{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:41:49Z","timestamp":1791906109446,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401435"],"award-info":[{"award-number":["82401435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101351"],"award-info":[{"award-number":["82101351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Municipal Science and Technology Plan Project","award":["22JCQNJC01050"],"award-info":[{"award-number":["22JCQNJC01050"]}]},{"name":"Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2022KJ226"],"award-info":[{"award-number":["2022KJ226"]}]},{"name":"Pioneer Incubation Fund","award":["GWRX-2023-6"],"award-info":[{"award-number":["GWRX-2023-6"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-025-02287-4","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T23:47:01Z","timestamp":1741996021000},"page":"3606-3617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Microglial Annexin A3 Downregulation Alleviates Ischemic Injury by Inhibiting NF-\u03baB\/NLRP3-mediated Inflammation"],"prefix":"10.1007","volume":"48","author":[{"given":"Zengli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"2287_CR1","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1001\/jama.2022.1420","volume":"327","author":"K Walter","year":"2022","unstructured":"Walter, K. 2022. What Is Acute Ischemic Stroke? JAMA 327: 885.","journal-title":"JAMA"},{"key":"2287_CR2","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1001\/jamacardio.2021.3702","volume":"6","author":"DE Singer","year":"2021","unstructured":"Singer, D.E., P.D. Ziegler, J.L. Koehler, S. Sarkar, and R.S. Passman. 2021. Temporal association between episodes of atrial fibrillation and risk of ischemic stroke. JAMA Cardiology 6: 1364\u20131369.","journal-title":"JAMA Cardiology"},{"key":"2287_CR3","doi-asserted-by":"publisher","first-page":"107848","DOI":"10.1016\/j.pharmthera.2021.107848","volume":"225","author":"A Ajoolabady","year":"2021","unstructured":"Ajoolabady, A., S. Wang, G. Kroemer, J.M. Penninger, V.N. Uversky, D. Pratico, N. Henninger, R.J. Reiter, A. Bruno, K. Joshipura, H. Aslkhodapasandhokmabad, D.J. Klionsky, and J. Ren. 2021. Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics. Pharmacology & Therapeutics 225: 107848.","journal-title":"Pharmacology & Therapeutics"},{"key":"2287_CR4","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1001\/jama.2021.13827","volume":"326","author":"B Lapergue","year":"2021","unstructured":"Lapergue, B., R. Blanc, V. Costalat, H. Desal, S. Saleme, L. Spelle, G. Marnat, E. Shotar, F. Eugene, M. Mazighi, E. Houdart, A. Consoli, G. Rodesch, R. Bourcier, S. Bracard, A. Duhamel, M. Ben Maacha, D. Lopez, N. Renaud, J. Labreuche, B. Gory, and M. Piotin. 2021. Effect of thrombectomy with combined contact aspiration and stent retriever vs stent retriever alone on revascularization in patients with acute ischemic stroke and large vessel occlusion: The ASTER2 randomized clinical trial. JAMA 326: 1158\u20131169.","journal-title":"JAMA"},{"key":"2287_CR5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","volume":"15","author":"\u00c1 Chamorro","year":"2016","unstructured":"Chamorro, \u00c1., U. Dirnagl, X. Urra, and A.M. Planas. 2016. Neuroprotection in acute stroke: Targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurology 15: 869\u2013881.","journal-title":"Lancet Neurology"},{"key":"2287_CR6","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1172\/JCI135530","volume":"130","author":"C Iadecola","year":"2020","unstructured":"Iadecola, C., M.S. Buckwalter, and J. Anrather. 2020. Immune responses to stroke: Mechanisms, modulation, and therapeutic potential. The Journal of Clinical Investigation 130: 2777\u20132788.","journal-title":"The Journal of Clinical Investigation"},{"key":"2287_CR7","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1161\/CIRCRESAHA.121.319994","volume":"130","author":"M Endres","year":"2022","unstructured":"Endres, M., M.A. Moro, C.H. Nolte, C. Dames, M.S. Buckwalter, and A. Meisel. 2022. Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke. Circulation Research 130: 1167\u20131186.","journal-title":"Circulation Research"},{"key":"2287_CR8","doi-asserted-by":"publisher","first-page":"16076","DOI":"10.1021\/acsnano.1c04753","volume":"15","author":"J Yuan","year":"2021","unstructured":"Yuan, J., L. Li, Q. Yang, H. Ran, J. Wang, K. Hu, W. Pu, J. Huang, L. Wen, L. Zhou, Y. Jiang, X. Xiong, J. Zhang, and Z. Zhou. 2021. Targeted treatment of ischemic stroke by bioactive nanoparticle-derived reactive oxygen species responsive and inflammation-resolving nanotherapies. ACS Nano 15: 16076\u201316094.","journal-title":"ACS Nano"},{"key":"2287_CR9","first-page":"eadi8343","volume":"9","author":"J Wu","year":"2023","unstructured":"Wu, J., Y. Han, H. Xu, H. Sun, R. Wang, H. Ren, and G. Wang. 2023. Deficient chaperone-mediated autophagy facilitates LPS-induced microglial activation via regulation of the p300\/NF-\u03baB\/NLRP3 pathway. Sciences Advances 9: eadi8343.","journal-title":"Sciences Advances"},{"key":"2287_CR10","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1038\/s41467-022-29552-6","volume":"13","author":"C Wang","year":"2022","unstructured":"Wang, C., L. Fan, R.R. Khawaja, B. Liu, L. Zhan, L. Kodama, M. Chin, Y. Li, D. Le, Y. Zhou, C. Condello, L.T. Grinberg, W.W. Seeley, B.L. Miller, S.A. Mok, J.E. Gestwicki, A.M. Cuervo, W. Luo, and L. Gan. 2022. Microglial NF-\u03baB drives tau spreading and toxicity in a mouse model of tauopathy. Nature Communications 13: 1969.","journal-title":"Nature Communications"},{"key":"2287_CR11","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","volume":"11","author":"I Choi","year":"2020","unstructured":"Choi, I., Y. Zhang, S.P. Seegobin, M. Pruvost, Q. Wang, K. Purtell, B. Zhang, and Z. Yue. 2020. Microglia clear neuron-released \u03b1-synuclein via selective autophagy and prevent neurodegeneration. Nature Communications 11: 1386.","journal-title":"Nature Communications"},{"key":"2287_CR12","doi-asserted-by":"publisher","first-page":"1552127","DOI":"10.1155\/2021\/1552127","volume":"2021","author":"Y Ran","year":"2021","unstructured":"Ran, Y., W. Su, F. Gao, Z. Ding, S. Yang, L. Ye, X. Chen, G. Tian, J. Xi, and Z. Liu. 2021. Curcumin ameliorates white matter injury after ischemic stroke by inhibiting microglia\/macrophage pyroptosis through NF-\u03baB Suppression and NLRP3 inflammasome inhibition. Oxidative Medicine and Cellular Longevity 2021: 1552127.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"2287_CR13","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3389\/fncel.2019.00553","volume":"13","author":"Y Ye","year":"2019","unstructured":"Ye, Y., T. Jin, X. Zhang, Z. Zeng, B. Ye, J. Wang, Y. Zhong, X. Xiong, and L. Gu. 2019. Meisoindigo protects against focal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia\/macrophage polarization via TLR4\/NF-\u03baB signaling pathway. Frontiers in Cellular Neuroscience 13: 553.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"2287_CR14","doi-asserted-by":"publisher","first-page":"mjac077","DOI":"10.1093\/jmcb\/mjac077","volume":"14","author":"K Xue","year":"2023","unstructured":"Xue, K., M. Qi, T. She, Z. Jiang, Y. Zhang, X. Wang, G. Wang, L. Xu, B. Peng, J. Liu, X. Song, Y. Yuan, and X. Li. 2023. Argon mitigates post-stroke neuroinflammation by regulating M1\/M2 polarization and inhibiting NF-\u03baB\/NLRP3 inflammasome signaling. Journal of Molecular Cell Biology 14: mjac077.","journal-title":"Journal of Molecular Cell Biology"},{"key":"2287_CR15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12974-022-02501-2","volume":"19","author":"L Luo","year":"2022","unstructured":"Luo, L., M. Liu, Y. Fan, J. Zhang, L. Liu, Y. Li, Q. Zhang, H. Xie, C. Jiang, J. Wu, X. Xiao, and Y. Wu. 2022. Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NF\u03baB\/NLRP3 signaling pathway in cerebral ischemic mice. Journal of Neuroinflammation 19: 141.","journal-title":"Journal of Neuroinflammation"},{"key":"2287_CR16","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1002\/glia.20581","volume":"55","author":"H Junker","year":"2007","unstructured":"Junker, H., Y. Suofu, S. Venz, M. Sascau, J.G. Herndon, C. Kessler, R. Walther, and A. Popa-Wagner. 2007. Proteomic identification of an upregulated isoform of annexin A3 in the rat brain following reversible cerebral ischemia. Glia 55: 1630\u20131637.","journal-title":"Glia"},{"key":"2287_CR17","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1186\/s40001-023-01564-y","volume":"28","author":"L Liu","year":"2023","unstructured":"Liu, L., Y. Cai, and C. Deng. 2023. Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke. European Journal of Medical Research 28: 596.","journal-title":"European Journal of Medical Research"},{"key":"2287_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/imm.13239","volume":"161","author":"M Toufiq","year":"2020","unstructured":"Toufiq, M., J. Roelands, and M. Alfaki. 2020. Syed Ahamed Kabeer B, Saadaoui M, Lakshmanan AP, Bangarusamy DK, Murugesan S, Bedognetti D, Hendrickx W, Al Khodor S, Terranegra A, Rinchai D, Chaussabel D, Garand M: Annexin A3 in sepsis: Novel perspectives from an exploration of public transcriptome data. Immunology 161: 291\u2013302.","journal-title":"Immunology"},{"key":"2287_CR19","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1186\/s12967-022-03562-w","volume":"20","author":"PF Zheng","year":"2022","unstructured":"Zheng, P.F., L.Z. Chen, P. Liu, H.W. Pan, W.J. Fan, and Z.Y. Liu. 2022. Identification of immune-related key genes in the peripheral blood of ischaemic stroke patients using a weighted gene coexpression network analysis and machine learning. Journal of Translational Medicine 20: 361.","journal-title":"Journal of Translational Medicine"},{"key":"2287_CR20","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1089\/hum.2017.064","volume":"29","author":"W He","year":"2018","unstructured":"He, W., D. Wei, D. Cai, S. Chen, S. Li, and W. Chen. 2018. Altered Long Non-Coding RNA transcriptomic profiles in ischemic stroke. Human Gene Therapy 29: 719\u2013732.","journal-title":"Human Gene Therapy"},{"key":"2287_CR21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.molimm.2024.01.006","volume":"167","author":"J Liang","year":"2024","unstructured":"Liang, J., J. Zhang, J. Fan, S. Chen, and W. Wu. 2024. ANXA3 interference inactivates ERK\/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury. Molecular Immunology 167: 25\u201333.","journal-title":"Molecular Immunology"},{"key":"2287_CR22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainresbull.2020.04.021","volume":"161","author":"XL Min","year":"2020","unstructured":"Min, X.L., M. He, Y. Shi, L. Xie, X.J. Ma, and Y. Cao. 2020. miR-18b attenuates cerebral ischemia\/reperfusion injury through regulation of ANXA3 and PI3K\/Akt signaling pathway. Brain Research Bulletin 161: 55\u201364.","journal-title":"Brain Research Bulletin"},{"key":"2287_CR23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41419-017-0143-z","volume":"9","author":"R Du","year":"2018","unstructured":"Du, R., B. Liu, L. Zhou, D. Wang, X. He, X. Xu, L. Zhang, C. Niu, and S. Liu. 2018. Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer. Cell Death & Disease 9: 126.","journal-title":"Cell Death & Disease"},{"key":"2287_CR24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00335-021-09883-3","volume":"32","author":"S Gao","year":"2021","unstructured":"Gao, S., Z. Wang, X. Liu, B. Xu, and F. Liu. 2021. The calcimedin annexin A3 displays tumor-promoting effect in esophageal squamous cell carcinoma by activating NF-\u03baB signaling. Mammalian Genome 32: 381\u2013388.","journal-title":"Mammalian Genome"},{"key":"2287_CR25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12974-018-1246-x","volume":"15","author":"Z Zhang","year":"2018","unstructured":"Zhang, Z., P. Qin, Y. Deng, Z. Ma, H. Guo, H. Guo, Y. Hou, S. Wang, W. Zou, Y. Sun, Y. Ma, and W. Hou. 2018. The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation. Journal of Neuroinflammation 15: 206.","journal-title":"Journal of Neuroinflammation"},{"key":"2287_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12974-019-1464-x","volume":"16","author":"X Zhang","year":"2019","unstructured":"Zhang, X., X.L. Zhu, B.Y. Ji, X. Cao, L.J. Yu, Y. Zhang, X.Y. Bao, Y. Xu, and J.L. Jin. 2019. LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. Journal of Neuroinflammation 16: 75.","journal-title":"Journal of Neuroinflammation"},{"key":"2287_CR27","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1097\/j.pain.0000000000001962","volume":"161","author":"Z Zhang","year":"2020","unstructured":"Zhang, Z., M. Deng, J. Huang, J. Wu, Z. Li, M. Xing, J. Wang, Q. Guo, and W. Zou. 2020. Microglial annexin A3 downregulation alleviates bone cancer-induced pain through inhibiting the Hif-1\u03b1\/vascular endothelial growth factor signaling pathway. Pain 161: 2750\u20132762.","journal-title":"Pain"},{"key":"2287_CR28","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3389\/fncel.2019.00537","volume":"13","author":"Z Ma","year":"2019","unstructured":"Ma, Z., Z. Zhang, F. Bai, T. Jiang, C. Yan, and Q. Wang. 2019. Electroacupuncture pretreatment alleviates cerebral ischemic injury through \u03b17 nicotinic acetylcholine receptor-mediated phenotypic conversion of microglia. Frontiers in Cellular Neuroscience 13: 537.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"2287_CR29","doi-asserted-by":"publisher","first-page":"20847","DOI":"10.1002\/jcp.28689","volume":"234","author":"Z Zhang","year":"2019","unstructured":"Zhang, Z., Z. Ma, W. Zou, L. Zhang, Y. Li, J. Zhang, M. Liu, W. Hou, and Y. Ma. 2019. N-myc downstream-regulated gene 2 controls astrocyte morphology via Rho-GTPase signaling. Journal of Cellular Physiology 234: 20847\u201320858.","journal-title":"Journal of Cellular Physiology"},{"key":"2287_CR30","doi-asserted-by":"publisher","first-page":"108938","DOI":"10.1016\/j.neuropharm.2021.108938","volume":"206","author":"M Deng","year":"2022","unstructured":"Deng, M., Z. Zhang, M. Xing, X. Liang, Z. Li, J. Wu, S. Jiang, Y. Weng, Q. Guo, and W. Zou. 2022. LncRNA MRAK159688 facilitates morphine tolerance by promoting REST-mediated inhibition of mu opioid receptor in rats. Neuropharmacology 206: 108938.","journal-title":"Neuropharmacology"},{"key":"2287_CR31","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/ALN.0000000000002044","volume":"128","author":"YL Deng","year":"2018","unstructured":"Deng, Y.L., Y.L. Ma, Z.L. Zhang, L.X. Zhang, H. Guo, P. Qin, Y.S. Hou, Z.J. Gao, and W.G. Hou. 2018. Astrocytic N-myc downstream-regulated gene-2 is involved in nuclear transcription factor \u03baB-mediated inflammation induced by global cerebral ischemia. Anesthesiology 128: 574\u2013586.","journal-title":"Anesthesiology"},{"key":"2287_CR32","doi-asserted-by":"publisher","first-page":"5575090","DOI":"10.1155\/2021\/5575090","volume":"2021","author":"Z Zhang","year":"2021","unstructured":"Zhang, Z., Z. Li, Z. Ma, M. Deng, M. Xing, J. Wu, S. Jiang, Q. Wang, Q. Guo, and W. Zou. 2021. Annexin A3 as a marker protein for microglia in the central nervous system of rats. Neural Plasticity 2021: 5575090.","journal-title":"Neural Plasticity"},{"key":"2287_CR33","doi-asserted-by":"publisher","first-page":"10535","DOI":"10.1002\/jcp.27717","volume":"234","author":"H Meng","year":"2019","unstructured":"Meng, H., Y. Zhang, S.T. An, and Y. Chen. 2019. Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K\/Akt signaling pathway in rats with acute myocardial infarction. Journal of Cellular Physiology 234: 10535\u201310546.","journal-title":"Journal of Cellular Physiology"},{"key":"2287_CR34","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/hipo.20441","volume":"18","author":"R Weitzd\u00f6rfer","year":"2008","unstructured":"Weitzd\u00f6rfer, R., H. H\u00f6ger, K.S. Shim, L. Cekici, A. Pollak, and G. Lubec. 2008. Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Hippocampus 18: 807\u2013813.","journal-title":"Hippocampus"},{"key":"2287_CR35","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3389\/fnins.2017.00484","volume":"11","author":"W Zou","year":"2017","unstructured":"Zou, W., W. Xu, Z. Song, T. Zhong, Y. Weng, C. Huang, M. Li, C. Zhang, X. Zhan, and Q. Guo. 2017. Proteomic Identification of an Upregulated Isoform of Annexin A3 in the Spinal Cords of Rats in a Neuropathic Pain Model. Frontiers in Neuroscience 11: 484.","journal-title":"Frontiers in Neuroscience"},{"key":"2287_CR36","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/glia.20327","volume":"53","author":"H Konishi","year":"2006","unstructured":"Konishi, H., K. Namikawa, and H. Kiyama. 2006. Annexin III implicated in the microglial response to motor nerve injury. Glia 53: 723\u2013732.","journal-title":"Glia"},{"key":"2287_CR37","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/glia.24501","volume":"72","author":"AM Planas","year":"2024","unstructured":"Planas, A.M. 2024. Role of microglia in stroke. Glia 72: 1016\u20131053.","journal-title":"Glia"},{"key":"2287_CR38","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.cytogfr.2023.07.005","volume":"74","author":"C Dordoe","year":"2023","unstructured":"Dordoe, C., W. Huang, C. Bwalya, X. Wang, B. Shen, H. Wang, J. Wang, S. Ye, P. Wang, B. Xiaoyan, X. Li, and L. Lin. 2023. The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors. Cytokine & Growth Factor Reviews 74: 122\u2013133.","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"2287_CR39","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1038\/s41598-018-24350-x","volume":"8","author":"S Ismael","year":"2018","unstructured":"Ismael, S., L. Zhao, S. Nasoohi, and T. Ishrat. 2018. Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. Science and Reports 8: 5971.","journal-title":"Science and Reports"},{"key":"2287_CR40","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1158\/0008-5472.CAN-09-4204","volume":"70","author":"Z Zhang","year":"2010","unstructured":"Zhang, Z., L. Huang, W. Zhao, and B. Rigas. 2010. Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: Anticancer effects in vitro and in vivo. Cancer Research 70: 2379\u20132388.","journal-title":"Cancer Research"},{"key":"2287_CR41","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S0092-8674(00)81698-0","volume":"95","author":"MD Jacobs","year":"1998","unstructured":"Jacobs, M.D., and S.C. Harrison. 1998. Structure of an IkappaBalpha\/NF-kappaB complex. Cell 95: 749\u2013758.","journal-title":"Cell"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02287-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-025-02287-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02287-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:06:49Z","timestamp":1762880809000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-025-02287-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,15]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["2287"],"URL":"https:\/\/doi.org\/10.1007\/s10753-025-02287-4","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,15]]},"assertion":[{"value":"11 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were performed according to institutional guidelines and approved by the Animal Care and Use Committee of Tianjin Medical University Cancer Institute and Hospital (reference number: YYJC-AE-2022023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}