{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:36:59Z","timestamp":1790905019170,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Greifswald"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute pancreatitis (AP) is an inflammatory disease characterized by a prominent local infiltration and activation of innate immune cells, but also accompanied by a systemic T cell activation. The mechanisms which link the local immune response to the systemic immune activation are not well understood. Here, we identified Interleukin-6 (IL-6) as a crucial mediator of systemic T cell activation, which is mainly released by pancreatic macrophages and necrotic acinar cells. IL-6 triggers the systemic T cell activation of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T helper cells. After the onset of acute pancreatitis IL-6 serum levels increase rapidly and affect the systemic immune reaction. A CD4\n                    <jats:sup>+<\/jats:sup>\n                    specific knock out of the IL-6 receptor glycoprotein 130 receptor (GP130R), showed reduced proliferation and a higher apoptosis rate of T cells after induction of caerulein-induced AP. This diminished T cell activation results in a significant decrease of pancreatic macrophage proliferation and a milder disease course. Our data indicate a critical role of IL-6 in the crosstalk between local and systemic immune responses during AP, as well as a triggering role in adaptive immune mechanisms.\n                  <\/jats:p>","DOI":"10.1007\/s10753-025-02329-x","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:24:11Z","timestamp":1750818251000},"page":"4330-4341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Interleukin-6 Mediated T Cell Activation in Experimental Acute Pancreatitis"],"prefix":"10.1007","volume":"48","author":[{"given":"Juliane","family":"Glaubitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zimdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zeissig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Ulrich","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Sendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2329_CR1","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","volume":"156","author":"PK Garg","year":"2019","unstructured":"Garg, P. K., and V. P. Singh. 2019. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology 156:2008\u20132023.","journal-title":"Gastroenterology"},{"key":"2329_CR2","doi-asserted-by":"crossref","unstructured":"Mayerle, J. et al. 2019. Genetics, cell biology, and pathophysiology of pancreatitis. 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