{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:26:32Z","timestamp":1777130792759,"version":"3.51.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"a Grant-in-Aid for Scientific Research (C) of the Japan Society for the Promotion of Science","award":["JP19K07380"],"award-info":[{"award-number":["JP19K07380"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-024-02212-1","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T13:18:12Z","timestamp":1734614292000},"page":"2588-2599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["5-Aminolevulinic Acid (5-ALA) Plays an Important Role in the Function of Innate Immune Cells"],"prefix":"10.1007","volume":"48","author":[{"given":"Shinichi","family":"Saitoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risako","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Asao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"2212_CR1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.pharmthera.2007.02.001","volume":"114","author":"P Krishnamurthy","year":"2007","unstructured":"Krishnamurthy, P., T. Xie, and J. Schuetz. 2007. The role of transporters in cellular heme and porphyrin homeostasis. Pharmacology and Therapeutics 114: 345\u2013358. https:\/\/doi.org\/10.1016\/j.pharmthera.2007.02.001.","journal-title":"Pharmacology and Therapeutics"},{"key":"2212_CR2","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.bbapap.2015.04.019","volume":"1854","author":"Y Lin","year":"2015","unstructured":"Lin, Y. 2015. The broad diversity of heme-protein cross-links: An overview. Biochimica et Biophysica Acta-Proteins and Proteomics 1854: 844\u2013859. https:\/\/doi.org\/10.1016\/j.bbapap.2015.04.019.","journal-title":"Biochimica et Biophysica Acta-Proteins and Proteomics"},{"key":"2212_CR3","doi-asserted-by":"publisher","unstructured":"Zoneff, E., Y. Wang, C. Jackson, O. Smith, S. Duchi, C. Onofrillo, B. Farrugia, S. Moulton, R. Williams, C. Parish, D. Nisbet, and L. Caballero-Aguilar. 2024. Controlled oxygen delivery to power tissue regeneration. Nature Communications 15. https:\/\/doi.org\/10.1038\/s41467-024-48719-x.","DOI":"10.1038\/s41467-024-48719-x"},{"key":"2212_CR4","doi-asserted-by":"publisher","unstructured":"Schr\u00f6der, G., Smit, M., and Opperman, D. 2023. Harnessing heme chemistry: Recent advances in the biocatalytic applications of cytochrome P450 monooxgenases. Current Opinion in Green and Sustainable Chemistry 39. https:\/\/doi.org\/10.1016\/j.cogsc.2022.100734.","DOI":"10.1016\/j.cogsc.2022.100734"},{"key":"2212_CR5","doi-asserted-by":"publisher","unstructured":"Chertkova, R., N. Brazhe, T. Bryantseva, A. Nekrasov, D. Dolgikh, A. Yusipovich, O. Sosnovtseva, G. Maksimov, A. Rubin, and M. Kirpichnikov. 2017. New insight into the mechanism of mitochondrial cytochrome c function. Plos One 12. https:\/\/doi.org\/10.1371\/journal.pone.0178280.","DOI":"10.1371\/journal.pone.0178280"},{"key":"2212_CR6","doi-asserted-by":"publisher","unstructured":"Duvigneau, J., Esterbauer, H., and Kozlov, A. 2019. Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways. Antioxidants 8. https:\/\/doi.org\/10.3390\/antiox8100475.","DOI":"10.3390\/antiox8100475"},{"key":"2212_CR7","doi-asserted-by":"publisher","unstructured":"San-Millan, I. 2023. The Key Role of Mitochondrial Function in Health and Disease. Antioxidants 12. https:\/\/doi.org\/10.3390\/antiox12040782","DOI":"10.3390\/antiox12040782"},{"key":"2212_CR8","doi-asserted-by":"publisher","unstructured":"Poli, A., Schmitt, C., Moulouel, B., Mirmiran, A., Puy, H., Lef\u00e8bvre, T., and Gouya, L. 2021. Iron, Heme Synthesis and Erythropoietic Porphyrias: A Complex Interplay. Metabolites 11. https:\/\/doi.org\/10.3390\/metabo11120798.","DOI":"10.3390\/metabo11120798"},{"key":"2212_CR9","doi-asserted-by":"publisher","first-page":"48410","DOI":"10.1074\/jbc.M108362200","volume":"276","author":"H Atamna","year":"2001","unstructured":"Atamna, H., J. Liu, and B. Ames. 2001. Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts - Relevance to aging. Journal of Biological Chemistry 276: 48410\u201348416. https:\/\/doi.org\/10.1074\/jbc.M108362200.","journal-title":"Journal of Biological Chemistry"},{"key":"2212_CR10","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.14336\/AD.2019.1125","volume":"11","author":"K Wong","year":"2020","unstructured":"Wong, K., J. Roy, M. Fung, B. Heng, C. Zhang, and L. Lim. 2020. Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer\u2019s Disease. Aging and Disease 11: 1291\u20131316. https:\/\/doi.org\/10.14336\/AD.2019.1125.","journal-title":"Aging and Disease"},{"key":"2212_CR11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.pharmthera.2005.10.017","volume":"111","author":"A Tsiftsoglou","year":"2006","unstructured":"Tsiftsoglou, A., A. Tsamadou, and L. Papadopoulou. 2006. Heme as key regulator of major mammalian cellular functions: Molecular, cellular, and pharmacological aspects. Pharmacology and Therapeutics 111: 327\u2013345. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.10.017.","journal-title":"Pharmacology and Therapeutics"},{"key":"2212_CR12","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pdpdt.2014.12.008","volume":"12","author":"K Matsumoto","year":"2015","unstructured":"Matsumoto, K., Y. Hagiya, Y. Endo, M. Nakajima, M. Ishizuka, T. Tanaka, and S. Ogura. 2015. Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia. Photodiagnosis and Photodynamic Therapy 12: 45\u201351. https:\/\/doi.org\/10.1016\/j.pdpdt.2014.12.008.","journal-title":"Photodiagnosis and Photodynamic Therapy"},{"key":"2212_CR13","doi-asserted-by":"publisher","unstructured":"Obi, C., Bhuiyan, T., Dailey, H., and Medlock, A. 2022. Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria. Frontiers in Cell and Developmental Biology 10. https:\/\/doi.org\/10.3389\/fcell.2022.894591.","DOI":"10.3389\/fcell.2022.894591"},{"key":"2212_CR14","doi-asserted-by":"publisher","unstructured":"Kiening, M., and Lange, N. 2022. A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells. International Journal of Molecular Sciences 23(14). https:\/\/doi.org\/10.3390\/ijms23147974.","DOI":"10.3390\/ijms23147974"},{"key":"2212_CR15","doi-asserted-by":"publisher","unstructured":"Kaur, P., Nagar, S., Bhagwat, M., Uddin, M., Zhu, Y., Vancurova, I., and Vancura, A. 2021. Activated heme synthesis regulates glycolysis and oxidative metabolism in breast and ovarian cancer cells. Plos One 16(11). https:\/\/doi.org\/10.1371\/journal.pone.0260400.","DOI":"10.1371\/journal.pone.0260400"},{"key":"2212_CR16","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1210\/er.2009-0027","volume":"31","author":"M Patti","year":"2010","unstructured":"Patti, M., and S. Corvera. 2010. The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes. Endocrine Reviews 31: 364\u2013395. https:\/\/doi.org\/10.1210\/er.2009-0027.","journal-title":"Endocrine Reviews"},{"key":"2212_CR17","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1007\/s40200-020-00679-x","volume":"19","author":"P Prasun","year":"2020","unstructured":"Prasun, P. 2020. Role of mitochondria in pathogenesis of type 2 diabetes mellitus. Journal of Diabetes and Metabolic Disorders 19: 2017\u20132022. https:\/\/doi.org\/10.1007\/s40200-020-00679-x.","journal-title":"Journal of Diabetes and Metabolic Disorders"},{"key":"2212_CR18","doi-asserted-by":"publisher","unstructured":"Al-Saber, F., W. Aldosari, M. Alselaiti, H. Khalfan, A. Kaladari, G. Khan, G. Harb, R. Rehani, S. Kudo, A. Koda, T. Tanaka, M. Nakajima, and A. Darwish. 2016. The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. Journal of Diabetes Research 2016. https:\/\/doi.org\/10.1155\/2016\/8294805.","DOI":"10.1155\/2016\/8294805"},{"issue":"4","key":"2212_CR19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1752-8062.2012.00421.x","volume":"5","author":"BL Rodriguez","year":"2012","unstructured":"Rodriguez, B.L., J.D. Curb, J. Davis, T. Shintani, M.H. Perez, N. Apau-Ludlum, C. Johnson, and R. Harrigan. 2012. Use of the Dietary Supplement 5-Aminiolevulinic Acid (5-ALA) and Its Relationship with Glucose Levels and Hemoglobin A1C among Individuals with Prediabetes. Cts-Clinical and Translational Science 5 (4): 314\u2013320. https:\/\/doi.org\/10.1111\/j.1752-8062.2012.00421.x.","journal-title":"Cts-Clinical and Translational Science"},{"issue":"7\u20138","key":"2212_CR20","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.nut.2013.02.008","volume":"29","author":"F Higashikawa","year":"2013","unstructured":"Higashikawa, F., M. Noda, T. Awaya, T. Tanaka, and M. Sugiyama. 2013. 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects. Nutrition 29 (7\u20138): 1030\u20131036. https:\/\/doi.org\/10.1016\/j.nut.2013.02.008.","journal-title":"Nutrition"},{"issue":"1","key":"2212_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1365-2443.2009.01366.x","volume":"11","author":"S Okano","year":"2010","unstructured":"Okano, S., L.Y. Zhou, T. Kusaka, K. Shibata, K. Shimizu, X. Gao, Y. Kikuchi, Y. Togashi, T. Hosoya, S. Takahashi, O. Nakajima, and M. Yamamoto. 2010. Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse. Genes to Cells 11 (1): 77\u201389. https:\/\/doi.org\/10.1111\/j.1365-2443.2009.01366.x.","journal-title":"Genes to Cells"},{"key":"2212_CR22","doi-asserted-by":"publisher","unstructured":"Saitoh, S., S. Okano, H. Nohara, H. Nakano, N. Shirasawa, A. Naito, M. Yamamoto, V.P. Kelly, K. Takahashi, T. Tanaka, M. Nakajima, and O. Nakajima. 2018. 5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice. Plos One 13(1). https:\/\/doi.org\/10.1371\/journal.pone.0189593.","DOI":"10.1371\/journal.pone.0189593"},{"key":"2212_CR23","doi-asserted-by":"publisher","unstructured":"van Wijk, K., T. Akabane, T. Kimura, S. Saitoh, S. Okano, V.P. Kelly, M. Takagi, K. Kodama, K. Takahashi, T. Tanaka, M. Nakajima, and O. Nakajima. 2021. Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. Archives of Biochemistry and Biophysics 697. https:\/\/doi.org\/10.1016\/j.abb.2020.108721.","DOI":"10.1016\/j.abb.2020.108721"},{"issue":"10","key":"2212_CR24","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1021\/acs.jcim.1c00613","volume":"61","author":"C Gonz\u00e1lez-Fern\u00e1ndez","year":"2021","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez, C., A. Basauri, M. Fallanza, E. Bringas, C. Oostenbrink, and I. Ortiz. 2021. Fighting Against Bacterial Lipopolysaccharide-Caused Infections through Molecular Dynamics Simulations: A Review. Journal of Chemical Information and Modeling 61 (10): 4839\u20134851. https:\/\/doi.org\/10.1021\/acs.jcim.1c00613.","journal-title":"Journal of Chemical Information and Modeling"},{"key":"2212_CR25","doi-asserted-by":"publisher","unstructured":"Vizuete, A.F.K., F. Froes, M. Seady, C. Zanotto, L.D. Bobermin, A.C. Roginski, M. Wajner, A. Quincozes-Santos, and C.A. Goncalves. 2022. Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. Journal of Neuroinflammation 19(1). https:\/\/doi.org\/10.1186\/s12974-022-02612-w.","DOI":"10.1186\/s12974-022-02612-w"},{"issue":"1","key":"2212_CR26","doi-asserted-by":"publisher","first-page":"219","DOI":"10.4161\/viru.25965","volume":"5","author":"AS Cross","year":"2014","unstructured":"Cross, A.S. 2014. Anti-endotoxin vaccines Back to the future. Virulence 5 (1): 219\u2013225. https:\/\/doi.org\/10.4161\/viru.25965.","journal-title":"Virulence"},{"issue":"5","key":"2212_CR27","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","volume":"20","author":"VAK Rathinam","year":"2019","unstructured":"Rathinam, V.A.K., Y. Zhao, and F. Shao. 2019. Innate immunity to intracellular LPS. Nature Immunology 20 (5): 527\u2013533. https:\/\/doi.org\/10.1038\/s41590-019-0368-3.","journal-title":"Nature Immunology"},{"issue":"5","key":"2212_CR28","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1189\/jlb.0910536","volume":"89","author":"MT Silva","year":"2011","unstructured":"Silva, M.T. 2011. Macrophage phagocytosis of neutrophils at inflammatory\/infectious foci: A cooperative mechanism in the control of infection and infectious inflammation. Journal of Leukocyte Biology 89 (5): 675\u2013683. https:\/\/doi.org\/10.1189\/jlb.0910536.","journal-title":"Journal of Leukocyte Biology"},{"issue":"7","key":"2212_CR29","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/ni.2921","volume":"15","author":"WM Nauseef","year":"2014","unstructured":"Nauseef, W.M., and N. Borregaard. 2014. Neutrophils at work. Nature Immunology 15 (7): 602\u2013611. https:\/\/doi.org\/10.1038\/ni.2921.","journal-title":"Nature Immunology"},{"issue":"6","key":"2212_CR30","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.immuni.2015.05.018","volume":"42","author":"J Helft","year":"2015","unstructured":"Helft, J., J. Bottcher, P. Chakravarty, S. Zelenay, J. Huotari, B.U. Schraml, D. Goubau, and C.R.E. Sousa. 2015. GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells. Immunity 42 (6): 1197\u20131211. https:\/\/doi.org\/10.1016\/j.immuni.2015.05.018.","journal-title":"Immunity"},{"issue":"4","key":"2212_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41590-019-0313-5","volume":"20","author":"Z Erlich","year":"2019","unstructured":"Erlich, Z., I. Shlomovitz, L. Edry-Botzer, H. Cohen, D. Frank, H.Q. Wang, A.M. Lew, K.E. Lawlor, Y.F. Zhan, J.E. Vince, and M. Gerlic. 2019. Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model. Nature Immunology 20 (4): 397\u2013406. https:\/\/doi.org\/10.1038\/s41590-019-0313-5.","journal-title":"Nature Immunology"},{"issue":"4","key":"2212_CR32","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1002\/oby.23705","volume":"31","author":"N Kitamura","year":"2023","unstructured":"Kitamura, N., S.Y. Zhang, J.D. Morel, U. Nagano, T. Taworntawat, S. Hosoda, A. Nakamura, Y. Ogawa, G. Benegiamo, J. Auwerx, K. Tsubota, Y. Yokoyama, and M. Watanabe. 2023. Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health. Obesity 31 (4): 1038\u20131049. https:\/\/doi.org\/10.1002\/oby.23705.","journal-title":"Obesity"},{"key":"2212_CR33","doi-asserted-by":"publisher","unstructured":"Jablonski, K. A., Amici, S. A., Webb, L. M., Ruiz-Rosado, J. D., Popovich, P. G., Partida-Sanchez, S., and Guerau-de-Arellano, M. 2015. Novel Markers to Delineate Murine M1 and M2 Macrophages. Plos One 10(12). https:\/\/doi.org\/10.1371\/journal.pone.0145342.","DOI":"10.1371\/journal.pone.0145342"},{"issue":"10","key":"2212_CR34","doi-asserted-by":"publisher","first-page":"734","DOI":"10.14348\/molcells.2016.0160","volume":"39","author":"YR Na","year":"2016","unstructured":"Na, Y.R., D. Jung, G.J. Gu, and S.H. Seok. 2016. GM-CSF Grown Bone Marrow Derived Cells Are Composed of Phenotypically Different Dendritic Cells and Macrophages. Molecules and Cells 39 (10): 734\u2013741. https:\/\/doi.org\/10.14348\/molcells.2016.0160.","journal-title":"Molecules and Cells"},{"issue":"4","key":"2212_CR35","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s00421-012-2504-8","volume":"113","author":"N Psilander","year":"2013","unstructured":"Psilander, N., P. Frank, M. Flockhart, and K. Sahlin. 2013. Exercise with low glycogen increases PGC-1 alpha gene expression in human skeletal muscle. European Journal of Applied Physiology 113 (4): 951\u2013963. https:\/\/doi.org\/10.1007\/s00421-012-2504-8.","journal-title":"European Journal of Applied Physiology"},{"issue":"1","key":"2212_CR36","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/mi.2015.39","volume":"9","author":"F Konrad","year":"2016","unstructured":"Konrad, F., U. Knausberg, R. H\u00f6ne, K. Ngamsri, and J. Reutershan. 2016. Tissue heme oxygenase-1 exerts anti-inflammatory effects on LPS-induced pulmonary inflammation. Mucosal Immunology 9 (1): 98\u2013111. https:\/\/doi.org\/10.1038\/mi.2015.39.","journal-title":"Mucosal Immunology"},{"issue":"9","key":"2212_CR37","doi-asserted-by":"publisher","first-page":"5506","DOI":"10.4049\/jimmunol.1002433","volume":"186","author":"S Sheikh","year":"2011","unstructured":"Sheikh, S., R. Hegazi, T. Kobayashi, J. Onyiah, S. Russo, K. Matsuoka, A. Sepulveda, F. Li, L. Otterbein, and S. Plevy. 2011. An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis. Journal of Immunology 186 (9): 5506\u20135513. https:\/\/doi.org\/10.4049\/jimmunol.1002433.","journal-title":"Journal of Immunology"},{"issue":"4","key":"2212_CR38","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.imbio.2012.05.029","volume":"218","author":"N Lewkowicz","year":"2013","unstructured":"Lewkowicz, N., M. Klink, M. Mycko, and P. Lewkowicz. 2013. Neutrophil-CD4+CD25+ T regulatory cell interactions: A possible new mechanism of infectious tolerance. Immunobiology 218 (4): 455\u2013464. https:\/\/doi.org\/10.1016\/j.imbio.2012.05.029.","journal-title":"Immunobiology"},{"key":"2212_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12865-018-0277-5","volume":"19","author":"Y Sugiyama","year":"2018","unstructured":"Sugiyama, Y., Y. Hiraiwa, Y. Hagiya, M. Nakajima, T. Tanaka, and S. Ogura. 2018. 5-Aminolevulinic acid regulates the immune response in LPS-stimulated RAW 264.7 macrophages. Bmc Immunology 19: 41. https:\/\/doi.org\/10.1186\/s12865-018-0277-5.","journal-title":"Bmc Immunology"},{"issue":"2","key":"2212_CR40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","volume":"19","author":"A Herrero-Cervera","year":"2022","unstructured":"Herrero-Cervera, A., O. Soehnlein, and E. Kenne. 2022. Neutrophils in chronic inflammatory diseases. Cellular and Molecular Immunology 19 (2): 177\u2013191. https:\/\/doi.org\/10.1038\/s41423-021-00832-3.","journal-title":"Cellular and Molecular Immunology"},{"issue":"4","key":"2212_CR41","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s13577-023-00905-7","volume":"36","author":"PY Thimmappa","year":"2023","unstructured":"Thimmappa, P.Y., S. Vasishta, K. Ganesh, A.S. Nair, and M.B. Joshi. 2023. Neutrophil (dys)function due to altered immuno-metabolic axis in type 2 diabetes: Implications in combating infections. Human Cell 36 (4): 1265\u20131282. https:\/\/doi.org\/10.1007\/s13577-023-00905-7.","journal-title":"Human Cell"},{"key":"2212_CR42","doi-asserted-by":"publisher","unstructured":"George, S. T., Lai, J., Ma, J. L., Stacey, H. D., Miller, M. S., and Mullarkey, C. E. 2021. Neutrophils and Influenza: A Thin Line between Helpful and Harmful. Vaccines 9(6). https:\/\/doi.org\/10.3390\/vaccines9060597.","DOI":"10.3390\/vaccines9060597"},{"key":"2212_CR43","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/dme.13205","volume":"34","author":"J Hine","year":"2017","unstructured":"Hine, J., S. de Lusignan, D. Burleigh, S. Pathirannehelage, A. McGovern, P. Gatenby, S. Jones, D. Jiang, J. Williams, A. Elliot, G. Smith, J. Brownrigg, R. Hinchliffe, and N. Munro. 2017. Association between glycaemic control and common infections in people with Type 2 diabetes: A cohort study. Diabetic Medicine 34: 551\u2013557. https:\/\/doi.org\/10.1111\/dme.13205.","journal-title":"Diabetic Medicine"},{"key":"2212_CR44","doi-asserted-by":"publisher","unstructured":"Paudel, S., John, P., Poorbaghi, S., Randis, T., and Kulkarni, R. 2022. Systematic Review of Literature Examining Bacterial Urinary Tract Infections in Diabetes. Journal of Diabetes Research 2022. https:\/\/doi.org\/10.1155\/2022\/3588297.","DOI":"10.1155\/2022\/3588297"},{"key":"2212_CR45","doi-asserted-by":"publisher","unstructured":"Al-Sayyar, A., Hulme, K., Thibaut, R., Bayry, J., Sheedy, F., Short, K., and Alzaid, F. 2022. Respiratory Tract Infections in Diabetes - Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity. Frontiers in Endocrinology 13. https:\/\/doi.org\/10.3389\/fendo.2022.919223.","DOI":"10.3389\/fendo.2022.919223"},{"key":"2212_CR46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tem.2007.10.004","volume":"19","author":"J Fern\u00e1ndez-Real","year":"2008","unstructured":"Fern\u00e1ndez-Real, J., and J. Pickup. 2008. Innate immunity, insulin resistance and type 2 diabetes. Trends in Endocrinology and Metabolism 19: 10\u201316. https:\/\/doi.org\/10.1016\/j.tem.2007.10.004.","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"2212_CR47","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.tem.2018.04.008","volume":"29","author":"J Ratter","year":"2018","unstructured":"Ratter, J., C. Tack, M. Netea, and R. Stienstra. 2018. Environmental Signals Influencing Myeloid Cell Metabolism and Function in Diabetes. Trends in Endocrinology and Metabolism 29: 468\u2013480. https:\/\/doi.org\/10.1016\/j.tem.2018.04.008.","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"6554","key":"2212_CR48","doi-asserted-by":"publisher","first-page":"eabd2893","DOI":"10.1126\/science.abd2893","volume":"373","author":"R Choa","year":"2021","unstructured":"Choa, R., J. Tohyama, S. Wada, H. Meng, J. Hu, M. Okumura, R.M. May, T.F. Robertson, R.A.L. Pai, A. Nace, C. Hopkins, E.A. Jacobsen, M. Haldar, G.A. FitzGerald, E.M. Behrens, A.J. Minn, P. Seale, G. Cotsarelis, B. Kim, J.T. Seykora, M.Y. Li, Z. Arany, and T. Kambayashi. 2021. Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Science 373 (6554): eabd2893. https:\/\/doi.org\/10.1126\/science.abd2893.","journal-title":"Science"},{"issue":"6627","key":"2212_CR49","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1126\/science.abj8894","volume":"379","author":"M Hata","year":"2023","unstructured":"Hata, M., E. Andriessen, R. Diaz-Marin, F. Fournier, S. Crespo-Garcia, G. Blot, R. Juneau, F. Pilon, A. Dejda, V. Guber, E. Heckel, C. Daneault, V. Calderon, C. Des Rosiers, H.J. Melichar, T. Langmann, J.S. Joyal, A.M. Wilson, and P. Sapieha. 2023. Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation. Science 379 (6627): 45\u201361. https:\/\/doi.org\/10.1126\/science.abj8894.","journal-title":"Science"},{"key":"2212_CR50","doi-asserted-by":"publisher","unstructured":"Antar, S., N. Ashour, M. Sharaky, M. Khattab, N. Ashour, R. Zaid, E. Roh, A. Elkamhawy, and A. Al-Karmalawy. 2023. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomedicine and Pharmacotherapy 168. https:\/\/doi.org\/10.1016\/j.biopha.2023.115734.","DOI":"10.1016\/j.biopha.2023.115734"},{"issue":"8","key":"2212_CR51","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1210\/en.2011-1031","volume":"152","author":"P Fischer-Posovszky","year":"2011","unstructured":"Fischer-Posovszky, P., Q.A. Wang, I.W. Asterholm, J.M. Rutkowski, and P.E. Scherer. 2011. Targeted Deletion of Adipocytes by Apoptosis Leads to Adipose Tissue Recruitment of Alternatively Activated M2 Macrophages. Endocrinology 152 (8): 3074\u20133081. https:\/\/doi.org\/10.1210\/en.2011-1031.","journal-title":"Endocrinology"},{"issue":"3","key":"2212_CR52","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cmet.2013.08.003","volume":"18","author":"YH Lee","year":"2013","unstructured":"Lee, Y.H., A.P. Petkova, and J.G. Granneman. 2013. Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration. Cell Metabolism 18 (3): 355\u2013367. https:\/\/doi.org\/10.1016\/j.cmet.2013.08.003.","journal-title":"Cell Metabolism"},{"issue":"19","key":"2212_CR53","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1016\/j.cell.2022.08.005","volume":"185","author":"Y Kawano","year":"2022","unstructured":"Kawano, Y., M. Edwards, Y.M. Huang, A.M. Bilate, L.P. Araujo, T. Tanoue, K. Atarashi, M.S. Ladinsky, S.L. Reiner, H.H. Wang, D. Mucida, K. Honda, and I.I. Ivanov. 2022. Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome. Cell 185 (19): 3501\u20133519. https:\/\/doi.org\/10.1016\/j.cell.2022.08.005.","journal-title":"Cell"},{"key":"2212_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/SHK.0b013e3181e7e61b","volume":"34","author":"JC Alves","year":"2010","unstructured":"Alves, J.C., F. Spiller, and F.Q. Cunha. 2010. Neutrophil paralysis in sepsis. Shock 34: 15\u201321. https:\/\/doi.org\/10.1097\/SHK.0b013e3181e7e61b.","journal-title":"Shock"},{"issue":"6","key":"2212_CR55","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nri.2016.49","volume":"16","author":"S de Oliveira","year":"2016","unstructured":"de Oliveira, S., E.E. Rosowski, and A. Huttenlocher. 2016. Neutrophil migration in infection and wound repair: Going forward in reverse. Nature Reviews Immunology 16 (6): 378\u2013391. https:\/\/doi.org\/10.1038\/nri.2016.49.","journal-title":"Nature Reviews Immunology"},{"issue":"4","key":"2212_CR56","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41590-023-01452-x","volume":"24","author":"M Palomino-Segura","year":"2023","unstructured":"Palomino-Segura, M., J. Sicilia, I. Ballesteros, and A. Hidalgo. 2023. Strategies of neutrophil diversification. Nature Immunology 24 (4): 575\u2013584. https:\/\/doi.org\/10.1038\/s41590-023-01452-x.","journal-title":"Nature Immunology"},{"issue":"4","key":"2212_CR57","doi-asserted-by":"publisher","first-page":"L738","DOI":"10.1152\/ajplung.00045.2009","volume":"297","author":"SP Kantrow","year":"2009","unstructured":"Kantrow, S.P., Z.W. Shen, T. Jagneaux, P. Zhang, and S. Nelson. 2009. Neutrophil-mediated lung permeability and host defense proteins. American Journal of Physiology-Lung Cellular and Molecular Physiology 297 (4): L738\u2013L745. https:\/\/doi.org\/10.1152\/ajplung.00045.2009.","journal-title":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},{"issue":"22","key":"2212_CR58","doi-asserted-by":"publisher","first-page":"12281","DOI":"10.1073\/pnas.1918508117\/-\/DCSupplemental","volume":"117","author":"I Santos","year":"2020","unstructured":"Santos, I., H.G. Cola\u00e7o, A. Neves-Costaa, E. Seixas, T.R. Velho, D. Pedroso, A. Barros, R. Martins, N. Carvalho, D. Payen, S. Weis, H.S. Yi, M. Shong, and L.F. Moita. 2020. CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis. Proceedings of the National Academy of Sciences of the United States of America 117 (22): 12281\u201312287. https:\/\/doi.org\/10.1073\/pnas.1918508117\/-\/DCSupplemental.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"26","key":"2212_CR59","doi-asserted-by":"publisher","first-page":"6764","DOI":"10.1073\/pnas.1702293114","volume":"114","author":"F Magnani","year":"2017","unstructured":"Magnani, F., S. Nenci, E.M. Fananas, M. Ceccon, E. Romero, M.W. Fraaije, and A. Mattevi. 2017. Crystal structures and atomic model of NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America 114 (26): 6764\u20136769. https:\/\/doi.org\/10.1073\/pnas.1702293114.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2212_CR60","doi-asserted-by":"publisher","unstructured":"Lopes, L.G.D., F.S. Gouveia, A.K.M. Holanda, I.M.M. de Carvalho, E. Longhinotti, T.F. Paulo, D.S. Abreu, P.V. Bernhardt, M.A. Gilles-Gonzalez, I.C.N. Diogenes, and E.H.S. Sousa. 2021. Bioinorganic systems responsive to the diatomic gases O-2, NO, and CO: From biological sensors to therapy. Coordination Chemistry Reviews 445. https:\/\/doi.org\/10.1016\/j.ccr.2021.214096.","DOI":"10.1016\/j.ccr.2021.214096"},{"issue":"24","key":"2212_CR61","doi-asserted-by":"publisher","first-page":"23328","DOI":"10.1074\/jbc.M414548200","volume":"280","author":"N Ueno","year":"2005","unstructured":"Ueno, N., R. Takeya, K. Miyano, H. Kikuchi, and H. Sumimoto. 2005. The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner. Journal of Biological Chemistry 280 (24): 23328\u201323339. https:\/\/doi.org\/10.1074\/jbc.M414548200.","journal-title":"Journal of Biological Chemistry"},{"issue":"13","key":"2212_CR62","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1111\/j.1742-4658.2008.06488.x","volume":"275","author":"H Sumimoto","year":"2008","unstructured":"Sumimoto, H. 2008. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. Febs Journal 275 (13): 3249\u20133277. https:\/\/doi.org\/10.1111\/j.1742-4658.2008.06488.x.","journal-title":"Febs Journal"},{"key":"2212_CR63","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.sbi.2019.03.001","volume":"59","author":"F Magnani","year":"2019","unstructured":"Magnani, F., and A. Mattevi. 2019. Structure and mechanisms of ROS generation by NADPH oxidases. Current Opinion in Structural Biology 59: 91\u201397. https:\/\/doi.org\/10.1016\/j.sbi.2019.03.001.","journal-title":"Current Opinion in Structural Biology"},{"issue":"1","key":"2212_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1620\/tjem.213.1","volume":"213","author":"K Furuyama","year":"2007","unstructured":"Furuyama, K., K. Kaneko, and P.D. Vargas. 2007. Heme as a magnificent molecule with multiple missions: Heme determines its own fate and governs cellular homeostasis. Tohoku Journal of Experimental Medicine 213 (1): 1\u201316. https:\/\/doi.org\/10.1620\/tjem.213.1.","journal-title":"Tohoku Journal of Experimental Medicine"},{"issue":"1\u20132","key":"2212_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.gene.2010.10.008","volume":"472","author":"S Gotoh","year":"2011","unstructured":"Gotoh, S., T. Nakamura, T. Kataoka, and S. Taketani. 2011. Egr-1 regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme. Gene 472 (1\u20132): 28\u201336. https:\/\/doi.org\/10.1016\/j.gene.2010.10.008.","journal-title":"Gene"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02212-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-024-02212-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-024-02212-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T02:21:40Z","timestamp":1754878900000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-024-02212-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["2212"],"URL":"https:\/\/doi.org\/10.1007\/s10753-024-02212-1","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"26 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal studies were conducted in accordance with The Regulation of Animal Experiments in Yamagata University and approved by The Institutional Animal Care and Use Committee of Yamagata University (license no. R5019).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}