{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:15:05Z","timestamp":1793834105215,"version":"4.6.1"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammation"],"DOI":"10.1007\/s10753-025-02339-9","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T01:44:09Z","timestamp":1753062249000},"page":"3785-3799","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Kynurenine Pathway in Psoriasis: Mechanisms and Therapeutic Opportunities"],"prefix":"10.1007","volume":"48","author":[{"given":"Shan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"issue":"10281","key":"2339_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"CEM Griffiths","year":"2021","unstructured":"Griffiths, C. E. M., A. W. Armstrong, J. E. Gudjonsson, and J. N. W. N. Barker. 2021. Psoriasis. Lancet 397 (10281): 1301\u20131315.","journal-title":"Lancet"},{"issue":"19","key":"2339_CR2","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong, A. W., and C. Read. 2020. Pathophysiology, clinical presentation, and treatment of psoriasis a review. JAMA-Journal of the American Medical Association 323 (19): 1945\u20131960.","journal-title":"JAMA-Journal of the American Medical Association"},{"key":"2339_CR3","unstructured":"National Psoriasis Foundation. Available from: https:\/\/www.psoriasis.org\/content\/statistics."},{"key":"2339_CR4","doi-asserted-by":"crossref","unstructured":"Huang, S., and Y. Bai. 2023. Knowledge mapping and research hotspots of comorbidities in psoriasis: A bibliometric analysis from 2004 to 2022. Medicina (Kaunas) 59 (2): 393.","DOI":"10.3390\/medicina59020393"},{"issue":"3","key":"2339_CR5","doi-asserted-by":"publisher","first-page":"425-+","DOI":"10.1016\/j.jaad.2017.05.019","volume":"77","author":"S Singh","year":"2017","unstructured":"Singh, S., C. Taylor, H. Kornmehl, and A. W. Armstrong. 2017. Psoriasis and suicidality: A systematic review and meta-analysis. Journal of the American Academy of Dermatology 77 (3): 425\u2013440.","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"1","key":"2339_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jaad.2020.04.139","volume":"84","author":"S Mehrmal","year":"2021","unstructured":"Mehrmal, S., P. Uppal, N. Nedley, R. L. Giesey, and G. R. Delost. 2021. The global, regional, and National burden of psoriasis in 195 countries and territories, 1990 to 2017: A systematic analysis from the global burden of disease study 2017. Journal of the American Academy of Dermatology 84 (1): 46\u201352.","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"1","key":"2339_CR7","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","volume":"8","author":"J Guo","year":"2023","unstructured":"Guo, J., H. Zhang, W. Lin, L. Lu, J. Su, and X. Chen. 2023. Signaling pathways and targeted therapies for psoriasis. Signal Transduction and Targeted Therapy 8 (1): 437.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"10275","key":"2339_CR8","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","volume":"397","author":"K Ghoreschi","year":"2021","unstructured":"Ghoreschi, K., A. Balato, C. Enerback, and R. Sabat. 2021. Therapeutics targeting the Il-23 and Il-17 pathway in psoriasis. Lancet 397 (10275): 754\u2013766.","journal-title":"Lancet"},{"issue":"6","key":"2339_CR9","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1080\/09546634.2022.2079597","volume":"33","author":"D Montoya-Londo\u00f1o","year":"2022","unstructured":"Montoya-Londo\u00f1o, D., C. A. G\u00f3mez-Mercado, J. I. Estrada-Acevedo, J. Madrigal-Cadavid, A. Segura, N. A. Giraldo-Alzate, and A. M. Londo\u00f1o. 2022. Therapeutic failure in moderate and severe psoriasis patients in a health Institution - a transversal study of prevalence and demographic determinants. The Journal of Dermatological Treatment 33 (6): 2821\u20132826.","journal-title":"The Journal of Dermatological Treatment"},{"issue":"24","key":"2339_CR10","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.1097\/CM9.0000000000001232","volume":"133","author":"Xiao-Yu Wang","year":"2020","unstructured":"Wang, Xiao-Yu, Chun-Lei Zhang, and Wen-Hui Wang. 2020. Time to relapse after treatment withdrawal for different biologics used to treat plaque psoriasis. Chinese Medical Journal 133 (24): 2998\u20133000.","journal-title":"Chinese Medical Journal"},{"key":"2339_CR11","first-page":"17","volume":"24","author":"HJ Lee","year":"2023","unstructured":"Lee, H. J., and M. Kim. 2023. Challenges and future trends in the treatment of psoriasis. International Journal of Molecular Sciences 24 (17):13313.","journal-title":"International Journal of Molecular Sciences"},{"issue":"8","key":"2339_CR12","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.jid.2023.01.021","volume":"143","author":"A Al-Janabi","year":"2023","unstructured":"Al-Janabi, A., S. Eyre, A. C. Foulkes, A. R. Khan, N. Dand, E. Burova, B. DeSilva, A. Makrygeorgou, E. Davies, C. H. Smith, C. E. M. Griffiths, A. P. Morris, and R. B. Warren. 2023. Atopic polygenic risk score is associated with paradoxical eczema developing in patients with psoriasis treated with biologics. Journal of Investigative Dermatology  143 (8): 1470\u20131478.","journal-title":"Journal of Investigative Dermatology "},{"issue":"8","key":"2339_CR13","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","volume":"35","author":"C Xue","year":"2023","unstructured":"Xue, C., G. Li, Q. Zheng, X. Gu, Q. Shi, Y. Su, Q. Chu, X. Yuan, Z. Bao, J. Lu, and L. Li. 2023. Tryptophan metabolism in health and disease. Cell Metabolism 35 (8): 1304\u20131326.","journal-title":"Cell Metabolism"},{"key":"2339_CR14","doi-asserted-by":"crossref","unstructured":"Wang, Y., Y. Zhang, W. Wang, Y. Zhang, X. Dong, and Y. Liu. 2025. Diverse physiological roles of kynurenine pathway metabolites: updated implications for health and disease. Metabolites 15 (3): 210.","DOI":"10.3390\/metabo15030210"},{"issue":"3","key":"2339_CR15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jdermsci.2004.08.012","volume":"36","author":"M Ito","year":"2004","unstructured":"Ito, M., K. Ogawa, K. Takeuchi, A. Nakada, M. Heishi, H. Suto, K. Mitsuishi, Y. Sugita, H. Ogawa, and C. Ra. 2004. Gene expression of enzymes for Tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis. Journal of Dermatological Science 36 (3): 157\u2013164.","journal-title":"Journal of Dermatological Science"},{"issue":"7","key":"2339_CR16","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.tips.2023.04.006","volume":"44","author":"TW Stone","year":"2023","unstructured":"Stone, T. W., and R. O. Williams. 2023. Modulation of T cells by Tryptophan metabolites in the kynurenine pathway. Trends in Pharmacological Sciences 44 (7): 442\u2013456.","journal-title":"Trends in Pharmacological Sciences"},{"key":"2339_CR17","doi-asserted-by":"crossref","unstructured":"Szelest, M., K. Walczak, and T. Plech. 2021. A new insight into the potential role of Tryptophan-Derived Ahr ligands in skin physiological and pathological processes.\u00a0International Journal of Molecular Sciences 22 (3): 1104.","DOI":"10.3390\/ijms22031104"},{"issue":"9","key":"2339_CR18","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/15622975.2018.1468031","volume":"20","author":"A Messaoud","year":"2019","unstructured":"Messaoud, A., R. Mensi, W. Douki, F. Neffati, M. F. Najjar, G. Gobbi, F. Valtorta, L. Gaha, and S. Comai. 2019. Reduced peripheral availability of Tryptophan and increased activation of the kynurenine pathway and cortisol correlate with major depression and suicide. The World Journal of Biological Psychiatry: the official Journal of the World Federation of Societies of Biological Psychiatry 20 (9): 703\u2013711.","journal-title":"The World Journal of Biological Psychiatry: the official Journal of the World Federation of Societies of Biological Psychiatry"},{"issue":"2","key":"2339_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/1348-0421.12562","volume":"62","author":"L Zhao","year":"2018","unstructured":"Zhao, L., Y. Suolang, D. Zhou, Y. Tang, and Y. Zhang. 2018. Bifidobacteria alleviate experimentally induced colitis by upregulating indoleamine 2, 3-Dioxygenase expression. Microbiology and Immunology 62 (2): 71\u201379.","journal-title":"Microbiology and Immunology"},{"issue":"2","key":"2339_CR20","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/j.ijcard.2012.12.090","volume":"168","author":"G Sulo","year":"2013","unstructured":"Sulo, G., S. E. Vollset, O. Nyg\u00e5rd, \u00d8. Midttun, P. M. Ueland, S. J. Eussen, E. R. Pedersen, and G. S. Tell. 2013. Neopterin and Kynurenine-Tryptophan ratio as predictors of coronary events in older adults, the Hordaland health study. International Journal of Cardiology 168 (2): 1435\u20131440.","journal-title":"International Journal of Cardiology"},{"issue":"2","key":"2339_CR21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1161\/ATVBAHA.114.304674","volume":"35","author":"ER Pedersen","year":"2015","unstructured":"Pedersen, E. R., N. Tuseth, S. J. Eussen, P. M. Ueland, E. Strand, G. F. Svingen, \u00d8. Midttun, K. Meyer, G. Mellgren, A. Ulvik, J. E. Nordrehaug, D. W. Nilsen, and O. Nyg\u00e5rd. 2015. Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. Arteriosclerosis, Thrombosis, and Vascular Biology 35 (2): 455\u2013462.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"8","key":"2339_CR22","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s13555-023-00958-4","volume":"13","author":"A Stepaniuk","year":"2023","unstructured":"Stepaniuk, A., A. Baran, and I. Flisiak. 2023. Kynurenine pathway in Psoriasis-a promising link? Dermatologic Therapy (Heidelberg) 13 (8): 1617\u20131627.","journal-title":"Dermatologic Therapy (Heidelberg)"},{"key":"2339_CR23","doi-asserted-by":"crossref","unstructured":"Cervenka, I., L.Z. Agudelo, and J.L. Ruas. 2017. Kynurenines: Tryptophan\u2019s metabolites in exercise, inflammation, and mental health. Science 357\u00a0(6349):\u00a09794.","DOI":"10.1126\/science.aaf9794"},{"key":"2339_CR24","doi-asserted-by":"crossref","unstructured":"Mor, A., A. Tankiewicz-Kwedlo, M. Ciwun, J. Lewkowicz, and D. Pawlak. 2024. Kynurenines as a novel target for the treatment of inflammatory disorders. Cells 13 (15): 1259.","DOI":"10.3390\/cells13151259"},{"key":"2339_CR25","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.3389\/fimmu.2017.01957","volume":"8","author":"E Wirthgen","year":"2017","unstructured":"Wirthgen, E., A. Hoeflich, A. Rebl, and J. G\u00fcnther. 2017. Kynurenic acid: The Janus-Faced role of an immunomodulatory tryptophan metabolite and its link to pathological conditions.\u00a0Frontiers in Immunology 8:1957.","journal-title":"Frontiers in Immunology"},{"issue":"9","key":"2339_CR26","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1016\/j.celrep.2016.10.079","volume":"17","author":"LA Van de Velde","year":"2016","unstructured":"Van de Velde, L. A., X. J. Guo, L. Barbaric, A. M. Smith, T. H. Oguin 3rd, P. G. Thomas, and P. J. Murray. 2016. Stress kinase Gcn2 controls the proliferative fitness and trafficking of cytotoxic T cells independent of environmental amino acid sensing. Cell Reports 17 (9): 2247\u20132258.","journal-title":"Cell Reports"},{"key":"2339_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.coi.2020.12.001","volume":"70","author":"A Fiore","year":"2021","unstructured":"Fiore, A., and P. J. Murray. 2021. Tryptophan and Indole metabolism in immune regulation. Current Opinion in Immunology 70:7\u201314.","journal-title":"Current Opinion in Immunology"},{"key":"2339_CR28","doi-asserted-by":"crossref","unstructured":"Liu, Y., X. Liang, W. Dong, Y. Fang, J. Lv, T. Zhang, R. Fiskesund, J. Xie, J. Liu, X. Yin, X. Jin, D. Chen, K. Tang, J. Ma, H. Zhang, J. Yu, J. Yan, H. Liang, S. Mo, F. Cheng, Y. Zhou, H. Zhang, J. Wang, J. Li, Y. Chen, B. Cui, Z.W. Hu, X. Cao, F. Xiao-Feng, Qin, and B. Huang. 2018. Tumor-repopulating cells induce Pd-1 expression in Cd8(+) T cells by transferring kynurenine and Ahr activation. Cancer Cell 33 (3): 480\u2013497.","DOI":"10.1016\/j.ccell.2018.02.005"},{"issue":"6265","key":"2339_CR29","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1126\/science.aac4854","volume":"350","author":"E Verdin","year":"2015","unstructured":"Verdin, E. 2015. Nad\u207a in aging, metabolism, and neurodegeneration. Science 350 (6265): 1208\u20131213.","journal-title":"Science"},{"issue":"3","key":"2339_CR30","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/bjd.14779","volume":"176","author":"M Llamas-Velasco","year":"2017","unstructured":"Llamas-Velasco, M., P. Bonay, M. J. Concha-Garz\u00f3n, L. Corvo-Vill\u00e9n, A. Vara, D. Cibri\u00e1n, A. Sanguino-Pascual, F. S\u00e1nchez-Madrid, H. de la Fuente, and E. Daud\u00e9n. 2017. Immune cells from patients with psoriasis are defective in inducing indoleamine 2,3-Dioxygenase expression in response to inflammatory stimuli. British Journal of Dermatology 176 (3): 695\u2013704.","journal-title":"British Journal of Dermatology"},{"key":"2339_CR31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1136\/jitc-2023-006728","volume":"11","author":"M Solvay","year":"2023","unstructured":"Solvay, M., P. Holfelder, S. Klaessens, L. Pilotte, V. Stroobant, J. Lamy, S. Naulaerts, Q. Spillier, R. Fr\u00e9d\u00e9rick, E. De Plaen, C. Sers, C. A. Opitz, B. J. Van den Eynde, and J. Zhu. 2023. Tryptophan depletion sensitizes the Ahr pathway by increasing Ahr expression and Gcn2\/Lat1-Mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes. Journal for Immunotherapy of Cancer 11 (6): e006728.","journal-title":"Journal for Immunotherapy of Cancer"},{"key":"2339_CR32","doi-asserted-by":"crossref","unstructured":"Carrillo-Mora, P., C. Landa-Sol\u00eds, D. Valle-Garcia, A. Luna-Angulo, H. Avil\u00e9s-Arnaut, B. Robles-Ba\u00f1uelos, L. S\u00e1nchez-Chapul, and E. Rangel-L\u00f3pez. 2024. Kynurenines and inflammation: A remarkable Axis for multiple sclerosis treatment. Pharmaceuticals (Basel) 17 (8): 983.","DOI":"10.3390\/ph17080983"},{"issue":"1","key":"2339_CR33","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1038\/s41467-020-17750-z","volume":"11","author":"LF Campesato","year":"2020","unstructured":"Campesato, L. F., S. Budhu, J. Tchaicha, C. H. Weng, M. Gigoux, I. J. Cohen, D. Redmond, L. Mangarin, S. Pourpe, C. Liu, R. Zappasodi, D. Zamarin, J. Cavanaugh, A. C. Castro, M. G. Manfredi, K. McGovern, T. Merghoub, and J. D. Wolchok. 2020. Blockade of the Ahr restricts a treg-macrophage suppressive axis induced by L-Kynurenine. Nature Communications 11 (1): 4011.","journal-title":"Nature Communications"},{"key":"2339_CR34","doi-asserted-by":"crossref","unstructured":"Yu, N., C. Peng, W. J. Chen, Z. W. Sun, J. F. Zheng, S. J. Zhang, Y. F. Ding, and Y. L. Shi. 2021. Circulating metabolomic signature in generalized pustular psoriasis blunts monocyte hyperinflammation by triggering amino acid response. Frontiers in Immunology 12:739514.","DOI":"10.3389\/fimmu.2021.739514"},{"key":"2339_CR35","doi-asserted-by":"crossref","unstructured":"Guo, L., C. Wu, B. Song, and H. Z. Jin. 2024. Exploration of circulating metabolic signature of erythrodermic psoriasis based on Lc-Ms metabolomics. Experimental Dermatology 33 (5): e15103.","DOI":"10.1111\/exd.15103"},{"issue":"9","key":"2339_CR36","first-page":"3940","volume":"23","author":"SS Li","year":"2019","unstructured":"Li, S. S., Y. Liu, H. Li, L. P. Wang, L. F. Xue, G. S. Yin, and X. S. Wu. 2019. Identification of psoriasis vulgaris biomarkers in human plasma by Non-Targeted metabolomics based on Uplc-Q-Tof\/Ms. European Review for Medical and Pharmacological Sciences 23 (9): 3940\u20133950.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"2339_CR37","doi-asserted-by":"crossref","unstructured":"Stepaniuk, A., A. Baran, J.M. Hermanowicz, B. Sieklucka, D. Pawlak, and I. Flisiak. 2025. Peripheral Kynurenine pathway metabolites in patients with psoriasis. International Journal of Molecular Sciences 26(7).","DOI":"10.3390\/ijms26073139"},{"issue":"3","key":"2339_CR38","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1177\/0963689718757482","volume":"27","author":"SS Elizei","year":"2018","unstructured":"Elizei, S. S., M. Pakyari, M. Ghoreishi, R. Kilani, S. Mahmoudi, and A. Ghahary. 2018. Ido-expressing fibroblasts suppress the development of imiquimod-induced psoriasis-like dermatitis. Cell Transplantation 27 (3): 557\u2013570.","journal-title":"Cell Transplantation"},{"issue":"9","key":"2339_CR39","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/s41551-023-01025-1","volume":"7","author":"E Bracho-Sanchez","year":"2023","unstructured":"Bracho-Sanchez, E., F. G. Rocha, S. K. Bedingfield, B. D. Partain, S. L. Macias, M. A. Brusko, J. M. Colazo, M. M. Fettis, S. A. Farhadi, E. Y. Helm, K. Koenders, A. J. Kwiatkowski, A. Restuccia, B. S. Morales, A. Wanchoo, D. Avram, K. D. Allen, C. L. Duvall, S. M. Wallet, G. A. Hudalla, and B. G. Keselowsky. 2023. Suppression of local inflammation via galectin-anchored indoleamine 2,3-Dioxygenase. Nature Biomedical Engineering 7 (9): 1156\u20131169.","journal-title":"Nature Biomedical Engineering"},{"key":"2339_CR40","doi-asserted-by":"publisher","first-page":"117864692210781","DOI":"10.1177\/11786469221078191","volume":"15","author":"V Choudhary","year":"2022","unstructured":"Choudhary, V., E. Ajebo, R. Uaratanawong, S. C. Spaulding, S. Hossack, X. Chen, J. Xu, M. Choudhary, D. L. Irsik, C.M. Isales, and B. Bollag. 2022. Loss of Indoleamine-2,3-Dioxygenase-1 (Ido1) in knockout mice does not affect the development of skin lesions in the imiquimod-induced mouse model of psoriasis. International Journal of Tryptophan Research 15:11786469221078192.","journal-title":"International Journal of Tryptophan Research"},{"issue":"3","key":"2339_CR41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/jid.2010.340","volume":"131","author":"A Chiricozzi","year":"2011","unstructured":"Chiricozzi, A., E. Guttman-Yassky, M. Su\u00e1rez-Fari\u00f1as, K. E. Nograles, S. Tian, I. Cardinale, S. Chimenti, and J. G. Krueger. 2011. Integrative responses to Il-17 and Tnf-\u0391 in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. The Journal of Investigative Dermatology 131 (3): 677\u2013687.","journal-title":"The Journal of Investigative Dermatology"},{"issue":"6","key":"2339_CR42","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/j.jaci.2015.09.055","volume":"137","author":"JL Harden","year":"2016","unstructured":"Harden, J. L., S. M. Lewis, S. R. Lish, M. Su\u00e1rez-Fari\u00f1as, D. Gareau, T. Lentini, L. M. Johnson-Huang, J. G. Krueger, and M. A. Lowes. 2016. The Tryptophan metabolism enzyme L-Kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases. The Journal of Allergy and Clinical Immunology 137 (6): 1830\u20131840.","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"2339_CR43","doi-asserted-by":"crossref","unstructured":"Emami, Z., S. S. Shobeiri, R. Khorrami, N. Haghnavaz, M. A. Rezaee, M. Moghadam, S. Pordel, and M. Sankian. 2024. Evaluation of Kynu, Defb2, Camp, and penk\u2009expression levels as psoriasis marker in the imiquimod-induced psoriasis model. Mediators of Inflammation 2024:5821996.","DOI":"10.1155\/2024\/5821996"},{"issue":"1","key":"2339_CR44","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1002\/jcp.30587","volume":"237","author":"M Wang","year":"2022","unstructured":"Wang, M., Y. Wang, M. Zhang, Q. Duan, C. Chen, Q. Sun, M. Liu, Y. Zheng, and Y. Shao. 2022. Kynureninase contributes to the pathogenesis of psoriasis through Pro-Inflammatory effect. Journal of Cellular Physiology 237 (1): 1044\u20131056.","journal-title":"Journal of Cellular Physiology"},{"key":"2339_CR45","doi-asserted-by":"crossref","unstructured":"Fiore, A., L. Zeitler, M. Russier, A. Gro\u00df, M. K. Hiller, J. L. Parker, L. Stier, T. K\u00f6cher, S. Newstead, and P. J. Murray. 2022. Kynurenine importation by Slc7a11 propagates anti-ferroptotic signaling. Molecular Cell 82 (5): 920\u2013932.","DOI":"10.1016\/j.molcel.2022.02.007"},{"issue":"4","key":"2339_CR46","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.jcmgh.2021.05.018","volume":"12","author":"X Zhang","year":"2021","unstructured":"Zhang, X., X. Liu, W. Zhou, Q. Du, M. Yang, Y. Ding, and R. Hu. 2021. Blockade of Ido-Kynurenine-Ahr Axis ameliorated colitis-associated colon cancer via inhibiting immune tolerance. Cellular and Molecular Gastroenterology and Hepatology 12 (4): 1179\u20131199.","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"2339_CR47","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3389\/fimmu.2017.00880","volume":"8","author":"EF de Ara\u00fajo","year":"2017","unstructured":"de Ara\u00fajo, E. F., C. Feriotti, N. A. L. Galdino, N. W. Preite, V. L. G. Calich, and F. V. Loures. 2017. The Ido-Ahr Axis controls Th17\/Treg immunity in a pulmonary model of fungal infection. Frontiers in Immunology 8:880.","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"2339_CR48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13045-017-0541-9","volume":"10","author":"B Liu","year":"2017","unstructured":"Liu, B., Y. Song, and D. Liu. 2017. Recent development in clinical applications of Pd-1 and Pd-L1 antibodies for cancer immunotherapy. Journal of Hematology & Oncology 10 (1): 174.","journal-title":"Journal of Hematology & Oncology"},{"issue":"1\u20132","key":"2339_CR49","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11010-017-2975-3","volume":"431","author":"SS Elizei","year":"2017","unstructured":"Elizei, S. S., M. S. Poormasjedi-Meibod, X. Wang, M. Kheirandish, and A. Ghahary. 2017. Kynurenic acid downregulates Il-17\/1l-23 Axis in vitro. Molecular and Cellular Biochemistry 431 (1\u20132): 55\u201365.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"1","key":"2339_CR50","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1515\/tjb-2024-0135","volume":"50","author":"F Akyurek","year":"2025","unstructured":"Akyurek, F., F. Tuncez-Akyurek, and F. Sengul. 2025. The role of kynurenine and kynurenine metabolites in psoriasis. Turkish Journal of Biochemistry 50 (1): 144\u2013151.","journal-title":"Turkish Journal of Biochemistry"},{"key":"2339_CR51","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.bbi.2019.02.009","volume":"79","author":"X Zheng","year":"2019","unstructured":"Zheng, X., M. Hu, X. Zang, Q. Fan, Y. Liu, Y. Che, X. Guan, Y. Hou, G. Wang, and H. Hao. 2019. Kynurenic Acid\/Gpr35 Axis restricts Nlrp3 inflammasome activation and exacerbates colitis in mice with social stress. Brain, Behavior, and Immunity 79:244\u2013255.","journal-title":"Brain, Behavior, and Immunity"},{"key":"2339_CR52","doi-asserted-by":"publisher","first-page":"110510","DOI":"10.1016\/j.mce.2019.110510","volume":"495","author":"T Lee","year":"2019","unstructured":"Lee, T., H. S. Park, J. H. Jeong, and T. W. Jung. 2019. Kynurenic acid attenuates Pro-Inflammatory reactions in Lipopolysaccharide-Stimulated endothelial cells through the Ppar\u03b4\/Ho-1-Dependent pathway. Molecular and Cellular Endocrinology 495:110510.","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2339_CR53","doi-asserted-by":"publisher","first-page":"113651","DOI":"10.1016\/j.intimp.2024.113651","volume":"147","author":"F Wang","year":"2025","unstructured":"Wang, F., M. Zhang, L. Yin, Z. Zhou, Z. Peng, W. Li, H. Chen, G. Yu, and J. Tang. 2025. The Tryptophan metabolite kynurenic acid ameliorates septic colonic injury through activation of the Ppar\u03b3 signaling pathway. International Immunopharmacology 147:113651.","journal-title":"International Immunopharmacology"},{"issue":"29","key":"2339_CR54","doi-asserted-by":"publisher","first-page":"19189","DOI":"10.1074\/jbc.M109.024042","volume":"284","author":"MC Barth","year":"2009","unstructured":"Barth, M. C., N. Ahluwalia, T. J. Anderson, G. J. Hardy, S. Sinha, J. A. Alvarez-Cardona, I. E. Pruitt, E. P. Rhee, R. A. Colvin, and R. E. Gerszten. 2009. Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions. Journal of Biological Chemistry 284 (29): 19189\u201319195.","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"2339_CR55","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00210-011-0605-2","volume":"383","author":"Z Tiszlavicz","year":"2011","unstructured":"Tiszlavicz, Z., B. N\u00e9meth, F. F\u00fcl\u00f6p, L. V\u00e9csei, K. T\u00e1pai, I. Ocsovszky, and Y. M\u00e1ndi. 2011. Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis Factor-\u0391 (Tnf-\u0391) production by mononuclear cells, Hmgb1 production by monocytes and Hnp1-3 secretion by neutrophils. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology 383 (5): 447\u2013455.","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"issue":"1","key":"2339_CR56","doi-asserted-by":"publisher","first-page":"6","DOI":"10.5114\/ceji.2014.42115","volume":"39","author":"J Ma\u0142aczewska","year":"2014","unstructured":"Ma\u0142aczewska, J., A. K. Siwicki, R. M. W\u00f3jcik, E. Kaczorek, and W. A. Turski. 2014. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Central European Journal of Immunology 39 (1): 6\u201313.","journal-title":"Central European Journal of Immunology"},{"issue":"8","key":"2339_CR57","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1016\/j.jid.2022.01.010","volume":"142","author":"P Qiao","year":"2022","unstructured":"Qiao, P., C. Zhang, J. L. Yu, S. Shao, J. Y. Zhang, H. Fang, J. L. Chen, Y. X. Luo, D. L. Zhi, Q. Y. Li, J. Y. Ma, M. Fu, E. L. Dang, W. Yin, and G. Wang. 2022. Quinolinic acid, a Tryptophan metabolite of the skin microbiota, negatively regulates Nlrp3 inflammasome Ahr in psoriasis. Journal of Investigative Dermatology 142 (8): 2184\u2013 2193.","journal-title":"Journal of Investigative Dermatology"},{"key":"2339_CR58","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3389\/fphar.2019.00452","volume":"10","author":"Y Bansal","year":"2019","unstructured":"Bansal, Y., R. Singh, I. Parhar, A. Kuhad, and T. Soga. 2019. Quinolinic acid and nuclear factor erythroid 2-Related factor 2 in depression: Role in neuroprogression. Frontiers in Pharmacology 10:452.","journal-title":"Frontiers in Pharmacology"},{"issue":"5","key":"2339_CR59","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s10495-017-1363-5","volume":"22","author":"W Feng","year":"2017","unstructured":"Feng, W., Y. Wang, Z. Q. Liu, X. Zhang, R. Han, Y. Z. Miao, and Z. H. Qin. 2017. Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through Tnf-\u0391. Apoptosis 22 (5): 696\u2013709.","journal-title":"Apoptosis"},{"key":"2339_CR60","doi-asserted-by":"crossref","unstructured":"Clement, C. C., A. D\u2019Alessandro, S. Thangaswamy, S. Chalmers, R. Furtado, S. Spada, G. Mondanelli, F. Ianni, S. Gehrke, M. Gargaro, G. Manni, L. C. L. Cara, P. Runge, W. X. L. Tsai, S. Karaman, J. Arasa, R. Fernandez-Rodriguez, A. Beck, A. Macchiarulo, M. Gadina, C. Halin, F. Fallarino, M. Skobe, M. Veldhoen, S. Moretti, S. Formenti, S. Demaria, R. K. Soni, R. Galarini, R. Sardella, G. Lauvau, C. Putterman, K. Alitalo, U. Grohmann, and L. Santambrogio. 2021. 3-Hydroxy-L-Kynurenamine is an immunomodulatory biogenic amine. Nature Communications 12 (1): 4447.","DOI":"10.1038\/s41467-021-24785-3"},{"key":"2339_CR61","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.2147\/JIR.S372543","volume":"15","author":"SH Lee","year":"2022","unstructured":"Lee, S. H., H. J. Kim, G. S. Oh, S. B. Lee, D. Khadka, W. Cao, S. K. Choe, H. Shim, C. D. Kim, T. H. Kwak, and H. S. So. 2022. Augmentation of Nad(+) by Dunnione ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Journal of Inflammation Research 15:4623\u20134636.","journal-title":"Journal of Inflammation Research"},{"issue":"1","key":"2339_CR62","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000096170","volume":"20","author":"A Wozniacka","year":"2007","unstructured":"Wozniacka, A., P. Szajerski, J. Adamus, J. Gebicki, and A. Sysa-Jedrzejowska. 2007. In search for new antipsoriatic agents: Nad topical composition. Skin Pharmacology and Physiology 20 (1): 37\u201342.","journal-title":"Skin Pharmacology and Physiology"},{"key":"2339_CR63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/ijms21155515","volume":"21","author":"K Fujii","year":"2020","unstructured":"Fujii, K., Y. Yamamoto, Y. Mizutani, K. Saito, and M. Seishima. 2020. Indoleamine 2,3-Dioxygenase 2 deficiency exacerbates Imiquimod-Induced Psoriasis-Like skin inflammation. International Journal of Molecular Sciences 21:15.","journal-title":"International Journal of Molecular Sciences"},{"key":"2339_CR64","doi-asserted-by":"publisher","first-page":"643449","DOI":"10.3389\/fmicb.2021.643449","volume":"12","author":"D Chen","year":"2021","unstructured":"Chen, D., J. He, J. Li, Q. Zou, J. Si, Y. Guo, J. Yu, C. Li, F. Wang, T. Chan, and H. Shi. 2021. Microbiome and metabolome analyses reveal novel interplay between the skin microbiota and plasma metabolites in psoriasis. Frontiers in Microbiology 12:643449.","journal-title":"Frontiers in Microbiology"},{"key":"2339_CR65","doi-asserted-by":"crossref","unstructured":"Dobric\u0103, E. C., M. A. Cozma, M. A. G\u0103man, and V. M. Voiculescu. 2022. and A. M. G\u0103man. The involvement of oxidative stress in psoriasis: A systematic review. Antioxidants (Basel) 11 (2): 282.","DOI":"10.3390\/antiox11020282"},{"issue":"10","key":"2339_CR66","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1016\/j.jid.2017.05.015","volume":"137","author":"L Yang","year":"2017","unstructured":"Yang, L., X. Fan, T. Cui, E. Dang, and G. Wang. 2017. Nrf2 promotes keratinocyte proliferation in psoriasis through up-Regulation of keratin 6, keratin 16, and keratin 17. The Journal of Investigative Dermatology 137 (10): 2168\u20132176.","journal-title":"The Journal of Investigative Dermatology"},{"key":"2339_CR67","doi-asserted-by":"publisher","first-page":"107754","DOI":"10.1016\/j.intimp.2021.107754","volume":"96","author":"R Sangaraju","year":"2021","unstructured":"Sangaraju, R., S. Alavala, N. Nalban, M. K. Jerald, and R. Sistla. 2021. Galangin ameliorates Imiquimod-Induced Psoriasis-Like skin inflammation in balb\/c mice via down regulating Nf-\u039ab and activation of Nrf2 signaling pathways. International Immunopharmacology 96:107754.","journal-title":"International Immunopharmacology"},{"issue":"6","key":"2339_CR68","doi-asserted-by":"publisher","first-page":"415","DOI":"10.2174\/1568026623666221223111309","volume":"23","author":"H Sipahi","year":"2023","unstructured":"Sipahi, H., A. F. Mat, Y. Ozhan, and A. Aydin. 2023. The interrelation between oxidative stress, depression and inflammation through the kynurenine pathway. Current Topics in Medicinal Chemistry 23 (6): 415\u2013425.","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"2339_CR69","doi-asserted-by":"publisher","first-page":"105363","DOI":"10.1016\/j.neuint.2022.105363","volume":"158","author":"M Obara-Michlewska","year":"2022","unstructured":"Obara-Michlewska, M. 2022. The Tryptophan metabolism, kynurenine pathway and oxidative Stress - Implications for glioma pathobiology. Neurochemistry International 158:105363.","journal-title":"Neurochemistry International"},{"key":"2339_CR70","doi-asserted-by":"crossref","unstructured":"Hestad, K., J. Alexander, H. Rootwelt, and J. O. Aaseth. 2022. The role of tryptophan dysmetabolism and quinolinic acid in depressive and neurodegenerative diseases. Biomolecules 12 (7): 998.","DOI":"10.3390\/biom12070998"},{"issue":"8","key":"2339_CR71","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ijdevneu.2005.08.004","volume":"23","author":"G Leipnitz","year":"2005","unstructured":"Leipnitz, G., C. Schumacher, K. Scussiato, K. B. Dalcin, C. M. Wannmacher, A. T. Wyse, C. S. Dutra-Filho, M. Wajner, and A. Latini. 2005. Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats. International Journal of Developmental Neuroscience 23 (8): 695\u2013701.","journal-title":"International Journal of Developmental Neuroscience"},{"issue":"3","key":"2339_CR72","doi-asserted-by":"publisher","first-page":"e91146","DOI":"10.1371\/journal.pone.0091146","volume":"9","author":"HR Kim","year":"2014","unstructured":"Kim, H. R., A. Lee, E. J. Choi, M. P. Hong, J. H. Kie, W. Lim, H. K. Lee, B. I. Moon, and J. Y. Seoh. 2014. Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function. Plos One 9 (3): e91146.","journal-title":"Plos One"},{"issue":"1","key":"2339_CR73","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.tox.2003.08.007","volume":"195","author":"JH Jeong","year":"2004","unstructured":"Jeong, J. H., H. J. Kim, T. J. Lee, M. K. Kim, E. S. Park, and B. S. Choi. 2004. Epigallocatechin 3-gallate attenuates neuronal damage induced by 3-hydroxykynurenine. Toxicology 195 (1): 53\u201360.","journal-title":"Toxicology"},{"issue":"11","key":"2339_CR74","doi-asserted-by":"publisher","first-page":"8538","DOI":"10.1007\/s12035-018-1003-2","volume":"55","author":"FS Ferreira","year":"2018","unstructured":"Ferreira, F. S., H. Biasibetti-Brendler, P. Pierozan, F. Schmitz, C. G. Bert\u00f3, C. A. Prezzi, V. Manfredini, and A. T. S. Wyse. 2018. Kynurenic acid restores Nrf2 levels and prevents quinolinic acid-Induced toxicity in rat striatal slices. Molecular Neurobiology 55 (11): 8538\u20138549.","journal-title":"Molecular Neurobiology"},{"issue":"4","key":"2339_CR75","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1007\/s12640-021-00368-4","volume":"39","author":"A Bhat","year":"2021","unstructured":"Bhat, A., V. Tan, B. Heng, S. Chow, S. Basappa, M. M. Essa, S. B. Chidambaram, and G. J. Guillemin. 2021. Papaverine, a phosphodiesterase 10a inhibitor, ameliorates quinolinic Acid-Induced synaptotoxicity in human cortical neurons. Neurotoxicity Research 39 (4): 1238\u20131250.","journal-title":"Neurotoxicity Research"},{"key":"2339_CR76","doi-asserted-by":"crossref","unstructured":"Sas, K., E. Szab\u00f3, and L. V\u00e9csei. 2018. Mitochondria, oxidative stress and the kynurenine system, with a focus on ageing and neuroprotection. Molecules 23 (1): 191.","DOI":"10.3390\/molecules23010191"},{"key":"2339_CR77","doi-asserted-by":"publisher","first-page":"2371895","DOI":"10.1155\/2017\/2371895","volume":"2017","author":"D Ram\u00edrez-Ortega","year":"2017","unstructured":"Ram\u00edrez-Ortega, D., A. Ramiro-Salazar, D. Gonz\u00e1lez-Esquivel, C. R\u00edos, B. Pineda, and V. P\u00e9rez de la Cruz. 2017. 3-Hydroxykynurenine and 3-Hydroxyanthranilic acid enhance the toxicity induced by copper in rat astrocyte culture. Oxidative Medicine and Cellular Longevity 2017:2371895.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"2339_CR78","first-page":"6","volume":"10","author":"EJ Han","year":"2021","unstructured":"Han, E. J., I. P. S. Fernando, H. S. Kim, D. S. Lee, A. Kim, J. G. Je, M. J. Seo, Y. H. Jee, Y. J. Jeon, S. Y. Kim, and G. Ahn. 2021. (-)-Loliolide isolated from Sargassum Horneri suppressed oxidative stress and inflammation by activating Nrf2\/Ho-1 signaling in Ifn-\u0393\/Tnf-\u0391-Stimulated Hacat keratinocytes. Antioxidants (Basel) 10:6.","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"2339_CR79","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1111\/bjd.16081","volume":"178","author":"EA Langan","year":"2018","unstructured":"Langan, E. A., C. E. M. Griffiths, W. Solbach, J. K. Knobloch, D. Zillikens, and D. Tha\u00e7i. 2018. The role of the Microbiome in psoriasis: Moving from disease description to treatment selection? British Journal of Dermatology 178 (5): 1020\u20131027.","journal-title":"British Journal of Dermatology"},{"key":"2339_CR80","doi-asserted-by":"crossref","unstructured":"Nikolaus, S., B. Schulte, N. Al-Massad, F. Thieme, D. M. Schulte, J. Bethge, A. Rehman, F. Tran, K. Aden, R. H\u00e4sler, N. Moll, G. Sch\u00fctze, M. J. Schwarz, G. H. Waetzig, P. Rosenstiel, M. Krawczak, S. Szymczak, and S. Schreiber. 2017. Increased Tryptophan metabolism is associated with activity of inflammatory bowel diseases. Gastroenterology 153 (6): 1504\u20131516.","DOI":"10.1053\/j.gastro.2017.08.028"},{"key":"2339_CR81","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/jcm13206147","volume":"13","author":"E Payda\u015f Hataysal","year":"2024","unstructured":"Payda\u015f Hataysal, E., M. K. K\u00f6rez, E. M. Guler, H. Vatansev, K. Bozal\u0131, M. Basaranoglu, and H. Vatansev. 2024. Impaired kynurenine pathway in inflammatory bowel disease. Journal of Clinical Medicine 13:20.","journal-title":"Journal of Clinical Medicine"},{"issue":"4","key":"2339_CR82","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/bjd\/ljac132","volume":"188","author":"EI Adesanya","year":"2023","unstructured":"Adesanya, E. I., J. Matthewman, Y. Schonmann, J. F. Hayes, A. Henderson, R. Mathur, A. R. Mulick, C. H. Smith, S. M. Langan, and K. E. Mansfield. 2023. Factors associated with depression, anxiety and severe mental illness among adults with atopic eczema or psoriasis: A systematic review and meta-Aaalysis. British Journal of Dermatology 188 (4): 460\u2013470.","journal-title":"British Journal of Dermatology"},{"issue":"6","key":"2339_CR83","first-page":"497","volume":"157","author":"F Bardazzi","year":"2022","unstructured":"Bardazzi, F., C. Bonci, L. Sacchelli, D. I. Altobrando, A. Iommi M., P. Rucci, P. Sacchelli, D. Berardi, A. Patrizi, and V. Tengattini. 2022. Suicide risk and depression in patients with psoriasis. Italian Journal of Dermatology and Venereology 157 (6): 497\u2013501.","journal-title":"Italian Journal of Dermatology and Venereology"},{"issue":"3","key":"2339_CR84","doi-asserted-by":"publisher","first-page":"e70019","DOI":"10.1111\/apha.70019","volume":"241","author":"EL Keenan","year":"2025","unstructured":"Keenan, E. L., and R. D. Granstein. 2025. Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxiety. Acta Physiologica\u00a0(Oxford) 241 (3): e70019.","journal-title":"Acta Physiologica\u00a0(Oxford)"},{"key":"2339_CR85","doi-asserted-by":"crossref","unstructured":"Tsuboi, H., H. Sakakibara, Y. Minamida, H. Tsujiguchi, M. Matsunaga, A. Hara, and H. Nakamura. 2018. Elevated levels of serum Il-17a in community-dwelling women with higher depressive symptoms. Behavioral Sciences (Basel) 8 (11): 102.","DOI":"10.3390\/bs8110102"},{"issue":"1","key":"2339_CR86","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s12974-018-1374-3","volume":"15","author":"P Ni","year":"2018","unstructured":"Ni, P., H. Dong, Y. Wang, Q. Zhou, M. Xu, Y. Qian, and J. Sun. 2018. Il-17a contributes to perioperative neurocognitive disorders through Blood-Brain barrier disruption in aged mice. Journal of Neuroinflammation 15 (1): 332.","journal-title":"Journal of Neuroinflammation"},{"key":"2339_CR87","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","volume":"81","author":"Z Liu","year":"2019","unstructured":"Liu, Z., A. W. Qiu, Y. Huang, Y. Yang, J. N. Chen, T. T. Gu, B. B. Cao, Y. H. Qiu, and Y. P. Peng. 2019. Il-17a exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of parkinson\u2019s disease. Brain, Behavior, and Immunity 81:630\u2013645.","journal-title":"Brain, Behavior, and Immunity"},{"issue":"3","key":"2339_CR88","first-page":"2954","volume":"20","author":"D Liu","year":"2019","unstructured":"Liu, D., X. Y. Hu, H. J. Xia, L. J. Wang, P. Shi, X. P. Chen, and Q. X. Zhou. 2019. Antidepressant effect of Venlafaxine in chronic unpredictable stress: Evidence of the involvement of key enzymes responsible for monoamine neurotransmitter synthesis and metabolism. Molecular Medicine Reports 20 (3): 2954\u20132962.","journal-title":"Molecular Medicine Reports"},{"issue":"4","key":"2339_CR89","doi-asserted-by":"publisher","first-page":"141","DOI":"10.5498\/wjp.v13.i4.141","volume":"13","author":"AA Badawy","year":"2023","unstructured":"Badawy, A. A., S. Dawood, and S. Bano. 2023. Kynurenine pathway of Tryptophan metabolism in pathophysiology and therapy of major depressive disorder. World Journal of Psychiatry 13 (4): 141\u2013148.","journal-title":"World Journal of Psychiatry"},{"key":"2339_CR90","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bbi.2022.07.011","volume":"105","author":"H Zheng","year":"2022","unstructured":"Zheng, H., T. K. Teague, F. C. Yeh, K. Burrows, L. K. Figueroa-Hall, R. L. Aupperle, S. S. Khalsa, M. P. Paulus, and J. Savitz. 2022. C-reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder. Brain, Behavior, and Immunity 105:180\u2013189.","journal-title":"Brain, Behavior, and Immunity"},{"key":"2339_CR91","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fimmu.2020.00031","volume":"11","author":"JR Moffett","year":"2020","unstructured":"Moffett, J. R., P. Arun, N. Puthillathu, R. Vengilote, J. A. Ives, A. A. Badawy, and A. M. Namboodiri. 2020. Quinolinate as a marker for kynurenine metabolite formation and the unresolved question of Nad(+) synthesis during inflammation and infection. Frontiers in Immunology 11:31.","journal-title":"Frontiers in Immunology"},{"key":"2339_CR92","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.pneurobio.2015.12.009","volume":"155","author":"CK Lim","year":"2017","unstructured":"Lim, C. K., F. J. Fern\u00e1ndez-Gomez, N. Braidy, C. Estrada, C. Costa, S. Costa, A. Bessede, E. Fernandez-Villalba, A. Zinger, M. T. Herrero, and G. J. Guillemin. 2017. Involvement of the kynurenine pathway in the pathogenesis of Parkinson\u2019s disease. Progress in Neurobiology 155:76\u201395.","journal-title":"Progress in Neurobiology"},{"key":"2339_CR93","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s10194-015-0581-x","volume":"16","author":"A Cs\u00e1ti","year":"2015","unstructured":"Cs\u00e1ti, A., L. Edvinsson, L. V\u00e9csei, J. Toldi, F. F\u00fcl\u00f6p, J. Tajti, and K. Warfvinge. 2015. Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion. The Journal of Headache and Pain 16:99.","journal-title":"The Journal of Headache and Pain"},{"key":"2339_CR94","doi-asserted-by":"publisher","first-page":"109169","DOI":"10.1016\/j.neuropharm.2022.109169","volume":"215","author":"Y Bansal","year":"2022","unstructured":"Bansal, Y., R. Singh, R. K. Sodhi, P. Khare, R. Dhingra, N. Dhingra, M. Bishnoi, K. K. Kondepudi, and A. Kuhad. 2022. Kynurenine monooxygenase Inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2\/Are pathway in mouse model of depression: In-vivo and in-silico studies. Neuropharmacology 215:109169.","journal-title":"Neuropharmacology"},{"issue":"3","key":"2339_CR95","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/ecco-jcc\/jjz152","volume":"14","author":"F Alinaghi","year":"2020","unstructured":"Alinaghi, F., H. G. Tekin, J. Burisch, J. J. Wu, J. P. Thyssen, and A. Egeberg. 2020. Global prevalence and bidirectional association between psoriasis and inflammatory bowel disease-a systematic review and meta-analysis. Journal of Crohn\u2019s and Colitis 14 (3): 351\u2013360.","journal-title":"Journal of Crohn's and Colitis"},{"issue":"2","key":"2339_CR96","doi-asserted-by":"publisher","first-page":"145","DOI":"10.4103\/ijdvl.IJDVL_875_17","volume":"85","author":"JY Lee","year":"2019","unstructured":"Lee, J. Y., S. Kang, J. M. Bae, S. J. Jo, S. J. Koh, and H. S. Park. 2019. Psoriasis increases the risk of concurrent inflammatory bowel disease: A Population-Based nationwide study in Korea. Indian Journal of Dermatology Venereology & Leprology 85 (2): 145\u2013152.","journal-title":"Indian Journal of Dermatology Venereology & Leprology"},{"issue":"6","key":"2339_CR97","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1159\/000500116","volume":"37","author":"M Cottone","year":"2019","unstructured":"Cottone, M., C. Sapienza, F. S. Macaluso, and M. Cannizzaro. 2019. Psoriasis and inflammatory bowel disease. Digestive Diseases 37 (6): 451\u2013457.","journal-title":"Digestive Diseases"},{"key":"2339_CR98","doi-asserted-by":"crossref","unstructured":"De Francesco, M. A., and A. Caruso. 2022. The gut microbiome in psoriasis and Crohn\u2019s disease: Is its perturbation a common denominator for their pathogenesis? Vaccines (Basel) 10 (2): 244.","DOI":"10.3390\/vaccines10020244"},{"issue":"2","key":"2339_CR99","doi-asserted-by":"publisher","first-page":"e13574","DOI":"10.1111\/srt.13574","volume":"30","author":"J Zhang","year":"2024","unstructured":"Zhang, J., S. Feng, M. Chen, W. Zhang, X. Zhang, S. Wang, X. Gan, Y. Zheng, and G. Wang. 2024. Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics. Skin Research and Technology: official Journal of International Society for Bioengineering and the Skin (Isbs) [And] International Society for Digital Imaging of Skin (Isdis) [And] International Society for Skin Imaging (Issi) 30 (2): e13574.","journal-title":"Skin Research and Technology: official Journal of International Society for Bioengineering and the Skin (Isbs) [And] International Society for Digital Imaging of Skin (Isdis) [And] International Society for Skin Imaging (Issi)"},{"issue":"1","key":"2339_CR100","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12974-021-02175-2","volume":"18","author":"LM Chen","year":"2021","unstructured":"Chen, L. M., C. H. Bao, Y. Wu, S. H. Liang, D. Wang, L. Y. Wu, Y. Huang, H. R. Liu, and H. G. Wu. 2021. Tryptophan-Kynurenine metabolism: A link between the gut and brain for depression in inflammatory bowel disease. Journal of Neuroinflammation 18 (1): 135.","journal-title":"Journal of Neuroinflammation"},{"key":"2339_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2020.12.026","volume":"123","author":"T Purton","year":"2021","unstructured":"Purton, T., L. Staskova, M. M. Lane, S. L. Dawson, M. West, J. Firth, G. Clarke, J. F. Cryan, M. Berk, A. O\u2019Neil, O. Dean, A. Hadi, C. Honan, and W. Marx. 2021. Prebiotic and probiotic supplementation and the Tryptophan-Kynurenine pathway: A systematic review and meta analysis. Neuroscience and Biobehavioral Reviews 123:1\u201313.","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"4","key":"2339_CR102","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.jaad.2012.08.015","volume":"68","author":"AW Armstrong","year":"2013","unstructured":"Armstrong, A. W., C. T. Harskamp, and E. J. Armstrong. 2013. Psoriasis and metabolic syndrome: A systematic review and Meta-Analysis of observational studies. Journal of the American Academy of Dermatology 68 (4): 654\u2013662.","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"4","key":"2339_CR103","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s40257-024-00857-0","volume":"25","author":"F Bellinato","year":"2024","unstructured":"Bellinato, F., M. Maurelli, D. Geat, G. Girolomoni, and P. Gisondi. 2024. Managing the patient with psoriasis and metabolic comorbidities. American Journal of Clinical Dermatology 25 (4): 527\u2013540.","journal-title":"American Journal of Clinical Dermatology"},{"issue":"12","key":"2339_CR104","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1080\/1744666X.2016.1201423","volume":"12","author":"A Chiricozzi","year":"2016","unstructured":"Chiricozzi, A., A. Raimondo, S. Lembo, F. Fausti, V. Dini, A. Costanzo, G. Monfrecola, N. Balato, F. Ayala, M. Romanelli, and A. Balato. 2016. Crosstalk between skin inflammation and adipose Tissue-Derived products: Pathogenic evidence linking psoriasis to increased adiposity. Expert Review of Clinical Immunology 12 (12): 1299\u20131308.","journal-title":"Expert Review of Clinical Immunology"},{"issue":"1","key":"2339_CR105","doi-asserted-by":"publisher","first-page":"2309305","DOI":"10.1080\/09546634.2024.2309305","volume":"35","author":"R Wang","year":"2024","unstructured":"Wang, R., C. Yu, Z. Tang, J. Sun, Y. Wang, Z. Zhao, B. Lin, and C. Li. 2024. Leptin induces altered differentiation of keratinocytes by inducing insulin resistance: Implications for metabolic Syndrome-Induced resistance of psoriatic therapy. The Journal of Dermatological Treatment 35 (1): 2309305.","journal-title":"The Journal of Dermatological Treatment"},{"issue":"4","key":"2339_CR106","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/rth2.12128","volume":"2","author":"Y Watanabe","year":"2018","unstructured":"Watanabe, Y., S. Koyama, A. Yamashita, Y. Matsuura, K. Nishihira, K. Kitamura, and Y. Asada. 2018. Indoleamine 2,3-Dioxygenase 1 in coronary atherosclerotic plaque enhances tissue factor expression in activated macrophages. Research and Practice in Thrombosis and Haemostasis 2 (4): 726\u2013735.","journal-title":"Research and Practice in Thrombosis and Haemostasis"},{"issue":"1","key":"2339_CR107","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1038\/s41467-022-31126-5","volume":"13","author":"T Huang","year":"2022","unstructured":"Huang, T., J. Song, J. Gao, J. Cheng, H. Xie, L. Zhang, Y. H. Wang, Z. Gao, Y. Wang, X. Wang, J. He, S. Liu, Q. Yu, S. Zhang, F. Xiong, Q. Zhou, and C. Y. Wang. 2022. Adipocyte-Derived kynurenine promotes obesity and insulin resistance by activating the Ahr\/Stat3\/Il-6 signaling. Nature Communications 13 (1): 3489.","journal-title":"Nature Communications"},{"issue":"5","key":"2339_CR108","doi-asserted-by":"publisher","first-page":"e22243","DOI":"10.1002\/ddr.22243","volume":"85","author":"Z Al-Qahtani","year":"2024","unstructured":"Al-Qahtani, Z., H. M. Al-Kuraishy, N. H. Ali, Y. H. A. Elewa, and G. E. Batiha. 2024. Kynurenine pathway in type 2 diabetes: role of metformin. Drug Development Research 85 (5): e22243.","journal-title":"Drug Development Research"},{"key":"2339_CR109","doi-asserted-by":"crossref","unstructured":"Zhou, Y., L. Han, Z. Wang, R. Fang, Y. Wan, Z. Yang, N. Guan, J. Li, and Q. Ni. 2023. Bioinformatic analysis of the potential common pathogenic mechanisms for psoriasis and metabolic syndrome. Inflammation 46 (4): 1381\u20131395.","DOI":"10.1007\/s10753-023-01815-4"},{"key":"2339_CR110","doi-asserted-by":"crossref","unstructured":"Bernard, A., C. Le May, A. Dastugue, A. Ayer, C. Blanchard, J. C. Martin, J. P. Pais de Barros, P. Delaby, C. Le Bourgot, S. Ledoux, and P. Besnard. 2021. The tryptophan\/kynurenine pathway: a novel cross-talk between nutritional obesity, bariatric surgery and taste of fat. Nutrients 13 (4): 1366.","DOI":"10.3390\/nu13041366"},{"issue":"3","key":"2339_CR111","doi-asserted-by":"publisher","first-page":"C444","DOI":"10.1152\/ajpcell.00448.2018","volume":"316","author":"DJ Allison","year":"2019","unstructured":"Allison, D. J., J. P. Nederveen, T. Snijders, K. E. Bell, D. Kumbhare, S. M. Phillips, G. Parise, and J. J. Heisz. 2019. Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway. American Journal of Physiology Cell Physiology 316 (3): C444\u2013C448.","journal-title":"American Journal of Physiology Cell Physiology"},{"issue":"1","key":"2339_CR112","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12929-017-0382-4","volume":"24","author":"MJ Paiva-Lopes","year":"2017","unstructured":"Paiva-Lopes, M. J., and J. Delgado Alves. 2017. Psoriasis-associated vascular disease: The role of Hdl. Journal of Biomedical Science 24 (1): 73.","journal-title":"Journal of Biomedical Science"},{"issue":"5","key":"2339_CR113","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1007\/s12325-020-01346-6","volume":"37","author":"W Masson","year":"2020","unstructured":"Masson, W., M. Lobo, and G. Molinero. 2020. Psoriasis and cardiovascular risk: A comprehensive review. Advances in Therapy 37 (5): 2017\u20132033.","journal-title":"Advances in Therapy"},{"issue":"1","key":"2339_CR114","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/jdv.15159","volume":"33","author":"JM Fern\u00e1ndez-Armenteros","year":"2019","unstructured":"Fern\u00e1ndez-Armenteros, J. M., X. G\u00f3mez-Arbon\u00e9s, M. Buti-Soler, A. Betriu-Bars, V. Sanmartin-Novell, M. Ortega-Bravo, M. Mart\u00ednez-Alonso, E. Gar\u00ed, M. Portero-Ot\u00edn, L. Santamaria-Babi, and J. M. Casanova-Seuma. 2019. Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study. Journal of the European Academy of Dermatology and Venereology 33 (1): 128\u2013135.","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"issue":"4","key":"2339_CR115","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1159\/000501483","volume":"44","author":"TB Dschietzig","year":"2019","unstructured":"Dschietzig, T. B., K. H. Kellner, K. Sasse, F. Boschann, R. Kl\u00fcsener, J. Ruppert, F. P. Armbruster, D. Bankovic, A. Meinitzer, V. Mitrovic, and C. Melzer. 2019. Plasma kynurenine predicts severity and complications of heart failure and associates with established biochemical and clinical markers of disease. Kidney & Blood Pressure Research 44 (4): 765\u2013776.","journal-title":"Kidney & Blood Pressure Research"},{"issue":"3","key":"2339_CR116","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1161\/CIRCRESAHA.114.302113","volume":"114","author":"Q Wang","year":"2014","unstructured":"Wang, Q., M. Zhang, Y. Ding, Q. Wang, W. Zhang, P. Song, and M. H. Zou. 2014. Activation of Nad(P)H oxidase by Tryptophan-derived 3-Hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo. Circulation Research 114 (3): 480\u2013492.","journal-title":"Circulation Research"},{"issue":"12","key":"2339_CR117","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1093\/cvr\/cvz258","volume":"116","author":"M Berg","year":"2020","unstructured":"Berg, M., K. A. Polyzos, H. Agardh, R. Baumgartner, M. J. Forteza, I. Kareinen, A. Gister\u00e5, G. Bottcher, E. Hurt-Camejo, G. K. Hansson, and D. F. J. Ketelhuth. 2020. 3-Hydroxyanthralinic acid metabolism controls the hepatic srebp\/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr-\/- mice. Cardiovascular Research 116 (12): 1948\u20131957.","journal-title":"Cardiovascular Research"}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02339-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10753-025-02339-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10753-025-02339-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T01:03:27Z","timestamp":1766451807000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10753-025-02339-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":117,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2339"],"URL":"https:\/\/doi.org\/10.1007\/s10753-025-02339-9","relation":{},"ISSN":["1573-2576"],"issn-type":[{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"2 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}