{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:54:21Z","timestamp":1790996061826,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471276"],"award-info":[{"award-number":["82471276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Projec","award":["TJYXZDXK-060B"],"award-info":[{"award-number":["TJYXZDXK-060B"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-025-02267-8","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T14:52:14Z","timestamp":1740581534000},"page":"3314-3325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["FDA-Approved Secukinumab Alleviates Glial Activation and Immune Cell Infiltration in MPTP-Induced Mouse Model of Parkinson\u2019s Disease"],"prefix":"10.1007","volume":"48","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipeng","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"6","key":"2267_CR1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","volume":"5","author":"LML de Lau","year":"2006","unstructured":"de Lau, L.M.L., and M.M.B. Breteler. 2006. Epidemiology of Parkinson\u2019s disease. Lancet Neurology 5 (6): 525\u2013535. https:\/\/doi.org\/10.1016\/S1474-4422(06)70471-9.","journal-title":"Lancet Neurology"},{"issue":"1","key":"2267_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cger.2019.08.002","volume":"36","author":"DK Simon","year":"2020","unstructured":"Simon, D.K., C.M. Tanner, and P. Brundin. 2020. Parkinson disease epidemiology, pathology, genetics, and pathophysiology. Clinics in Geriatric Medicine 36 (1): 1\u201312. https:\/\/doi.org\/10.1016\/j.cger.2019.08.002.","journal-title":"Clinics in Geriatric Medicine"},{"issue":"9996","key":"2267_CR3","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia, L.V., and A.E. Lang. 2015. Parkinson\u2019s disease. Lancet 386 (9996): 896\u2013912. https:\/\/doi.org\/10.1016\/S0140-6736(14)61393-3.","journal-title":"Lancet"},{"issue":"7","key":"2267_CR4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrn.2017.62","volume":"18","author":"AHV Schapira","year":"2017","unstructured":"Schapira, A.H.V., K.R. Chaudhuri, and P. Jenner. 2017. Non-motor features of Parkinson disease. Nature Reviews Neuroscience 18 (7): 435\u2013450. https:\/\/doi.org\/10.1038\/nrn.2017.62.","journal-title":"Nature Reviews Neuroscience"},{"issue":"s1","key":"2267_CR5","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.3233\/JPD-179006","volume":"7","author":"JW Langston","year":"2017","unstructured":"Langston, J.W. 2017. The MPTP Story. Journal of Parkinson\u2019s Disease 7 (s1): S11\u2013S19. https:\/\/doi.org\/10.3233\/JPD-179006.","journal-title":"Journal of Parkinson's Disease"},{"issue":"7","key":"2267_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nri2800","volume":"10","author":"DJ Cua","year":"2010","unstructured":"Cua, D.J., and C.M. Tato. 2010. Innate IL-17-producing cells: The sentinels of the immune system. Nature Reviews Immunology 10 (7): 479\u2013489. https:\/\/doi.org\/10.1038\/nri2800.","journal-title":"Nature Reviews Immunology"},{"issue":"4","key":"2267_CR7","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3233\/JPD-191699","volume":"9","author":"HF Green","year":"2019","unstructured":"Green, H.F., S. Khosousi, and P. Svenningsson. 2019. Plasma IL-6 and IL-17A correlate with severity of motor and non-motor symptoms in Parkinson\u2019s disease. Journal of Parkinson\u2019s Disease 9 (4): 705\u2013709. https:\/\/doi.org\/10.3233\/JPD-191699.","journal-title":"Journal of Parkinson\u2019s Disease"},{"issue":"4","key":"2267_CR8","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","volume":"50","author":"MJ McGeachy","year":"2019","unstructured":"McGeachy, M.J., D.J. Cua, and S.L. Gaffen. 2019. The IL-17 family of cytokines in health and disease. Immunity 50 (4): 892\u2013906. https:\/\/doi.org\/10.1016\/j.immuni.2019.03.021.","journal-title":"Immunity"},{"issue":"Pt B","key":"2267_CR9","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.pnpbp.2017.07.023","volume":"79","author":"F Tahmasebinia","year":"2017","unstructured":"Tahmasebinia, F., and A. Pourgholaminejad. 2017. The role of Th17 cells in auto-inflammatory neurological disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 79 (Pt B): 408\u2013416. https:\/\/doi.org\/10.1016\/j.pnpbp.2017.07.023.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"5","key":"2267_CR10","doi-asserted-by":"publisher","first-page":"e1036","DOI":"10.1212\/NXI.0000000000001036","volume":"8","author":"Z Yan","year":"2021","unstructured":"Yan, Z., W. Yang, H. Wei, et al. 2021. Dysregulation of the adaptive immune system in patients with early-stage Parkinson disease. Neuroimmunology & Neuroinflammation 8 (5): e1036. https:\/\/doi.org\/10.1212\/NXI.0000000000001036.","journal-title":"Neuroimmunology & Neuroinflammation"},{"issue":"1","key":"2267_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.stem.2018.06.015","volume":"23","author":"A Sommer","year":"2018","unstructured":"Sommer, A., F. Marxreiter, F. Krach, et al. 2018. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson\u2019s disease. Cell Stem Cell 23 (1): 123-131.e6. https:\/\/doi.org\/10.1016\/j.stem.2018.06.015.","journal-title":"Cell Stem Cell"},{"key":"2267_CR12","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","volume":"81","author":"Z Liu","year":"2019","unstructured":"Liu, Z., A.W. Qiu, Y. Huang, et al. 2019. IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson\u2019s disease. Brain, Behavior, and Immunity 81: 630\u2013645. https:\/\/doi.org\/10.1016\/j.bbi.2019.07.026.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"6569","key":"2267_CR13","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1126\/science.abf7266","volume":"374","author":"D Gate","year":"2021","unstructured":"Gate, D., E. Tapp, O. Leventhal, et al. 2021. CD4+ T cells contribute to neurodegeneration in Lewy body dementia. Science 374 (6569): 868\u2013874. https:\/\/doi.org\/10.1126\/science.abf7266.","journal-title":"Science"},{"issue":"26","key":"2267_CR14","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1056\/NEJMoa1505066","volume":"373","author":"D Baeten","year":"2015","unstructured":"Baeten, D., J. Sieper, J. Braun, et al. 2015. Secukinumab, an Interleukin-17A Inhibitor Ankylosing Spondylitis. New England Journal of Medicine 373 (26): 2534\u20132548. https:\/\/doi.org\/10.1056\/NEJMoa1505066.","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"2267_CR15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/2040622317738910","volume":"9","author":"J Frieder","year":"2018","unstructured":"Frieder, J., D. Kivelevitch, and A. Menter. 2018. Secukinumab: A review of the anti-IL-17A biologic for the treatment of psoriasis. Therapeutic Advances in Chronic Disease 9 (1): 5\u201321. https:\/\/doi.org\/10.1177\/2040622317738910.","journal-title":"Therapeutic Advances in Chronic Disease"},{"issue":"8","key":"2267_CR16","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1007\/s12035-020-01972-9","volume":"57","author":"AES Abdel-Maged","year":"2020","unstructured":"Abdel-Maged, A.E.S., A.M. Gad, L.A. Rashed, S.S. Azab, E.A. Mohamed, and A.S. Awad. 2020. Repurposing of secukinumab as neuroprotective in cuprizone-induced multiple sclerosis experimental model via inhibition of oxidative, inflammatory, and neurodegenerative signaling. Molecular Neurobiology 57 (8): 3291\u20133306. https:\/\/doi.org\/10.1007\/s12035-020-01972-9.","journal-title":"Molecular Neurobiology"},{"issue":"10","key":"2267_CR17","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1111\/cns.13144","volume":"25","author":"SP Liu","year":"2019","unstructured":"Liu, S.P., L. Huang, J. Flores, et al. 2019. Secukinumab attenuates reactive astrogliosis via IL-17RA\/(C\/EBP\u03b2)\/SIRT1 pathway in a rat model of germinal matrix hemorrhage. CNS Neuroscience & Therapeutics 25 (10): 1151\u20131161. https:\/\/doi.org\/10.1111\/cns.13144.","journal-title":"CNS Neuroscience & Therapeutics"},{"key":"2267_CR18","doi-asserted-by":"publisher","first-page":"109571","DOI":"10.1016\/j.intimp.2022.109571","volume":"114","author":"YT Mohamed","year":"2023","unstructured":"Mohamed, Y.T., A. Salama, M.A. Rabie, and M.A. Abd El Fattah. 2023. Neuroprotective effect of secukinumab against rotenone induced Parkinson\u2019s disease in rat model: Involvement of IL-17, HMGB-1\/TLR4 axis and BDNF\/TrKB cascade. International Immunopharmacology 114: 109571. https:\/\/doi.org\/10.1016\/j.intimp.2022.109571.","journal-title":"International Immunopharmacology"},{"key":"2267_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.yfrne.2017.09.002","volume":"50","author":"JC Jurado-Coronel","year":"2018","unstructured":"Jurado-Coronel, J.C., R. Cabezas, M.F. \u00c1vila Rodr\u00edguez, V. Echeverria, L.M. Garc\u00eda-Segura, and G.E. Barreto. 2018. Sex differences in Parkinson\u2019s disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics. Frontiers in Neuroendocrinology 50: 18\u201330. https:\/\/doi.org\/10.1016\/j.yfrne.2017.09.002.","journal-title":"Frontiers in Neuroendocrinology"},{"key":"2267_CR20","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbi.2021.08.220","volume":"98","author":"Z Liu","year":"2021","unstructured":"Liu, Z., X.R. Zhai, Z.S. Du, et al. 2021. Dopamine receptor D2 on CD4+ T cells is protective against neuroinflammation and neurodegeneration in a mouse model of Parkinson\u2019s disease. Brain, Behavior, and Immunity 98: 110\u2013121. https:\/\/doi.org\/10.1016\/j.bbi.2021.08.220.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"1","key":"2267_CR21","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1096\/fj.201600751R","volume":"31","author":"P Zhao","year":"2017","unstructured":"Zhao, P., X. Yang, L. Yang, et al. 2017. Neuroprotective effects of fingolimod in mouse models of Parkinson\u2019s disease. The FASEB Journal 31 (1): 172\u2013179. https:\/\/doi.org\/10.1096\/fj.201600751R.","journal-title":"The FASEB Journal"},{"issue":"18","key":"2267_CR22","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1182\/blood-2012-02-412726","volume":"120","author":"M Gelderblom","year":"2012","unstructured":"Gelderblom, M., A. Weymar, C. Bernreuther, et al. 2012. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood 120 (18): 3793\u20133802. https:\/\/doi.org\/10.1182\/blood-2012-02-412726.","journal-title":"Blood"},{"issue":"2","key":"2267_CR23","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.cyto.2013.07.022","volume":"64","author":"C Gu","year":"2013","unstructured":"Gu, C., L. Wu, and X. Li. 2013. IL-17 family: Cytokines, receptors and signaling. Cytokine 64 (2): 477\u2013485. https:\/\/doi.org\/10.1016\/j.cyto.2013.07.022.","journal-title":"Cytokine"},{"issue":"3","key":"2267_CR24","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.immuni.2010.03.004","volume":"32","author":"Z Kang","year":"2010","unstructured":"Kang, Z., C.Z. Altuntas, M.F. Gulen, et al. 2010. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 32 (3): 414\u2013425. https:\/\/doi.org\/10.1016\/j.immuni.2010.03.004.","journal-title":"Immunity"},{"issue":"13","key":"2267_CR25","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.3390\/ijms23137267","volume":"23","author":"RJ Ward","year":"2022","unstructured":"Ward, R.J., D.T. Dexter, and R.R. Crichton. 2022. Iron, Neuroinflammation and Neurodegeneration. International Journal of Molecular Sciences 23 (13): 7267. https:\/\/doi.org\/10.3390\/ijms23137267.","journal-title":"International Journal of Molecular Sciences"},{"key":"2267_CR26","doi-asserted-by":"publisher","first-page":"872134","DOI":"10.3389\/fnagi.2022.872134","volume":"14","author":"X Zang","year":"2022","unstructured":"Zang, X., S. Chen, J. Zhu, J. Ma, and Y. Zhai. 2022. The emerging role of central and peripheral immune systems in neurodegenerative diseases. Frontiers in Aging Neuroscience 14: 872134. https:\/\/doi.org\/10.3389\/fnagi.2022.872134.","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"2267_CR27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s12974-019-1636-8","volume":"16","author":"RH Earls","year":"2019","unstructured":"Earls, R.H., K.B. Menees, J. Chung, et al. 2019. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. Journal of Neuroinflammation 16 (1): 250. https:\/\/doi.org\/10.1186\/s12974-019-1636-8.","journal-title":"Journal of Neuroinflammation"},{"issue":"1","key":"2267_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s40478-017-0494-9","volume":"5","author":"AS Harms","year":"2017","unstructured":"Harms, A.S., V. Delic, A.D. Thome, et al. 2017. \u03b1-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. Acta Neuropathologica Communications 5 (1): 85. https:\/\/doi.org\/10.1186\/s40478-017-0494-9.","journal-title":"Acta Neuropathologica Communications"},{"issue":"10","key":"2267_CR29","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.it.2015.08.006","volume":"36","author":"A Louveau","year":"2015","unstructured":"Louveau, A., T.H. Harris, and J. Kipnis. 2015. Revisiting the mechanisms of CNS immune privilege. Trends in Immunology 36 (10): 569\u2013577. https:\/\/doi.org\/10.1016\/j.it.2015.08.006.","journal-title":"Trends in Immunology"},{"key":"2267_CR30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fneur.2019.00013","volume":"10","author":"E Storelli","year":"2019","unstructured":"Storelli, E., N. Cassina, E. Rasini, F. Marino, and M. Cosentino. 2019. Do Th17 lymphocytes and IL-17 contribute to Parkinson\u2019s disease? A systematic review of available evidence. Frontiers in Neurology 10: 13. https:\/\/doi.org\/10.3389\/fneur.2019.00013.","journal-title":"Frontiers in Neurology"},{"key":"2267_CR31","doi-asserted-by":"publisher","first-page":"154357","DOI":"10.1016\/j.phymed.2022.154357","volume":"105","author":"Y Wu","year":"2022","unstructured":"Wu, Y., H. Liu, Y. Wang, et al. 2022. DiHuangYin decoction protects dopaminergic neurons in a Parkinson\u2019s disease model by alleviating peripheral inflammation. Phytomedicine 105: 154357. https:\/\/doi.org\/10.1016\/j.phymed.2022.154357.","journal-title":"Phytomedicine"},{"issue":"2","key":"2267_CR32","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/cas.14267","volume":"111","author":"Y Fukuda","year":"2020","unstructured":"Fukuda, Y., T. Asaoka, H. Eguchi, et al. 2020. Endogenous CXCL9 affects prognosis by regulating tumor-infiltrating natural killer cells in intrahepatic cholangiocarcinoma. Cancer Science 111 (2): 323\u2013333. https:\/\/doi.org\/10.1111\/cas.14267.","journal-title":"Cancer Science"},{"issue":"13","key":"2267_CR33","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1096\/fasebj.8.13.7926371","volume":"8","author":"P Loetscher","year":"1994","unstructured":"Loetscher, P., M. Seitz, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1994. Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes. The FASEB Journal 8 (13): 1055\u20131060. https:\/\/doi.org\/10.1096\/fasebj.8.13.7926371.","journal-title":"The FASEB Journal"},{"issue":"1","key":"2267_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12974-017-0830-9","volume":"14","author":"VR Parillaud","year":"2017","unstructured":"Parillaud, V.R., G. Lornet, Y. Monnet, et al. 2017. Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes. Journal of Neuroinflammation 14 (1): 60. https:\/\/doi.org\/10.1186\/s12974-017-0830-9.","journal-title":"Journal of Neuroinflammation"},{"issue":"6","key":"2267_CR35","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1073\/pnas.86.6.1850","volume":"86","author":"EA Robinson","year":"1989","unstructured":"Robinson, E.A., T. Yoshimura, E.J. Leonard, et al. 1989. Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reactions. Proceedings of the National Academy of Sciences USA 86 (6): 1850\u20131854. https:\/\/doi.org\/10.1073\/pnas.86.6.1850.","journal-title":"Proceedings of the National Academy of Sciences USA"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02267-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-025-02267-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02267-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:15:27Z","timestamp":1762881327000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-025-02267-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["2267"],"URL":"https:\/\/doi.org\/10.1007\/s10753-025-02267-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5315653\/v1","asserted-by":"object"}]},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"23 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}