP Darveau","year":"2010","unstructured":"Darveau, R.P. 2010. Periodontitis: A polymicrobial disruption of host homeostasis. Nature Reviews Microbiology 8 (7): 481\u2013490.","journal-title":"Nature Reviews Microbiology"},{"issue":"7","key":"2024_CR4","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1111\/jcpe.13793","volume":"50","author":"M Iniesta","year":"2023","unstructured":"Iniesta, M., C. Chamorro, N. Ambrosio, M.J. Mar\u00edn, M. Sanz, and D. Herrera. 2023. Subgingival microbiome in periodontal health, gingivitis and different stages of periodontitis. Journal of Clinical Periodontology 50 (7): 905\u2013920.","journal-title":"Journal of Clinical Periodontology"},{"issue":"12","key":"2024_CR5","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont, R.J., H. Koo, and G. Hajishengallis. 2018. The oral microbiota: Dynamic communities and host interactions. Nature Reviews Microbiology 16 (12): 745\u2013759.","journal-title":"Nature Reviews Microbiology"},{"issue":"1","key":"2024_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/prd.12145","volume":"72","author":"PI Eke","year":"2016","unstructured":"Eke, P.I., L. Wei, W.S. Borgnakke, G. Thornton-Evans, X. Zhang, H. Lu, et al. 2016. Periodontitis prevalence in adults \u2265 65 years of age, in the USA. Periodontology 2000 72 (1): 76\u201395.","journal-title":"Periodontology 2000"},{"issue":"11","key":"2024_CR7","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum, N.J., E. Bernab\u00e9, M. Dahiya, B. Bhandari, C.J. Murray, and W. Marcenes. 2014. Global burden of severe periodontitis in 1990\u20132010: A systematic review and meta-regression. Journal of Dental Research 93 (11): 1045\u20131053.","journal-title":"Journal of Dental Research"},{"issue":"8","key":"2024_CR8","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1111\/jcpe.13813","volume":"50","author":"C Marruganti","year":"2023","unstructured":"Marruganti, C., M. Romandini, C. Gaeta, E.F. Cagidiaco, N. Discepoli, S. Parrini, et al. 2023. Healthy lifestyles are associated with a better response to periodontal therapy: A prospective cohort study. Journal of Clinical Periodontology 50 (8): 1089\u20131100.","journal-title":"Journal of Clinical Periodontology"},{"issue":"6","key":"2024_CR9","first-page":"1832","volume":"26","author":"MF Elsadek","year":"2022","unstructured":"Elsadek, M.F., and M.F. Farahat. 2022. Effectiveness of photodynamic therapy as an adjunct to periodontal scaling for treating periodontitis in geriatric patients. European Review for Medical and Pharmacological Sciences 26 (6): 1832\u20131838.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"1","key":"2024_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/prd.12332","volume":"84","author":"S S\u00e4lzer","year":"2020","unstructured":"S\u00e4lzer, S., C. Graetz, C.E. D\u00f6rfer, D.E. Slot, and F.A. Van der Weijden. 2020. Contemporary practices for mechanical oral hygiene to prevent periodontal disease. Periodontology 2000 84 (1): 35\u201344.","journal-title":"Periodontology 2000"},{"issue":"1","key":"2024_CR11","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/prd.12463","volume":"90","author":"J Slots","year":"2022","unstructured":"Slots, J. 2022. Concise evaluation and therapeutic guidelines for severe periodontitis: A public health perspective. Periodontology 2000 90 (1): 262\u2013265.","journal-title":"Periodontology 2000"},{"issue":"8","key":"2024_CR12","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1177\/0022034521995157","volume":"100","author":"MG Balta","year":"2021","unstructured":"Balta, M.G., E. Papathanasiou, I.J. Blix, and T.E. Van Dyke. 2021. Host Modulation and Treatment of Periodontal Disease. Journal of Dental Research 100 (8): 798\u2013809.","journal-title":"Journal of Dental Research"},{"issue":"10","key":"2024_CR13","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/j.cell.2022.03.043","volume":"185","author":"X Li","year":"2022","unstructured":"Li, X., H. Wang, X. Yu, G. Saha, L. Kalafati, C. Ioannidis, et al. 2022. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell 185 (10): 1709\u20131727.","journal-title":"Cell"},{"issue":"11","key":"2024_CR14","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1177\/0022034514551754","volume":"93","author":"O Carcuac","year":"2014","unstructured":"Carcuac, O., and T. Berglundh. 2014. Composition of human peri-implantitis and periodontitis lesions. Journal of Dental Research 93 (11): 1083\u20131088.","journal-title":"Journal of Dental Research"},{"issue":"2","key":"2024_CR15","first-page":"3044","volume":"8","author":"H Liu","year":"2015","unstructured":"Liu, H., X. Wu, N. Gang, S. Wang, W. Deng, L. Zan, et al. 2015. Macrophage functional phenotype can be consecutively and reversibly shifted to adapt to microenvironmental changes. International Journal of Clinical and Experimental Medicine 8 (2): 3044\u20133053.","journal-title":"International Journal of Clinical and Experimental Medicine"},{"issue":"6","key":"2024_CR16","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1111\/jre.13156","volume":"58","author":"OA Gonzalez","year":"2023","unstructured":"Gonzalez, O.A., S. Kirakodu, L. Nguyen, and J.L. Ebersole. 2023. Macrophage-related gingival transcriptomic patterns and microbiome alterations in experimental periodontitis in nonhuman primates. Journal of Periodontal Research 58 (6): 1148\u20131170.","journal-title":"Journal of Periodontal Research"},{"issue":"8","key":"2024_CR17","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1111\/jcpe.13156","volume":"46","author":"C Garaicoa-Pazmino","year":"2019","unstructured":"Garaicoa-Pazmino, C., T. Fretwurst, C.H. Squarize, T. Berglundh, W.V. Giannobile, L. Larsson, et al. 2019. Characterization of macrophage polarization in periodontal disease. Journal of Clinical Periodontology 46 (8): 830\u2013839.","journal-title":"Journal of Clinical Periodontology"},{"issue":"1","key":"2024_CR18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/odi.12983","volume":"25","author":"LN Zhou","year":"2019","unstructured":"Zhou, L.N., C.S. Bi, L.N. Gao, Y. An, F. Chen, and F.M. Chen. 2019. Macrophage polarization in human gingival tissue in response to periodontal disease. Oral Disease 25 (1): 265\u2013273.","journal-title":"Oral Disease"},{"issue":"12","key":"2024_CR19","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1038\/ijos.2017.45","volume":"9","author":"NC Huynh","year":"2017","unstructured":"Huynh, N.C., V. Everts, P. Pavasant, and R.S. Ampornaramveth. 2017. Interleukin-1\u03b2 induces human cementoblasts to support osteoclastogenesis. International Journal of Oral Science 9 (12): e5.","journal-title":"International Journal of Oral Science"},{"key":"2024_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/B978-0-12-800181-3.00007-5","volume":"74","author":"MR Cohen","year":"2014","unstructured":"Cohen, M.R., and V.Y. Moiseenkova-Bell. 2014. Structure of thermally activated TRP channels. 2014. Current Topics in Membranes 74: 181\u2013211.","journal-title":"Current Topics in Membranes"},{"issue":"6966","key":"2024_CR21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nature02196","volume":"426","author":"DE Clapham","year":"2003","unstructured":"Clapham, D.E. 2003. TRP channels as cellular sensors. Nature 426 (6966): 517\u2013524.","journal-title":"Nature"},{"key":"2024_CR22","doi-asserted-by":"publisher","first-page":"104258","DOI":"10.1016\/j.ebiom.2022.104258","volume":"84","author":"Z Lv","year":"2022","unstructured":"Lv, Z., J. Han, J. Li, H. Guo, Y. Fei, Z. Sun, et al. 2022. Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis. eBioMedicine 84: 104258.","journal-title":"eBioMedicine"},{"key":"2024_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jpsychires.2023.10.036","volume":"168","author":"M Dmitrzak-W\u0119glarz","year":"2023","unstructured":"Dmitrzak-W\u0119glarz, M., J. Rybakowski, A. Szczepankiewicz, P. Kapelski, M. Lesicka, E. Jab\u0142o\u0144ska, et al. 2023. Identification of shared disease marker genes and underlying mechanisms between major depression and rheumatoid arthritis. Journal of Psychiatric Research 168: 22\u201329.","journal-title":"Journal of Psychiatric Research"},{"issue":"1","key":"2024_CR24","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1038\/s41467-023-38128-x","volume":"14","author":"T Li","year":"2023","unstructured":"Li, T., S. Jiang, Y. Zhang, J. Luo, M. Li, H. Ke, et al. 2023. Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation. Nature Communication 14 (1): 2498.","journal-title":"Nature Communication"},{"key":"2024_CR25","doi-asserted-by":"publisher","first-page":"e13244","DOI":"10.1111\/bpa.13244","volume":"2","author":"CC Chen","year":"2024","unstructured":"Chen, C.C., C.H. Ke, C.H. Wu, H.F. Lee, Y. Chao, M.C. Tsai, et al. 2024. Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage. Brain Pathology 2: e13244.","journal-title":"Brain Pathology"},{"issue":"14","key":"2024_CR26","doi-asserted-by":"publisher","first-page":"11815","DOI":"10.3390\/ijms241411815","volume":"24","author":"A Lucius","year":"2023","unstructured":"Lucius, A., S. Chhatwal, M. Valtink, P.S. Reinach, A. Li, U. Pleyer, et al. 2023. L-Carnitine Suppresses Transient Receptor Potential Vanilloid Type 1 Activation in Human Corneal Epithelial Cells. International Journal of Molecular Science 24 (14): 11815.","journal-title":"International Journal of Molecular Science"},{"issue":"7941","key":"2024_CR27","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/s41586-022-05525-z","volume":"612","author":"L Dohnalov\u00e1","year":"2022","unstructured":"Dohnalov\u00e1, L., P. Lundgren, J.R.E. Carty, N. Goldstein, S.L. Wenski, P. Nanudorn, et al. 2022. A microbiome-dependent gut-brain pathway regulates motivation for exercise. Nature 612 (7941): 739\u2013747.","journal-title":"Nature"},{"issue":"1\u20132","key":"2024_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11010-018-3477-7","volume":"455","author":"S Yan","year":"2019","unstructured":"Yan, S., L. Miao, Y. Lu, and L. Wang. 2019. Sirtuin 1 inhibits TNF-\u03b1-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation. Molecular and Cellular Biochemistry 455 (1\u20132): 135\u2013145.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"1","key":"2024_CR29","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/all.15802","volume":"79","author":"MM Limberg","year":"2024","unstructured":"Limberg, M.M., D. Wiebe, N. Gray, T. Weihrauch, A.U. Br\u00e4uer, A.E. Kremer, et al. 2024. Functional expression of TRPV1 in human peripheral blood basophils and its regulation in atopic dermatitis. Allergy 79 (1): 225\u2013228.","journal-title":"Allergy"},{"issue":"11","key":"2024_CR30","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ni.3009","volume":"15","author":"S Bertin","year":"2014","unstructured":"Bertin, S., Y. Aoki-Nonaka, P.R. de Jong, L.L. Nohara, H. Xu, S.R. Stanwood, et al. 2014. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells. Nature Immunology 15 (11): 1055\u20131063.","journal-title":"Nature Immunology"},{"issue":"8","key":"2024_CR31","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1093\/ibd\/izac073","volume":"28","author":"C Tortora","year":"2022","unstructured":"Tortora, C., A. Di Paola, M. Creoli, et al. 2022. Effects of CB2 and TRPV1 Stimulation on Osteoclast Overactivity Induced by Iron in Pediatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases 28 (8): 1244\u20131253.","journal-title":"Inflammatory Bowel Diseases"},{"key":"2024_CR32","doi-asserted-by":"publisher","first-page":"29294","DOI":"10.1038\/srep29294","volume":"6","author":"N Takahashi","year":"2016","unstructured":"Takahashi, N., Y. Matsuda, K. Sato, P.R. de Jong, S. Bertin, K. Tabeta, et al. 2016. Neuronal TRPV1 activation regulates alveolar bone resorption by suppressing osteoclastogenesis via CGRP. Scientific Report 6: 29294.","journal-title":"Scientific Report"},{"issue":"6","key":"2024_CR33","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/JPER.19-0228","volume":"91","author":"YG Kim","year":"2020","unstructured":"Kim, Y.G., M.O. Kim, S.H. Kim, H.J. Kim, N.K. Pokhrel, J.H. Lee, et al. 2020. 6-Shogaol, an active ingredient of ginger, inhibits osteoclastogenesis and alveolar bone resorption in ligature-induced periodontitis in mice. Journal of Periodontology 91 (6): 809\u2013818.","journal-title":"Journal of Periodontology"},{"issue":"1","key":"2024_CR34","doi-asserted-by":"publisher","first-page":"6648","DOI":"10.1038\/s41467-022-34352-z","volume":"13","author":"T Yoshimoto","year":"2022","unstructured":"Yoshimoto, T., M. Kittaka, A.A.P. Doan, R. Urata, M. Prideaux, R.E. Rojas, et al. 2022. Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection. Nature Communications 13 (1): 6648.","journal-title":"Nature Communications"},{"key":"2024_CR35","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jare.2021.11.001","volume":"39","author":"L Zhang","year":"2022","unstructured":"Zhang, L., W. Lu, C. Lu, Y. Guo, X. Chen, J. Chen, et al. 2022. Beneficial effect of capsaicin via TRPV4\/EDH signals on mesenteric arterioles of normal and colitis mice. Journal of Advanced Research 39: 291\u2013303.","journal-title":"Journal of Advanced Research"},{"issue":"1","key":"2024_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41368-022-00177-1","volume":"14","author":"L Xin","year":"2022","unstructured":"Xin, L., F. Zhou, C. Zhang, W. Zhong, S. Xu, X. Jing, et al. 2022. Four-Octyl itaconate ameliorates periodontal destruction via Nrf2-dependent antioxidant system. International Journal of Oral Science 14 (1): 27.","journal-title":"International Journal of Oral Science"},{"key":"2024_CR37","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.freeradbiomed.2023.08.020","volume":"208","author":"M Yang","year":"2023","unstructured":"Yang, M., Z. Shen, X. Zhang, Z. Song, Y. Zhang, Z. Lin, et al. 2023. Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2\/FSP1\/ROS pathway. Free Radical Biology and Medicine 208: 334\u2013347.","journal-title":"Free Radical Biology and Medicine"},{"issue":"11","key":"2024_CR38","doi-asserted-by":"publisher","first-page":"e13111","DOI":"10.1111\/cpr.13111","volume":"54","author":"F Fontana","year":"2021","unstructured":"Fontana, F., M. Marzagalli, M. Raimondi, V. Zuco, N. Zaffaroni, and P. Limonta. 2021. \u03b4-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS\/MAPK-mediated apoptosis. Cell Proliferation 54 (11): e13111.","journal-title":"Cell Proliferation"},{"issue":"1","key":"2024_CR39","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/prd.12342","volume":"84","author":"FSC Sczepanik","year":"2020","unstructured":"Sczepanik, F.S.C., M.L. Grossi, M. Casati, M. Goldberg, M. Glogauer, N. Fine, et al. 2020. Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way. Periodontology 2000 84 (1): 45\u201368.","journal-title":"Periodontology 2000"},{"issue":"3","key":"2024_CR40","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.cmet.2023.01.012","volume":"35","author":"T Weiss-Sadan","year":"2023","unstructured":"Weiss-Sadan, T., M. Ge, M. Hayashi, M. Gohar, C.H. Yao, A. de Groot, et al. 2023. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metabolism 35 (3): 487\u2013503.","journal-title":"Cell Metabolism"},{"issue":"1","key":"2024_CR41","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nri3785","volume":"15","author":"G Hajishengallis","year":"2015","unstructured":"Hajishengallis, G. 2015. Periodontitis: From microbial immune subversion to systemic inflammation. Nature Reviews Immunology 15 (1): 30\u201344.","journal-title":"Nature Reviews Immunology"},{"issue":"6","key":"2024_CR42","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1177\/00220345211059418","volume":"101","author":"Y Han","year":"2022","unstructured":"Han, Y., Y. Huang, P. Gao, Q. Yang, L. Jia, Y. Zheng, et al. 2022. Leptin Aggravates Periodontitis by Promoting M1 Polarization via NLRP3. Journal of Dental Research 101 (6): 675\u2013685.","journal-title":"Journal of Dental Research"},{"issue":"1","key":"2024_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s12016-015-8519-2","volume":"51","author":"NJ Horwood","year":"2016","unstructured":"Horwood, N.J. 2016. Macrophage Polarization and Bone Formation: A review. Clinical Reviews in Allergy and Immunology 51 (1): 79\u201386.","journal-title":"Clinical Reviews in Allergy and Immunology"},{"issue":"1","key":"2024_CR44","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S8756-3282(01)00638-X","volume":"30","author":"CM Champagne","year":"2002","unstructured":"Champagne, C.M., J. Takebe, S. Offenbacher, and L.F. Cooper. 2002. Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2. Bone 30 (1): 26\u201331.","journal-title":"Bone"},{"issue":"2","key":"2024_CR45","doi-asserted-by":"publisher","first-page":"929","DOI":"10.7150\/thno.66148","volume":"12","author":"X Sun","year":"2022","unstructured":"Sun, X., K. Li, M. Hase, R. Zha, Y. Feng, B.Y. Li, and H. Yokota. 2022. Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1\/moesin-mediated inhibition of TGF\u03b2\/FN1\/CD44 signaling. Theranostics 12 (2): 929\u2013943.","journal-title":"Theranostics"},{"issue":"11","key":"2024_CR46","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1002\/jor.23553","volume":"35","author":"LY Lu","year":"2017","unstructured":"Lu, L.Y., F. Loi, K. Nathan, T.H. Lin, J. Pajarinen, E. Gibon, et al. 2017. Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway. Journal of Orthopaedic Research 35 (11): 2378\u20132385.","journal-title":"Journal of Orthopaedic Research"},{"issue":"1","key":"2024_CR47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41368-023-00225-4","volume":"15","author":"C Wang","year":"2023","unstructured":"Wang, C., Q. Zhao, C. Chen, J. Li, J. Zhang, S. Qu, et al. 2023. CD301b+ macrophage: The new booster for activating bone regeneration in periodontitis treatment. International Journal of Oral Science 15 (1): 19.","journal-title":"International Journal of Oral Science"},{"issue":"4","key":"2024_CR48","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1159\/000465455","volume":"41","author":"Q Wu","year":"2017","unstructured":"Wu, Q., X. Zhou, D. Huang, Y. Ji, and F. Kang. 2017. IL-6 enhances osteocyte-mediated osteoclastogenesis by promoting JAK2 and RANKL activity in vitro. Cellular Physiology and Biochemistry 41 (4): 1360\u20131369.","journal-title":"Cellular Physiology and Biochemistry"},{"issue":"7","key":"2024_CR49","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1902\/jop.2000.71.7.1167","volume":"71","author":"S Kimura","year":"2000","unstructured":"Kimura, S., A. Nagai, T. Onitsuka, T. Koga, T. Fujiwara, H. Kaya, et al. 2000. Induction of experimental periodontitis in mice with Porphyromonas gingivalis-adhered ligatures. Journal of Periodontology 71 (7): 1167\u20131173.","journal-title":"Journal of Periodontology"},{"issue":"9","key":"2024_CR50","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1177\/00220345211005677","volume":"100","author":"A Nagasaki","year":"2021","unstructured":"Nagasaki, A., K. Nagasaki, B.D. Kear, W.D. Tadesse, V. Thumbigere-Math, J.L. Mill\u00e1n, et al. 2021. Delivery of alkaline phosphatase promotes periodontal regeneration in mice. Journal of Dental Research 100 (9): 993\u20131001.","journal-title":"Journal of Dental Research"},{"issue":"10","key":"2024_CR51","doi-asserted-by":"publisher","first-page":"e12912","DOI":"10.1111\/cpr.12912","volume":"53","author":"SS Jin","year":"2020","unstructured":"Jin, S.S., D.Q. He, Y. Wang, T. Zhang, H.J. Yu, Z.X. Li, et al. 2020. Mechanical force modulates periodontal ligament stem cell characteristics during bone remodelling via TRPV4. Cell Proliferation 53 (10): e12912.","journal-title":"Cell Proliferation"},{"key":"2024_CR52","doi-asserted-by":"publisher","first-page":"102460","DOI":"10.1016\/j.redox.2022.102460","volume":"56","author":"K Liu","year":"2022","unstructured":"Liu, K., X. Gao, C. Hu, Y. Gui, S. Gui, Q. Ni, et al. 2022. Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress. Redox Biology 56: 102460.","journal-title":"Redox Biology"},{"issue":"9","key":"2024_CR53","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1111\/bph.14967","volume":"177","author":"C Yin","year":"2020","unstructured":"Yin, C., B. Liu, P. Wang, X. Li, Y. Li, X. Zheng, et al. 2020. Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. British Journal of Pharmacology 177 (9): 2042\u20132057.","journal-title":"British Journal of Pharmacology"},{"issue":"5","key":"2024_CR54","first-page":"635","volume":"25","author":"X Xu","year":"2022","unstructured":"Xu, X., Y. Li, Z. Yang, and Z. Zhou. 2022. Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K\/AKT signaling pathway. Iranian Journal of Basic Medical Sciences 25 (5): 635\u2013642.","journal-title":"Iranian Journal of Basic Medical Sciences"},{"issue":"3","key":"2024_CR55","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1177\/00220345221138523","volume":"102","author":"T Yamaguchi","year":"2023","unstructured":"Yamaguchi, T., Y. Yamamoto, K. Egashira, A. Sato, Y. Kondo, S. Saiki, et al. 2023. Oxidative stress inhibits endotoxin tolerance and may affect periodontitis. Journal of Dental Research 102 (3): 331\u2013339.","journal-title":"Journal of Dental Research"},{"issue":"6","key":"2024_CR56","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.7150\/thno.30206","volume":"9","author":"K Chen","year":"2019","unstructured":"Chen, K., P. Qiu, Y. Yuan, L. Zheng, J. He, C. Wang, et al. 2019. Pseurotin a inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species. Theranostics 9 (6): 1634\u20131650.","journal-title":"Theranostics"},{"key":"2024_CR57","doi-asserted-by":"publisher","first-page":"101849","DOI":"10.1016\/j.redox.2020.101849","volume":"40","author":"Y Weng","year":"2021","unstructured":"Weng, Y., H. Wang, L. Li, Y. Feng, S. Xu, and Z. Wang. 2021. Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. Redox Biology 40: 101849.","journal-title":"Redox Biology"},{"issue":"5","key":"2024_CR58","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/15548627.2019.1644076","volume":"16","author":"Z Deng","year":"2020","unstructured":"Deng, Z., J. Lim, Q. Wang, K. Purtell, S. Wu, G.M. Palomo, et al. 2020. ALS-FTLD-linked mutations of SQSTM1\/p62 disrupt selective autophagy and NFE2L2\/NRF2 anti-oxidative stress pathway. Autophagy 16 (5): 917\u2013931.","journal-title":"Autophagy"},{"key":"2024_CR59","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2021.01.023","volume":"165","author":"Shen K","year":"2021","unstructured":"Shen, K.,  Y. Jia, X. Wang, J. Zhang, K. Liu, J. Wang, et al. 2021. Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2\/HO-1 axis in macrophages. Free Radical Biology and Medicine 165: 54-66.\u00a0","journal-title":"Free Radical Biology and Medicine"},{"key":"2024_CR60","doi-asserted-by":"publisher","first-page":"116006","DOI":"10.1016\/j.biopha.2023.116006","volume":"170","author":"Huang S Y","year":"2024","unstructured":"Hung, S.Y., J.L. Chen, Y.K. Tu, H.Y. Tsai,  P.H. Lu, I.M. Jou, et al. 2024. Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2\/HO-1-mediated pathway. Biomedicine & Pharmacotherapy\u00a0170: 116006.\u00a0","journal-title":"Biomedicine & Pharmacotherapy"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02024-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-02024-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02024-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T07:07:52Z","timestamp":1732864072000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-02024-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2024"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-02024-3","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]},"assertion":[{"value":"9 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Animal Care and Use Committee, Sun Yat-Sen University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}]}}