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Efforts were made to minimize animal suffering and reduce the number of animals used. Anesthesia and analgesia were administered during surgical procedures to ensure animal welfare, and humane endpoints were established to prevent unnecessary distress. All experimental protocols were reviewed to ensure compliance with institutional and national ethical standards for animal research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}