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A male mouse model of DSS-induced colitis was employed with six distinct groups: a control group, a group subjected to DSS only,  three groups treated with varying scopoletin doses, and the final group treated with dexamethasone. The investigation included an assessment of the effects of scopoletin on colitis symptoms, including alterations in body weight, Disease Activity Index (DAI), and histopathological changes in colonic tissue. Furthermore, this study scrutinized the influence of scopoletin on cytokine production, PPAR\u03b3 and NF-\u03baB expression, NLRP3 inflammasome, and the composition of intestinal bacteria. Scopoletin treatment yielded noteworthy improvements in DSS-induced colitis in mice, as evidenced by reduced weight loss and colonic shortening (p\u2009&lt;\u20090.05,\u2009&lt;\u20090.01, respectively). It effectively diminished TNF-\u03b1, IL-1\u03b2, and IL-12 cytokine levels (p\u2009&lt;\u20090.01, p\u2009&lt;\u20090.05), attenuated NLRP3 inflammasome activation and the associated cytokine release (p\u2009&lt;\u20090.05, p\u2009&lt;\u20090.01), and modulated the immune response by elevating PPAR\u03b3 expression while suppressing NF-\u03baB pathway activation (p\u2009&lt;\u20090.05, p\u2009&lt;\u20090.01). Additionally, scopoletin induced alterations in the gut microbiota composition, augmenting beneficial Lactobacillus and Bifidobacteria while reducing E. coli (p\u2009&lt;\u20090.05). It also enhanced tight junction proteins, signifying an improvement in the intestinal barrier integrity (p\u2009&lt;\u20090.05,\u2009&lt;\u20090.01). Scopoletin is a promising therapeutic agent for managing ulcerative colitis, showing benefits that extend beyond mere anti-inflammatory actions to encompass regulatory effects on gut microbiota and restoration of intestinal integrity.<\/jats:p>","DOI":"10.1007\/s10753-024-02048-9","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T23:39:51Z","timestamp":1719358791000},"page":"575-589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring Scopoletin's Therapeutic Efficacy in DSS-Induced Ulcerative Colitis: Insights into Inflammatory Pathways, Immune Modulation, and Microbial Dynamics"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3721-8225","authenticated-orcid":false,"given":"Abdelrahim","family":"Alqudah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6203-4527","authenticated-orcid":false,"given":"Esam","family":"Qnais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-2652","authenticated-orcid":false,"given":"Omar","family":"Gammoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-5049","authenticated-orcid":false,"given":"Yousra","family":"Bseiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-5506","authenticated-orcid":false,"given":"Mohammed","family":"Wedyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-3115","authenticated-orcid":false,"given":"Mohammad","family":"Alqudah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A. 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American Journal of Pathology 159: 2001\u20132009.","journal-title":"American Journal of Pathology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02048-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-02048-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02048-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T05:04:56Z","timestamp":1746421496000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-02048-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["2048"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-02048-9","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"assertion":[{"value":"26 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experimental procedures were approved by the animal ethics committee at the Hashemite University (IRB number: 14\/4\/2021\/2022, 14 April 2022), and were in accordance with the guidelines of the US National Institutes of Health on the use and care of laboratory animals, and with the Animal Research: Reporting of\n                      in Vivo\n                      Experiments (ARRIVE) guidelines\n                      Experiment design and induction of colitis in mice.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}