{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:15:05Z","timestamp":1793128505754,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["No. 202303021221137"],"award-info":[{"award-number":["No. 202303021221137"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["No. 2021-079"],"award-info":[{"award-number":["No. 2021-079"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-024-02118-y","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T06:07:19Z","timestamp":1723010839000},"page":"1285-1299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of the S1P\/S1PR1 Signaling Pathway on High Glucose-Induced NRK-52E Epithelial-Mesenchymal Transition Via Regulation of ROS\/NLRP3"],"prefix":"10.1007","volume":"48","author":[{"given":"Jihua","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"2118_CR1","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1053\/j.ajkd.2017.10.026","volume":"71","author":"K Umanath","year":"2018","unstructured":"Umanath, K., and J. B. Lewis. 2018. Update on Diabetic Nephropathy: Core Curriculum 2018. American Journal of Kidney Diseases 71:884\u2013895.","journal-title":"American Journal of Kidney Diseases"},{"key":"2118_CR2","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1016\/S0735-1097(17)35426-8","volume":"69","author":"C Chen","year":"2017","unstructured":"Chen, C., Y. Zhao, and D. W. Wang. 2017. MiR-30C protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db\/db mice. Journal of the American College of Cardiology 69:2037.","journal-title":"Journal of the American College of Cardiology"},{"key":"2118_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21228577","volume":"21","author":"MK Kang","year":"2020","unstructured":"Kang, M. K., S. I. Kim, S. Y. Oh, W. Na, and Y. H. Kang. 2020. Tangeretin Ameliorates Glucose-Induced Podocyte Injury through Blocking Epithelial to Mesenchymal Transition Caused by Oxidative Stress and Hypoxia. International Journal of Molecular Sciences 21:1\u201317.","journal-title":"International Journal of Molecular Sciences"},{"key":"2118_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/imr.12760","volume":"289","author":"Dixit Dhaval","year":"2019","unstructured":"Dhaval, Dixit, Okuniewska Martyna, and Schwab Susan. 2019. Secrets and lyase: Control of sphingosine 1-phosphate distribution. Immunological Reviews 289:173.","journal-title":"Immunological Reviews"},{"key":"2118_CR5","doi-asserted-by":"publisher","first-page":"eaar5551-","DOI":"10.1126\/science.aar5551","volume":"366","author":"A Cartier","year":"2019","unstructured":"Cartier, A., and T. Hla. 2019. Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. Science 366:eaar5551-.","journal-title":"Science"},{"key":"2118_CR6","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1172\/JCI76369","volume":"125","author":"RL Proia","year":"2015","unstructured":"Proia, R. L., and T. Hla. 2015. Emerging biology of sphingosine-1-phosphate: Its role in pathogenesis and therapy. Journal of Clinical Investigation 125:1379.","journal-title":"Journal of Clinical Investigation"},{"key":"2118_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109861","volume":"78","author":"C Donati","year":"2021","unstructured":"Donati, C., F. Cencetti, C. Bernacchioni, V. Vannuzzi, and P. Bruni. 2021. Role of sphingosine 1-phosphate signalling in tissue fibrosis. Cellular Signalling 78:109861.","journal-title":"Cellular Signalling"},{"key":"2118_CR8","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.phrs.2016.05.035","volume":"11","author":"Z Yang","year":"2016","unstructured":"Yang, Z., F. Xiong, Y. Wang, W. Gong, J. Huang, C. Chen, et al. 2016. TGR5 activation suppressed S1P\/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. Pharmacological Research 11:226\u2013236.","journal-title":"Pharmacological Research"},{"key":"2118_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2021.10924","volume":"23","author":"Q Lin","year":"2021","unstructured":"Lin, Q., C. Long, Z. Wang, R. Wang, W. Shi, J. Qiu, et al. 2021. Hirudin, a thrombin inhibitor, attenuates TGF-\u03b2-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P\/S1PR2\/S1PR3 signaling. Experimental and Therapeutic Medicine 23:1.","journal-title":"Experimental and Therapeutic Medicine"},{"key":"2118_CR10","first-page":"1516","volume":"290","author":"AS Awad","year":"2006","unstructured":"Awad, A. S., H. Ye, L. Huang, L. Li, and M. D. Okusa. 2006. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology 290:1516\u20131524.","journal-title":"American Journal of Physiology"},{"key":"2118_CR11","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1038\/sj.ki.5000360","volume":"69","author":"YHH Lien","year":"2006","unstructured":"Lien, Y. H. H., K. C. Yong, C. Cho, S. Igarashi, and L. W. Lai. 2006. S1P1-selective agonist, SEW2871, ameliorates ischemic acute renal failure - ScienceDirect. Kidney International 69:1601\u20131608.","journal-title":"Kidney International"},{"key":"2118_CR12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S1388-1981(02)00341-4","volume":"1585","author":"M Maceyka","year":"2002","unstructured":"Maceyka, M., S. G. Payne, S. Milstien, and S. Spiegel. 2002. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochimica et Biophysica Acta 1585:193\u2013201.","journal-title":"Biochimica et Biophysica Acta"},{"key":"2118_CR13","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/381800a0","volume":"381","author":"O Cuvillier","year":"1996","unstructured":"Cuvillier, O., G. Pirianov, B. Kleuser, P. G. Vanek, and S. Spiegel. 1996. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381:800\u2013803.","journal-title":"Nature"},{"key":"2118_CR14","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1056\/NEJMoa0907839","volume":"362","author":"JA Cohen","year":"2010","unstructured":"Cohen, J. A., F. Barkhof, G. Comi, H. P. Hartung, and L. Kappos. 2010. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. New England Journal of Medicine 362:402\u2013415.","journal-title":"New England Journal of Medicine"},{"key":"2118_CR15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1056\/NEJMoa0909494","volume":"362","author":"L Kappos","year":"2010","unstructured":"Kappos, L., E. W. Radue, P. O\u2019Connor, C. Polman, R. Hohlfeld, P. Calabresi, et al. 2010. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. New England Journal of Medicine 362:387\u2013401.","journal-title":"New England Journal of Medicine"},{"key":"2118_CR16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.yexcr.2014.11.020","volume":"333","author":"Y Kihara","year":"2015","unstructured":"Kihara, Y., H. Mizuno, and J. Chun. 2015. Lysophospholipid receptors in drug discovery. Experimental Cell Research 333:171\u2013177.","journal-title":"Experimental Cell Research"},{"key":"2118_CR17","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1161\/CIRCULATIONAHA.115.012427","volume":"133","author":"CG Santos-Gallego","year":"2016","unstructured":"Santos-Gallego, C. G., T. P. Vahl, G. Goliasch, B. Picatoste, T. Arias, K. Ishikawa, et al. 2016. Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia\/ReperfusionCLINICAL PERSPECTIVE. Circulation 133:954\u2013966.","journal-title":"Circulation"},{"key":"2118_CR18","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1158\/0008-5472.CAN-07-2621","volume":"68","author":"JH Hung","year":"2008","unstructured":"Hung, J. H., Y. S. Lu, Y. C. Wang, Y. H. Ma, and C. S. Chen. 2008. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Research 68:1204\u20131212.","journal-title":"Cancer Research"},{"key":"2118_CR19","first-page":"1596","volume":"55","author":"VA Blaho","year":"2014","unstructured":"Blaho, V. A., and T. Hla. 2014. An update on the biology of sphingosine 1-phosphate receptors. JLR Papers In Press 55:1596.","journal-title":"JLR Papers In Press"},{"key":"2118_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21852","volume-title":"Differential expression of sphingosine-1-phosphate receptors 1\u20135 in the developing nervous system","author":"H Meng","year":"2009","unstructured":"Meng, H., and V. M. Lee. 2009. Differential expression of sphingosine-1-phosphate receptors 1\u20135 in the developing nervous system. Ltd: John Wiley & Sons."},{"key":"2118_CR21","first-page":"1","volume":"2016","author":"Z Shirong","year":"2016","unstructured":"Shirong, Z., D. W. Powell, Z. Feng, K. Phillip, and G. Luigi. 2016. Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis. Journal of Diabetes Research 2016:1\u20132.","journal-title":"Journal of Diabetes Research"},{"key":"2118_CR22","doi-asserted-by":"crossref","unstructured":"Duran-Salgado M, Rubio-Guerra A. Diabetic nephropathy and inflammation. World Journal of Diabetes 2014;5:393.","DOI":"10.4239\/wjd.v5.i3.393"},{"key":"2118_CR23","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","volume":"20","author":"N Kelley","year":"2019","unstructured":"Kelley, N., D. Jeltema, Y. Duan, and Y. He. 2019. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International Journal of Molecular Sciences 20:3328.","journal-title":"International Journal of Molecular Sciences"},{"key":"2118_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.lfs.2016.06.002","volume":"157","author":"YA Samra","year":"2016","unstructured":"Samra, Y. A., H. S. Said, N. M. Elsherbiny, G. I. Liou, M. M. El-Shishtawy, and L. A. Eissa. 2016. Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: Role of NF-\u03baB and NLRP3 inflammasome. Life Sciences 157:187\u2013199.","journal-title":"Life Sciences"},{"key":"2118_CR25","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ni.1831","volume":"11","author":"R Zhou","year":"2010","unstructured":"Zhou, R., A. Tardivel, B. Thorens, I. Choi, and J. Tschopp. 2010. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nature Immunology 11:136\u2013140.","journal-title":"Nature Immunology"},{"key":"2118_CR26","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3389\/fimmu.2020.01149","volume":"11","author":"L Hou","year":"2020","unstructured":"Hou, L., L. Yang, N. Chang, X. Zhao, and L. Li. 2020. Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome. Frontiers in Immunology 11:1149.","journal-title":"Frontiers in Immunology"},{"issue":"10","key":"2118_CR27","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.2337\/diabetes.51.10.3090","volume":"51","author":"A Flyvbjerg","year":"2002","unstructured":"Flyvbjerg, A., F. Dagn\u00e6s-Hansen, A. S. De Vriese, B. F. Schrijvers, R. G. Tilton, and R. Rasch. 2002. Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody. Diabetes 51 (10): 3090\u20133094.","journal-title":"Diabetes"},{"key":"2118_CR28","doi-asserted-by":"publisher","first-page":"154748","DOI":"10.1016\/j.metabol.2021.154748","volume":"118","author":"M Wu","year":"2021","unstructured":"Wu, M., Z. Yang, C. Zhang, Y. Shi, W. Han, S. Song, L. Mu, C. Du, and Y. Shi. 2021. Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy. Metabolism 118:154748.","journal-title":"Metabolism"},{"key":"2118_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.630401","volume":"9","author":"Y Cao","year":"2021","unstructured":"Cao, Y., Z. Yang, Y. Chen, S. Jiang, Z. Wu, B. Ding, et al. 2021. An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy. Frontiers in cell and developmental biology 9:630401.","journal-title":"Frontiers in cell and developmental biology"},{"key":"2118_CR30","first-page":"1","volume":"2021","author":"J Han","year":"2021","unstructured":"Han, J., X. Pang, X. Shi, Y. Zhang, Z. Peng, and Y. Xing. 2021. Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress. Hindawi Limited 2021:1.","journal-title":"Hindawi Limited"},{"key":"2118_CR31","doi-asserted-by":"publisher","first-page":"104314","DOI":"10.1016\/j.phrs.2019.104314","volume":"146","author":"Pitchai Balakumar","year":"2019","unstructured":"Balakumar, Pitchai, Ramanathan Sambathkumar, Nanjaian Mahadevan, et al. 2019. A potential role of the renin-angiotensin-aldosterone system in epithelial-to-mesenchymal transition-induced renal abnormalities: Mechanisms and therapeutic implications. Pharmacol Res 146:104314.","journal-title":"Pharmacol Res"},{"key":"2118_CR32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.matbio.2021.05.003","volume":"98","author":"F Imeri","year":"2021","unstructured":"Imeri, F., B. S. Tanturovska, S. Schwalm, S. Saha, J. Zeng-Brouwers, H. Pavenstdt, et al. 2021. Loss of sphingosine kinase 2 enhances Wilm\u2019s tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice. Matrix Biology 98:32\u201348.","journal-title":"Matrix Biology"},{"key":"2118_CR33","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1681\/ASN.2020050697","volume":"32","author":"Y Drexler","year":"2021","unstructured":"Drexler, Y., J. Molina, A. Mitrofanova, A. Fornoni, and S. Merscher. 2021. Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases. Journal of the American Society of Nephrology\u202f: JASN 32:9\u201331.","journal-title":"Journal of the American Society of Nephrology : JASN"},{"key":"2118_CR34","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1093\/abbs\/gmy058","volume":"50","author":"W Weina","year":"2018","unstructured":"Weina, W., W. Aimei, L. Guochang, M. Fengqiao, W. Xiaoming, and B. Yongyi. 2018. S1P1 receptor inhibits kidney epithelial mesenchymal transition triggered by ischemia\/reperfusion injury via the PI3K\/Akt pathway. Acta Biochimica Et Biophysica Sinica 50:651.","journal-title":"Acta Biochimica Et Biophysica Sinica"},{"issue":"8","key":"2118_CR35","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1111\/bph.15754","volume":"179","author":"MA Riemma","year":"2022","unstructured":"Riemma, M.A., I. Cerqua, B. Romano, E. Irollo, A. Bertolino, R. Camerlingo, E. Granato, G. Rea, S. Scala, M. Terlizzi, et al. 2022. Sphingosine-1-phosphate\/TGF-\u03b2 axis drives epithelial mesenchymal transition in asthma-like disease. British Journal of Pharmacology 179 (8): 1753\u20131768.","journal-title":"British Journal of Pharmacology"},{"key":"2118_CR36","doi-asserted-by":"publisher","first-page":"3790721","DOI":"10.1155\/2022\/3790721","volume":"2022","author":"K Ding","year":"2022","unstructured":"Ding, K., C. Song, H. Hu, K. Yin, H. Huang, and H. Tang. 2022. The Role of NLRP3 Inflammasome in Diabetic Cardiomyopathy and Its Therapeutic Implications. Oxidative medicine and cellular longevity 2022:3790721.","journal-title":"Oxidative medicine and cellular longevity"},{"key":"2118_CR37","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.intimp.2018.07.027","volume":"63","author":"W Song","year":"2018","unstructured":"Song, W., L. Wei, Y. Du, Y. Wang, and S. Jiang. 2018. Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-\u03baB\/p38 signaling pathway in high-fat diet\/streptozotocin-induced diabetic mice. International immunopharmacology 63:227\u2013238.","journal-title":"International immunopharmacology"},{"issue":"2","key":"2118_CR38","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.yexcr.2017.12.013","volume":"362","author":"X Li","year":"2018","unstructured":"Li, X., X. Yan, Y. Wang, J. Wang, F. Zhou, H. Wang, W. Xie, and H. Kong. 2018. NLRP3 inflammasome inhibition attenuates silica-induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells. Experimental Cell Research 362 (2): 489\u2013497.","journal-title":"Experimental Cell Research"},{"issue":"3","key":"2118_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1530\/JME-18-0069","volume":"61","author":"S Song","year":"2018","unstructured":"Song, S., D. Qiu, F. Luo, J. Wei, M. Wu, H. Wu, C. Du, Y. Du, Y. Ren, N. Chen, et al. 2018. Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells. Journal of Molecular Endocrinology 61 (3): 101\u2013113.","journal-title":"Journal of Molecular Endocrinology"},{"key":"2118_CR40","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.3389\/fimmu.2019.02538","volume":"10","author":"A Zahid","year":"2019","unstructured":"Zahid, A., B. Li, A. J. K. Kombe, T. Jin, and J. Tao. 2019. Pharmacological inhibitors of the NLRP3 inflammasome. Frontiers in immunology 10:2538.","journal-title":"Frontiers in immunology"},{"issue":"13","key":"2118_CR41","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","volume":"20","author":"N Kelley","year":"2019","unstructured":"Kelley, N., D. Jeltema, Y. Duan, and Y. He. 2019. The NLRP3 inflammasome: An overview of mechanisms of activation and regulation. International journal of molecular sciences 20 (13): 3328.","journal-title":"International journal of molecular sciences"},{"issue":"5","key":"2118_CR42","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3390\/molecules24050872","volume":"24","author":"R Wang","year":"2019","unstructured":"Wang, R., Z. Dong, X. Lan, Z. Liao, and M. Chen. 2019. Sweroside alleviated LPS-induced inflammation via SIRT1 mediating NF-\u03baB and FOXO1 signaling pathways in RAW264. 7 cells. Molecules 24 (5): 872.","journal-title":"Molecules"},{"key":"2118_CR43","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/bab.1700","volume":"66","author":"T Sho","year":"2019","unstructured":"Sho, T., and J. X. Xu. 2019. Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation. Biotechnol Appl Biochem 66:4.","journal-title":"Biotechnol Appl Biochem"},{"key":"2118_CR44","doi-asserted-by":"publisher","first-page":"153650","DOI":"10.1016\/j.phymed.2021.153650","volume":"91","author":"W Liu","year":"2021","unstructured":"Liu, W., L. Liang, Q. Zhang, Y. Li, and T. Lan. 2021. Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action. Phytomedicine international journal of phytotherapy and phytopharmacology 91:153650.","journal-title":"Phytomedicine international journal of phytotherapy and phytopharmacology"},{"key":"2118_CR45","doi-asserted-by":"publisher","first-page":"883","DOI":"10.3389\/fimmu.2020.00883","volume":"11","author":"AAA Alyaseer","year":"2020","unstructured":"Alyaseer, A. A. A., M. H. S. D. Lima, and T. T. Braga. 2020. The Role of NLRP3 Inflammasome Activation in the Epithelial to Mesenchymal Transition Process During the Fibrosis. Frontiers in Immunology 11:883.","journal-title":"Frontiers in Immunology"},{"key":"2118_CR46","doi-asserted-by":"publisher","first-page":"104314","DOI":"10.1016\/j.phrs.2019.104314","volume":"146","author":"A Pb","year":"2019","unstructured":"Pb, A., A. Rs, B. Nm, B. Abm, B. Aa, A. Nv, et al. 2019. A potential role of the renin-angiotensin-aldosterone system in epithelial-to-mesenchymal transition-induced renal abnormalities: Mechanisms and therapeutic implications. Pharmacological Research 146:104314.","journal-title":"Pharmacological Research"},{"issue":"10","key":"2118_CR47","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/ki.2010.544","volume":"79","author":"AS Awad","year":"2011","unstructured":"Awad, A. S., M. D. Rouse, K. Khutsishvili, L. Huang, W. Kline Bolton, K. R. Lynch, and M.D. Okusa. 2011. Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney International 79 (10): 1090\u20131098.","journal-title":"Kidney International"},{"issue":"12","key":"2118_CR48","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1038\/aps.2014.100","volume":"35","author":"M Xu","year":"2014","unstructured":"Xu, M., and D. Liu. 2014. Ding L-h, Ma K-l, Wu M, Lv L-l, Wen Y, Liu H, Tang R-n, Liu B-c: FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. Acta Pharmacologica Sinica 35 (12): 1537\u20131545.","journal-title":"Acta Pharmacologica Sinica"},{"issue":"1","key":"2118_CR49","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/cei.13003","volume":"190","author":"T Tian","year":"2017","unstructured":"Tian, T., J. Zhang, X. Zhu, S. Wen, D. Shi, and H. Zhou. 2017. FTY720 ameliorates renal fibrosis by simultaneously affecting leucocyte recruitment and TGF-\u03b2 signalling in fibroblasts. Clinical & Experimental Immunology 190 (1): 68.","journal-title":"Clinical & Experimental Immunology"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02118-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-02118-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02118-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T10:02:49Z","timestamp":1751968969000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-02118-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2118"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-02118-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4285508\/v1","asserted-by":"object"}]},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]},"assertion":[{"value":"18 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Shanxi Medical University Committee on Ethics approved the animal experiments, and the Animal Care and Use Committee of Shanxi Medical University approved the protocols for handling and housing the animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}