{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:34:52Z","timestamp":1785321292199,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-024-02203-2","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T21:21:17Z","timestamp":1733779277000},"page":"2476-2493","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["REG\u03b3-mediated Barrier Disruption and NF-\u03baB Activation Aggravates Intestinal Inflammation in Necrotizing Enterocolitis"],"prefix":"10.1007","volume":"48","author":[{"given":"Ya","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxia","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"issue":"1","key":"2203_CR1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12887-020-02231-5","volume":"20","author":"A Alsaied","year":"2020","unstructured":"Alsaied, A., N. Islam, and L. Thalib. 2020. Global incidence of necrotizing enterocolitis: A systematic review and meta-analysis. BMC Pediatrics 20 (1): 344.","journal-title":"BMC Pediatrics"},{"key":"2203_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jpeds.2019.11.011","volume":"220","author":"IH Jones","year":"2020","unstructured":"Jones, I.H., and N.J. Hall. 2020. Contemporary outcomes for infants with necrotizing enterocolitis-A systematic review. The Journal of Pediatrics 220:86-92 e83.","journal-title":"The Journal of Pediatrics"},{"issue":"3","key":"2203_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","volume":"364","author":"J Neu","year":"2011","unstructured":"Neu, J., and W.A. Walker. 2011. Necrotizing enterocolitis. New England Journal of Medicine 364 (3): 255\u2013264.","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"2203_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1055\/s-0032-1306263","volume":"22","author":"M Thyoka","year":"2012","unstructured":"Thyoka, M., P. de Coppi, S. Eaton, K. Khoo, N.J. Hall, J. Curry, et al. 2012. Advanced necrotizing enterocolitis part 1: Mortality. European Journal of Pediatric Surgery 22 (1): 8\u201312.","journal-title":"European Journal of Pediatric Surgery"},{"issue":"10","key":"2203_CR5","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nrgastro.2016.119","volume":"13","author":"DF Nino","year":"2016","unstructured":"Nino, D.F., C.P. Sodhi, and D.J. Hackam. 2016. Necrotizing enterocolitis: New insights into pathogenesis and mechanisms. Nature Reviews. Gastroenterology & Hepatology 13 (10): 590\u2013600.","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"25","key":"2203_CR6","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1056\/NEJMicm2020782","volume":"383","author":"W Kim","year":"2020","unstructured":"Kim, W., and J.M. Seo. 2020. Necrotizing enterocolitis. New England Journal of Medicine 383 (25): 2461.","journal-title":"New England Journal of Medicine"},{"issue":"3","key":"2203_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2023.151309","volume":"32","author":"DJ Scheese","year":"2023","unstructured":"Scheese, D.J., C.P. Sodhi, and D.J. Hackam. 2023. New insights into the pathogenesis of necrotizing enterocolitis and the dawn of potential therapeutics. Seminars in Pediatric Surgery 32 (3): 151309.","journal-title":"Seminars in Pediatric Surgery"},{"issue":"1","key":"2203_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2022.151689","volume":"47","author":"ME Barbian","year":"2023","unstructured":"Barbian, M.E., and R.M. Patel. 2023. Probiotics for prevention of necrotizing enterocolitis: Where do we stand? Seminars in Perinatology 47 (1): 151689.","journal-title":"Seminars in Perinatology"},{"issue":"1","key":"2203_CR9","doi-asserted-by":"publisher","first-page":"2221470","DOI":"10.1080\/19490976.2023.2221470","volume":"15","author":"JW Duess","year":"2023","unstructured":"Duess, J.W., M.E. Sampah, C.M. Lopez, K. Tsuboi, D.J. Scheese, C.P. Sodhi, et al. 2023. Necrotizing enterocolitis, gut microbes, and sepsis. Gut Microbes 15 (1): 2221470.","journal-title":"Gut Microbes"},{"issue":"1","key":"2203_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.pathophys.2014.01.001","volume":"21","author":"J Kandasamy","year":"2014","unstructured":"Kandasamy, J., S. Huda, N. Ambalavanan, and T. Jilling. 2014. Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis. Pathophysiology 21 (1): 67\u201380.","journal-title":"Pathophysiology"},{"issue":"1","key":"2203_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13357","volume":"91","author":"T Suzuki","year":"2020","unstructured":"Suzuki, T. 2020. Regulation of the intestinal barrier by nutrients: The role of tight junctions. Animal Science Journal 91 (1): e13357.","journal-title":"Animal Science Journal"},{"issue":"3","key":"2203_CR12","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ajpath.2018.11.015","volume":"189","author":"E Managlia","year":"2019","unstructured":"Managlia, E., S.X.L. Liu, X. Yan, X.D. Tan, P.M. Chou, T.A. Barrett, et al. 2019. Blocking NF-kappaB activation in Ly6c(+) monocytes attenuates necrotizing enterocolitis. American Journal of Pathology 189 (3): 604\u2013618.","journal-title":"American Journal of Pathology"},{"issue":"3","key":"2203_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41419-020-2378-3","volume":"11","author":"H Chen","year":"2020","unstructured":"Chen, H., H. Zhang, Y. Zheng, X. Min, Y. Luo, W. Zhou, et al. 2020. Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-kappaB-dependent mechanism. Cell Death & Disease 11 (3): 188.","journal-title":"Cell Death & Disease"},{"key":"2203_CR14","doi-asserted-by":"publisher","first-page":"10761","DOI":"10.1038\/ncomms10761","volume":"7","author":"J Xu","year":"2016","unstructured":"Xu, J., L. Zhou, L. Ji, F. Chen, K. Fortmann, K. Zhang, et al. 2016. The REGgamma-proteasome forms a regulatory circuit with IkappaBvarepsilon and NFkappaB in experimental colitis. Nature Communications 7:10761.","journal-title":"Nature Communications"},{"issue":"8","key":"2203_CR15","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1007\/s11427-021-2018-7","volume":"65","author":"X Zhu","year":"2022","unstructured":"Zhu, X., M. Yang, Z. Lin, S.K. Mael, Y. Li, L. Zhang, et al. 2022. REGgamma drives Lgr5(+) stem cells to potentiate radiation induced intestinal regeneration. Science China. Life Sciences 65 (8): 1608\u20131623.","journal-title":"Science China. Life Sciences"},{"issue":"5","key":"2203_CR16","first-page":"1961","volume":"43","author":"T Xie","year":"2019","unstructured":"Xie, T., H. Chen, S. Shen, T. Huang, B. Huang, G. Hu, et al. 2019. Proteasome activator REGgamma promotes inflammation in Leydig cells via IkBepsilon signaling. International Journal of Molecular Medicine 43 (5): 1961\u20131968.","journal-title":"International Journal of Molecular Medicine"},{"issue":"6","key":"2203_CR17","doi-asserted-by":"publisher","first-page":"106882","DOI":"10.1016\/j.isci.2023.106882","volume":"26","author":"T Guo","year":"2023","unstructured":"Guo, T., S. Hu, W. Xu, J. Zhou, F. Chen, T. Gao, et al. 2023. Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis. iScience 26 (6): 106882.","journal-title":"iScience"},{"issue":"12","key":"2203_CR18","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1016\/j.immuni.2022.11.003","volume":"55","author":"JE Kim","year":"2022","unstructured":"Kim, J.E., B. Li, L. Fei, R. Horne, D. Lee, A.K. Loe, et al. 2022. Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development. Immunity 55 (12): 2300-2317 e2306.","journal-title":"Immunity"},{"key":"2203_CR19","doi-asserted-by":"publisher","unstructured":"Garcia T M, Navis M, Wildenberg M E, van Elburg R M, Muncan V. 2019. Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids. Journal of Visualized Experiments (153). https:\/\/doi.org\/10.3791\/60470","DOI":"10.3791\/60470"},{"issue":"1","key":"2203_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00383-018-4369-3","volume":"35","author":"B Li","year":"2019","unstructured":"Li, B., C. Lee, M. Cadete, H. Miyake, D. Lee, and A. Pierro. 2019. Neonatal intestinal organoids as an ex vivo approach to study early intestinal epithelial disorders. Pediatric Surgery International 35 (1): 3\u20137.","journal-title":"Pediatric Surgery International"},{"issue":"2","key":"2203_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00383-019-04599-7","volume":"36","author":"H Miyake","year":"2020","unstructured":"Miyake, H., C. Lee, S. Chusilp, M. Bhalla, B. Li, M. Pitino, et al. 2020. Human breast milk exosomes attenuate intestinal damage. Pediatric Surgery International 36 (2): 155\u2013163.","journal-title":"Pediatric Surgery International"},{"issue":"7244","key":"2203_CR22","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature07935","volume":"459","author":"T Sato","year":"2009","unstructured":"Sato, T., R.G. Vries, H.J. Snippert, M. van de Wetering, N. Barker, D.E. Stange, et al. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459 (7244): 262\u2013265.","journal-title":"Nature"},{"key":"2203_CR23","doi-asserted-by":"publisher","first-page":"12497","DOI":"10.1038\/ncomms12497","volume":"7","author":"L Sun","year":"2016","unstructured":"Sun, L., G. Fan, P. Shan, X. Qiu, S. Dong, L. Liao, et al. 2016. Regulation of energy homeostasis by the ubiquitin-independent REGgamma proteasome. Nature Communications 7:12497.","journal-title":"Nature Communications"},{"key":"2203_CR24","doi-asserted-by":"publisher","first-page":"102282","DOI":"10.1016\/j.jaut.2019.05.010","volume":"103","author":"L Yao","year":"2019","unstructured":"Yao, L., L. Zhou, Y. Xuan, P. Zhang, X. Wang, T. Wang, et al. 2019. The proteasome activator REGgamma counteracts immunoproteasome expression and autoimmunity. Journal of Autoimmunity 103:102282.","journal-title":"Journal of Autoimmunity"},{"issue":"11","key":"2203_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102571","volume":"298","author":"J Tu","year":"2022","unstructured":"Tu, J., H. Zhang, T. Yang, Y. Liu, S. Kibreab, Y. Zhang, et al. 2022. Aging-associated REGgamma proteasome decline predisposes to tauopathy. Journal of Biological Chemistry 298 (11): 102571.","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"2203_CR26","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.ajpath.2024.02.008","volume":"194","author":"X Zhu","year":"2024","unstructured":"Zhu, X., Y. Li, X. Tian, Y. Jing, Z. Wang, L. Yue, et al. 2024. REGgamma mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis. American Journal of Pathology 194 (6): 975\u2013988.","journal-title":"American Journal of Pathology"},{"issue":"2","key":"2203_CR27","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1136\/gutjnl-2012-303735","volume":"63","author":"A Zani","year":"2014","unstructured":"Zani, A., M. Cananzi, F. Fascetti-Leon, G. Lauriti, V.V. Smith, S. Bollini, et al. 2014. Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut 63 (2): 300\u2013309.","journal-title":"Gut"},{"issue":"12","key":"2203_CR28","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.jpedsurg.2016.09.011","volume":"51","author":"SA Moore","year":"2016","unstructured":"Moore, S.A., P. Nighot, C. Reyes, M. Rawat, J. McKee, D. Lemon, et al. 2016. Intestinal barrier dysfunction in human necrotizing enterocolitis. Journal of Pediatric Surgery 51 (12): 1907\u20131913.","journal-title":"Journal of Pediatric Surgery"},{"issue":"1","key":"2203_CR29","doi-asserted-by":"publisher","first-page":"G23","DOI":"10.1152\/ajpgi.00233.2022","volume":"325","author":"CP Sodhi","year":"2023","unstructured":"Sodhi, C.P., R. Ahmad, W.B. Fulton, C.M. Lopez, B.O. Eke, D. Scheese, et al. 2023. Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology 325 (1): G23\u2013G41.","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"issue":"12","key":"2203_CR30","doi-asserted-by":"publisher","first-page":"19509","DOI":"10.1002\/jcb.29255","volume":"120","author":"H Shen","year":"2019","unstructured":"Shen, H., Y. Lei, X. He, D. Liu, and Z. He. 2019. Role of lactadherin in intestinal barrier integrity in experimental neonatal necrotizing enterocolitis. Journal of Cellular Biochemistry 120 (12): 19509\u201319517.","journal-title":"Journal of Cellular Biochemistry"},{"issue":"16","key":"2203_CR31","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1080\/15384101.2020.1788251","volume":"19","author":"M Bai","year":"2020","unstructured":"Bai, M., C. Lu, L. An, Q. Gao, W. Xie, F. Miao, et al. 2020. SIRT1 relieves Necrotizing Enterocolitis through inactivation of Hypoxia-inducible factor (HIF)-1a. Cell Cycle 19 (16): 2018\u20132027.","journal-title":"Cell Cycle"},{"issue":"3","key":"2203_CR32","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1007\/s10753-021-01618-5","volume":"45","author":"MM Guo","year":"2022","unstructured":"Guo, M.M., K. Zhang, and J.H. Zhang. 2022. Human breast milk-derived exosomal miR-148a-3p protects against necrotizing enterocolitis by regulating p53 and sirtuin 1. Inflammation 45 (3): 1254\u20131268.","journal-title":"Inflammation"},{"issue":"5","key":"2203_CR33","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1055\/s-0042-1758157","volume":"33","author":"RB Zhang","year":"2023","unstructured":"Zhang, R.B., L. Ren, D.P. Ding, H.D. Wang, J. Peng, and K. Zheng. 2023. Protective effect of the SIRT1-mediated NF-kappaB signaling pathway against necrotizing enterocolitis in neonatal mice. European Journal of Pediatric Surgery 33 (5): 386\u2013394.","journal-title":"European Journal of Pediatric Surgery"},{"issue":"3","key":"2203_CR34","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.cmet.2013.08.012","volume":"18","author":"S Dong","year":"2013","unstructured":"Dong, S., C. Jia, S. Zhang, G. Fan, Y. Li, P. Shan, et al. 2013. The REGgamma proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metabolism 18 (3): 380\u2013391.","journal-title":"Cell Metabolism"},{"issue":"6","key":"2203_CR35","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s41385-022-00579-8","volume":"15","author":"LC Frazer","year":"2022","unstructured":"Frazer, L.C., and M. Good. 2022. Intestinal epithelium in early life. Mucosal Immunology 15 (6): 1181\u20131187.","journal-title":"Mucosal Immunology"},{"issue":"7970","key":"2203_CR36","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/s41586-023-05915-x","volume":"619","author":"JW Hickey","year":"2023","unstructured":"Hickey, J.W., W.R. Becker, S.A. Nevins, A. Horning, A.E. Perez, C. Zhu, et al. 2023. Organization of the human intestine at single-cell resolution. Nature 619 (7970): 572\u2013584.","journal-title":"Nature"},{"issue":"2","key":"2203_CR37","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1172\/JCI83356","volume":"126","author":"CE Egan","year":"2016","unstructured":"Egan, C.E., C.P. Sodhi, M. Good, J. Lin, H. Jia, Y. Yamaguchi, et al. 2016. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. The Journal of Clinical Investigation 126 (2): 495\u2013508.","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"2203_CR38","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00011-021-01441-6","volume":"70","author":"X Xia","year":"2021","unstructured":"Xia, X., D. Wang, L. Yu, B. Wang, W. Wang, C. Jiao, et al. 2021. Activated M1 macrophages suppress c-kit expression via TNF-alpha-mediated upregulation of miR-222 in neonatal necrotizing enterocolitis. Inflammation Research 70 (3): 343\u2013358.","journal-title":"Inflammation Research"},{"issue":"5","key":"2203_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002124","volume":"21","author":"A Egozi","year":"2023","unstructured":"Egozi, A., O. Olaloye, L. Werner, T. Silva, B. McCourt, R.W. Pierce, et al. 2023. Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis. PLoS Biology 21 (5): e3002124.","journal-title":"PLoS Biology"},{"issue":"9","key":"2203_CR40","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","volume":"43","author":"D Capece","year":"2022","unstructured":"Capece, D., D. Verzella, I. Flati, P. Arboretto, J. Cornice, and G. Franzoso. 2022. NF-kappaB: Blending metabolism, immunity, and inflammation. Trends in Immunology 43 (9): 757\u2013775.","journal-title":"Trends in Immunology"},{"issue":"6","key":"2203_CR41","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1203\/pdr.0b013e3180534219","volume":"61","author":"IG De Plaen","year":"2007","unstructured":"De Plaen, I.G., S.X. Liu, R. Tian, I. Neequaye, M.J. May, X.B. Han, et al. 2007. Inhibition of nuclear factor-kappaB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis. Pediatric Research 61 (6): 716\u2013721.","journal-title":"Pediatric Research"},{"issue":"6","key":"2203_CR42","doi-asserted-by":"publisher","first-page":"C967","DOI":"10.1152\/ajpcell.00571.2019","volume":"319","author":"L Sun","year":"2020","unstructured":"Sun, L., M. Sun, K. Ma, and J. Liu. 2020. Let-7d-5p suppresses inflammatory response in neonatal rats with necrotizing enterocolitis via LGALS3-mediated TLR4\/NF-kappaB signaling pathway. American Journal of Physiology. Cell Physiology 319 (6): C967\u2013C979.","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"1","key":"2203_CR43","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12964-023-01433-5","volume":"22","author":"M Pakjoo","year":"2024","unstructured":"Pakjoo, M., S.E. Ahmadi, M. Zahedi, N. Jaafari, R. Khademi, A. Amini, et al. 2024. Interplay between proteasome inhibitors and NF-kappaB pathway in leukemia and lymphoma: A comprehensive review on challenges ahead of proteasome inhibitors. Cell Communication and Signaling: CCS 22 (1): 105.","journal-title":"Cell Communication and Signaling: CCS"},{"issue":"16","key":"2203_CR44","doi-asserted-by":"publisher","first-page":"8949","DOI":"10.3390\/ijms25168949","volume":"25","author":"P Tyrna","year":"2024","unstructured":"Tyrna, P., G. Procyk, L. Szeleszczuk, and I. Mlynarczuk-Bialy. 2024. Different strategies to overcome resistance to proteasome inhibitors-A summary 20 years after their introduction. International Journal of Molecular Sciences 25 (16): 8949.","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02203-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-02203-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02203-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T04:23:29Z","timestamp":1757132609000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-02203-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["2203"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-02203-2","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]},"assertion":[{"value":"24 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}